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Chowdhury","year":"2014"},{"key":"ref51","first-page":"12756","article-title":"Prohibitin Interacts with envelope proteins of white spot syndrome virus and prevents infection in the red swamp crayfish, Procambarus clarkii","volume":"87","author":"J. F. Lan","year":"2013"},{"key":"ref52","first-page":"5686","article-title":"Human SCARB2-dependent infection by coxsackievirus A7, A14, and A16 and enterovirus 71","volume":"86","author":"S. Yamayoshi","year":"2012"},{"key":"ref53","first-page":"103","article-title":"Viral and host proteins involved in picornavirus life cycle","volume":"16","author":"J. Y. Lin","year":"2009"},{"key":"ref54","first-page":"143","article-title":"The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease","volume":"59","author":"L. G. 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Thuaud","year":"2013"},{"key":"ref59","first-page":"2121","article-title":"A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection","volume":"86","author":"W. X. Khong","year":"2012"},{"key":"ref60","first-page":"3845","article-title":"Stomatin-like protein 2 binds cardiolipin and regulates mitochondrial biogenesis and function","volume":"31","author":"D. A. Christie","year":"2011"},{"key":"ref61","first-page":"10314","article-title":"Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling","volume":"83","author":"C. T. 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