{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:42:47Z","timestamp":1791873767629,"version":"4.3.4"},"reference-count":86,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T00:00:00Z","timestamp":1526601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2014-54336-R"],"award-info":[{"award-number":["SAF2014-54336-R"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d\u2019Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["Ajut 2014SGR-4"],"award-info":[{"award-number":["Ajut 2014SGR-4"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["BFU2014-54591-C2-1-P"],"award-info":[{"award-number":["BFU2014-54591-C2-1-P"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006527","name":"Direcci\u00f3n General de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica","doi-asserted-by":"publisher","award":["SAF2017-86192-R"],"award-info":[{"award-number":["SAF2017-86192-R"]}],"id":[{"id":"10.13039\/501100006527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006527","name":"Direcci\u00f3n General de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica","doi-asserted-by":"publisher","award":["BFU2017-82574-P"],"award-info":[{"award-number":["BFU2017-82574-P"]}],"id":[{"id":"10.13039\/501100006527","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007007","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T13:23:09Z","timestamp":1526649789000},"page":"e1007007","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":132,"title":["Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals"],"prefix":"10.1371","volume":"14","author":[{"given":"Nuria","family":"Trevijano-Contador","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5760-4209","authenticated-orcid":true,"given":"Haroldo Cesar","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Garc\u00eda-Rodas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-6909","authenticated-orcid":true,"given":"Su\u00e9len Andreia","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4664-8609","authenticated-orcid":true,"given":"Irene","family":"Llorente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Zaballos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-1154","authenticated-orcid":true,"given":"Guilhem","family":"Janbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-2987","authenticated-orcid":true,"given":"Joaqu\u00edn","family":"Ari\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-0845","authenticated-orcid":true,"given":"\u00d3scar","family":"Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,5,18]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/mmy.38.5.379.383","article-title":"Possible primary ecological niche of <italic>Cryptococcus neoformans<\/italic>","volume":"38","author":"MS Lazera","year":"2000","journal-title":"Medical mycology"},{"key":"ref2","article-title":"<italic>Cryptococcus neoformans<\/italic>","author":"A Casadevall","year":"1998"},{"issue":"10","key":"ref3","first-page":"2104","article-title":"Survival time of HIV-infected patients with cryptococcal meningitis","volume":"90","author":"S Chottanapund","year":"2007","journal-title":"J Med Assoc Thai"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1371\/journal.pmed.0040021","article-title":"Determinants of disease presentation and outcome during cryptococcosis: the CryptoA\/D study","volume":"4","author":"F Dromer","year":"2007","journal-title":"PLoS Med"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"BJ Park","year":"2009","journal-title":"AIDS"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"R Rajasingham","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.micro.62.081307.162753","article-title":"How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in <italic>Cryptococcus neoformans<\/italic>","volume":"63","author":"TL Doering","year":"2009","journal-title":"Annual review of microbiology"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/CMR.00001-12","article-title":"The <italic>Cryptococcus neoformans<\/italic> capsule: a sword and a shield","volume":"25","author":"TR O'Meara","year":"2012","journal-title":"Clinical microbiology reviews"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0065-2164(09)01204-0","article-title":"The capsule of the fungal pathogen <italic>Cryptococcus neoformans<\/italic>","volume":"68","author":"O Zaragoza","year":"2009","journal-title":"Adv Appl Microbiol"},{"key":"ref10","article-title":"<italic>Cryptococcus<\/italic>. From Human pathogen to model yeast","author":"J Heitman","year":"2011"},{"issue":"Pt 8","key":"ref11","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1099\/00221287-147-8-2355","article-title":"Dynamic changes in the morphology of <italic>Cryptococcus neoformans<\/italic> during murine pulmonary infection","volume":"147","author":"M Feldmesser","year":"2001","journal-title":"Microbiology"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1128\/IAI.70.9.4762-4771.2002","article-title":"Cryptococcal glucuronoxylomannan inhibits adhesion of neutrophils to stimulated endothelium in vitro by affecting both neutrophils and endothelial cells","volume":"70","author":"PM Ellerbroek","year":"2002","journal-title":"Infection and immunity"},{"issue":"1\u20132","key":"ref13","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0165-5728(00)00354-4","article-title":"Cryptococcal glucuronoxylomannan delays translocation of leukocytes across the blood-brain barrier in an animal model of acute bacterial meningitis","volume":"111","author":"MM Lipovsky","year":"2000","journal-title":"Journal of neuroimmunology"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/IAI.5.4.491-498.1972","article-title":"In vitro phagocytosis and intracellular fate of variously encapsulated strains of <italic>Cryptococcus neoformans<\/italic>","volume":"5","author":"TG Mitchell","year":"1972","journal-title":"Infection and immunity"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1128\/IAI.5.6.896-901.1972","article-title":"Immunological unresponsiveness induced by cryptococcal capsular polysaccharide assayed by the hemolytic plaque technique","volume":"5","author":"JW Murphy","year":"1972","journal-title":"Infection and immunity"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/IAI.68.7.4225-4237.2000","article-title":"<italic>Cryptococcus neoformans<\/italic> is a facultative intracellular pathogen in murine pulmonary infection","volume":"68","author":"M Feldmesser","year":"2000","journal-title":"Infection and immunity"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1073\/pnas.052702799","article-title":"Replication of <italic>Cryptococcus neoformans<\/italic> in macrophages is accompanied by phagosomal permeabilization and accumulation of vesicles containing polysaccharide in the cytoplasm","volume":"99","author":"SC Tucker","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","first-page":"441","article-title":"Cryptococcus From human pathogen to model yeast","author":"K Voelz","year":"2011"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1574-695X.2011.00871.x","article-title":"Catch me if you can: phagocytosis and killing avoidance by <italic>Cryptococcus neoformans<\/italic>","volume":"64","author":"R Garcia-Rodas","year":"2012","journal-title":"FEMS immunology and medical microbiology"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"e1000953","DOI":"10.1371\/journal.ppat.1000953","article-title":"Cryptococcal cell morphology affects host cell interactions and pathogenicity","volume":"6","author":"LH Okagaki","year":"2010","journal-title":"PLoS pathogens"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"e1000945","DOI":"10.1371\/journal.ppat.1000945","article-title":"Fungal cell gigantism during mammalian infection","volume":"6","author":"O Zaragoza","year":"2010","journal-title":"PLoS pathogens"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.mib.2013.03.006","article-title":"Titan cells in <italic>Cryptococcus neoformans<\/italic>: cells with a giant impact","volume":"16","author":"O Zaragoza","year":"2013","journal-title":"Current opinion in microbiology"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cmi.12488","article-title":"The formation of titan cells in <italic>Cryptococcus neoformans<\/italic> depends on the mouse strain and correlates with induction of Th2-type responses","volume":"18","author":"I Garcia-Barbazan","year":"2016","journal-title":"Cellular microbiology"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1128\/IAI.00507-12","article-title":"Titan cell production enhances the virulence of <italic>Cryptococcus neoformans<\/italic>","volume":"80","author":"JN Crabtree","year":"2012","journal-title":"Infection and immunity"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/EC.00121-12","article-title":"Titan cells confer protection from phagocytosis in <italic>Cryptococcus neoformans<\/italic> infections","volume":"11","author":"LH Okagaki","year":"2012","journal-title":"Eukaryotic cell"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"e01340","DOI":"10.1128\/mBio.01340-15","article-title":"Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation","volume":"6","author":"AC Gerstein","year":"2015","journal-title":"mBio"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1128\/EC.05179-11","article-title":"Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli","volume":"10","author":"LH Okagaki","year":"2011","journal-title":"Eukaryotic cell"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"e1002047","DOI":"10.1371\/journal.ppat.1002047","article-title":"Phospholipids trigger <italic>Cryptococcus neoformans<\/italic> capsular enlargement during interactions with amoebae and macrophages","volume":"7","author":"CJ Chrisman","year":"2011","journal-title":"PLoS pathogens"},{"issue":"40","key":"ref29","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1098\/rsif.2009.0203","article-title":"Quorum sensing and social networking in the microbial world","volume":"6","author":"S Atkinson","year":"2009","journal-title":"Journal of the Royal Society, Interface \/ the Royal Society"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"e00986","DOI":"10.1128\/mBio.00986-13","article-title":"Quorum sensing-mediated, cell density-dependent regulation of growth and virulence in <italic>Cryptococcus neoformans<\/italic>","volume":"5","author":"P Albuquerque","year":"2014","journal-title":"mBio"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2958.2007.05666.x","article-title":"<italic>TUP1<\/italic> disruption in <italic>Cryptococcus neoformans<\/italic> uncovers a peptide-mediated density-dependent growth phenomenon that mimics quorum sensing","volume":"64","author":"H Lee","year":"2007","journal-title":"Molecular microbiology"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.chom.2016.05.001","article-title":"Intracellular Action of a Secreted Peptide Required for Fungal Virulence","volume":"19","author":"CM Homer","year":"2016","journal-title":"Cell host & microbe"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/EC.00066-12","article-title":"Function of <italic>Cryptococcus neoformans KAR7<\/italic> (<italic>SEC66<\/italic>) in karyogamy during unisexual and opposite-sex mating","volume":"11","author":"SC Lee","year":"2012","journal-title":"Eukaryotic cell"},{"issue":"20","key":"ref34","doi-asserted-by":"crossref","first-page":"21144","DOI":"10.1074\/jbc.M312995200","article-title":"The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in <italic>Cryptococcus neoformans<\/italic>","volume":"279","author":"LJ Heung","year":"2004","journal-title":"The Journal of biological chemistry"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1128\/EC.00146-08","article-title":"PKC1 is essential for protection against both oxidative and nitrosative stresses, cell integrity, and normal manifestation of virulence factors in the pathogenic fungus <italic>Cryptococcus neoformans<\/italic>","volume":"7","author":"KJ Gerik","year":"2008","journal-title":"Eukaryotic cell"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2958.2012.08016.x","article-title":"Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in <italic>Cryptococcus neoformans<\/italic>","volume":"84","author":"H Lee","year":"2012","journal-title":"Molecular microbiology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fgb.2015.02.009","article-title":"Recognition of seven species in the <italic>Cryptococcus gattii<\/italic>\/<italic>Cryptococcus neoformans<\/italic> species complex","volume":"78","author":"F Hagen","year":"2015","journal-title":"Fungal Genet Biol"},{"issue":"1","key":"ref38","article-title":"The Case for Adopting the &quot;Species Complex&quot; Nomenclature for the Etiologic Agents of Cryptococcosis","volume":"2","author":"KJ Kwon-Chung","year":"2017","journal-title":"mSphere"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"e1000850","DOI":"10.1371\/journal.ppat.1000850","article-title":"Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States","volume":"6","author":"EJ, 3rd Byrnes","year":"2010","journal-title":"PLoS pathogens"},{"issue":"49","key":"ref40","doi-asserted-by":"crossref","first-page":"17258","DOI":"10.1073\/pnas.0402981101","article-title":"A rare genotype of <italic>Cryptococcus gattii<\/italic> caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)","volume":"101","author":"SE Kidd","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cell.2008.07.046","article-title":"Systematic genetic analysis of virulence in the human fungal pathogen <italic>Cryptococcus neoformans<\/italic>","volume":"135","author":"OW Liu","year":"2008","journal-title":"Cell"},{"issue":"12","key":"ref42","doi-asserted-by":"crossref","first-page":"e1002411","DOI":"10.1371\/journal.ppat.1002411","article-title":"Toward an integrated model of capsule regulation in <italic>Cryptococcus neoformans<\/italic>","volume":"7","author":"BC Haynes","year":"2011","journal-title":"PLoS pathogens"},{"issue":"22","key":"ref43","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.cub.2005.10.040","article-title":"Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence","volume":"15","author":"T Klengel","year":"2005","journal-title":"Current biology: CB"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/EC.5.1.103-111.2006","article-title":"<italic>Cryptococcus neoformans<\/italic> senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1","volume":"5","author":"EG Mogensen","year":"2006","journal-title":"Eukaryotic cell"},{"issue":"22","key":"ref45","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.cub.2005.09.047","article-title":"Carbonic anhydrase and CO<sub>2<\/sub> sensing during <italic>Cryptococcus neoformans<\/italic> growth, differentiation, and virulence","volume":"15","author":"YS Bahn","year":"2005","journal-title":"Current biology: CB"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/infdis\/jit029","article-title":"The Mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus <italic>Cryptococcus neoformans<\/italic>","volume":"207","author":"B Cadieux","year":"2013","journal-title":"The Journal of infectious diseases"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/j.1365-2958.2004.04474.x","article-title":"Iron-regulated transcription and capsule formation in the fungal pathogen <italic>Cryptococcus neoformans<\/italic>","volume":"55","author":"T Lian","year":"2005","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.1365-2958.2012.08134.x","article-title":"Regulated expression of cyclic AMP-dependent protein kinase A reveals an influence on cell size and the secretion of virulence factors in <italic>Cryptococcus neoformans<\/italic>","volume":"85","author":"J Choi","year":"2012","journal-title":"Molecular microbiology"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"e01862","DOI":"10.1128\/mBio.01862-15","article-title":"Analysis of the Protein Kinase A-Regulated Proteome of <italic>Cryptococcus neoformans<\/italic> Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation","volume":"7","author":"JM Geddes","year":"2016","journal-title":"mBio"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1128\/IAI.71.3.1538-1547.2003","article-title":"Role of PLB1 in pulmonary inflammation and cryptococcal eicosanoid production","volume":"71","author":"MC Noverr","year":"2003","journal-title":"Infection and immunity"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1046\/j.1365-2958.1999.01375.x","article-title":"The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in <italic>Saccharomyces cerevisiae<\/italic>","volume":"32","author":"JJ Heinisch","year":"1999","journal-title":"Molecular microbiology"},{"issue":"13","key":"ref52","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1101\/gad.9.13.1559","article-title":"The protein kinase C-activated MAP kinase pathway of <italic>Saccharomyces cerevisiae<\/italic> mediates a novel aspect of the heat shock response","volume":"9","author":"Y Kamada","year":"1995","journal-title":"Genes Dev"},{"issue":"50","key":"ref53","doi-asserted-by":"crossref","first-page":"30157","DOI":"10.1074\/jbc.270.50.30157","article-title":"A second osmosensing signal transduction pathway in yeast. Hypotonic shock activates the PKC1 protein kinase-regulated cell integrity pathway","volume":"270","author":"KR Davenport","year":"1995","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/j.1460-2075.1996.tb00336.x","article-title":"The SLT2(MPK1) MAP kinase is activated during periods of polarized cell growth in yeast","volume":"15","author":"P Zarzov","year":"1996","journal-title":"The EMBO journal"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1172\/JCI112000","article-title":"Virulence of <italic>Cryptococcus neoformans<\/italic>. Regulation of capsule synthesis by carbon dioxide","volume":"76","author":"DL Granger","year":"1985","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1091\/mbc.e04-11-0987","article-title":"Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans","volume":"16","author":"YS Bahn","year":"2005","journal-title":"Molecular biology of the cell"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4161\/viru.19396","article-title":"Protein kinase A and fungal virulence: a sinister side to a conserved nutrient sensing pathway","volume":"3","author":"KK Fuller","year":"2012","journal-title":"Virulence"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1286-4579(03)00028-5","article-title":"Identification of metabolites of importance in the pathogenesis of pulmonary cryptococcoma using nuclear magnetic resonance spectroscopy","volume":"5","author":"U Himmelreich","year":"2003","journal-title":"Microbes and infection \/ Institut Pasteur"},{"issue":"14","key":"ref59","first-page":"1427","article-title":"Metabolites released by <italic>Cryptococcus neoformans<\/italic> var. <italic>neoformans<\/italic> and var. <italic>gattii<\/italic> differentially affect human neutrophil function. Microbes and infection \/","volume":"4","author":"L Wright","year":"2002","journal-title":"Institut Pasteur"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1128\/JB.104.1.313-322.1970","article-title":"Cellular control of the synthesis and activity of the bacterial luminescent system","volume":"104","author":"KH Nealson","year":"1970","journal-title":"Journal of bacteriology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.cellbio.21.012704.131001","article-title":"Quorum sensing: cell-to-cell communication in bacteria","volume":"21","author":"CM Waters","year":"2005","journal-title":"Annual review of cell and developmental biology"},{"issue":"6","key":"ref62","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1128\/JCM.22.6.1068-1070.1985","article-title":"Large <italic>Cryptococcus neoformans<\/italic> isolated from brain abscess","volume":"22","author":"GL Love","year":"1985","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/AEM.25.2.309-312.1973","article-title":"<italic>Cryptococcus neoformans<\/italic> of unusual morphology","volume":"25","author":"JG Cruickshank","year":"1973","journal-title":"Appl Microbiol"},{"issue":"8","key":"ref64","first-page":"4837","article-title":"Clinicopathological features of pulmonary cryptococcosis with cryptococcal titan cells: a comparative analysis of 27 cases","volume":"7","author":"JM Wang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1365-2958.2005.04928.x","article-title":"The polysaccharide capsule of the pathogenic fungus <italic>Cryptococcus neoformans<\/italic> enlarges by distal growth and is rearranged during budding","volume":"59","author":"O Zaragoza","year":"2006","journal-title":"Molecular microbiology"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"e00945","DOI":"10.1128\/mBio.00945-14","article-title":"Capsule growth in <italic>Cryptococcus neoformans<\/italic> is coordinated with cell cycle progression","volume":"5","author":"R Garcia-Rodas","year":"2014","journal-title":"mBio"},{"issue":"9","key":"ref67","doi-asserted-by":"crossref","first-page":"e24485","DOI":"10.1371\/journal.pone.0024485","article-title":"<italic>Cryptococcus neoformans<\/italic> capsular enlargement and cellular gigantism during Galleria mellonella infection","volume":"6","author":"R Garcia-Rodas","year":"2011","journal-title":"PloS one"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2217\/fmb-2016-0090","article-title":"The putative autophagy regulator Atg7 affects the physiology and pathogenic mechanisms of <italic>Cryptococcus neoformans<\/italic>","volume":"11","author":"DL Oliveira","year":"2016","journal-title":"Future Microbiol"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/infdis\/167.1.186","article-title":"Regulation of cryptococcal capsular polysaccharide by iron","volume":"167","author":"SE Vartivarian","year":"1993","journal-title":"The Journal of infectious diseases"},{"issue":"9","key":"ref70","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tim.2013.05.007","article-title":"An encapsulation of iron homeostasis and virulence in <italic>Cryptococcus neoformans<\/italic>","volume":"21","author":"JW Kronstad","year":"2013","journal-title":"Trends in microbiology"},{"issue":"1","key":"ref71","first-page":"177","article-title":"Chronic cryptococcal meningitis: a new experimental model in rabbits","volume":"101","author":"JR Perfect","year":"1980","journal-title":"Am J Pathol"},{"issue":"6","key":"ref72","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/EC.3.6.1601-1608.2004","article-title":"UGD1, encoding the <italic>Cryptococcus neoformans<\/italic> UDP-glucose dehydrogenase, is essential for growth at 37 degrees C and for capsule biosynthesis","volume":"3","author":"F Moyrand","year":"2004","journal-title":"Eukaryotic cell"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1128\/IAI.71.9.4831-4841.2003","article-title":"Sexual cycle of <italic>Cryptococcus neoformans<\/italic> var. <italic>grubii<\/italic> and virulence of congenic a and alpha isolates","volume":"71","author":"K Nielsen","year":"2003","journal-title":"Infection and immunity"},{"issue":"5","key":"ref74","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1128\/jb.175.5.1405-1411.1993","article-title":"Gene transfer in <italic>Cryptococcus neoformans<\/italic> by use of biolistic delivery of DNA","volume":"175","author":"DL Toffaletti","year":"1993","journal-title":"Journal of bacteriology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1251\/bpo68","article-title":"Experimental modulation of capsule size in <italic>Cryptococcus neoformans<\/italic>","volume":"6","author":"O Zaragoza","year":"2004","journal-title":"Biol Proced Online"},{"issue":"6","key":"ref76","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/infdis\/165.6.1086","article-title":"Antibodies elicited by a <italic>Cryptococcus neoformans<\/italic>-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection","volume":"165","author":"A Casadevall","year":"1992","journal-title":"The Journal of infectious diseases"},{"issue":"12","key":"ref77","doi-asserted-by":"crossref","first-page":"e15968","DOI":"10.1371\/journal.pone.0015968","article-title":"Automated analysis of cryptococcal macrophage parasitism using GFP-tagged cryptococci","volume":"5","author":"K Voelz","year":"2010","journal-title":"PloS one"},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4161\/21505594.2014.986412","article-title":"<italic>Cryptococcus neoformans<\/italic> induces antimicrobial responses and behaves as a facultative intracellular pathogen in the non mammalian model <italic>Galleria mellonella<\/italic>","volume":"6","author":"N Trevijano-Contador","year":"2015","journal-title":"Virulence"},{"issue":"4","key":"ref79","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"B Langmead","year":"2012","journal-title":"Nature methods"},{"issue":"12","key":"ref80","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/bioinformatics\/btu627","article-title":"FungiFun2: a comprehensive online resource for systematic analysis of gene lists from fungal species","volume":"31","author":"S Priebe","year":"2015","journal-title":"Bioinformatics"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/EC.1.1.75-84.2002","article-title":"Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of <italic>Cryptococcus neoformans<\/italic>","volume":"1","author":"JA Alspaugh","year":"2002","journal-title":"Eukaryotic cell"},{"issue":"4","key":"ref83","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2307\/3758800","article-title":"Morphogenesis of <italic>Filobasidiella neoformans<\/italic>, the sexual state of <italic>Cryptococcus neoformans<\/italic>","volume":"68","author":"KJ Kwon-Chung","year":"1976","journal-title":"Mycologia"},{"issue":"3","key":"ref84","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1534\/genetics.107.078923","article-title":"Genetic analyses of a hybrid cross between serotypes A and D strains of the human pathogenic fungus <italic>Cryptococcus neoformans<\/italic>","volume":"177","author":"S Sun","year":"2007","journal-title":"Genetics"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.fgb.2014.09.007","article-title":"Distinct and redundant roles of exonucleases in <italic>Cryptococcus neoformans<\/italic>: Implications for virulence and mating","volume":"73","author":"C Wollschlaeger","year":"2014","journal-title":"Fungal Genet Biol"},{"issue":"1\u20132","key":"ref86","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0378-1119(95)00640-0","article-title":"Further analysis of the <italic>CAP59<\/italic> locus of <italic>Cryptococcus neoformans<\/italic>: structure defined by forced expression and description of a new ribosomal protein-encoding gene","volume":"167","author":"YC Chang","year":"1995","journal-title":"Gene"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T23:52:57Z","timestamp":1604274777000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007007"}},"subtitle":[],"editor":[{"given":"Aaron P.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,18]]},"references-count":86,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007007","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/193540","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,18]]}}}