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McGill","year":"2010","journal-title":"J Exp Med"},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1073\/pnas.91.11.4940","article-title":"The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells","volume":"91","author":"R.N. Bamford","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"ref44","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1002\/j.1460-2075.1995.tb00035.x","article-title":"Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor","volume":"14","author":"J.G. Giri","year":"1995","journal-title":"EMBO J"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4110\/in.2015.15.4.186","article-title":"Cytomegalovirus Infection and Memory T Cell Inflation","volume":"15","author":"J. Kim","year":"2015","journal-title":"Immune Netw"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1128\/JVI.64.11.5457-5464.1990","article-title":"Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes","volume":"64","author":"S. Jonjic","year":"1990","journal-title":"J Virol"},{"issue":"Pt 10","key":"ref47","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1099\/0022-1317-77-10-2605","article-title":"Effect of host genotype in determining the relative roles of natural killer cells and T cells in mediating protection against murine cytomegalovirus infection","volume":"77","author":"L.J. Lathbury","year":"1996","journal-title":"J Gen Virol"},{"issue":"Pt 9","key":"ref48","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1099\/0022-1317-79-9-2099","article-title":"Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantation","volume":"79","author":"J. Podlech","year":"1998","journal-title":"J Gen Virol"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.188.6.1047","article-title":"Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection","volume":"188","author":"B. 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Kennedy","year":"2000","journal-title":"J Exp Med"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/jaut.1994.0025","article-title":"Pancreatic lymph nodes are early targets of T cells during adoptive transfer of diabetes in NOD mice","volume":"8","author":"N. Fabien","year":"1995","journal-title":"J Autoimmun"},{"issue":"2","key":"ref67","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.4049\/jimmunol.181.2.1128","article-title":"The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection","volume":"181","author":"S.M. Walton","year":"2008","journal-title":"J Immunol"},{"key":"ref68","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1907s43","article-title":"A mouse model for cytomegalovirus infection","author":"W. 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Anderson","year":"2012","journal-title":"J Immunol"},{"issue":"9","key":"ref72","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1002\/eji.201243026","article-title":"IL-15 modulates the balance between Bcl-2 and Bim via a Jak3\/1-PI3K-Akt-ERK pathway to promote CD8alphaalpha+ intestinal intraepithelial lymphocyte survival","volume":"43","author":"Y.G. Lai","year":"2013","journal-title":"Eur J Immunol"},{"issue":"8","key":"ref73","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1002\/eji.201344238","article-title":"IL-15 regulates Bcl-2 family members Bim and Mcl-1 through JAK\/STAT and PI3K\/AKT pathways in T cells","volume":"44","author":"A.R. Shenoy","year":"2014","journal-title":"Eur J Immunol"},{"issue":"5284","key":"ref74","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","article-title":"Phenotypic analysis of antigen-specific T lymphocytes","volume":"274","author":"J.D. Altman","year":"1996","journal-title":"Science"},{"issue":"10","key":"ref75","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1084\/jem.20130291","article-title":"Epidermal IL-15Ralpha acts as an endogenous antagonist of psoriasiform inflammation in mouse and man","volume":"210","author":"G. Bouchaud","year":"2013","journal-title":"J Exp Med"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"K.J. Livak","year":"2001","journal-title":"Methods"},{"issue":"6","key":"ref77","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"T.D. 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