{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:36Z","timestamp":1790467236047,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007066","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome Trust Strategic Award \u2018Flatworm Functional Genomics Initiative (FUGI)\u2019","award":["107475\/Z\/15\/Z"],"award-info":[{"award-number":["107475\/Z\/15\/Z"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007066","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T14:44:01Z","timestamp":1526913841000},"page":"e1007066","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni"],"prefix":"10.1371","volume":"14","author":[{"given":"David","family":"Roquis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-2306","authenticated-orcid":true,"given":"Aaron","family":"Taudt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin K.","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Padalino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3932-5502","authenticated-orcid":true,"given":"Karl F.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-7151","authenticated-orcid":true,"given":"Nancy","family":"Holroyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-0377","authenticated-orcid":true,"given":"Matt","family":"Berriman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-7004","authenticated-orcid":true,"given":"Beno\u00eet","family":"Aliaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-349X","authenticated-orcid":true,"given":"Cristian","family":"Chaparro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2161-412X","authenticated-orcid":true,"given":"Christoph","family":"Grunau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-0043","authenticated-orcid":true,"given":"Ronaldo de Carvalho","family":"Augusto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Articles Global, regional, and national age\u2013sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","year":"2014","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1756-8935-6-40","article-title":"Parasite epigenetics and immune evasion: lessons from budding yeast","volume":"6","author":"BA Wyse","year":"2013","journal-title":"Epigenetics & Chromatin"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/cmi.12471","article-title":"Host-parasite interactions: an intimate epigenetic relationship","volume":"17","author":"K Cheeseman","year":"2015","journal-title":"Cell Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.chom.2016.04.020","article-title":"Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa","volume":"19","author":"MT Duraisingh","year":"2016","journal-title":"Cell Host and Microbe"},{"key":"ref5","first-page":"1","article-title":"The role of epigenetics in host\u2013parasite coevolution: lessons from the model host insects Galleria mellonella and Tribolium castaneum","author":"A Vilcinkas","year":"2016","journal-title":"Zoology"},{"key":"ref6","first-page":"1","article-title":"Epigenetics: A New Model for Intracellular Parasite\u2013Host Cell Regulation","author":"WR McMaster","year":"2016","journal-title":"Trends Parasitol"},{"key":"ref7","first-page":"1","article-title":"The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite","author":"G Batugedara","year":"2017","journal-title":"Trends Parasitol"},{"key":"ref8","first-page":"1","article-title":"Epigenetics_ A way to bridge the gap between biological fields","author":"A Nicoglou","year":"2017","journal-title":"Studies in History and Philosophy of Biol & Biomed Sci"},{"key":"ref9","unstructured":"WHO. Schistosomiasis, Fact Sheet No 115; World Health Organization. Available at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en\/<\/ext-link>. 2018."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/oxfordjournals.molbev.a003769","article-title":"Evolutionary relationships and biogeography of Biomphalaria (Gastropoda: Planorbidae) with implications regarding its role as host of the human bloodfluke, Schistosoma mansoni","volume":"18","author":"RJ DeJong","year":"2001","journal-title":"Molecular Biology and Evolution"},{"key":"ref11","first-page":"931","article-title":"Non-human vertebrate hosts of Schistosoma haematobium and <italic>Schistosoma mansoni<\/italic>","volume":"18","author":"AV Martins","year":"1957","journal-title":"Bull World Health Organ"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"e0005789","DOI":"10.1371\/journal.pntd.0005789","article-title":"Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites","volume":"11","author":"RC Augusto","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1111\/mec.13555","article-title":"Frequency and mitotic heritability of epimutations in <italic>Schistosoma mansoni<\/italic>","volume":"25","author":"D Roquis","year":"2016","journal-title":"Molecular Ecology"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1590\/S0074-02762004000200003","article-title":"Phenotypic Plasticity in Adult Worms of <italic>Schistosoma mansoni<\/italic> (Trematoda:Schistosomatidae) Evidenced by Brightfield and Confocal Laser Scanning Microscopies","volume":"99","author":"RH Neves","year":"2004","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fgene.2014.00207","article-title":"\u201cExposure to Hycanthone Alters Chromatin Structure around Specific Gene Functions and Specific Repeats in <italic>Schistosoma Mansoni<\/italic>.\u201d","volume":"5","author":"D Roquis","year":"2014","journal-title":"Front Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e0003853","DOI":"10.1371\/journal.pntd.0003853","article-title":"The epigenome of <italic>Schistosoma mansoni<\/italic> provides insight about how cercariae poise transcription until infection","volume":"9","author":"D Roquis","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e0004930","DOI":"10.1371\/journal.pntd.0004930","article-title":"Sex-Biased Transcriptome of <italic>Schistosoma mansoni<\/italic>: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation","volume":"10","author":"MAL Picard","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"e0005246","DOI":"10.1371\/journal.pntd.0005246","article-title":"The <italic>Biomphalaria glabrata<\/italic> DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni","volume":"11","author":"KK1 Geyer","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/1471-2164-11-387","article-title":"Whole-genome in-silico subtractive hybridization (WISH)\u2014using massive sequencing for the identification of unique and repetitive sex-specific sequences: the example of Schistosoma mansoni","volume":"11","author":"J Portela","year":"2010","journal-title":"BMC Genomics"},{"issue":"Pt 4","key":"ref20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1017\/S0031182099006393","article-title":"Experimental observations on the sex ratio of adult <italic>Schistosoma mansoni<\/italic>, with comments on the natural male bias","volume":"121","author":"J Boissier","year":"2000","journal-title":"Parasitology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"RH Duvall","year":"1967","journal-title":"Am J Trop Med Hyg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","article-title":"The infection of laboratory hosts with cercariae of <italic>Schistosoma mansoni<\/italic> and the recovery of the adult worms","volume":"55","author":"S.R. Smithers","year":"1965","journal-title":"Parasitology"},{"key":"ref23","article-title":"Current Protocols in Immunology","author":"F.A. Lewis","year":"1998"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/ml3003346","article-title":"Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2","volume":"3","author":"Sharad K. Verma","year":"2012","journal-title":"ACS Med. Chem. Lett"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1021\/ml400496h","article-title":"Discovery and development of potent and selective inhibitors of histone methyltransferase g9a","volume":"5","author":"RF Sweis","year":"2014","journal-title":"ACS Med Chem Lett"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"e0131716","DOI":"10.1371\/journal.pone.0131716","article-title":"The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a\/GLP in the Epigenetics of Leukemia","volume":"10","author":"William N. Pappano","journal-title":"PLoS ONE"},{"key":"ref27","article-title":"Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform","author":"T Wagner","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-61779-316-5_15","article-title":"Native chromatin immunoprecipitation","volume":"791","author":"C Cosseau","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1186\/gb-2010-11-8-r86","article-title":"Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences","volume":"11","author":"J Goecks","year":"2010","journal-title":"Genome Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1455","DOI":"10.1371\/journal.pntd.0001455","article-title":"A systematically improved high quality genome and transcriptome of the human blood fluke <italic>Schistosoma mansoni<\/italic>","volume":"6","author":"AV Protasio","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"B Langmead","year":"2012","journal-title":"Nat Meth"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1471-2105-12-139","article-title":"PeakRanger: A cloud-enabled peak caller for ChIP-seq data","volume":"12","author":"X Feng","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"H Thorvaldsdottir","year":"2013","journal-title":"Briefings in Bioinformatics"},{"key":"ref35","first-page":"1","article-title":"chromstaR: Tracking combinatorial chromatin state dynamics in space and time","author":"A Taudt","year":"2016","journal-title":"chromstaR: Tracking combinatorial chromatin state dynamics in space and time"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.exppara.2012.02.010","article-title":"Combination of de novo assembly of massive sequencing reads with classical repeat prediction improves identification of repetitive sequences in <italic>Schistosoma mansoni<\/italic>","volume":"130","author":"JMJ Lepesant","year":"2012","journal-title":"Exp Parasitol"},{"key":"ref37","first-page":"1","article-title":"Salmon provides accurate, fast, and bias-aware transcript expression estimates using dual-phase inference","author":"R Patro","year":"2016","journal-title":"Salmon provides accurate, fast, and bias-aware transcript expression estimates using dual-phase inference"},{"key":"ref38","first-page":"31","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"key":"ref39","first-page":"529","article-title":"A positive role for polycomb in transcriptional regulation via H4K20me1","volume":"26","author":"X Lv","year":"2016","journal-title":"Nature Publishing Group"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-Resolution Profiling of Histone Methylations in the Human Genome","volume":"129","author":"A Barski","year":"2007","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature05915","article-title":"The complex language of chromatin regulation during transcription","volume":"447","author":"SL Berger","year":"2007","journal-title":"Nature"},{"key":"ref42","first-page":"73","article-title":"Partitioning the C. elegans genome by nucleosome modification, occupancy, and positioning","volume":"119","author":"SG Gu","year":"2009","journal-title":"Chromosoma"},{"key":"ref43","first-page":"1","article-title":"Comprehensive analysis of the chromatin landscape in Drosophila melanogaster","author":"PV Kharchenko","year":"2010","journal-title":"Nature"},{"key":"ref44","first-page":"259","article-title":"Regulation of nucleosome dynamics by histone modifications","volume":"20","author":"GE Zentner","year":"2013","journal-title":"Nature Publishing Group"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e201600095","DOI":"10.1002\/bies.201600095","article-title":"Is H3K4me3 instructive for transcription activation?","volume":"39","author":"FS Howe","year":"2016","journal-title":"BioEssays"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","article-title":"Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing","volume":"298","author":"R Cao","year":"2002","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2007.09.011","article-title":"Facultative heterochromatin: is there a distinctive molecular signature?","volume":"28","author":"P Trojer","year":"2007","journal-title":"Molecular Cell"},{"key":"ref48","first-page":"381","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"AJ Bannister","year":"2011","journal-title":"Nature Publishing Group"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature04120","article-title":"Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs","volume":"438","author":"N Lee","year":"2005","journal-title":"Nature"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/embor.2009.102","article-title":"Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes","volume":"10","author":"T Shaw","year":"2009","journal-title":"EMBO Rep"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"19889","DOI":"10.1073\/pnas.0904132106","article-title":"A histone demethylase is necessary for regeneration in zebrafish","volume":"106","author":"S Stewart","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref52","first-page":"51","article-title":"Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts","volume":"10","author":"B Bao","year":"2017","journal-title":"Front. Mol. Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e00768","DOI":"10.7554\/eLife.00768","article-title":"Functional genomic characterization of neoblast-like stem cells in larval <italic>Schistosoma mansoni<\/italic>","volume":"2","author":"B Wang","year":"2013","journal-title":"Elife"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ceb.2012.03.009","article-title":"Bivalent histone modifications in early embryogenesis","volume":"24","author":"NL Vastenhouw","year":"2012","journal-title":"Current Opinion in Cell Biology"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1017\/S0031182000055323","article-title":"Transmission of <italic>Schistosoma mansoni<\/italic> from man to snail: experimental studies of miracidial survival and infectivity in relation to larval age, water temperature, host size and host age","volume":"85","author":"RM Anderson","year":"1982","journal-title":"Parasitol"},{"key":"ref56","article-title":"Recherche des facteurs susceptibles d&apos;emp\u00eacher la r\u00e9alisation du cycle de <italic>Schistosoma mansoni<\/italic> dans les mares de la Grande Terre de Guadeloupe","author":"A Th\u00e9ron","year":"1985","journal-title":"(Antilles \u2026. Ann Parasitol Hum Comp"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrg.2017.57","article-title":"The interplay of epigenetic marks during stem cell differentiation and development","volume":"18","author":"Y Atlasi","year":"2017","journal-title":"Nature Reviews Genetics"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.exppara.2008.11.010","article-title":"<italic>Schistosoma mansoni<\/italic>: developmental arrest of miracidia treated with histone deacetylase inhibitors","volume":"121","author":"A Azzi","year":"2009","journal-title":"Exp Parasitol"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"e0005539","DOI":"10.1371\/journal.pntd.0005539","article-title":"Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in <italic>Schistosoma mansoni<\/italic>","volume":"11","author":"L Anderson","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/13543776.2017.1316976","article-title":"EZH2 inhibitors: a patent review (2014\u20132016)","volume":"27","author":"G Stazi","year":"2017","journal-title":"Expert Opin Ther Pat"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e8570","DOI":"10.1371\/journal.pone.0008570","article-title":"Structural Biology of Human H3K9 Methyltransferases","volume":"5","author":"H Wu","year":"2010","journal-title":"PLoS ONE"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"18709","DOI":"10.1038\/srep18709","article-title":"G9a orchestrates PCL3 and KDM7A to promote histone H3K27 Methylation","volume":"5","author":"MR Pan","year":"2015","journal-title":"Sci Rep"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1093\/nar\/gkt012","article-title":"Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity","volume":"41","author":"S Jorgensen","year":"2013","journal-title":"Nucleic Acids Research"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1091\/mbc.e12-07-0529","article-title":"H4K20 methylation regulates quiescence and chromatin compaction","volume":"24","author":"AG Evertts","year":"2013","journal-title":"Molecular Biology of the Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ng.154","article-title":"Combinatorial patterns of histone acetylations and methylations in the human genome","volume":"40","author":"Z Wang","year":"2008","journal-title":"Nat Genet"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1128\/MCB.01768-08","article-title":"Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse Development","volume":"29","author":"H Oda","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","article-title":"The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism","volume":"137","author":"R Kopan","year":"2009","journal-title":"Cell"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1101\/gr.080861.108","article-title":"H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome","volume":"19","author":"FM Pauler","year":"2008","journal-title":"Genome Research"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007066","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T04:10:06Z","timestamp":1540354206000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007066"}},"subtitle":[],"editor":[{"given":"Michael H.","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,21]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007066","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007066","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,21]]}}}