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Arpaia","year":"2011","journal-title":"Cell"},{"issue":"6","key":"ref61","doi-asserted-by":"crossref","first-page":"C1666","DOI":"10.1152\/ajpcell.1996.270.6.C1666","article-title":"Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype","volume":"270","author":"M Bens","year":"1996","journal-title":"The American journal of physiology"},{"issue":"9","key":"ref62","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1091\/mbc.8.9.1687","article-title":"The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes","volume":"8","author":"TH Chuang","year":"1997","journal-title":"Mol Biol Cell"},{"issue":"8","key":"ref63","doi-asserted-by":"crossref","first-page":"e12477","DOI":"10.1371\/journal.pone.0012477","article-title":"In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin","volume":"5","author":"C Hoffmann","year":"2010","journal-title":"PloS one"},{"issue":"9","key":"ref64","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/cmi.12290","article-title":"The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration","volume":"16","author":"TA Agbor","year":"2014","journal-title":"Cellular microbiology"},{"issue":"9","key":"ref65","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1111\/j.1462-5822.2007.00960.x","article-title":"Identification of the Salmonella enterica serotype typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium","volume":"9","author":"DM Wall","year":"2007","journal-title":"Cellular microbiology"},{"issue":"6002","key":"ref66","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1194598","article-title":"Salmonella pathogenesis and processing of secreted effectors by caspase-3","volume":"330","author":"CV Srikanth","year":"2010","journal-title":"Science"},{"issue":"5","key":"ref67","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1128\/IAI.00337-12","article-title":"The actin-polymerizing activity of SipA is not essential for Salmonella enterica serovar Typhimurium-induced mucosal inflammation","volume":"81","author":"D Li","year":"2013","journal-title":"Infection and immunity"},{"issue":"6","key":"ref68","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/cmi.12406","article-title":"PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation","volume":"17","author":"KN Hallstrom","year":"2015","journal-title":"Cellular microbiology"},{"issue":"9","key":"ref69","doi-asserted-by":"crossref","first-page":"e0161965","DOI":"10.1371\/journal.pone.0161965","article-title":"A Genome-Wide siRNA Screen Implicates Spire1\/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion","volume":"11","author":"D Andritschke","year":"2016","journal-title":"PloS one"},{"issue":"5","key":"ref70","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/cmi.12542","article-title":"Dual 4- and 5-phosphatase activities regulate SopB-dependent phosphoinositide dynamics to promote bacterial entry","volume":"18","author":"HL Piscatelli","year":"2016","journal-title":"Cellular microbiology"},{"issue":"4","key":"ref71","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.chom.2011.03.009","article-title":"Activation of a RhoA\/myosin II-dependent but Arp2\/3 complex-independent pathway facilitates Salmonella invasion","volume":"9","author":"J Hanisch","year":"2011","journal-title":"Cell host & microbe"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.chom.2012.01.006","article-title":"Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion","volume":"11","author":"D Humphreys","year":"2012","journal-title":"Cell host & microbe"},{"issue":"1","key":"ref73","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1462-5822.2002.00170.x","article-title":"The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells","volume":"4","author":"O Steele-Mortimer","year":"2002","journal-title":"Cellular microbiology"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.chom.2007.02.001","article-title":"Salmonella SPI1 effector SipA persists after entry and cooperates with a SPI2 effector to regulate phagosome maturation and intracellular replication","volume":"1","author":"LC Brawn","year":"2007","journal-title":"Cell host & microbe"},{"issue":"4","key":"ref75","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1083\/jcb.200804131","article-title":"SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34","volume":"182","author":"GV Mallo","year":"2008","journal-title":"The Journal of cell biology"},{"issue":"6","key":"ref76","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.chom.2010.05.011","article-title":"The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole","volume":"7","author":"MA Bakowski","year":"2010","journal-title":"Cell host & microbe"},{"issue":"12","key":"ref77","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1111\/cmi.12333","article-title":"The Salmonella Typhimurium effector protein SopE transiently localizes to the early SCV and contributes to intracellular replication","volume":"16","author":"P Vonaesch","year":"2014","journal-title":"Cellular microbiology"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"e1005552","DOI":"10.1371\/journal.ppat.1005552","article-title":"The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members","volume":"12","author":"J Kamanova","year":"2016","journal-title":"PLoS pathogens"},{"issue":"6","key":"ref79","article-title":"A Salmonella virulence factor activates the NOD1\/NOD2 signaling pathway","volume":"2","author":"AM Keestra","year":"2011","journal-title":"mBio"},{"issue":"9","key":"ref80","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.189.9.1479","article-title":"Requirement of p21-activated kinase (PAK) for Salmonella typhimurium-induced nuclear responses","volume":"189","author":"LM Chen","year":"1999","journal-title":"The Journal of experimental medicine"},{"issue":"8","key":"ref81","doi-asserted-by":"crossref","first-page":"e1000538","DOI":"10.1371\/journal.ppat.1000538","article-title":"Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells","volume":"5","author":"VM Bruno","year":"2009","journal-title":"PLoS pathogens"},{"issue":"6","key":"ref82","doi-asserted-by":"crossref","first-page":"G1024","DOI":"10.1152\/ajpgi.00299.2003","article-title":"Salmonella typhimurium SipA-induced neutrophil transepithelial migration: involvement of a PKC-alpha-dependent signal transduction pathway","volume":"286","author":"M Silva","year":"2004","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molimm.2017.07.011","article-title":"Cirtical role for Salmonella effector SopB in regulating inflammasome activation","volume":"90","author":"GQ Hu","year":"2017","journal-title":"Mol Immunol"},{"issue":"2","key":"ref84","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.bbrc.2016.07.116","article-title":"The Salmonella effector SopB prevents ROS-induced apoptosis of epithelial cells by retarding TRAF6 recruitment to mitochondria","volume":"478","author":"H Ruan","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"6569","key":"ref85","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/380075a0","article-title":"Requirement for ceramide-initiated SAPK\/JNK signalling in stress-induced apoptosis","volume":"380","author":"M Verheij","year":"1996","journal-title":"Nature"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"e0172630","DOI":"10.1371\/journal.pone.0172630","article-title":"Scarless deletion of up to seven methyl-accepting chemotaxis genes with an optimized method highlights key function of CheM in Salmonella Typhimurium","volume":"12","author":"S Hoffmann","year":"2017","journal-title":"PloS one"},{"issue":"4","key":"ref87","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1084\/jem.20050625","article-title":"Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells","volume":"203","author":"M Lotz","year":"2006","journal-title":"The Journal of experimental medicine"},{"issue":"5","key":"ref88","doi-asserted-by":"crossref","first-page":"e1005616","DOI":"10.1371\/journal.ppat.1005616","article-title":"Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice","volume":"12","author":"A Dupont","year":"2016","journal-title":"PLoS pathogens"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2249.2007.03551.x","article-title":"Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration","volume":"151","author":"BP Hurley","year":"2008","journal-title":"Clin Exp 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