{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:34:19Z","timestamp":1789086859736,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006967","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000}}],"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA154228"],"award-info":[{"award-number":["1R01CA154228"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01-CA103646"],"award-info":[{"award-number":["R01-CA103646"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["5K99 DE024969-01"],"award-info":[{"award-number":["5K99 DE024969-01"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006967","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T17:33:52Z","timestamp":1523900032000},"page":"e1006967","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["KSHV induces immunoglobulin rearrangements in mature B lymphocytes"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8444-8536","authenticated-orcid":true,"given":"Jennifer","family":"Totonchy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1242-4962","authenticated-orcid":true,"given":"Jessica M.","family":"Osborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-8638","authenticated-orcid":true,"given":"Amy","family":"Chadburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramina","family":"Nabiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissenya","family":"Argueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Mikita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel","family":"Cesarman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1126\/science.7997879","article-title":"Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi&apos;s sarcoma","volume":"266","author":"Y Chang","year":"1994","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A review of human carcinogens\u2014Part B: biological agents","author":"V Bouvard","year":"2009","journal-title":"The lancet oncology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJM199505043321802","article-title":"Kaposi&apos;s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas","volume":"332","author":"E Cesarman","year":"1995","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1182\/blood.V86.4.1276.bloodjournal8641276","article-title":"Kaposi\u201cs sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman\u201ds disease","volume":"86","author":"J Soulier","year":"1995","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-immunol-072710-081639","article-title":"Pathogenesis and Host Control of Gammaherpesviruses: Lessons from the Mouse","volume":"29","author":"E Barton","year":"2011","journal-title":"Annu Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1084\/jem.183.5.2385","article-title":"Human herpesvirus-8\/Kaposi&apos;s sarcoma-associated herpesvirus is a new transmissible virus that infects B cells","volume":"183","author":"EA Mesri","year":"1996","journal-title":"J Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1172\/JCI43755","article-title":"Active lytic infection of human primary tonsillar B cells by KSHV and its noncytolytic control by activated CD4+ T cells","volume":"121","author":"J Myoung","year":"2011","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2010.12.036","article-title":"Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cells","volume":"413","author":"J Myoung","year":"2011","journal-title":"Virology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1172\/JCI44185","article-title":"KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation","volume":"121","author":"LM Hassman","year":"2011","journal-title":"J Clin Invest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nri1939","article-title":"Receptor editing in lymphocyte development and central tolerance","volume":"6","author":"D Nemazee","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1093\/clinchem\/38.12.2454","article-title":"Reference values for immunoglobulin kappa and lambda light chains and the kappa\/lambda ratio in children&apos;s serum","volume":"38","author":"M Saitta","year":"1992","journal-title":"Clin Chem"},{"key":"ref12","first-page":"513","article-title":"Immunophenotypic analysis of the Kaposi sarcoma herpesvirus (KSHV; HHV-8)-infected B cells in HIV+ multicentric Castleman disease (MCD)","volume":"53","author":"A Chadburn","year":"2008","journal-title":"Histopathology. Blackwell Publishing Ltd"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1182\/blood.V97.7.2130","article-title":"Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders","volume":"97","author":"MQ Du","year":"2001","journal-title":"Blood"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/S0002-9440(10)65749-5","article-title":"Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation","volume":"153","author":"A Matolcsy","year":"1998","journal-title":"Am J Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","article-title":"Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways","volume":"118","author":"MA Berkowska","year":"2011","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1084\/jem.20060964","article-title":"Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion","volume":"204","author":"MC van Zelm","year":"2007","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"9964","DOI":"10.1128\/JVI.74.21.9964-9971.2000","article-title":"Cells expressing the Epstein-Barr virus growth program are present in and restricted to the naive B-cell subset of healthy tonsils","volume":"74","author":"AM Joseph","year":"2000","journal-title":"J Virol"},{"key":"ref18","first-page":"4905","article-title":"Human CD27+IgM+IgD+ B cells: T-cell or TLR-dependent?","volume":"120","author":"MC van Zelm","year":"2012","journal-title":"Blood. American Society of Hematology"},{"key":"ref19","first-page":"4189","article-title":"Human and viral interleukin-6 and other cytokines in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease","volume":"122","author":"MN Polizzotto","year":"2013","journal-title":"Blood. American Society of Hematology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"JJM van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/jmbi.1997.0956","article-title":"The creation of diversity in the human immunoglobulin V(lambda) repertoire","volume":"268","author":"O Ignatovich","year":"1997","journal-title":"J Mol Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/290372a0","article-title":"Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression","volume":"290","author":"C Coleclough","year":"1981","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0065-230X(08)60470-4","article-title":"The pathogenesis of Burkitt&apos;s lymphoma","volume":"55","author":"I Magrath","year":"1990","journal-title":"Adv Cancer Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"8155","DOI":"10.1128\/JVI.69.12.8155-8158.1995","article-title":"Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2","volume":"69","author":"SK Srinivas","year":"1995","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1182\/blood.V85.5.1289.bloodjournal8551289","article-title":"Expression of recombination activating genes (RAG-1 and RAG-2) in Epstein-Barr virus-bearing B cells","volume":"85","author":"I Kuhn-Hallek","year":"1995","journal-title":"Blood"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1163>3.0.CO;2-M","article-title":"Expression of the recombination activating genes (RAG1 and RAG2) is not detectable in Epstein-Barr virus-associated human lymphomas","volume":"92","author":"N Meru","year":"2001","journal-title":"Int J Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/aje\/kwn125","article-title":"Early childhood infection by human herpesvirus 8 in Zambia and the role of human immunodeficiency virus type 1 coinfection in a highly endemic area","volume":"168","author":"V Minhas","year":"2008","journal-title":"Am J Epidemiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1002\/jmv.24546","article-title":"Longitudinal analysis of the humoral response to Kaposi&apos;s sarcoma-associated herpesvirus after primary infection in children","volume":"88","author":"LN Olp","year":"2016","journal-title":"J Med Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jmv.1031","article-title":"Longitudinal sero-reactivity to human herpesvirus 8 (KSHV) in the Swiss HIV Cohort 4.7 years before KS","volume":"64","author":"EB Quinlivan","year":"2001","journal-title":"J Med Virol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.coviro.2017.07.016","article-title":"Extrafollicular activities: perspectives on HIV infection, germinal center-independent maturation pathways, and KSHV-mediated lymphoproliferation","volume":"26","author":"J Totonchy","year":"2017","journal-title":"Curr Opin Virol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/infdis\/jiw076","article-title":"Prospective Characterization of the Risk Factors for Transmission and Symptoms of Primary Human Herpesvirus Infections Among Ugandan Infants","volume":"214","author":"S Gantt","year":"2016","journal-title":"J Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.191.11.1813","article-title":"Revising B cell receptors","volume":"191","author":"D Nemazee","year":"2000","journal-title":"J Exp Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1002\/1521-4141(200112)31:12<3638::AID-IMMU3638>3.0.CO;2-G","article-title":"Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation","volume":"31","author":"T Goossens","year":"2001","journal-title":"Eur J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature08159","article-title":"Mechanisms promoting translocations in editing and switching peripheral B cells","volume":"460","author":"JH Wang","year":"2009","journal-title":"Nature"},{"key":"ref35","first-page":"42","article-title":"Secondary mechanisms of diversification in the human antibody repertoire","volume":"4","author":"BS Briney","year":"2013","journal-title":"Front Immunol. Frontiers"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.it.2007.12.004","article-title":"Receptor editing and receptor revision in rheumatic autoimmune diseases","volume":"29","author":"M Zouali","year":"2008","journal-title":"Trends Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.coi.2014.01.012","article-title":"ScienceDirectDual immunoglobulin light chain B cells: Trojan horses of autoimmunity?","volume":"27","author":"R Pelanda","year":"2014","journal-title":"Current Opinion in Immunology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/eji.201545599","article-title":"Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus","volume":"45","author":"LD Fraser","year":"2015","journal-title":"Eur J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/QCO.0b013e3283210006","article-title":"Autoimmunity and HIV","volume":"22","author":"R Stratton","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/cid\/cis1009","article-title":"Human herpesvirus 8-related Castleman disease in the absence of HIV infection","volume":"56","author":"A Dossier","year":"2013","journal-title":"CLIN INFECT DIS"},{"key":"ref41","first-page":"1","article-title":"Autoimmune thrombotic thrombocytopenic purpura associated with HHV8-related Multicentric Castleman disease","author":"J London","year":"2016","journal-title":"Br J Haematol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/BOR.0b013e32834db525","article-title":"Castleman disease and associated autoimmune disease","volume":"24","author":"TW Muskardin","year":"2012","journal-title":"Curr Opin Rheumatol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jviromet.2011.03.012","article-title":"Generation of a doxycycline-inducible KSHV producer cell line of endothelial origin: maintenance of tight latency with efficient reactivation upon induction","volume":"174","author":"J Myoung","year":"2011","journal-title":"J Virol Methods"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9708","DOI":"10.1128\/JVI.01019-12","article-title":"Construction and manipulation of a new Kaposi&apos;s sarcoma-associated herpesvirus bacterial artificial chromosome clone","volume":"86","author":"KF Brulois","year":"2012","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2007.09.017","article-title":"Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning","volume":"329","author":"T Tiller","year":"2008","journal-title":"Journal of Immunological Methods"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep05885","article-title":"A tool kit for rapid cloning and expression of recombinant antibodies","volume":"4","author":"TS Dodev","year":"2014","journal-title":"Sci Rep"},{"key":"ref47"},{"key":"ref48","author":"H Wickham"},{"key":"ref49","unstructured":"Neuwirth E. RColorBrewer: ColorBrewer Palettes [Internet]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/CRAN.R-project.org\/package=RColorBrewer\" xlink:type=\"simple\">https:\/\/CRAN.R-project.org\/package=RColorBrewer<\/ext-link>"},{"key":"ref50","author":"J Fox","year":"2011"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting Linear Mixed-Effects Models Using lme4","volume":"67","author":"D Bates","year":"2015","journal-title":"J Stat Soft"},{"key":"ref52","unstructured":"Kuznetsova A, Brockhoff PB, Christensen R. lmerTest: Tests for Random and Fixed Effects for Linear Mixed Effect Models (lmer Objects of lme4 Package): R Package Version 2.0\u201330. Available online \u2026. \u2026 <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/rproject.org\/web\/packages\/lmerTest\" xlink:type=\"simple\">rproject.org\/web\/packages\/lmerTest<\/ext-link> \u2026; 2016."}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006967","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T04:17:07Z","timestamp":1693628227000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006967"}},"subtitle":[],"editor":[{"given":"Laurent","family":"Coscoy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006967","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006967","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]}}}