{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:04:44Z","timestamp":1790762684420,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006949","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1054324"],"award-info":[{"award-number":["OPP1054324"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1119043"],"award-info":[{"award-number":["OPP1119043"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L018756\/1"],"award-info":[{"award-number":["MR\/L018756\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K01207X\/1"],"award-info":[{"award-number":["MR\/K01207X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006949","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T17:34:05Z","timestamp":1521221645000},"page":"e1006949","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-5476","authenticated-orcid":true,"given":"Joseph D.","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2379-4945","authenticated-orcid":true,"given":"Nicolas","family":"Pionnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-8650","authenticated-orcid":true,"given":"Julio","family":"Furlong-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1948-6779","authenticated-orcid":true,"given":"Hanna","family":"Sjoberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-9891","authenticated-orcid":true,"given":"Stephen","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-1110","authenticated-orcid":true,"given":"Alice","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-5136","authenticated-orcid":true,"given":"Ana F.","family":"Guimaraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren A. N.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-562X","authenticated-orcid":true,"given":"Andrew","family":"Steven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Van Rooijen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-066X","authenticated-orcid":true,"given":"Judith E.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0233-5424","authenticated-orcid":true,"given":"Stephen J.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-9275","authenticated-orcid":true,"given":"Mark J.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2174\/092986712799828337","article-title":"Granulocytes in Helminth Infection\u2014Who is Calling the Shots?","volume":"19","author":"BL Makepeace","year":"2012","journal-title":"Curr Med Chem"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"e1003988","DOI":"10.1371\/journal.ppat.1003988","article-title":"Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae","volume":"10","author":"ET Cadman","year":"2014","journal-title":"PLoS pathogens"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"e1000525","DOI":"10.1371\/journal.pbio.1000525","article-title":"Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy","volume":"8","author":"SA Babayan","year":"2010","journal-title":"PLoS biology"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1128\/IAI.00329-06","article-title":"Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection","volume":"74","author":"S Specht","year":"2006","journal-title":"Infection and immunity"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1128\/IAI.73.12.8442-8443.2005","article-title":"Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection","volume":"73","author":"T Ramalingam","year":"2005","journal-title":"Infection and immunity"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4049\/jimmunol.1402219","article-title":"Eosinophils mediate protective immunity against secondary nematode infection","volume":"194","author":"L Huang","year":"2015","journal-title":"Journal of immunology"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1128\/IAI.00931-10","article-title":"Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice","volume":"79","author":"AE O'Connell","year":"2011","journal-title":"Infection and immunity"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.immuni.2016.03.003","article-title":"Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis","volume":"44","author":"SP Matthews","year":"2016","journal-title":"Immunity"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"e1001323","DOI":"10.1371\/journal.ppat.1001323","article-title":"Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells","volume":"7","author":"PC Cook","year":"2011","journal-title":"PLoS pathogens"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"e1005347","DOI":"10.1371\/journal.ppat.1005347","article-title":"Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury","volume":"11","author":"L Huang","year":"2015","journal-title":"PLoS pathogens"},{"issue":"5520","key":"ref11","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/256727a0","article-title":"Eosinophils as mediators of antibody-dependent damage to schistosomula","volume":"256","author":"AE Butterworth","year":"1975","journal-title":"Nature"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.4049\/jimmunol.127.4.1611","article-title":"Cellular killing of microfilariae of Onchocerca volvulus: eosinophil and neutrophil-mediated immune serum-dependent destruction","volume":"127","author":"BM Greene","year":"1981","journal-title":"Journal of immunology"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/425014","article-title":"T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans","volume":"190","author":"JA Jackson","year":"2004","journal-title":"The Journal of infectious diseases"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1086\/422256","article-title":"Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection","volume":"190","author":"RJ Quinnell","year":"2004","journal-title":"The Journal of infectious diseases"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1053\/j.gastro.2006.05.019","article-title":"Allergy controls the population density of Necator americanus in the small intestine","volume":"131","author":"J Croese","year":"2006","journal-title":"Gastroenterology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"e1002520","DOI":"10.1371\/journal.ppat.1002520","article-title":"Characterising the mucosal and systemic immune responses to experimental human hookworm infection","volume":"8","author":"S Gaze","year":"2012","journal-title":"PLoS pathogens"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/imr.12221","article-title":"Macrophage proliferation, provenance, and plasticity in macroparasite infection","volume":"262","author":"D Ruckerl","year":"2014","journal-title":"Immunological reviews"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nm.2628","article-title":"An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection","volume":"18","author":"F Chen","year":"2012","journal-title":"Nature medicine"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"e1004778","DOI":"10.1371\/journal.ppat.1004778","article-title":"Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair","volume":"11","author":"J Esser-von Bieren","year":"2015","journal-title":"PLoS pathogens"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1074-7613(04)00107-4","article-title":"Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology","volume":"20","author":"DR Herbert","year":"2004","journal-title":"Immunity"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3476","article-title":"Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths","volume":"13","author":"WC Gause","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20082048","article-title":"Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung","volume":"206","author":"MG Nair","year":"2009","journal-title":"The Journal of experimental medicine"},{"issue":"20","key":"ref23","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1182\/blood-2013-08-520619","article-title":"Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct","volume":"123","author":"UM Gundra","year":"2014","journal-title":"Blood"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"e1004080","DOI":"10.1371\/journal.ppat.1004080","article-title":"Ly6C(high) monocytes become alternatively activated macrophages in schistosome granulomas with help from CD4+ cells","volume":"10","author":"NM Girgis","year":"2014","journal-title":"PLoS pathogens"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"6918","DOI":"10.4049\/jimmunol.176.11.6918","article-title":"F4\/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection","volume":"176","author":"MD Taylor","year":"2006","journal-title":"Journal of immunology"},{"issue":"6035","key":"ref26","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1126\/science.1204351","article-title":"Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation","volume":"332","author":"SJ Jenkins","year":"2011","journal-title":"Science"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1084\/jem.20121999","article-title":"IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1","volume":"210","author":"SJ Jenkins","year":"2013","journal-title":"The Journal of experimental medicine"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1084\/jem.20020170","article-title":"Essential and instructive roles of GATA factors in eosinophil development","volume":"195","author":"R Hirasawa","year":"2002","journal-title":"The Journal of experimental medicine"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/jlb.65.6.846","article-title":"Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3)","volume":"65","author":"JC Grimaldi","year":"1999","journal-title":"Journal of leukocyte biology"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1073\/pnas.261462598","article-title":"The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness","volume":"99","author":"AA Humbles","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/intimm\/10.10.1583","article-title":"The L3 of Brugia induces a Th2-polarized response following activation of an IL-4-producing CD4-CD8- alphabeta T cell population","volume":"10","author":"J Osborne","year":"1998","journal-title":"International immunology"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"e1003771","DOI":"10.1371\/journal.ppat.1003771","article-title":"Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Ralpha-independent alternative differentiation of macrophages","volume":"9","author":"J Esser-von Bieren","year":"2013","journal-title":"PLoS pathogens"},{"issue":"6026","key":"ref33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1201475","article-title":"Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis","volume":"332","author":"D Wu","year":"2011","journal-title":"Science"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20121964","article-title":"Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages","volume":"210","author":"AB Molofsky","year":"2013","journal-title":"The Journal of experimental medicine"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/eji.201646442","article-title":"IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha","volume":"46","author":"LH Jackson-Jones","year":"2016","journal-title":"European journal of immunology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/s13071-014-0472-z","article-title":"A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis","volume":"7","author":"A Halliday","year":"2014","journal-title":"Parasites & vectors"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/jpet.105.099812","article-title":"Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation","volume":"318","author":"AM Das","year":"2006","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nm1451","article-title":"Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites","volume":"12","author":"RM Anthony","year":"2006","journal-title":"Nature medicine"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1084\/jem.20130761","article-title":"The skin is an important bulwark of acquired immunity against intestinal helminths","volume":"210","author":"K Obata-Ninomiya","year":"2013","journal-title":"The Journal of experimental medicine"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/ni.2984","article-title":"Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion","volume":"15","author":"F Chen","year":"2014","journal-title":"Nature immunology"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1128\/IAI.00625-13","article-title":"Human and Mouse Macrophages Collaborate with Neutrophils To Kill Larval Strongyloides stercoralis","volume":"81","author":"S Bonne-Annee","year":"2013","journal-title":"Infection and immunity"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.4049\/jimmunol.1400502","article-title":"Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation","volume":"193","author":"MC Little","year":"2014","journal-title":"Journal of immunology"},{"issue":"6342","key":"ref43","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.aaj2067","article-title":"Local amplifiers of IL-4Ralpha-mediated macrophage activation promote repair in lung and liver","volume":"356","author":"CM Minutti","year":"2017","journal-title":"Science"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.4049\/jimmunol.1301176","article-title":"Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice","volume":"191","author":"E Hams","year":"2013","journal-title":"Journal of immunology"},{"issue":"46","key":"ref45","doi-asserted-by":"crossref","first-page":"18620","DOI":"10.1073\/pnas.1311668110","article-title":"GATA-1 regulates the generation and function of basophils","volume":"110","author":"Y Nei","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1084\/jem.20020656","article-title":"Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo","volume":"195","author":"C Yu","year":"2002","journal-title":"The Journal of experimental medicine"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1189\/jlb.1106686","article-title":"Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages","volume":"81","author":"D Voehringer","year":"2007","journal-title":"Journal of leukocyte biology"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.20052448","article-title":"Type 2 immunity is controlled by IL-4\/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system","volume":"203","author":"D Voehringer","year":"2006","journal-title":"The Journal of experimental medicine"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"ncomms11852","DOI":"10.1038\/ncomms11852","article-title":"Long-lived self-renewing bone marrow-derived macrophages displace embryo-derived cells to inhabit adult serous cavities","volume":"7","author":"CC Bain","year":"2016","journal-title":"Nat Commun"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.30947","article-title":"Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection","volume":"7","author":"SM Campbell","year":"2018","journal-title":"Elife"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1128\/IAI.71.8.4361-4367.2003","article-title":"Kinetics of cellular responses to intraperitoneal Brugia pahangi infections in normal and immunodeficient mice","volume":"71","author":"T Ramalingam","year":"2003","journal-title":"Infection and immunity"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2172-13-6","article-title":"Adoptive transfer of IL-4Ralpha+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation","volume":"13","author":"AQ Ford","year":"2012","journal-title":"BMC Immunol"},{"issue":"25","key":"ref53","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1182\/blood-2012-07-442640","article-title":"The biology of nematode- and IL4Ralpha-dependent murine macrophage polarization in vivo as defined by RNA-Seq and targeted lipidomics","volume":"120","author":"GD Thomas","year":"2012","journal-title":"Blood"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-4894(02)00015-2","article-title":"Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses","volume":"100","author":"TV Rajan","year":"2002","journal-title":"Exp Parasitol"},{"issue":"25","key":"ref55","doi-asserted-by":"crossref","first-page":"9977","DOI":"10.1073\/pnas.1121231109","article-title":"Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo","volume":"109","author":"PC Cook","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006949","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006949","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T17:12:47Z","timestamp":1693588367000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006949"}},"subtitle":[],"editor":[{"given":"William C.","family":"Gause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":55,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006949","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006949","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,16]]}}}