{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:50:53Z","timestamp":1792025453629,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006788","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000}}],"reference-count":110,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Health and Medical Research Council (AU)","award":["APP1078468"],"award-info":[{"award-number":["APP1078468"]}]},{"name":"Australian Infectious Disease Research Centre","award":["Intramural seed funding"],"award-info":[{"award-number":["Intramural seed funding"]}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["Principle Research Fellowship"],"award-info":[{"award-number":["Principle Research Fellowship"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008914","name":"Advance Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005927","name":"Daiichi Sankyo Foundation of Life Science (JP)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005927","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sao Paulo Research Foundation"},{"name":"Queensland Tropical Health Alliance","award":["BSL3 equipment"],"award-info":[{"award-number":["BSL3 equipment"]}]},{"name":"Professor Ed Westaway (Roya Australian Air Force Association)"},{"name":"Dr Jim Aylward (Oncolin Pty Ltd)"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006788","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T19:15:19Z","timestamp":1514402119000},"page":"e1006788","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Lower temperatures reduce type I interferon activity and promote alphaviral arthritis"],"prefix":"10.1371","volume":"13","author":[{"given":"Natalie A.","family":"Prow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7159-3961","authenticated-orcid":true,"given":"Adam","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee S.","family":"Poo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3967-8121","authenticated-orcid":true,"given":"Thiago D. C.","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5297-9108","authenticated-orcid":true,"given":"Helder I.","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii","family":"Slonchak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3141-8410","authenticated-orcid":true,"given":"Suresh","family":"Mahalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne A.","family":"Schroder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Klimstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-9025","authenticated-orcid":true,"given":"Andreas","family":"Suhrbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1547-5069.1997.tb01145.x","article-title":"Sister Elizabeth Kenny, an Australian nurse, and treatment of poliomyelitis victims","volume":"29","author":"SR Oppewal","year":"1997","journal-title":"Image J Nurs Sch"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1891\/1062-8061.18.189","article-title":"Nurse Irene Shea studies the &quot;Kenny method&quot; of treatment of infantile paralysis, 1942\u20131943","volume":"18","author":"J Golden","year":"2010","journal-title":"Nurs Hist Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e1000791","DOI":"10.1371\/journal.ppat.1000791","article-title":"Limited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon response","volume":"6","author":"KZ Lancaster","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8496","DOI":"10.1073\/pnas.1601942113","article-title":"Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperature","volume":"113","author":"EF Foxman","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1073\/pnas.1411030112","article-title":"Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells","volume":"112","author":"EF Foxman","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","article-title":"Exposure to cold impairs interferon-induced antiviral defense","author":"C Boonarkart","year":"2017","journal-title":"Arch Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"E244","DOI":"10.3390\/v8090244","article-title":"A Decrease in Temperature and Humidity Precedes Human Rhinovirus Infections in a Cold Climate","volume":"8","author":"TM Ikaheimo","year":"2016","journal-title":"Viruses"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e0125874","DOI":"10.1371\/journal.pone.0125874","article-title":"Environmental Conditions Affect Exhalation of H3N2 Seasonal and Variant Influenza Viruses and Respiratory Droplet Transmission in Ferrets","volume":"10","author":"KM Gustin","year":"2015","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/infdis\/145.4.520","article-title":"Elevation of nasal viral levels by suppression of fever in ferrets infected with influenza viruses of differing virulence","volume":"145","author":"RH Husseini","year":"1982","journal-title":"J Infect Dis"},{"issue":"Suppl 1","key":"ref10","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1016\/j.ctim.2011.08.002","article-title":"Perspective on fever: the basic science and conventional medicine","volume":"21","author":"JG Cannon","year":"2013","journal-title":"Complement Ther Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"20132570","DOI":"10.1098\/rspb.2013.2570","article-title":"Population-level effects of suppressing fever","volume":"281","author":"DJ Earn","year":"2014","journal-title":"Proc Biol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0140-6736(91)91648-E","article-title":"Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin","volume":"337","author":"MS Kramer","year":"1991","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"20176","DOI":"10.1073\/pnas.1304291110","article-title":"Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature","volume":"110","author":"KM Kokolus","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fsi.2017.07.029","article-title":"The influence of temperature on viral replication and antiviral-related genes response in hirame rhabdovirus-infected flounder (Paralichthys olivaceus)","volume":"68","author":"J Zhang","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.fsi.2012.03.025","article-title":"Temperature-dependent viral replication and antiviral apoptotic response in viral haemorrhagic septicaemia virus (VHSV)-infected olive flounder (Paralichthys olivaceus)","volume":"32","author":"S Avunje","year":"2012","journal-title":"Fish Shellfish Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.fsi.2013.02.012","article-title":"Impaired TLR2 and TLR7 response in olive flounder infected with viral haemorrhagic septicaemia virus at host susceptible 15 degrees C but high at non-susceptible 20 degrees C","volume":"34","author":"S Avunje","year":"2013","journal-title":"Fish Shellfish Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e2239","DOI":"10.1371\/journal.pntd.0002239","article-title":"Cooler temperatures destabilize RNA interference and increase susceptibility of disease vector mosquitoes to viral infection","volume":"7","author":"ZN Adelman","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrrheum.2012.64","article-title":"Arthritogenic alphaviruses\u2014an overview","volume":"8","author":"A Suhrbier","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.antiviral.2015.04.016","article-title":"Chikungunya: Evolutionary history and recent epidemic spread","volume":"120","author":"SC Weaver","year":"2015","journal-title":"Antiviral Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12916-015-0348-x","article-title":"Emergence and potential for spread of Chikungunya virus in Brazil","volume":"13","author":"MR Nunes","year":"2015","journal-title":"BMC Med"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.EI10-0017-2016","article-title":"Chikungunya Virus: Current Perspectives on a Reemerging Virus","volume":"4","author":"CR Morrison","year":"2016","journal-title":"Microbiol Spectr"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijid.2017.03.006","article-title":"Global expansion of chikungunya virus: mapping the 64-year history","volume":"58","author":"B Wahid","year":"2017","journal-title":"Int J Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1128\/CMR.14.4.909-932.2001","article-title":"Ross River virus transmission, infection, and disease: a cross-disciplinary review","volume":"14","author":"D Harley","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e0003603","DOI":"10.1371\/journal.pntd.0003603","article-title":"Specific management of post-chikungunya rheumatic disorders: a retrospective study of 159 cases in Reunion Island from 2006\u20132012","volume":"9","author":"E Javelle","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.3201\/eid1911.130777","article-title":"Mayaro virus infection, Amazon Basin region, Peru, 2010\u20132013","volume":"19","author":"ES Halsey","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1086\/517537","article-title":"Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients","volume":"44","author":"G Borgherini","year":"2007","journal-title":"Clin Infect Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e1006155","DOI":"10.1371\/journal.ppat.1006155","article-title":"RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation","volume":"13","author":"JA Wilson","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pharmthera.2009.09.005","article-title":"The immunobiology of viral arthritides","volume":"124","author":"A Suhrbier","year":"2009","journal-title":"Pharmacol Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1172\/JCI84417","article-title":"Chikungunya virus: epidemiology, replication, disease mechanisms, and prospective intervention strategies","volume":"127","author":"LA Silva","year":"2017","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.4049\/jimmunol.0900255","article-title":"Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response","volume":"184","author":"JJ Hoarau","year":"2010","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/1529-0131(200002)43:2<365::AID-ANR16>3.0.CO;2-E","article-title":"Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infection","volume":"43","author":"M Soden","year":"2000","journal-title":"Arthritis Rheum"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1128\/JVI.02603-09","article-title":"Chikungunya virus arthritis in adult wild-type mice","volume":"84","author":"J Gardner","year":"2010","journal-title":"J Virol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1128\/JVI.80.2.737-749.2006","article-title":"Characterization of Ross River virus tropism and virus-induced inflammation in a mouse model of viral arthritis and myositis","volume":"80","author":"TE Morrison","year":"2006","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1002\/art.24682","article-title":"Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins","volume":"60","author":"NE Rulli","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1371\/journal.ppat.0040029","article-title":"A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease","volume":"4","author":"T Couderc","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e3354","DOI":"10.1371\/journal.pntd.0003354","article-title":"Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection","volume":"8","author":"YS Poo","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"S482","DOI":"10.1093\/infdis\/jiw284","article-title":"Animal Models of Chikungunya Virus Infection and Disease","volume":"214","author":"NN Haese","year":"2016","journal-title":"J Infect Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-065X.2008.00670.x","article-title":"Host responses to alphavirus infection","volume":"225","author":"KD Ryman","year":"2008","journal-title":"Immunol Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1084\/jem.20090851","article-title":"Type I IFN controls chikungunya virus via its action on nonhematopoietic cells","volume":"207","author":"C Schilte","year":"2010","journal-title":"J Exp Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40475-015-0037-z","article-title":"Protective and Pathogenic Responses to Chikungunya Virus Infection","volume":"2","author":"KM Long","year":"2015","journal-title":"Curr Trop Med Rep"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1128\/JVI.00956-12","article-title":"Interferon response factors 3 and 7 protect against chikungunya virus hemorrhagic fever and shock","volume":"86","author":"PA Rudd","year":"2012","journal-title":"J Virol"},{"key":"ref42","article-title":"Persistent RNA virus infections: do PAMPS drive chronic disease?","author":"MK McCarthy","year":"2017","journal-title":"Curr Opin Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI40104","article-title":"Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages","volume":"120","author":"K Labadie","year":"2010","journal-title":"J Clin Invest"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1099\/jgv.0.000002","article-title":"Monoclonal antibodies specific for the capsid protein of chikungunya virus suitable for multiple applications","volume":"96","author":"LY Goh","year":"2015","journal-title":"J Gen Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2106\/00004623-200209000-00009","article-title":"Ice reduces edema. A study of microvascular permeability in rats","volume":"84-A","author":"DN Deal","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3181\/00379727-136-35272","article-title":"Kinetics of serum interferon response in mice after single and multiple injections of polyI-poly C","volume":"136","author":"CE Buckler","year":"1971","journal-title":"Proc Soc Exp Biol Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/art.21517","article-title":"Requirement of type I interferon signaling for arthritis triggered by double-stranded RNA","volume":"54","author":"M Magnusson","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nature03464","article-title":"IRF-7 is the master regulator of type-I interferon-dependent immune responses","volume":"434","author":"K Honda","year":"2005","journal-title":"Nature"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S1074-7613(00)00053-4","article-title":"Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha\/beta gene induction","volume":"13","author":"M Sato","year":"2000","journal-title":"Immunity"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jcv.2015.11.017","article-title":"Study of viremic profile in febrile specimens of chikungunya in Bandung, Indonesia","volume":"74","author":"SF Riswari","year":"2016","journal-title":"J Clin Virol"},{"key":"ref51","first-page":"965","article-title":"Skin temperatures in children","volume":"42","author":"FB Talbot","year":"1931","journal-title":"Am J Dis Child"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1128\/JVI.79.7.4460-4469.2005","article-title":"The alpha\/beta interferon response controls tissue tropism and pathogenicity of poliovirus","volume":"79","author":"M Ida-Hosonuma","year":"2005","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"17022","DOI":"10.1038\/nmicrobiol.2017.22","article-title":"Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation","volume":"2","author":"S Soonthornvacharin","year":"2017","journal-title":"Nat Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1101\/gr.169508.113","article-title":"ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs","volume":"24","author":"PJ Balwierz","year":"2014","journal-title":"Genome Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(01)00611-0","article-title":"XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor","volume":"107","author":"H Yoshida","year":"2001","journal-title":"Cell"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12864-016-2664-8","article-title":"The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation","volume":"17","author":"J Zhao","year":"2016","journal-title":"BMC Genomics"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.4049\/jimmunol.1500204","article-title":"ATF3 Is a Key Regulator of Macrophage IFN Responses","volume":"195","author":"LI Labzin","year":"2015","journal-title":"J Immunol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.4049\/jimmunol.0902579","article-title":"Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3","volume":"184","author":"R Takii","year":"2010","journal-title":"J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/ni.2784","article-title":"High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3","volume":"15","author":"D De Nardo","year":"2014","journal-title":"Nat Immunol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1083\/jcb.201503107","article-title":"The unpredictability of prolonged activation of stress response pathways","volume":"209","author":"LT Lamech","year":"2015","journal-title":"J Cell Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"E152","DOI":"10.1073\/pnas.1619234114","article-title":"Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response","volume":"114","author":"MC Truttmann","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00294-016-0638-7","article-title":"Size doesn\u2019t matter in the heat shock response","volume":"63","author":"D Pincus","year":"2017","journal-title":"Curr Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/rheumatology\/35.9.909","article-title":"Dengue arthritis","volume":"35","author":"AO Adebajo","year":"1996","journal-title":"Br J Rheumatol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1128\/IAI.40.1.22-28.1983","article-title":"Prospective immunological assessment of arthritis induced by rubella vaccine","volume":"40","author":"AJ Tingle","year":"1983","journal-title":"Infect Immun"},{"key":"ref65","first-page":"2444","article-title":"Parvovirus arthropathy outbreak in southwestern United States","volume":"27","author":"DA Scroggie","year":"2000","journal-title":"J Rheumatol"},{"key":"ref66","first-page":"770","article-title":"Viral arthritis","volume":"42","author":"R Holland","year":"2013","journal-title":"Aust Fam Physician"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e0005987","DOI":"10.1371\/journal.pntd.0005987","article-title":"Health-related impact on quality of life and coping strategies for chikungunya: A qualitative study in Curacao","volume":"11","author":"J Elsinga","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref68","article-title":"Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection","author":"R Abdelnabi","year":"2017","journal-title":"Antiviral Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"601","DOI":"10.4269\/ajtmh.1986.35.601","article-title":"Air conditioning and television as protective factors in arboviral encephalitis risk","volume":"35","author":"PM Gahlinger","year":"1986","journal-title":"Am J Trop Med Hyg"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"356","DOI":"10.5694\/j.1326-5377.2002.tb04837.x","article-title":"Natural history of Ross River virus-induced epidemic polyarthritis","volume":"177","author":"AD Mylonas","year":"2002","journal-title":"Med J Aust"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.medmal.2015.05.007","article-title":"French guidelines for the management of chikungunya (acute and persistent presentations). November 2014","volume":"45","author":"F Simon","year":"2015","journal-title":"Med Mal Infect"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"S471","DOI":"10.1093\/infdis\/jiw274","article-title":"Laboratory Diagnosis of Chikungunya Virus Infections and Commercial Sources for Diagnostic Assays","volume":"214","author":"BW Johnson","year":"2016","journal-title":"J Infect Dis"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"7955","DOI":"10.1128\/JVI.00909-15","article-title":"Caribbean and La Reunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology","volume":"89","author":"TH Teo","year":"2015","journal-title":"J Virol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1128\/JVI.00370-14","article-title":"High level of vector competence of Aedes aegypti and Aedes albopictus from ten American countries as a crucial factor in the spread of Chikungunya virus","volume":"88","author":"A Vega-Rua","year":"2014","journal-title":"J Virol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1186\/s13071-016-1838-1","article-title":"Chikungunya virus transmission between Aedes albopictus and laboratory mice","volume":"9","author":"LE Hugo","year":"2016","journal-title":"Parasit Vectors"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fmicb.2014.00222","article-title":"A new paradigm: innate immune sensing of viruses via the unfolded protein response","volume":"5","author":"JA Smith","year":"2014","journal-title":"Front Microbiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/ni.2991","article-title":"Emerging functions of the unfolded protein response in immunity","volume":"15","author":"S Janssens","year":"2014","journal-title":"Nat Immunol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3389\/fmicb.2016.01233","article-title":"Interplay between Inflammation and Cellular Stress Triggered by Flaviviridae Viruses","volume":"7","author":"AL Valadao","year":"2016","journal-title":"Front Microbiol"},{"key":"ref79","article-title":"Inflammation initiated by stressed organelles","author":"F Martinon","year":"2017","journal-title":"Joint Bone Spine"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"e12734","DOI":"10.1111\/cmi.12734","article-title":"The role of the unfolded protein response in dengue virus pathogenesis","volume":"19","author":"N Perera","year":"2017","journal-title":"Cell Microbiol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"FSO198","DOI":"10.4155\/fsoa-2017-0020","article-title":"Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites","volume":"3","author":"L Galluzzi","year":"2017","journal-title":"Future Sci OA"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.4049\/jimmunol.1102737","article-title":"Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3","volume":"189","author":"YP Liu","year":"2012","journal-title":"J Immunol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/eji.201040831","article-title":"ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells","volume":"41","author":"F Hu","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cyto.2017.04.006","article-title":"TLR7-mediated activation of XBP1 correlates with the IFNalpha production in humans","volume":"94","author":"C Beisel","year":"2017","journal-title":"Cytokine"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.chom.2013.03.011","article-title":"The unfolded protein response element IRE1alpha senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling","volume":"13","author":"JA Cho","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.fsi.2017.06.055","article-title":"Molecular characterization and expression pattern of X box-binding protein-1 (XBP1) in common carp (Cyprinus carpio L.): Indications for a role of XBP1 in antibacterial and antiviral immunity","volume":"67","author":"T Li","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.4049\/jimmunol.0903052","article-title":"XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages","volume":"185","author":"L Zeng","year":"2010","journal-title":"J Immunol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.it.2015.05.006","article-title":"Innate immunity at mucosal surfaces: the IRE1-RIDD-RIG-I pathway","volume":"36","author":"WI Lencer","year":"2015","journal-title":"Trends Immunol"},{"key":"ref89","first-page":"487","article-title":"Type 1 plasminogen activator inhibitor: its role in biological reactions","volume":"32","author":"J Mimuro","year":"1991","journal-title":"Rinsho Ketsueki"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1073\/pnas.032307099","article-title":"Type I collagen is thermally unstable at body temperature","volume":"99","author":"E Leikina","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1083\/jcb.122.6.1267","article-title":"Protein denaturation in intact hepatocytes and isolated cellular organelles during heat shock","volume":"122","author":"JR Lepock","year":"1993","journal-title":"J Cell Biol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nmeth.3475","article-title":"Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells","volume":"12","author":"I Konig","year":"2015","journal-title":"Nat Methods"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.clpt.6100055","article-title":"GARDASIL: prophylactic human papillomavirus vaccine development\u2014from bench top to bed-side","volume":"81","author":"L Shi","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"761","DOI":"10.15252\/embj.201695000","article-title":"Protein synthesis inhibition and GADD34 control IFN-beta heterogeneous expression in response to dsRNA","volume":"36","author":"A Dalet","year":"2017","journal-title":"EMBO J"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"e1002708","DOI":"10.1371\/journal.ppat.1002708","article-title":"Induction of GADD34 is necessary for dsRNA-dependent interferon-beta production and participates in the control of Chikungunya virus infection","volume":"8","author":"G Clavarino","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1099\/vir.0.071845-0","article-title":"Chikungunya virus non-structural protein 2-mediated host shut-off disables the unfolded protein response","volume":"96","author":"JJ Fros","year":"2015","journal-title":"J Gen Virol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"e11275","DOI":"10.7554\/eLife.11275","article-title":"Comparative analysis of viral RNA signatures on different RIG-I-like receptors","volume":"5","author":"RY Sanchez David","year":"2016","journal-title":"Elife"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fmicb.2014.00292","article-title":"Can\u2019t RIDD off viruses","volume":"5","author":"S Bhattacharyya","year":"2014","journal-title":"Front Microbiol"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.molimm.2013.07.009","article-title":"microRNA control of interferons and interferon induced anti-viral activity","volume":"56","author":"LM Sedger","year":"2013","journal-title":"Mol Immunol"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1089\/jir.2013.0117","article-title":"Post-transcriptional regulation of interferons and their signaling pathways","volume":"34","author":"R Savan","year":"2014","journal-title":"J Interferon Cytokine Res"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2702.2009.02945.x","article-title":"A systematic review of body temperature variations in older people","volume":"19","author":"SH Lu","year":"2010","journal-title":"J Clin Nurs"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1111\/j.1365-2702.2007.02272.x","article-title":"Does the body temperature change in older people?","volume":"17","author":"UY Gunes","year":"2008","journal-title":"J Clin Nurs"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.3201\/eid1212.060710","article-title":"Chikungunya disease outbreak, Reunion Island","volume":"12","author":"L Josseran","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"727","DOI":"10.4269\/ajtmh.2007.77.727","article-title":"A major epidemic of chikungunya virus infection on Reunion Island, France, 2005\u20132006","volume":"77","author":"P Renault","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.pt.2017.04.003","article-title":"Mosquito Biting Modulates Skin Response to Virus Infection","volume":"33","author":"M Pingen","year":"2017","journal-title":"Trends Parasitol"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1289\/ehp.1408104","article-title":"Global Association of Cold Spells and Adverse Health Effects: A Systematic Review and Meta-Analysis","volume":"124","author":"NR Ryti","year":"2016","journal-title":"Environ Health Perspect"},{"key":"ref107","article-title":"Temperature dependence of multiple sclerosis mortality rates in the United States","author":"H Sun","year":"2017","journal-title":"Mult Scler"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"e34866","DOI":"10.1371\/journal.pone.0034866","article-title":"Seasonal distribution of psychiatric births in England","volume":"7","author":"G Disanto","year":"2012","journal-title":"PLoS One"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.4049\/jimmunol.178.12.7540","article-title":"Type I IFN contributes to NK cell homeostasis, activation, and antitumor function","volume":"178","author":"JB Swann","year":"2007","journal-title":"J Immunol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.15252\/embr.201642195","article-title":"The integrated stress response","volume":"17","author":"K Pakos-Zebrucka","year":"2016","journal-title":"EMBO Rep"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006788","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T00:00:00Z","timestamp":1516060800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T10:04:09Z","timestamp":1660212249000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006788"}},"subtitle":[],"editor":[{"given":"Richard J.","family":"Kuhn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,27]]},"references-count":110,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006788","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006788","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,27]]}}}