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Wickham","year":"1993","journal-title":"Cell"},{"key":"ref68","first-page":"479","article-title":"Adenovirus membrane penetration: Tickling the tail of a sleeping dragon","author":"CM Wiethoff","year":"2015","journal-title":"Virology"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1128\/JVI.75.1.480-489.2001","article-title":"Functional and selective targeting of adenovirus to high-affinity Fcgamma receptor I-positive cells by using a bispecific hybrid adapter","volume":"75","author":"C Ebbinghaus","year":"2001","journal-title":"J Virol"},{"issue":"15","key":"ref70","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1001\/jama.2016.4218","article-title":"Safety and Immunogenicity of Novel Adenovirus Type 26- and Modified Vaccinia Ankara-Vectored Ebola Vaccines: A Randomized Clinical Trial","volume":"315","author":"ID Milligan","year":"2016","journal-title":"JAMA"},{"issue":"18","key":"ref71","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1182\/blood-2016-04-711580","article-title":"In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors","volume":"128","author":"M Richter","year":"2016","journal-title":"Blood"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1016\/S2214-109X(16)30367-9","article-title":"Immunity duration of a recombinant adenovirus type-5 vector-based Ebola vaccine and a homologous prime-boost immunisation in healthy adults in China: final report of a randomised, double-blind, placebo-controlled, phase 1 trial","volume":"5","author":"JX Li","year":"2017","journal-title":"Lancet Glob Health"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.4049\/jimmunol.175.9.6058","article-title":"MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages","volume":"175","author":"MS Arredouani","year":"2005","journal-title":"J Immunol"},{"issue":"5","key":"ref74","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1165\/rcmb.2010-0349OC","article-title":"MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome","volume":"45","author":"S Ghosh","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"ref75","doi-asserted-by":"crossref","first-page":"e1000474","DOI":"10.1371\/journal.ppat.1000474","article-title":"MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis","volume":"5","author":"DM Bowdish","year":"2009","journal-title":"PLoS Pathog"},{"issue":"8","key":"ref76","doi-asserted-by":"crossref","first-page":"e104148","DOI":"10.1371\/journal.pone.0104148","article-title":"The scavenger receptor MARCO modulates TLR-induced responses in dendritic cells","volume":"9","author":"HT Kissick","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref77","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1182\/blood-2010-03-276733","article-title":"SR-A\/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens","volume":"117","author":"S Mukhopadhyay","year":"2011","journal-title":"Blood"},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/jid.2014.330","article-title":"Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes","volume":"135","author":"DT MacLeod","year":"2015","journal-title":"J Invest Dermatol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2350-14-47","article-title":"Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population","volume":"14","author":"DM Bowdish","year":"2013","journal-title":"BMC Med Genet"},{"issue":"8","key":"ref80","doi-asserted-by":"crossref","first-page":"e24069","DOI":"10.1371\/journal.pone.0024069","article-title":"Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population","volume":"6","author":"MJ Ma","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cell.2016.09.024","article-title":"Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations","volume":"167","author":"H Quach","year":"2016","journal-title":"Cell"},{"issue":"12","key":"ref82","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1038\/mt.2012.162","article-title":"Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery","volume":"20","author":"L Coughlan","year":"2012","journal-title":"Mol Ther"},{"issue":"3","key":"ref83","doi-asserted-by":"crossref","first-page":"e1004035","DOI":"10.1371\/journal.ppat.1004035","article-title":"IL-1alpha and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells","volume":"10","author":"NC Di Paolo","year":"2014","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref84","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/viro.2001.1204","article-title":"Critical role for SV40 small-t antigen in human cell transformation","volume":"290","author":"J Yu","year":"2001","journal-title":"Virology"},{"issue":"18","key":"ref85","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1093\/nar\/gkh887","article-title":"Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization","volume":"32","author":"T May","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"ref86","first-page":"251","article-title":"Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier","volume":"33","author":"A Kuehn","year":"2016","journal-title":"ALTEX"},{"key":"ref87","first-page":"217","article-title":"Adenovirus methods and protocols, in Meth Mol Med","volume":"21","author":"UF Greber","year":"1998"},{"issue":"8","key":"ref88","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1002\/j.1460-2075.1996.tb00525.x","article-title":"The role of the adenovirus protease on virus entry into cells","volume":"15","author":"UF Greber","year":"1996","journal-title":"EMBO J"},{"issue":"3","key":"ref89","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0092-8674(93)90382-Z","article-title":"Stepwise dismantling of adenovirus 2 during entry into cells","volume":"75","author":"UF Greber","year":"1993","journal-title":"Cell"},{"issue":"Pt 11","key":"ref90","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1099\/vir.0.83142-0","article-title":"Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor","volume":"88","author":"C Fleischli","year":"2007","journal-title":"J Gen Virol"},{"issue":"19","key":"ref91","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1038\/sj.gt.3302058","article-title":"The alphavbeta5 integrin of hematopoietic and nonhematopoietic cells is a transduction receptor of RGD-4C fiber-modified adenoviruses","volume":"10","author":"H Nagel","year":"2003","journal-title":"Gene Ther"},{"issue":"1","key":"ref92","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ab.2007.05.025","article-title":"Nuclear localization of enhanced green fluorescent protein homomultimers","volume":"368","author":"NM Seibel","year":"2007","journal-title":"Anal Biochem"},{"issue":"5","key":"ref93","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","article-title":"A simplified system for generating recombinant adenoviruses","volume":"95","author":"TC He","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref94","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41467-017-02707-6","article-title":"Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control","volume":"9","author":"M Schmid","year":"2018","journal-title":"Nat Commun"},{"issue":"2","key":"ref95","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/viro.2002.1406","article-title":"Evaluation of accuracy and precision of adenovirus absorptivity at 260 nm under conditions of complete DNA disruption","volume":"295","author":"JA Sweeney","year":"2002","journal-title":"Virology"},{"issue":"8","key":"ref96","doi-asserted-by":"crossref","first-page":"e6529","DOI":"10.1371\/journal.pone.0006529","article-title":"A versatile viral system for expression and depletion of proteins in mammalian cells","volume":"4","author":"E Campeau","year":"2009","journal-title":"PLoS ONE"},{"issue":"22","key":"ref97","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1128\/JVI.78.22.12320-12332.2004","article-title":"Postentry neutralization of adenovirus type 5 by an antihexon antibody","volume":"78","author":"R Varghese","year":"2004","journal-title":"J Virol"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nature 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