{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:48:38Z","timestamp":1791946118723,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006810","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI124093"],"award-info":[{"award-number":["R01 AI124093"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI007485"],"award-info":[{"award-number":["T32 AI007485"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI007485"],"award-info":[{"award-number":["T32 AI007485"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA086862"],"award-info":[{"award-number":["P30 CA086862"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006810","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T20:30:35Z","timestamp":1514925035000},"page":"e1006810","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":120,"title":["Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection"],"prefix":"10.1371","volume":"14","author":[{"given":"Megan E.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1229-7732","authenticated-orcid":true,"given":"Cory J.","family":"Knudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-113X","authenticated-orcid":true,"given":"Stacey M.","family":"Hartwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lecia L.","family":"Pewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Meyerholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A.","family":"Langlois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Harty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-4290","authenticated-orcid":true,"given":"Steven M.","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/INF.0b013e31812e52e6","article-title":"Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain","volume":"26","author":"C Calvo","year":"2007","journal-title":"The Pediatric infectious disease journal"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"e341","DOI":"10.1542\/peds.2013-0303","article-title":"Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age","volume":"132","author":"CB Hall","year":"2013","journal-title":"Pediatrics"},{"issue":"Suppl 1","key":"ref3","first-page":"77","article-title":"Respiratory syncytial virus infection in elderly and high-risk adults","volume":"31","author":"AR Falsey","year":"2005","journal-title":"Exp Lung Res"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1532-5415.1992.tb01929.x","article-title":"Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings","volume":"40","author":"AR Falsey","year":"1992","journal-title":"Journal of the American Geriatrics Society"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM198607103150201","article-title":"Respiratory syncytial viral infection in children with compromised immune function","volume":"315","author":"CB Hall","year":"1986","journal-title":"The New England journal of medicine"},{"issue":"9725","key":"ref6","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(10)60206-1","article-title":"Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis","volume":"375","author":"H Nair","year":"2010","journal-title":"Lancet"},{"issue":"15","key":"ref7","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","article-title":"Bronchiolitis-associated hospitalizations among US children, 1980\u20131996","volume":"282","author":"DK Shay","year":"1999","journal-title":"Jama"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1001\/archpedi.155.1.95","article-title":"The economic burden of respiratory syncytial virus-associated bronchiolitis hospitalizations","volume":"155","author":"P Stang","year":"2001","journal-title":"Archives of pediatrics & adolescent medicine"},{"issue":"5 Suppl","key":"ref9","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1067\/S0022-3476(03)00510-9","article-title":"Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000","volume":"143","author":"S Leader","year":"2003","journal-title":"The Journal of pediatrics"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00431-005-1705-0","article-title":"Economic impact of community-acquired and nosocomial lower respiratory tract infections in young children in Germany","volume":"164","author":"B Ehlken","year":"2005","journal-title":"European journal of pediatrics"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1586\/erp.12.45","article-title":"A review of cost-effectiveness of palivizumab for respiratory syncytial virus","volume":"12","author":"JM Hussman","year":"2012","journal-title":"Expert review of pharmacoeconomics & outcomes research"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1172\/JCI115362","article-title":"Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice","volume":"88","author":"BS Graham","year":"1991","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"ref13","first-page":"133","article-title":"Clearance of persistent respiratory syncytial virus infections in immunodeficient mice following transfer of primed T cells","volume":"62","author":"MJ Cannon","year":"1987","journal-title":"Immunology"},{"issue":"6","key":"ref14","first-page":"543","article-title":"Risk of primary infection and reinfection with respiratory syncytial virus","volume":"140","author":"WP Glezen","year":"1986","journal-title":"American journal of diseases of children"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0022-3476(81)80829-3","article-title":"Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level","volume":"98","author":"WP Glezen","year":"1981","journal-title":"The Journal of pediatrics"},{"issue":"21","key":"ref16","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1056\/NEJM199311183292102","article-title":"Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. The Respiratory Syncytial Virus Immune Globulin Study Group","volume":"329","author":"JR Groothuis","year":"1993","journal-title":"The New England journal of medicine"},{"issue":"24","key":"ref17","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1016\/S0264-410X(03)00355-4","article-title":"Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies","volume":"21","author":"PA Piedra","year":"2003","journal-title":"Vaccine"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"e1004757","DOI":"10.1371\/journal.ppat.1004757","article-title":"RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets","volume":"11","author":"CJ Knudson","year":"2015","journal-title":"PLoS pathogens"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1128\/JVI.66.12.7444-7451.1992","article-title":"Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB\/c mice is abrogated by depletion of CD4+ T cells","volume":"66","author":"M Connors","year":"1992","journal-title":"Journal of virology"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1084\/jem.179.1.81","article-title":"Distinct types of lung disease caused by functional subsets of antiviral T cells","volume":"179","author":"WH Alwan","year":"1994","journal-title":"The Journal of experimental medicine"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1365-2249.1992.tb06482.x","article-title":"CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells","volume":"88","author":"WH Alwan","year":"1992","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.168.3.1163","article-title":"Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus","volume":"168","author":"MJ Cannon","year":"1988","journal-title":"The Journal of experimental medicine"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/1521-4141(200208)32:8<2117::AID-IMMU2117>3.0.CO;2-C","article-title":"Virus clearance and immunopathology by CD8(+) T cells during infection with respiratory syncytial virus are mediated by IFN-gamma","volume":"32","author":"T Ostler","year":"2002","journal-title":"European journal of immunology"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/infdis\/163.4.693","article-title":"Immunity to and frequency of reinfection with respiratory syncytial virus","volume":"163","author":"CB Hall","year":"1991","journal-title":"The Journal of infectious diseases"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.immuni.2013.09.013","article-title":"Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus","volume":"39","author":"B Slutter","year":"2013","journal-title":"Immunity"},{"issue":"19","key":"ref26","doi-asserted-by":"crossref","first-page":"11034","DOI":"10.1128\/JVI.01505-14","article-title":"Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection","volume":"88","author":"R Channappanavar","year":"2014","journal-title":"Journal of virology"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm1257","article-title":"Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination","volume":"11","author":"VP Badovinac","year":"2005","journal-title":"Nature medicine"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/514208","article-title":"Respiratory syncytial virus affects pulmonary function in BALB\/c mice","volume":"177","author":"SM van Schaik","year":"1998","journal-title":"The Journal of infectious diseases"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1465-9921-8-6","article-title":"Human metapneumovirus induces more severe disease and stronger innate immune response in BALB\/c mice as compared with respiratory syncytial virus","volume":"8","author":"B Huck","year":"2007","journal-title":"Respiratory research"},{"key":"ref30","first-page":"376","article-title":"Ackerman\u2019s Surgical Pathology","author":"J Rosai","year":"2004"},{"issue":"10058","key":"ref31","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/S0140-6736(16)00578-X","article-title":"Acute respiratory distress syndrome","volume":"388","author":"RM Sweeney","year":"2016","journal-title":"Lancet"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.4049\/jimmunol.179.12.8264","article-title":"Influence of a single viral epitope on T cell response and disease after infection of mice with respiratory syncytial virus","volume":"179","author":"S Vallbracht","year":"2007","journal-title":"Journal of immunology"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.4049\/jimmunol.167.8.4254","article-title":"Visualization and characterization of respiratory syncytial virus F-specific CD8(+) T cells during experimental virus infection","volume":"167","author":"J Chang","year":"2001","journal-title":"Journal of immunology"},{"issue":"19","key":"ref34","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1128\/JVI.00816-11","article-title":"Major histocompatibility complex-dependent cytotoxic T lymphocyte repertoire and functional avidity contribute to strain-specific disease susceptibility after murine respiratory syncytial virus infection","volume":"85","author":"B Jessen","year":"2011","journal-title":"Journal of virology"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.virol.2005.04.032","article-title":"Identification of an H-2D(b)-restricted CD8+ cytotoxic T lymphocyte epitope in the matrix protein of respiratory syncytial virus","volume":"337","author":"JA Rutigliano","year":"2005","journal-title":"Virology"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1128\/JVI.01853-08","article-title":"A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunction","volume":"83","author":"ML Moore","year":"2009","journal-title":"Journal of virology"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.4049\/jimmunol.1201682","article-title":"Cutting edge: intravascular staining redefines lung CD8 T cell responses","volume":"189","author":"KG Anderson","year":"2012","journal-title":"Journal of immunology"},{"issue":"16","key":"ref38","doi-asserted-by":"crossref","first-page":"9010","DOI":"10.1128\/JVI.00329-14","article-title":"The pulmonary localization of virus-specific T lymphocytes is governed by the tissue tropism of infection","volume":"88","author":"CJ Knudson","year":"2014","journal-title":"Journal of virology"},{"issue":"6189","key":"ref39","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/335448a0","article-title":"Structure and function of human perforin","volume":"335","author":"MG Lichtenheld","year":"1988","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1749-6632.1988.tb36347.x","article-title":"Function of granule perforin and esterases in T cell-mediated reactions. Components required for delivery of molecules to target cells","volume":"532","author":"ER Podack","year":"1988","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/1074-7613(94)90063-9","article-title":"Lymphocyte-mediated cytotoxicity: two pathways and multiple effector molecules","volume":"1","author":"PA Henkart","year":"1994","journal-title":"Immunity"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.4049\/jimmunol.173.5.3408","article-title":"Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infection","volume":"173","author":"JA Rutigliano","year":"2004","journal-title":"Journal of immunology"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.4049\/jimmunol.174.10.5936","article-title":"Cutting edge: re-evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections","volume":"174","author":"F Liu","year":"2005","journal-title":"Journal of immunology"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.4049\/jimmunol.0902874","article-title":"Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts","volume":"183","author":"D Rai","year":"2009","journal-title":"Journal of immunology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.coi.2015.04.005","article-title":"Novel antigens for RSV vaccines","volume":"35","author":"BS Graham","year":"2015","journal-title":"Current opinion in immunology"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"e1005486","DOI":"10.1371\/journal.ppat.1005486","article-title":"A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology","volume":"12","author":"J Liu","year":"2016","journal-title":"PLoS pathogens"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1128\/JVI.76.11.5654-5666.2002","article-title":"Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology","volume":"76","author":"L Zhang","year":"2002","journal-title":"Journal of virology"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1128\/IAI.26.2.621-629.1979","article-title":"Infection of cultured human type II pneumonocytes with certain respiratory viruses","volume":"26","author":"DA Tyrrell","year":"1979","journal-title":"Infection and immunity"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1128\/JVI.01625-07","article-title":"Viral and host factors in human respiratory syncytial virus pathogenesis","volume":"82","author":"PL Collins","year":"2008","journal-title":"Journal of virology"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.20020943","article-title":"Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood","volume":"196","author":"FJ Culley","year":"2002","journal-title":"The Journal of experimental medicine"},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.4049\/jimmunol.168.6.2944","article-title":"The role of IFN in respiratory syncytial virus pathogenesis","volume":"168","author":"JE Durbin","year":"2002","journal-title":"Journal of immunology"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/1096-9071(200010)62:2<257::AID-JMV19>3.0.CO;2-M","article-title":"Role of interferon gamma in the pathogenesis of primary respiratory syncytial virus infection in BALB\/c mice","volume":"62","author":"SM van Schaik","year":"2000","journal-title":"Journal of medical virology"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1089\/jir.2009.0084","article-title":"IFN-gamma treatment at early stages of influenza virus infection protects mice from death in a NK cell-dependent manner","volume":"30","author":"ID Weiss","year":"2010","journal-title":"Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1002\/(SICI)1521-4141(199910)29:10<3262::AID-IMMU3262>3.0.CO;2-A","article-title":"Homeostatic regulation of CD8+ T cells by perforin","volume":"29","author":"D Kagi","year":"1999","journal-title":"European journal of immunology"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1074-7613(03)00079-7","article-title":"Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice","volume":"18","author":"VP Badovinac","year":"2003","journal-title":"Immunity"},{"issue":"23","key":"ref56","doi-asserted-by":"crossref","first-page":"13016","DOI":"10.1128\/JVI.01770-12","article-title":"Vaccine-elicited CD8+ T cells protect against respiratory syncytial virus strain A2-line19F-induced pathogenesis in BALB\/c mice","volume":"86","author":"S Lee","year":"2012","journal-title":"Journal of virology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"10224","DOI":"10.1038\/ncomms10224","article-title":"RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection","volume":"6","author":"A Jozwik","year":"2015","journal-title":"Nature communications"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1165\/rcmb.2015-0297OC","article-title":"Airway CD8(+) T Cells Are Associated with Lung Injury during Infant Viral Respiratory Tract Infection","volume":"54","author":"TJ Connors","year":"2016","journal-title":"American journal of respiratory cell and molecular biology"},{"issue":"8","key":"ref59","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1086\/512615","article-title":"Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses","volume":"195","author":"TP Welliver","year":"2007","journal-title":"The Journal of infectious diseases"},{"issue":"12","key":"ref60","doi-asserted-by":"crossref","first-page":"8410","DOI":"10.4049\/jimmunol.179.12.8410","article-title":"CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections","volume":"179","author":"J Heidema","year":"2007","journal-title":"Journal of immunology"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"980","DOI":"10.4049\/jimmunol.162.2.980","article-title":"Perforin-deficient CD8+ T cells: in vivo priming and antigen-specific immunity against Listeria monocytogenes","volume":"162","author":"DW White","year":"1999","journal-title":"Journal of immunology"},{"issue":"23","key":"ref62","doi-asserted-by":"crossref","first-page":"10854","DOI":"10.1073\/pnas.91.23.10854","article-title":"Immune function in mice lacking the perforin gene","volume":"91","author":"CM Walsh","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"24","key":"ref63","doi-asserted-by":"crossref","first-page":"11890","DOI":"10.1073\/pnas.90.24.11890","article-title":"Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells","volume":"90","author":"RA Brundage","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"15","key":"ref64","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1128\/JB.184.15.4177-4186.2002","article-title":"Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors","volume":"184","author":"P Lauer","year":"2002","journal-title":"Journal of bacteriology"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.4049\/jimmunol.139.6.2005","article-title":"Adoptive transfer of immunity to Listeria monocytogenes. The influence of in vitro stimulation on lymphocyte subset requirements","volume":"139","author":"DK Bishop","year":"1987","journal-title":"Journal of immunology"},{"issue":"11","key":"ref66","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1073\/pnas.100133697","article-title":"A DNA transfection system for generation of influenza A virus from eight plasmids","volume":"97","author":"E Hoffmann","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"50","key":"ref67","doi-asserted-by":"crossref","first-page":"20248","DOI":"10.1073\/pnas.1320524110","article-title":"Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins","volume":"110","author":"NS Heaton","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref68","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.4049\/jimmunol.180.4.2376","article-title":"IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease","volume":"180","author":"EM Castilow","year":"2008","journal-title":"Journal of immunology"},{"issue":"6","key":"ref69","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/0300985813485099","article-title":"Principles for valid histopathologic scoring in research","volume":"50","author":"KN Gibson-Corley","year":"2013","journal-title":"Veterinary pathology"},{"issue":"4","key":"ref70","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.4049\/jimmunol.1000423","article-title":"Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection","volume":"185","author":"RB Fulton","year":"2010","journal-title":"Journal of immunology"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.4049\/jimmunol.1100764","article-title":"Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection","volume":"187","author":"KA Weiss","year":"2011","journal-title":"Journal of immunology"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006810","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:04:40Z","timestamp":1693389880000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006810"}},"subtitle":[],"editor":[{"given":"Christopher M.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,2]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006810","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006810","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,2]]}}}