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Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fifth Informational Supplement. CLSI document M100-S25 (ISBN 1-56238-989-0 [Print]; ISBN 1-56238-990-4 [Electronic]). Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087 USA, 2015."},{"key":"ref11","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 7.1, 2017. [Cited on 9 February 2018]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.eucast.org\" xlink:type=\"simple\">http:\/\/www.eucast.org<\/ext-link>."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1128\/AAC.00722-08","article-title":"Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant <italic>Escherichia coli<\/italic> clinical isolates","volume":"53","author":"L Becnel Boyd","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1128\/AAC.48.11.4460-4462.2004","article-title":"Quinolone-resistant <italic>Haemophilus influenzae<\/italic>: determination of mutant selection window for ciprofloxacin, garenoxacin, levofloxacin, and moxifloxacin","volume":"48","author":"X Li","year":"2004","journal-title":"Antimicrob Agents 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Morgan-Linnell","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/prot.22600","article-title":"Crystal structure of the DNA gyrase GyrA N-terminal domain from <italic>Mycobacterium tuberculosis<\/italic>","volume":"78","author":"EM Tretter","year":"2010","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bbapap.2008.11.005","article-title":"Outer membrane permeability and antibiotic resistance","volume":"1794","author":"AH Delcour","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/CMR.00043-12","article-title":"Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance","volume":"25","author":"L Fern\u00e1ndez","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/AAC.44.9.2233-2241.2000","article-title":"Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria","volume":"44","author":"K Poole","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1073\/pnas.0502890102","article-title":"Quorum sensing and multidrug transporters in <italic>Escherichia coli<\/italic>","volume":"103","author":"S Yang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.cell.2007.03.004","article-title":"Molecular mechanisms of antibacterial multidrug resistance","volume":"128","author":"MN Alekshun","year":"2007","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1128\/AAC.47.9.2831-2837.2003","article-title":"Role of AcrR and ramA in fluoroquinolone resistance in clinical <italic>Klebsiella pneumoniae<\/italic> isolates from Singapore","volume":"47","author":"T Schneiders","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1128\/AAC.45.5.1515-1521.2001","article-title":"Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical <italic>Escherichia coli<\/italic> Strains from China: Role of acrR Mutations","volume":"45","author":"H Wang","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1128\/AAC.45.1.38-43.2001","article-title":"A soxRS-Constitutive Mutation Contributing to Antibiotic Resistance in a Clinical Isolate of <italic>Salmonella enterica<\/italic> (<italic>Serovar Typhimurium<\/italic>)","volume":"45","author":"A Koutsolioutsou","year":"2001","journal-title":"Antimicrob Agents 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A"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1128\/AAC.00143-07","article-title":"Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in <italic>Escherichia coli<\/italic>","volume":"51","author":"B P\u00e9richon","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1128\/AAC.00339-07","article-title":"New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an <italic>Escherichia coli<\/italic> clinical isolate","volume":"51","author":"K Yamane","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm1347","article-title":"Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase","volume":"12","author":"A Robicsek","year":"2006","journal-title":"Nat Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"a025320","DOI":"10.1101\/cshperspect.a025320","article-title":"Topoisomerase inhibitors: Fluoroquinolone mechanisms of action and resistance","volume":"6","author":"DC Hooper","year":"2016","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1128\/AAC.00665-08","article-title":"Mechanisms accounting for fluoroquinolone resistance in <italic>Escherichia coli<\/italic> clinical isolates","volume":"53","author":"SK Morgan-Linnell","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e65961","DOI":"10.1371\/journal.pone.0065961","article-title":"Novel conserved genotypes correspond to antibiotic resistance phenotypes of <italic>E<\/italic>. <italic>coli<\/italic> clinical isolates","volume":"8","author":"MC Swick","year":"2013","journal-title":"PLoS ONE"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.anaerobe.2016.06.008","article-title":"Reclassification of <italic>Clostridium difficile<\/italic> as <italic>Clostridioides difficile<\/italic> (Hall and O\u2019Toole 1935) Prevot 1938","volume":"40","author":"PA Lawson","year":"2016","journal-title":"Anaerobe"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"S341","DOI":"10.1086\/382690","article-title":"\u201cCollateral Damage\u201d from cephalosporin or quinolone antibiotic therapy","volume":"38","author":"DL Paterson","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"17092","DOI":"10.1038\/nmicrobiol.2017.92","article-title":"A decade of discovery: CRISPR functions and applications","volume":"2","author":"R Barrangou","year":"2017","journal-title":"Nat Microbiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nature02241","article-title":"SOS response promotes horizontal dissemination of antibiotic resistance genes","volume":"427","author":"JW Beaber","year":"2004","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/AAC.00123-06","article-title":"Fluoroquinolone-Resistant Urinary Isolates of <italic>Escherichia coli<\/italic> from Outpatients Are Frequently Multidrug Resistant: Results from the North American Urinary Tract Infection Collaborative Alliance-Quinolone Resistance Study","volume":"50","author":"JA Karlowsky","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1086\/520427","article-title":"Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA)","volume":"29","author":"JW Warren","year":"1999","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"ref41","article-title":"Cipro loses share in traditional market, as doctors seek other cures in shortage","author":"S Hensley","year":"2001","journal-title":"Wall Street Journal"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","article-title":"International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases","volume":"52","author":"K Gupta","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref43","unstructured":"Antibiotic resistance threats in the United States, 2013 [Internet]. US Department of Health and Human Services Centers for Disease Control and Prevention; 2013[Cited 4 October 2017]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/<\/ext-link>."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1056\/NEJMoa051639","article-title":"A predominantly clonal multi-institutional outbreak of <italic>Clostridium difficile<\/italic>-associated diarrhea with high morbidity and mortality","volume":"353","author":"VG Loo","year":"2005","journal-title":"N Engl J Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1056\/NEJMoa051590","article-title":"An epidemic, toxin gene-variant strain of <italic>Clostridium difficile<\/italic>","volume":"353","author":"LC McDonald","year":"2005","journal-title":"N Engl J Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0140-6736(05)67420-X","article-title":"Toxin production by an emerging strain of <italic>Clostridium difficile<\/italic> associated with outbreaks of severe disease in North America and Europe","volume":"366","author":"M Warny","year":"2005","journal-title":"Lancet Lond Engl"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/cid\/civ254","article-title":"<italic>Clostridium difficile<\/italic> ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality","volume":"61","author":"K Rao","year":"2015","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ng.2478","article-title":"Emergence and global spread of epidemic healthcare-associated <italic>Clostridium difficile<\/italic>","volume":"45","author":"M He","year":"2013","journal-title":"Nat Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1093\/cid\/cir183","article-title":"Randomized, placebo-controlled phase 2 trial of a <italic>Lactobacillus crispatus<\/italic> probiotic given intravaginally for prevention of recurrent urinary tract infection","volume":"52","author":"AE Stapleton","year":"2011","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"ref50","unstructured":"Department of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Drug Use Review. 2012. [Cited 4 October 2017]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/InformationbyDrugClass\/UCM319435.pdf\" xlink:type=\"simple\">https:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/InformationbyDrugClass\/UCM319435.pdf<\/ext-link>."},{"key":"ref51","unstructured":"2011 Summary Report On Antimicrobials Sold or Distributed for Use in Food-Producing Animals. 2011. [Cited 4 October 2017]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.fda.gov\/downloads\/ForIndustry\/UserFees\/AnimalDrugUserFeeActADUFA\/UCM338170.pdf\" xlink:type=\"simple\">https:\/\/www.fda.gov\/downloads\/ForIndustry\/UserFees\/AnimalDrugUserFeeActADUFA\/UCM338170.pdf<\/ext-link>."},{"key":"ref52","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.watres.2017.07.061","article-title":"Fate of antibiotic resistance genes and their associations with bacterial community in livestock breeding wastewater and its receiving river water","volume":"124","author":"S Jia","year":"2017","journal-title":"Water Res"},{"key":"ref53","first-page":"188","article-title":"Molecular characterization of antibiotic resistance in cultivable multidrug-resistant bacteria from livestock manure","volume":"229","author":"Q Yang","year":"2017","journal-title":"Environ Pollut Barking Essex 1987"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/lam.12724","article-title":"Antibiotic resistance in <italic>Escherichia coli<\/italic> in husbandry animals: the African perspective","volume":"64","author":"CA Alonso","year":"2017","journal-title":"Lett Appl Microbiol"},{"key":"ref55","unstructured":"Critically important antimicrobials for human medicine 5th revision. World Health Organization. 2017. [Cited 4 October 2017]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/foodsafety\/publications\/antimicrobials-fifth\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/foodsafety\/publications\/antimicrobials-fifth\/en\/<\/ext-link>."},{"key":"ref56","unstructured":"Antimicrobial Resistance. World Organization for Animal Health. 2015. [Cited 4 October 2017]. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.oie.int\/fileadmin\/Home\/eng\/Media_Center\/docs\/pdf\/Fact_sheets\/ANTIBIO_EN.pdf\" xlink:type=\"simple\">http:\/\/www.oie.int\/fileadmin\/Home\/eng\/Media_Center\/docs\/pdf\/Fact_sheets\/ANTIBIO_EN.pdf<\/ext-link>."},{"key":"ref57","unstructured":"Fleming A. Penicillin\u2019s finder assays its future. New York Times. 26 Jun 1945: 21."},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1128\/JCM.02316-16","article-title":"In Vitro Activity of Imipenem against Carbapenemase-Positive Enterobacteriaceae Isolates Collected by the SMART Global Surveillance Program from 2008 to 2014","volume":"55","author":"JA Karlowsky","year":"2017","journal-title":"J Clin Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/ofid\/ofu051.75","article-title":"Can rapid molecular diagnostics assist in the choice of \u03b2-Lactam antibiotics? An analysis of data from PRIMERS-II of the Antibiotic Resistance Leadership Group (ARLG)","volume":"1","author":"AM Hujer","year":"2014","journal-title":"Open Forum Infect Dis"},{"key":"ref60","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500183","article-title":"The microbiome of uncontacted Amerindians","volume":"1","author":"JC Clemente","year":"2015","journal-title":"Sci Adv"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1128\/AAC.04819-14","article-title":"Amdinocillin (Mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of <italic>Escherichia coli<\/italic>","volume":"59","author":"E Thulin","year":"2015","journal-title":"Antimicrob Agents Chemother"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T22:04:05Z","timestamp":1603922645000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006805"}},"subtitle":[],"editor":[{"given":"William E.","family":"Goldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006805","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,1]]}}}