{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:02:50Z","timestamp":1791842570208,"version":"4.3.4"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16PRE29860000"],"award-info":[{"award-number":["16PRE29860000"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI135158"],"award-info":[{"award-number":["AI135158"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK051406"],"award-info":[{"award-number":["DK051406"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI10874901"],"award-info":[{"award-number":["AI10874901"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P50-DK0645400"],"award-info":[{"award-number":["P50-DK0645400"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI1114926"],"award-info":[{"award-number":["AI1114926"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17SDG33350092"],"award-info":[{"award-number":["17SDG33350092"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007188","name":"Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["RO733973"],"award-info":[{"award-number":["RO733973"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007102","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T14:16:43Z","timestamp":1537453003000},"page":"e1007102","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":77,"title":["Manganese acquisition is essential for virulence of Enterococcus faecalis"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0103-4977","authenticated-orcid":true,"given":"Cristina","family":"Colomer-Winter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"Flores-Mireles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5925-246X","authenticated-orcid":true,"given":"Shannon P.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-3380","authenticated-orcid":true,"given":"Kristi L.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-5265","authenticated-orcid":true,"given":"Aaron J. L.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Hultgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6097-7583","authenticated-orcid":true,"given":"Todd","family":"Kitten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0791-5863","authenticated-orcid":true,"given":"Jos\u00e9 A.","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,9,20]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrmicro2761","article-title":"The rise of the <italic>Enterococcus<\/italic>: beyond vancomycin resistance","volume":"10","author":"CA Arias","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/1469-0691.12166","article-title":"Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study","volume":"19","author":"C Chirouze","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: epidemiology, mechanisms of infection and treatment options","volume":"13","author":"AL Flores-Mireles","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tim.2017.01.004","article-title":"Multidrug-Resistant Enterococcal Infections: New Compounds, Novel Antimicrobial Therapies?","volume":"25","author":"RM van Harten","year":"2017","journal-title":"Trends Microbiol"},{"key":"ref5","first-page":"65","article-title":"Enterococci: From Commensals to Leading Causes of Drug Resistant Infection","author":"NI Agudelo Higuita","year":"2014"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"e00260","DOI":"10.1128\/IAI.00260-17","article-title":"Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of <italic>Enterococcus faecalis<\/italic>","volume":"85","author":"C Colomer-Winter","year":"2017","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev.micro.60.080805.142149","article-title":"Manganese transport and the role of manganese in virulence","volume":"60","author":"KM Papp-Wallace","year":"2006","journal-title":"Annu Rev Microbiol"},{"issue":"2\u20133","key":"ref8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0168-6445(03)00052-4","article-title":"Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria","volume":"27","author":"DG Kehres","year":"2003","journal-title":"FEMS Microbiol Rev"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s00775-008-0404-5","article-title":"Metal ions in biological catalysis: from enzyme databases to general principles","volume":"13","author":"C Andreini","year":"2008","journal-title":"J Biol Inorg Chem"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1081\/CLT-100102427","article-title":"Manganese","volume":"37","author":"DG Barceloux","year":"1999","journal-title":"J Toxicol Clin Toxicol"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.etap.2004.12.053","article-title":"Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration","volume":"19","author":"KM Erikson","year":"2005","journal-title":"Environ Toxicol Pharmacol"},{"issue":"4\u20135","key":"ref12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.mam.2005.07.003","article-title":"Nutritional aspects of manganese homeostasis","volume":"26","author":"JL Aschner","year":"2005","journal-title":"Mol Aspects Med"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cbpa.2009.11.008","article-title":"Nutritional immunity beyond iron: a role for manganese and zinc","volume":"14","author":"TE Kehl-Fie","year":"2010","journal-title":"Curr Opin Chem Biol"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"e1000949","DOI":"10.1371\/journal.ppat.1000949","article-title":"The battle for iron between bacterial pathogens and their vertebrate hosts","volume":"6","author":"EP Skaar","year":"2010","journal-title":"PLoS Pathog"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1073\/pnas.1220341110","article-title":"Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens","volume":"110","author":"SM Damo","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0092-8674(93)90135-D","article-title":"Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg","volume":"73","author":"SM Vidal","year":"1993","journal-title":"Cell"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1128\/IAI.00420-13","article-title":"MntABC and MntH contribute to systemic <italic>Staphylococcus aureus<\/italic> infection by competing with calprotectin for nutrient manganese","volume":"81","author":"TE Kehl-Fie","year":"2013","journal-title":"Infect Immun"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/mmi.13034","article-title":"Manganese homeostasis and utilization in pathogenic bacteria","volume":"97","author":"LJ Juttukonda","year":"2015","journal-title":"Mol Microbiol"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1128\/IAI.70.11.6032-6042.2002","article-title":"Acquisition of Mn(II) in addition to Fe(II) is required for full virulence of <italic>Salmonella enterica<\/italic> serovar Typhimurium","volume":"70","author":"E Boyer","year":"2002","journal-title":"Infect Immun"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1046\/j.1365-2958.2002.02944.x","article-title":"MntR modulates expression of the PerR regulon and superoxide resistance in <italic>Staphylococcus aureus<\/italic> through control of manganese uptake","volume":"44","author":"MJ Horsburgh","year":"2002","journal-title":"Mol Microbiol"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1128\/IAI.68.8.4441-4451.2000","article-title":"Genetic characterization of a <italic>Streptococcus mutans<\/italic> LraI family operon and role in virulence","volume":"68","author":"T Kitten","year":"2000","journal-title":"Infect Immun"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1128\/IAI.70.10.5706-5714.2002","article-title":"The divergently transcribed <italic>Streptococcus parasanguis<\/italic> virulence-associated <italic>fimA<\/italic> operon encoding an Mn(2+)-responsive metal transporter and <italic>pepO<\/italic> encoding a zinc metallopeptidase are not coordinately regulated","volume":"70","author":"J Oetjen","year":"2002","journal-title":"Infect Immun"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1128\/IAI.63.12.4669-4674.1995","article-title":"FimA, a major virulence factor associated with <italic>Streptococcus parasanguis<\/italic> endocarditis","volume":"63","author":"D Burnette-Curley","year":"1995","journal-title":"Infect Immun"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1128\/IAI.71.5.2656-2664.2003","article-title":"MtsABC is important for manganese and iron transport, oxidative stress resistance, and virulence of <italic>Streptococcus pyogenes<\/italic>","volume":"71","author":"R Janulczyk","year":"2003","journal-title":"Infect Immun"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/mmi.12625","article-title":"The relationship of the lipoprotein SsaB, manganese and superoxide dismutase in <italic>Streptococcus sanguinis<\/italic> virulence for endocarditis","volume":"92","author":"KE Crump","year":"2014","journal-title":"Mol Microbiol"},{"issue":"Pt 5","key":"ref26","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1099\/00221287-148-5-1483","article-title":"<italic>In vivo<\/italic> characterization of the <italic>psa<\/italic> genes from <italic>Streptococcus pneumoniae<\/italic> in multiple models of infection","volume":"148","author":"A Marra","year":"2002","journal-title":"Microbiology"},{"issue":"5615","key":"ref27","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1126\/science.1080613","article-title":"Role of mobile DNA in the evolution of vancomycin-resistant <italic>Enterococcus faecalis<\/italic>","volume":"299","author":"IT Paulsen","year":"2003","journal-title":"Science"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/gb-2008-9-7-r110","article-title":"Large scale variation in <italic>Enterococcus faecalis<\/italic> illustrated by the genome analysis of strain OG1RF","volume":"9","author":"A Bourgogne","year":"2008","journal-title":"Genome biol"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"e7660","DOI":"10.1371\/journal.pone.0007660","article-title":"The transcriptome of the nosocomial pathogen <italic>Enterococcus faecalis<\/italic> V583 reveals adaptive responses to growth in blood","volume":"4","author":"HC Veb\u00f8","year":"2009","journal-title":"PloS One"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"e12489","DOI":"10.1371\/journal.pone.0012489","article-title":"Comparative genomic analysis of pathogenic and probiotic <italic>Enterococcus faecalis<\/italic> isolates, and their transcriptional responses to growth in human urine","volume":"5","author":"HC Veb\u00f8","year":"2010","journal-title":"PloS One"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"e0126143","DOI":"10.1371\/journal.pone.0126143","article-title":"The Intraperitoneal Transcriptome of the Opportunistic Pathogen <italic>Enterococcus faecalis<\/italic> in Mice","volume":"10","author":"C Muller","year":"2015","journal-title":"PloS One"},{"issue":"Pt 2","key":"ref32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1099\/jmm.0.05039-0","article-title":"Manganese-dependent regulation of the endocarditis-associated virulence factor EfaA of <italic>Enterococcus faecalis<\/italic>","volume":"52","author":"YL Low","year":"2003","journal-title":"J Med Microbiol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1128\/IAI.06377-11","article-title":"EfaR is a major regulator of <italic>Enterococcus faecalis<\/italic> manganese transporters and influences processes involved in host colonization and infection","volume":"81","author":"MC Abrantes","year":"2013","journal-title":"Infect Immun"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"e26519","DOI":"10.1371\/journal.pone.0026519","article-title":"Impact of manganese, copper and zinc ions on the transcriptome of the nosocomial pathogen <italic>Enterococcus faecalis<\/italic> V583","volume":"6","author":"MC Abrantes","year":"2011","journal-title":"PloS One"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1128\/JCM.28.2.195-200.1990","article-title":"Serological response in <italic>Enterococcus faecalis<\/italic> endocarditis determined by enzyme-linked immunosorbent assay","volume":"28","author":"PJ Shorrock","year":"1990","journal-title":"J Clin Microbiol"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1574-695X.1998.tb01180.x","article-title":"<italic>In vivo<\/italic> testing of an <italic>Enterococcus faecalis efaA<\/italic> mutant and use of <italic>efaA<\/italic> homologs for species identification","volume":"21","author":"KV Singh","year":"1998","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.plasmid.2006.08.003","article-title":"Development of a host-genotype-independent counterselectable marker and a high-frequency conjugative delivery system and their use in genetic analysis of <italic>Enterococcus faecalis<\/italic>","volume":"57","author":"CJ Kristich","year":"2007","journal-title":"Plasmid"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fcimb.2013.00091","article-title":"Manganese acquisition and homeostasis at the host-pathogen interface","volume":"3","author":"JP Lisher","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen-host interface","volume":"10","author":"MI Hood","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ceca.2012.11.006","article-title":"Evolution of the S100 family of calcium sensor proteins","volume":"53","author":"DB Zimmer","year":"2013","journal-title":"Cell Calcium"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1748-5967.2004.tb00103.x","article-title":"Molecular Cloning and Characterization of Transferrin from Wax Moth, <italic>Galleria mellonella<\/italic>","volume":"34","author":"J Han","year":"2004","journal-title":"Entomol Res"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/arch.1030","article-title":"Cloning and expression of a ferritin subunit for <italic>Galleria mellonella<\/italic>","volume":"47","author":"BS Kim","year":"2001","journal-title":"Arch Insect Biochem Phys"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nchembio.1891","article-title":"Human calprotectin is an iron-sequestering host-defense protein","volume":"11","author":"TG Nakashige","year":"2015","journal-title":"Nat Chem Biol"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.1074\/jbc.M113.533620","article-title":"Genetic characterization and role in virulence of the ribonucleotide reductases of <italic>Streptococcus sanguinis<\/italic>","volume":"289","author":"DV Rhodes","year":"2014","journal-title":"J Biol Chem"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"e0126694","DOI":"10.1371\/journal.pone.0126694","article-title":"Proteomic Investigation of the Response of <italic>Enterococcus faecalis<\/italic> V583 when Cultivated in Urine","volume":"10","author":"MO Arntzen","year":"2015","journal-title":"PloS One"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41522-017-0036-z","article-title":"Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection","volume":"3","author":"W Xu","year":"2017","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"254","key":"ref47","article-title":"EbpA vaccine antibodies block binding of <italic>Enterococcus faecalis<\/italic> to fibrinogen to prevent catheter-associated bladder infection in mice","volume":"6","author":"AL Flores-Mireles","year":"2014","journal-title":"Sci Transl Med"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1128\/IAI.00711-10","article-title":"Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections","volume":"78","author":"PS Guiton","year":"2010","journal-title":"Infect Immunity"},{"issue":"7","key":"ref49","doi-asserted-by":"crossref","first-page":"e68813","DOI":"10.1371\/journal.pone.0068813","article-title":"Contribution of individual Ebp Pilus subunits of <italic>Enterococcus faecalis<\/italic> OG1RF to pilus biogenesis, biofilm formation and urinary tract infection","volume":"8","author":"J Sillanpaa","year":"2013","journal-title":"PloS One"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"e00177","DOI":"10.1128\/mBio.00177-12","article-title":"The metal ion-dependent adhesion site motif of the <italic>Enterococcus faecalis<\/italic> EbpA pilin mediates pilus function in catheter-associated urinary tract infection","volume":"3","author":"HV Nielsen","year":"2012","journal-title":"mBio"},{"issue":"19","key":"ref51","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1128\/JB.05305-11","article-title":"TroA of <italic>Streptococcus suis<\/italic> is required for manganese acquisition and full virulence","volume":"193","author":"PJ Wichgers Schreur","year":"2011","journal-title":"J Bacteriol"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-2958.2004.04164.x","article-title":"Molecular analysis of the <italic>psa<\/italic> permease complex of <italic>Streptococcus pneumoniae<\/italic>","volume":"53","author":"LJ McAllister","year":"2004","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10534-015-9826-z","article-title":"Manganese uptake and streptococcal virulence","volume":"28","author":"BA Eijkelkamp","year":"2015","journal-title":"Biometals"},{"issue":"Pt 4","key":"ref54","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1099\/mic.0.27375-0","article-title":"Genome-based <italic>in silico<\/italic> detection of putative manganese transport systems in <italic>Lactobacillus plantarum<\/italic> and their genetic analysis","volume":"151","author":"MN Groot","year":"2005","journal-title":"Microbiology"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.chom.2017.08.009","article-title":"Dietary Manganese Promotes Staphylococcal Infection of the Heart","volume":"22","author":"LJ Juttukonda","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"13","key":"ref56","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1073\/pnas.1100410108","article-title":"Iron enzyme ribulose-5-phosphate 3-epimerase in <italic>Escherichia coli<\/italic> is rapidly damaged by hydrogen peroxide but can be protected by manganese","volume":"108","author":"JM Sobota","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/mmi.13207","article-title":"MntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in <italic>Mycobacterium tuberculosis<\/italic>","volume":"98","author":"R Pandey","year":"2015","journal-title":"Mol Microbiol"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1046\/j.1365-2958.2001.02460.x","article-title":"Accumulation of manganese in <italic>Neisseria gonorrhoeae<\/italic> correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity","volume":"40","author":"HJ Tseng","year":"2001","journal-title":"Mol Microbiol"},{"issue":"12","key":"ref59","doi-asserted-by":"crossref","first-page":"e115839","DOI":"10.1371\/journal.pone.0115839","article-title":"Transcriptome analysis of <italic>Enterococcus faecalis<\/italic> during mammalian infection shows cells undergo adaptation and exist in a stringent response state","volume":"9","author":"KL Frank","year":"2014","journal-title":"PloS One"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.mib.2005.02.007","article-title":"Metal ion homeostasis in <italic>Bacillus subtilis<\/italic>","volume":"8","author":"CM Moore","year":"2005","journal-title":"Curr Opin Microbiol"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1128\/JB.187.3.912-922.2005","article-title":"Transcriptional regulation of <italic>sitABCD<\/italic> of <italic>Salmonella enterica<\/italic> serovar Typhimurium by MntR and Fur","volume":"187","author":"JS Ikeda","year":"2005","journal-title":"J Bacteriol"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"e00626","DOI":"10.1128\/mBio.00626-17","article-title":"Extracellular electron transfer powers <italic>Enterococcus faecalis<\/italic> biofilm metabolism","volume":"9","author":"D Keogh","year":"2018","journal-title":"mBio"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/mmi.13335","article-title":"A streptococcal NRAMP homologue is crucial for the survival of <italic>Streptococcus agalactiae<\/italic> under low pH conditions","volume":"100","author":"S Shabayek","year":"2016","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref64","article-title":"Copper Is a Host Effector Mobilized to Urine during Urinary Tract Infection To Impair Bacterial Colonization","volume":"85","author":"AN Hyre","year":"2017","journal-title":"Infect Immun"},{"issue":"51","key":"ref65","doi-asserted-by":"crossref","first-page":"18327","DOI":"10.1073\/pnas.1415959112","article-title":"Host-specific induction of <italic>Escherichia coli<\/italic> fitness genes during human urinary tract infection","volume":"111","author":"S Subashchandrabose","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref66","doi-asserted-by":"crossref","first-page":"e0136625","DOI":"10.1371\/journal.pone.0136625","article-title":"Characterization of Two Metal Binding Lipoproteins as Vaccine Candidates for Enterococcal Infections","volume":"10","author":"F Romero-Saavedra","year":"2015","journal-title":"PloS One"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1128\/IAI.73.4.2461-2468.2005","article-title":"<italic>Enterococcus faecalis<\/italic> tropism for the kidneys in the urinary tract of C57BL\/6J mice","volume":"73","author":"AL Kau","year":"2005","journal-title":"Infect Immun"},{"issue":"1\u20132","key":"ref68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s004380050315","article-title":"A general system for generating unlabelled gene replacements in bacterial chromosomes","volume":"253","author":"K Leenhouts","year":"1996","journal-title":"Mol Gen Genet"},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/plas.2000.1484","article-title":"Improved vectors for nisin-controlled expression in gram-positive bacteria","volume":"44","author":"EM Bryan","year":"2000","journal-title":"Plasmid"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF00259462","article-title":"High efficiency introduction of plasmid DNA into glycine treated <italic>Enterococcus faecalis<\/italic> by electroporation","volume":"224","author":"AL Cruz-Rodz","year":"1990","journal-title":"Molecular & general genetics: MGG"},{"issue":"4","key":"ref71","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1128\/IAI.11.4.649-655.1975","article-title":"Growth of several cariogenic strains of oral streptococci in a chemically defined medium","volume":"11","author":"B Terleckyj","year":"1975","journal-title":"Infection and immunity"},{"issue":"8718","key":"ref72","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0140-6736(90)93237-J","article-title":"Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin","volume":"336","author":"M Steinbakk","year":"1990","journal-title":"Lancet"},{"issue":"5865","key":"ref73","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1126\/science.1152449","article-title":"Metal chelation and inhibition of bacterial growth in tissue abscesses","volume":"319","author":"BD Corbin","year":"2008","journal-title":"Science"},{"issue":"Pt 8","key":"ref74","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1099\/mic.0.060236-0","article-title":"Global transcriptional analysis of the stringent response in <italic>Enterococcus faecalis<\/italic>","volume":"158","author":"AO Gaca","year":"2012","journal-title":"Microbiology"},{"issue":"5","key":"ref75","article-title":"Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections","volume":"7","author":"AL Flores-Mireles","year":"2016","journal-title":"mBio"},{"key":"ref76","article-title":"Basal levels of (p)ppGpp differentially affect the pathogenesis of infective endocarditis in <italic>Enterococcus faecalis<\/italic>","author":"C Colomer-Winter","year":"2018","journal-title":"Microbiology"},{"issue":"10","key":"ref77","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1128\/AEM.70.10.6047-6052.2004","article-title":"Galactose metabolism by <italic>Streptococcus mutans<\/italic>","volume":"70","author":"J Abranches","year":"2004","journal-title":"Appl Environ Microbiol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T06:19:21Z","timestamp":1604989161000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007102"}},"subtitle":[],"editor":[{"given":"Eric P.","family":"Skaar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,20]]},"references-count":77,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007102","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/323832","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,20]]}}}