{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:52:19Z","timestamp":1790664739529,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007010","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI064046"],"award-info":[{"award-number":["AI064046"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA206309"],"award-info":[{"award-number":["CA206309"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI080302"],"award-info":[{"award-number":["AI080302"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM117839"],"award-info":[{"award-number":["GM117839"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007010","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T17:29:37Z","timestamp":1524245377000},"page":"e1007010","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G"],"prefix":"10.1371","volume":"14","author":[{"given":"Terumasa","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-9881","authenticated-orcid":true,"given":"Menelaos","family":"Symeonides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Albin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Thali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9034-9112","authenticated-orcid":true,"given":"Reuben S.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/gb-2008-9-6-229","article-title":"The AID\/APOBEC family of nucleic acid mutators","volume":"9","author":"SG Conticello","year":"2008","journal-title":"Genome Biol"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nri1489","article-title":"Retroviral restriction by APOBEC proteins","volume":"4","author":"RS Harris","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.jmb.2013.10.033","article-title":"Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all","volume":"426","author":"BA Desimmie","year":"2014","journal-title":"J Mol Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.virol.2015.03.012","article-title":"APOBECs and virus restriction","volume":"479\u2013480C","author":"RS Harris","year":"2015","journal-title":"Virology"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/ni.3156","article-title":"Intrinsic host restrictions to HIV-1 and mechanisms of viral escape","volume":"16","author":"V Simon","year":"2015","journal-title":"Nat Immunol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tig.2015.10.005","article-title":"DNA editing by APOBECs: A genomic preserver and transformer","volume":"32","author":"BA Knisbacher","year":"2016","journal-title":"Trends Genet"},{"issue":"21","key":"ref7","doi-asserted-by":"crossref","first-page":"11220","DOI":"10.1128\/JVI.05238-11","article-title":"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1","volume":"85","author":"JF Hultquist","year":"2011","journal-title":"J Virol"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"e1002800","DOI":"10.1371\/journal.ppat.1002800","article-title":"Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n","volume":"8","author":"EW Refsland","year":"2012","journal-title":"PLoS Pathog"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.chom.2013.09.006","article-title":"HIV-1 Vif adaptation to human APOBEC3H haplotypes","volume":"14","author":"M Ooms","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"e1004761","DOI":"10.1371\/journal.pgen.1004761","article-title":"Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity","volume":"10","author":"EW Refsland","year":"2014","journal-title":"PLoS Genet"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"e1500296","DOI":"10.1126\/sciadv.1500296","article-title":"Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-beta\/RUNX axis","volume":"1","author":"BD Anderson","year":"2015","journal-title":"Sci Adv"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cub.2008.04.073","article-title":"Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G","volume":"18","author":"G Hach\u00e9","year":"2008","journal-title":"Curr Biol"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1128\/JVI.00045-09","article-title":"Optimal translation initiation enables Vif-deficient human immunodeficiency virus type 1 to escape restriction by APOBEC3G","volume":"83","author":"G Hach\u00e9","year":"2009","journal-title":"J Virol"},{"issue":"19","key":"ref14","doi-asserted-by":"crossref","first-page":"10209","DOI":"10.1128\/JVI.00632-10","article-title":"Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function","volume":"84","author":"JS Albin","year":"2010","journal-title":"J Virol"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1128\/JVI.02964-12","article-title":"Transmitted\/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5","volume":"87","author":"ZF Parker","year":"2013","journal-title":"J Virol"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.molcel.2010.02.012","article-title":"Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions","volume":"37","author":"A Finzi","year":"2010","journal-title":"Mol Cell"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1074\/jbc.M607298200","article-title":"APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G","volume":"282","author":"RK Holmes","year":"2007","journal-title":"J Biol Chem"},{"issue":"49","key":"ref18","doi-asserted-by":"crossref","first-page":"40841","DOI":"10.1074\/jbc.R112.406272","article-title":"HIV entry and envelope glycoprotein-mediated fusion","volume":"287","author":"R Blumenthal","year":"2012","journal-title":"J Biol Chem"},{"issue":"13","key":"ref19","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1128\/JVI.00550-14","article-title":"Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion","volume":"88","author":"NH Roy","year":"2014","journal-title":"J Virol"},{"issue":"32","key":"ref20","doi-asserted-by":"crossref","first-page":"33177","DOI":"10.1074\/jbc.M402062200","article-title":"The interaction between HIV-1 Gag and APOBEC3G","volume":"279","author":"S Cen","year":"2004","journal-title":"J Biol Chem"},{"issue":"21","key":"ref21","doi-asserted-by":"crossref","first-page":"12058","DOI":"10.1128\/JVI.78.21.12058-12061.2004","article-title":"APOBEC3G incorporation into human immunodeficiency virus type 1 particles","volume":"78","author":"V Zennou","year":"2004","journal-title":"J Virol"},{"issue":"21","key":"ref22","doi-asserted-by":"crossref","first-page":"11841","DOI":"10.1128\/JVI.78.21.11841-11852.2004","article-title":"Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging","volume":"78","author":"K Luo","year":"2004","journal-title":"J Virol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.virol.2004.08.006","article-title":"Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor","volume":"328","author":"A Schafer","year":"2004","journal-title":"Virology"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2004.07.005","article-title":"HIV-1 and MLV Gag proteins are sufficient to recruit APOBEC3G into virus-like particles","volume":"321","author":"M Douaisi","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"33","key":"ref25","doi-asserted-by":"crossref","first-page":"34083","DOI":"10.1074\/jbc.C400235200","article-title":"APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein","volume":"279","author":"TM Alce","year":"2004","journal-title":"J Biol Chem"},{"issue":"34","key":"ref26","doi-asserted-by":"crossref","first-page":"35822","DOI":"10.1074\/jbc.M405761200","article-title":"Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs","volume":"279","author":"ES Svarovskaia","year":"2004","journal-title":"J Biol Chem"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jmb.2011.04.042","article-title":"HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation","volume":"410","author":"MA Checkley","year":"2011","journal-title":"J Mol Biol"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1128\/JVI.02053-12","article-title":"The tale of the long tail: the cytoplasmic domain of HIV-1 gp41","volume":"87","author":"TS Postler","year":"2013","journal-title":"J Virol"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1073\/pnas.0908661107","article-title":"Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain","volume":"107","author":"V Chukkapalli","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jmb.2010.11.051","article-title":"HIV-1 Gag extension: conformational changes require simultaneous interaction with membrane and nucleic acid","volume":"406","author":"SA Datta","year":"2011","journal-title":"J Mol Biol"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1128\/JVI.73.10.8824-8830.1999","article-title":"Association of Nef with the human immunodeficiency virus type 1 core","volume":"73","author":"A Kotov","year":"1999","journal-title":"J Virol"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chom.2011.12.005","article-title":"The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-kappaB activation through TGF-beta-activated kinase 1","volume":"11","author":"TS Postler","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"30","key":"ref33","doi-asserted-by":"crossref","first-page":"26568","DOI":"10.1074\/jbc.M111.235721","article-title":"Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein","volume":"286","author":"ZL Demorest","year":"2011","journal-title":"J Biol Chem"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nsmb.1497","article-title":"Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif","volume":"15","author":"K Shirakawa","year":"2008","journal-title":"Nat Struct Mol Biol"},{"issue":"6944","key":"ref35","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature01707","article-title":"The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA","volume":"424","author":"H Zhang","year":"2003","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-59745-170-3_5","article-title":"Real-time PCR analysis of HIV-1 replication post-entry events","volume":"485","author":"JL Mbisa","year":"2009","journal-title":"Methods Mol Biol"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/87979","article-title":"A quantitative assay for HIV DNA integration in vivo","volume":"7","author":"SL Butler","year":"2001","journal-title":"Nat Med"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.cub.2004.12.068","article-title":"Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity","volume":"15","author":"EN Newman","year":"2005","journal-title":"Curr Biol"},{"issue":"18","key":"ref39","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1128\/JVI.00377-08","article-title":"Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation","volume":"82","author":"JL DeHart","year":"2008","journal-title":"J Virol"},{"key":"ref40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18296","article-title":"Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants","volume":"5","author":"EJ Greenwood","year":"2016","journal-title":"Elife"},{"issue":"2","key":"ref41","first-page":"121","article-title":"Ribosomal frameshifting: an emerging drug target for HIV","volume":"10","author":"PC Gareiss","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1517\/14728222.2012.665879","article-title":"Targeting frameshifting in the human immunodeficiency virus","volume":"16","author":"L Brakier-Gingras","year":"2012","journal-title":"Expert Opin Ther Targets"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41564-017-0063-9","article-title":"Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G","volume":"3","author":"D Pollpeter","year":"2018","journal-title":"Nat Microbiol"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1128\/JVI.00062-14","article-title":"Quantification of deaminase activity-dependent and -independent restriction of HIV-1 replication mediated by APOBEC3F and APOBEC3G through experimental-mathematical investigation","volume":"88","author":"T Kobayashi","year":"2014","journal-title":"J Virol"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"e1004024","DOI":"10.1371\/journal.ppat.1004024","article-title":"Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms","volume":"10","author":"A Ara","year":"2014","journal-title":"PLoS Pathog"},{"issue":"49","key":"ref46","doi-asserted-by":"crossref","first-page":"E4780","DOI":"10.1073\/pnas.1315996110","article-title":"Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes","volume":"110","author":"RC Burdick","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4848","key":"ref47","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.2832945","article-title":"Biologic features of HIV-1 that correlate with virulence in the host","volume":"240","author":"C Cheng-Mayer","year":"1988","journal-title":"Science"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/JVI.65.1.356-363.1991","article-title":"Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture","volume":"65","author":"H Schuitemaker","year":"1991","journal-title":"J Virol"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1128\/JVI.66.3.1354-1360.1992","article-title":"Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population","volume":"66","author":"H Schuitemaker","year":"1992","journal-title":"J Virol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.virol.2017.04.033","article-title":"Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor","volume":"508","author":"N Espy","year":"2017","journal-title":"Virology"},{"issue":"22","key":"ref51","doi-asserted-by":"crossref","first-page":"7982","DOI":"10.1073\/pnas.0501445102","article-title":"The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein","volume":"102","author":"M Lochelt","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"ref52","doi-asserted-by":"crossref","first-page":"8724","DOI":"10.1128\/JVI.79.14.8724-8731.2005","article-title":"Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors","volume":"79","author":"RA Russell","year":"2005","journal-title":"J Virol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1742-4690-10-76","article-title":"Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction","volume":"10","author":"DS Lukic","year":"2013","journal-title":"Retrovirology"},{"issue":"9","key":"ref54","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.1074\/jbc.M808853200","article-title":"Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet","volume":"284","author":"M Perkovic","year":"2009","journal-title":"J Biol Chem"},{"issue":"8","key":"ref55","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1073\/pnas.0609444104","article-title":"Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid","volume":"104","author":"D Derse","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7130","key":"ref56","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nature05540","article-title":"APOBEC3 inhibits mouse mammary tumour virus replication in vivo","volume":"445","author":"CM Okeoma","year":"2007","journal-title":"Nature"},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.bbamem.2013.08.020","article-title":"Mutations in the feline immunodeficiency virus envelope glycoprotein confer resistance to a dominant-negative fragment of Tsg101 by enhancing infectivity and cell-to-cell virus transmission","volume":"1838","author":"BG Luttge","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/aid.1987.3.283","article-title":"Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibody","volume":"3","author":"PL Nara","year":"1987","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"9","key":"ref59","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1073\/pnas.94.9.4653","article-title":"A new reporter cell line to monitor HIV infection and drug susceptibility in vitro","volume":"94","author":"A Gervaix","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref60","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1128\/JVI.73.11.8966-8974.1999","article-title":"A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 coreceptor","volume":"73","author":"A Trkola","year":"1999","journal-title":"J Virol"},{"issue":"6","key":"ref61","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1128\/AAC.46.6.1896-1905.2002","article-title":"Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy","volume":"46","author":"X Wei","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virol.2013.11.041","article-title":"Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus","volume":"450\u2013451","author":"JS Albin","year":"2014","journal-title":"Virology"},{"issue":"7381","key":"ref63","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature10693","article-title":"Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection","volume":"481","author":"S J\u00e4ger","year":"2012","journal-title":"Nature"},{"issue":"19","key":"ref64","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1074\/jbc.M109.067090","article-title":"Conformational changes of the HIV-1 envelope protein during membrane fusion are inhibited by the replacement of its membrane-spanning domain","volume":"285","author":"N Kondo","year":"2010","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"ref65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1099\/vir.0.80426-0","article-title":"Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR","volume":"86","author":"R Susp\u00e8ne","year":"2005","journal-title":"J Gen Virol"},{"issue":"20","key":"ref66","doi-asserted-by":"crossref","first-page":"16965","DOI":"10.1074\/jbc.M111.310839","article-title":"Signals in APOBEC3F N-terminal and C-terminal deaminase domains each contribute to encapsidation in HIV-1 virions and are both required for HIV-1 restriction","volume":"287","author":"C Song","year":"2012","journal-title":"J Biol Chem"},{"issue":"12","key":"ref67","doi-asserted-by":"crossref","first-page":"e1000231","DOI":"10.1371\/journal.ppat.1000231","article-title":"APOBEC3G inhibits elongation of HIV-1 reverse transcripts","volume":"4","author":"KN Bishop","year":"2008","journal-title":"PLoS Pathog"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3390\/v6031078","article-title":"Evidence showing that tetraspanins inhibit HIV-1-induced cell-cell fusion at a post-hemifusion stage","volume":"6","author":"M Symeonides","year":"2014","journal-title":"Viruses"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007010","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T02:44:07Z","timestamp":1604198647000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007010"}},"subtitle":[],"editor":[{"given":"Guido","family":"Silvestri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,20]]},"references-count":68,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007010","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007010","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,20]]}}}