{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:00:46Z","timestamp":1782309646898,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.ppat.1006975","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000}}],"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T00:00:00Z","timestamp":1523232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K012665"],"award-info":[{"award-number":["MR\/K012665"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["1052221\/z\/14\/Z"],"award-info":[{"award-number":["1052221\/z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M011151\/1"],"award-info":[{"award-number":["BB\/M011151\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C427\/A11976"],"award-info":[{"award-number":["C427\/A11976"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N023498\/1"],"award-info":[{"award-number":["MR\/N023498\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1006975","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T13:39:56Z","timestamp":1523281196000},"page":"e1006975","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle"],"prefix":"10.1371","volume":"14","author":[{"given":"Ethan L.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6558-4738","authenticated-orcid":true,"given":"Christopher W.","family":"Wasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kealy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieisha","family":"Pentland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Scarpini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-1958","authenticated-orcid":true,"given":"J. Simon C.","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-4211","authenticated-orcid":true,"given":"Joanna L.","family":"Parish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-9442","authenticated-orcid":true,"given":"Sally","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5978-4693","authenticated-orcid":true,"given":"Andrew","family":"Macdonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.virol.2013.06.007","article-title":"Diseases associated with human papillomavirus infection","volume":"445","author":"HA Cubie","year":"2013","journal-title":"Virology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1093\/annonc\/mdr015","article-title":"Worldwide burden of cervical cancer in 2008","volume":"22","author":"M Arbyn","year":"2011","journal-title":"Ann Oncol. Oxford University Press"},{"key":"ref3","first-page":"791024","article-title":"Human Papilloma Virus Associated Squamous Cell Carcinoma of the Head and Neck","volume":"2015","author":"V Ajila","year":"2015","journal-title":"J Sex Transm Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.bjc.6601024","article-title":"Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis","volume":"89","author":"GM Clifford","year":"2003","journal-title":"Br J Cancer"},{"key":"ref5","first-page":"1","article-title":"eLS","author":"S Roberts","year":"2001"},{"key":"ref6","first-page":"27","article-title":"Human papillomavirus E5 oncoprotein: function and potential target for antiviral therapeutics","volume":"10","author":"M M\u00fcller","year":"2015","journal-title":"Future Medicine Ltd London, UK"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-3-642-38965-8_8","article-title":"The role of human papillomaviruses in oncogenesis","volume":"193","author":"KK Mighty","year":"2014","journal-title":"Recent Results Cancer Res. Berlin, Heidelberg: Springer Berlin Heidelberg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.2537532","article-title":"The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product","volume":"243","author":"N Dyson","year":"1989","journal-title":"Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/j.1460-2075.1990.tb08091.x","article-title":"The region of the HPV E7 oncoprotein homologous to adenovirus E1a and Sv40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation","volume":"9","author":"MS Barbosa","year":"1990","journal-title":"EMBO J. European Molecular Biology Organization"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1002\/j.1460-2075.1991.tb04990.x","article-title":"A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18","volume":"10","author":"JM Huibregtse","year":"1991","journal-title":"EMBO J. European Molecular Biology Organization"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","article-title":"The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53","volume":"63","author":"M Scheffner","year":"1990","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.3390\/v7072785","article-title":"The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy","volume":"7","author":"K Ganti","year":"2015","journal-title":"Viruses"},{"key":"ref13","first-page":"9463","article-title":"The role of protein kinase A regulation of the E6 PDZ-binding domain during the differentiation-dependent life cycle of human papillomavirus type 18","volume":"87","author":"CP Delury","year":"2013","journal-title":"Journal of Virology. American Society for Microbiology"},{"key":"ref14","first-page":"12366","article-title":"Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31","volume":"78","author":"C Lee","year":"2004","journal-title":"Journal of Virology. American Society for Microbiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e1003717","DOI":"10.1371\/journal.ppat.1003717","article-title":"Inactivation of p53 rescues the maintenance of high risk HPV DNA genomes deficient in expression of E6","volume":"9","author":"LD Lorenz","year":"2013","journal-title":"PLoS Pathog. Public Library of Science"},{"key":"ref16","article-title":"Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein","volume":"5","author":"EK Marsh","year":"2017","journal-title":"Oncotarget. Impact Journals"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.1496401","article-title":"Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor","volume":"257","author":"C Schindler","year":"1992","journal-title":"Science"},{"key":"ref18","first-page":"2628","article-title":"Serine phosphorylation of STATs","volume":"19","author":"T Decker","year":"2000","journal-title":"Oncogene. Nature Publishing Group"},{"key":"ref19","first-page":"621","article-title":"Transcriptional responses to polypeptide ligands: the JAK-STAT pathway","volume":"64","author":"C Schindler","year":"1995","journal-title":"Annu Rev Biochem. Annual Reviews 4139 El Camino Way, P.O. Box 10139, Palo Alto, CA 94303\u20130139, USA"},{"key":"ref20","first-page":"20059","article-title":"JAK-STAT signaling: from interferons to cytokines","volume":"282","author":"C Schindler","year":"2007","journal-title":"J Biol Chem. American Society for Biochemistry and Molecular Biology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrc1275","article-title":"The STATs of cancer\u2014new molecular targets come of age","volume":"4","author":"H Yu","year":"2004","journal-title":"Nat Rev Cancer. Nature Publishing Group"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1126\/science.7701321","article-title":"Requirement of serine phosphorylation for formation of STAT-promoter complexes","volume":"267","author":"X Zhang","year":"1995","journal-title":"Science"},{"key":"ref23","first-page":"5857","article-title":"Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest","volume":"45","author":"X Shi","year":"2006","journal-title":"Biochemistry. American Chemical Society"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/exd.12585","article-title":"Constitutive STAT3 activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints","volume":"24","author":"V Orecchia","year":"2015","journal-title":"Exp Dermatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/jid.2010.255","article-title":"Stat3 as a therapeutic target for the treatment of psoriasis: a clinical feasibility study with STA-21, a Stat3 inhibitor","volume":"131","author":"K Miyoshi","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.3892\/ijo.2012.1594","article-title":"STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma","volume":"41","author":"L Naher","year":"2012","journal-title":"Int J Oncol. Spandidos Publications"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2007.05.016","article-title":"Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases","volume":"50","author":"S Sano","year":"2008","journal-title":"J Dermatol Sci"},{"key":"ref28","first-page":"1087","article-title":"Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis","volume":"27","author":"KS Chan","year":"2008","journal-title":"Oncogene. Nature Publishing Group"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1158\/0008-5472.CAN-04-4359","article-title":"Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation","volume":"65","author":"S Sano","year":"2005","journal-title":"Cancer Research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"9","author":"H Yu","year":"2009","journal-title":"Nat Rev Cancer. Nature Publishing Group"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: new and unexpected biological functions","volume":"14","author":"H Yu","year":"2014","journal-title":"Nat Rev Cancer. Nature Research"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.virol.2011.01.007","article-title":"A cyclin-binding motif in human papillomavirus type 18 (HPV18) E1^E4 is necessary for association with CDK-cyclin complexes and G2\/M cell cycle arrest of keratinocytes, but is not required for differentiation-dependent viral genome amplification or L1 capsid protein expression","volume":"412","author":"GL Knight","year":"2011","journal-title":"Virology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"103581","DOI":"10.18632\/oncotarget.21658","article-title":"Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle","volume":"8","author":"CW Wasson","year":"2017","journal-title":"Oncotarget"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1099\/vir.0.19691-0","article-title":"The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity","volume":"85","author":"A Macdonald","year":"2004","journal-title":"J Gen Virol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nm1392","article-title":"Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake","volume":"12","author":"T Kitamura","year":"2006","journal-title":"Nat Med. Nature Publishing Group"},{"key":"ref36","first-page":"1792","article-title":"Transcriptional regulation of the beta-casein gene by cytokines: cross-talk between STAT5 and other signaling molecules","volume":"12","author":"D Chida","year":"1998","journal-title":"Mol Endocrinol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e1003295","DOI":"10.1371\/journal.ppat.1003295","article-title":"The JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiation","volume":"9","author":"S Hong","year":"2013","journal-title":"PLoS Pathog. Public Library of Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1005766","DOI":"10.1371\/journal.ppat.1005766","article-title":"Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic Potential","volume":"12","author":"M Thomas","year":"2016","journal-title":"PLoS Pathog. Public Library of Science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.virol.2012.11.004","article-title":"Interactions between E6AP and E6 proteins from alpha and beta HPV types","volume":"435","author":"M Thomas","year":"2013","journal-title":"Virology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(93)90384-3","article-title":"The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53","volume":"75","author":"M Scheffner","year":"1993","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"7542","DOI":"10.1073\/pnas.1304855110","article-title":"HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures","volume":"110","author":"E-Y Kho","year":"2013","journal-title":"Proceedings of the National Academy of Sciences. National Acad Sciences"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1128\/MCB.13.8.4918","article-title":"Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins","volume":"13","author":"JM Huibregtse","year":"1993","journal-title":"Mol Cell Biol. American Society for Microbiology (ASM)"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e67849","DOI":"10.1371\/journal.pone.0067849","article-title":"Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis","volume":"8","author":"S Shukla","year":"2013","journal-title":"PLoS ONE. Public Library of Science"},{"key":"ref44","first-page":"2784","article-title":"Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback","volume":"189","author":"MJ Pattison","year":"2012","journal-title":"J Immunol. American Association of Immunologists"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ccr.2008.02.009","article-title":"Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera","volume":"13","author":"G Wernig","year":"2008","journal-title":"Cancer Cell"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.molimm.2015.06.015","article-title":"Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727","volume":"67","author":"E Lam","year":"2015","journal-title":"Molecular Immunology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.yexcr.2009.01.026","article-title":"mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3","volume":"315","author":"S Busch","year":"2009","journal-title":"Exp Cell Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1073\/pnas.0500679102","article-title":"STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation","volume":"102","author":"H Kojima","year":"2005","journal-title":"Proc Natl Acad Sci USA. National Acad Sciences"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"24392","DOI":"10.1074\/jbc.274.34.24392","article-title":"Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner","volume":"274","author":"N Jain","year":"1999","journal-title":"J Biol Chem"},{"key":"ref50","first-page":"646","article-title":"Protein kinase Cepsilon interacts with Stat3 and regulates its activation that is essential for the development of skin cancer","volume":"46","author":"MH Aziz","year":"2007","journal-title":"Mol Carcinog. Wiley Subscription Services, Inc., A Wiley Company"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200804038","article-title":"Erk1\/2 MAP kinases are required for epidermal G2\/M progression","volume":"185","author":"PA Dumesic","year":"2009","journal-title":"J Cell Biol. Rockefeller Univ Press"},{"key":"ref52","first-page":"20530","article-title":"Inhibition of JNK promotes differentiation of epidermal keratinocytes","volume":"281","author":"A Gazel","year":"2006","journal-title":"J Biol Chem. American Society for Biochemistry and Molecular Biology"},{"key":"ref53","first-page":"1020","article-title":"Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome","volume":"7","author":"C Ding","year":"2006","journal-title":"Curr Opin Investig Drugs"},{"key":"ref54","first-page":"13304","article-title":"Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types","volume":"280","author":"BA D\u00fcmmler","year":"2005","journal-title":"J Biol Chem. American Society for Biochemistry and Molecular Biology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.chembiol.2011.11.010","article-title":"Discovery of potent and selective covalent inhibitors of JNK","volume":"19","author":"T Zhang","year":"2012","journal-title":"Chem Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1093\/nar\/25.11.2062","article-title":"Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3","volume":"25","author":"Z Wen","year":"1997","journal-title":"Nucleic Acids Res. Oxford University Press"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"10121","DOI":"10.1158\/0008-5472.CAN-08-2121","article-title":"The high-mobility group A1a\/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?","volume":"68","author":"J Hillion","year":"2008","journal-title":"Cancer Research"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.virol.2013.07.016","article-title":"Epigenetics of human papillomaviruses","volume":"445","author":"E Johannsen","year":"2013","journal-title":"Virology"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1128\/JVI.80.9.4356-4362.2006","article-title":"Characterization of transcription factor binding to human papillomavirus type 16 DNA during cellular differentiation","volume":"80","author":"A Carson","year":"2006","journal-title":"Journal of Virology"},{"key":"ref60","first-page":"4770","article-title":"CCCTC-binding factor recruitment to the early region of the human papillomavirus 18 genome regulates viral oncogene expression","volume":"89","author":"C Paris","year":"2015","journal-title":"Journal of Virology. American Society for Microbiology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.canlet.2007.08.019","article-title":"Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line","volume":"258","author":"MB Gariboldi","year":"2007","journal-title":"Cancer Lett"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1091\/mbc.E04-08-0654","article-title":"Transcriptional regulation by a DNA-associated form of cyclin D1","volume":"16","author":"F Bienvenu","year":"2005","journal-title":"Mol Biol Cell. American Society for Cell Biology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.4161\/cc.8.9.8242","article-title":"A highly efficient system to produce infectious human papillomavirus: Elucidation of natural virus-host interactions","volume":"8","author":"LT Chow","year":"2009","journal-title":"Cell Cycle"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.virol.2013.07.008","article-title":"The E4 protein; structure, function and patterns of expression","volume":"445","author":"J Doorbar","year":"2013","journal-title":"Virology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1073\/pnas.92.5.1654","article-title":"Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis","volume":"92","author":"S Jeon","year":"1995","journal-title":"Proc Natl Acad Sci USA. National Academy of Sciences"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.1400683111","article-title":"STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation","volume":"111","author":"S Koganti","year":"2014","journal-title":"Proceedings of the National Academy of Sciences. National Acad Sciences"},{"key":"ref67","first-page":"11359","article-title":"Genetic analysis of high-risk e6 in episomal maintenance of human papillomavirus genomes in primary human keratinocytes","volume":"76","author":"RB Park","year":"2002","journal-title":"Journal of Virology. American Society for Microbiology (ASM)"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1172\/JCI200421032","article-title":"Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis","volume":"114","author":"KS Chan","year":"2004","journal-title":"J Clin Invest. American Society for Clinical Investigation"},{"key":"ref69","first-page":"15473","article-title":"Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes","volume":"286","author":"NS Banerjee","year":"2011","journal-title":"Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1365-2613.2010.00734.x","article-title":"STAT3 modulates the DNA damage response pathway","volume":"91","author":"SP Barry","year":"2010","journal-title":"Int J Exp Pathol. Blackwell Publishing Ltd"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e1000605","DOI":"10.1371\/journal.ppat.1000605","article-title":"Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation","volume":"5","author":"CA Moody","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1099\/vir.0.81067-0","article-title":"Effects of human papillomavirus type 16 oncoproteins on survivin gene expression","volume":"87","author":"AA Borb\u00e9ly","year":"2006","journal-title":"J Gen Virol. Microbiology Society"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/MCB.17.11.6508","article-title":"STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation","volume":"17","author":"J Chung","year":"1997","journal-title":"Mol Cell Biol. American Society for Microbiology (ASM)"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"e1003237","DOI":"10.1371\/journal.ppat.1003237","article-title":"The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species","volume":"9","author":"JM Spangle","year":"2013","journal-title":"PLoS Pathog. Public Library of Science"},{"key":"ref75","first-page":"386","article-title":"Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma","volume":"232","author":"MM Caffarel","year":"2014","journal-title":"J Pathol. John Wiley & Sons, Ltd"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1016\/j.ejca.2013.07.140","article-title":"Activation of interleukin-6\/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment","volume":"49","author":"C Ren","year":"2013","journal-title":"Eur J Cancer"},{"key":"ref77","first-page":"1919","article-title":"p38MAPK and MK2 pathways are important for the differentiation-dependent human papillomavirus life cycle","volume":"89","author":"A Satsuka","year":"2015","journal-title":"Journal of Virology. American Society for Microbiology"},{"key":"ref78","first-page":"13174","article-title":"Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity","volume":"86","author":"EA White","year":"2012","journal-title":"Journal of Virology. American Society for Microbiology"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.virol.2012.09.046","article-title":"Proteomic approaches to the study of papillomavirus-host interactions","volume":"435","author":"EA White","year":"2013","journal-title":"Virology"},{"key":"ref80","first-page":"95","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"SP Davies","year":"2000","journal-title":"Biochem J. Portland Press Ltd"},{"key":"ref81","first-page":"347","article-title":"Characterization of the cellular action of the MSK inhibitor SB-747651A","volume":"441","author":"S Naqvi","year":"2012","journal-title":"Biochem J. Portland Press Ltd"},{"key":"ref82","first-page":"12523","article-title":"YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins","volume":"5","author":"M M\u00fcller","year":"2015","journal-title":"Sci Rep. Nature Publishing Group"},{"key":"ref83","first-page":"5341","article-title":"High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors","volume":"86","author":"LF Wetherill","year":"2012","journal-title":"Journal of Virology. American Society for Microbiology"},{"key":"ref84","first-page":"673","article-title":"The ND10 component promyelocytic leukemia protein relocates to human papillomavirus type 1 E4 intranuclear inclusion bodies in cultured keratinocytes and in warts","volume":"77","author":"S Roberts","year":"2003","journal-title":"Journal of Virology. American Society for Microbiology (ASM)"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"12922","DOI":"10.1038\/srep12922","article-title":"The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes","volume":"5","author":"KH Richards","year":"2015","journal-title":"Sci Rep"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"26765","DOI":"10.1074\/jbc.M109.092304","article-title":"The cdk5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition","volume":"285","author":"S Courapied","year":"2010","journal-title":"Journal of Biological Chemistry"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1006975","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1006975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T15:54:05Z","timestamp":1571068445000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1006975"}},"subtitle":[],"editor":[{"given":"Denise A.","family":"Galloway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,9]]},"references-count":87,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1006975","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1006975","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,9]]}}}