{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:38:18Z","timestamp":1790069898130,"version":"4.0.1"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/K005448\/1"],"award-info":[{"award-number":["BB\/K005448\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107475\/Z\/15\/Z"],"award-info":[{"award-number":["107475\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007107","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T13:27:20Z","timestamp":1530192440000},"page":"e1007107","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Methyl-CpG-binding (SmMBD2\/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni"],"prefix":"10.1371","volume":"14","author":[{"given":"Kathrin K.","family":"Geyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-4513","authenticated-orcid":true,"given":"Sabrina E.","family":"Munshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L.","family":"Whiteland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6421-1080","authenticated-orcid":true,"given":"Narcis","family":"Fernandez-Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-5727","authenticated-orcid":true,"given":"Dylan W.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3932-5502","authenticated-orcid":true,"given":"Karl F.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1371\/journal.pntd.0000485","article-title":"Schistosomiasis in Africa: an emerging tragedy in our new global health decade","volume":"3","author":"PJ Hotez","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.6826.1","article-title":"Early lessons from schistosomiasis mass drug administration programs","volume":"4","author":"WE Secor","year":"2015","journal-title":"F1000Res"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/s41467-017-02084-0","article-title":"The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand","volume":"8","author":"JD Chan","year":"2017","journal-title":"Nat Commun"},{"issue":"13","key":"ref4","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1017\/S0031182009000493","article-title":"Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs","volume":"136","author":"MJ Doenhoff","year":"2009","journal-title":"Parasitology"},{"key":"ref5","unstructured":"WHO. Accelerating work to overcome the global impact of neglected tropical diseases: A roadmap for implementation <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/neglected_diseases\/resources\/WHO_HTM_NTD_2012.1\/en\/:\" xlink:type=\"simple\">http:\/\/www.who.int\/neglected_diseases\/resources\/WHO_HTM_NTD_2012.1\/en\/:<\/ext-link> WHO; 2012. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/.who.int\/neglected_diseases\/resources\/WHO_HTM_NTD_2012.1\/en\/\" xlink:type=\"simple\">http:\/\/.who.int\/neglected_diseases\/resources\/WHO_HTM_NTD_2012.1\/en\/<\/ext-link>."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijpara.2012.02.003","article-title":"Epigenetics: A key regulator of platyhelminth developmental biology?","volume":"42","author":"KK Geyer","year":"2012","journal-title":"International journal for parasitology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fgene.2014.00317","article-title":"Epigenetic control of gene function in schistosomes: a source of therapeutic targets?","volume":"5","author":"A Cabezas-Cruz","year":"2014","journal-title":"Front Genet"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"e1003645","DOI":"10.1371\/journal.ppat.1003645","article-title":"Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni","volume":"9","author":"M Marek","year":"2013","journal-title":"PLoS Pathog"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"e0003853","DOI":"10.1371\/journal.pntd.0003853","article-title":"The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection","volume":"9","author":"D Roquis","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"e0004930","DOI":"10.1371\/journal.pntd.0004930","article-title":"Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation","volume":"10","author":"MA Picard","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molbiopara.2009.06.001","article-title":"Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni","volume":"168","author":"F Dubois","year":"2009","journal-title":"Mol Biochem Parasitol"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"e1004116","DOI":"10.1371\/journal.ppat.1004116","article-title":"Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis","volume":"10","author":"VC Carneiro","year":"2014","journal-title":"PLoS Pathog"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"e1005963","DOI":"10.1371\/journal.ppat.1005963","article-title":"Tissue Degeneration following Loss of Schistosoma mansoni cbp1 Is Associated with Increased Stem Cell Proliferation and Parasite Death In Vivo","volume":"12","author":"JN Collins","year":"2016","journal-title":"PLoS Pathog"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/ncomms1433","article-title":"Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni","volume":"2","author":"KK Geyer","year":"2011","journal-title":"Nat Commun"},{"issue":"21","key":"ref15","doi-asserted-by":"crossref","first-page":"8627","DOI":"10.1073\/pnas.1306723110","article-title":"Dnmt2-dependent methylomes lack defined DNA methylation patterns","volume":"110","author":"G Raddatz","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.2217\/epi.15.39","article-title":"Methyl-CpG-binding domain proteins: readers of the epigenome","volume":"7","author":"Q Du","year":"2015","journal-title":"Epigenomics"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0168-9525(03)00080-5","article-title":"The methyl-CpG binding domain and the evolving role of DNA methylation in animals","volume":"19","author":"B Hendrich","year":"2003","journal-title":"Trends in genetics: TIG"},{"issue":"24","key":"ref18","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1242\/dev.01531","article-title":"The Drosophila MBD2\/3 protein mediates interactions between the MI-2 chromatin complex and CpT\/A-methylated DNA","volume":"131","author":"J Marhold","year":"2004","journal-title":"Development"},{"issue":"21","key":"ref19","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1242\/dev.00716","article-title":"A Dnmt2-like protein mediates DNA methylation in Drosophila","volume":"130","author":"N Kunert","year":"2003","journal-title":"Development"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ydbio.2013.09.020","article-title":"Planarian MBD2\/3 is required for adult stem cell pluripotency independently of DNA methylation","volume":"384","author":"F Jaber-Hijazi","year":"2013","journal-title":"Dev Biol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0092-8674(01)00324-5","article-title":"Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA","volume":"105","author":"I Ohki","year":"2001","journal-title":"Cell"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"e0005246","DOI":"10.1371\/journal.pntd.0005246","article-title":"The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni","volume":"11","author":"KK Geyer","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","article-title":"The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms","volume":"55","author":"SR Smithers","year":"1965","journal-title":"Parasitology"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic acids research"},{"key":"ref25","first-page":"8","article-title":"Expression, purification and characterization of methyl DNA binding protein from Bombyx mori","volume":"5","author":"T Uno","year":"2005","journal-title":"J Insect Sci"},{"issue":"15","key":"ref26","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1093\/nar\/gkr262","article-title":"Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence","volume":"39","author":"JN Scarsdale","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gkm341","article-title":"M4T: a comparative protein structure modeling server","volume":"35","author":"N Fernandez-Fuentes","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"19","key":"ref28","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1093\/bioinformatics\/btm377","article-title":"Comparative protein structure modeling by combining multiple templates and optimizing sequence-to-structure alignments","volume":"23","author":"N Fernandez-Fuentes","year":"2007","journal-title":"Bioinformatics"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"HM Berman","year":"2000","journal-title":"Nucleic acids research"},{"issue":"5540","key":"ref30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1065659","article-title":"Protein structure prediction and structural genomics","volume":"294","author":"D Baker","year":"2001","journal-title":"Science"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/prot.340170404","article-title":"Recognition of errors in three-dimensional structures of proteins","volume":"17","author":"MJ Sippl","year":"1993","journal-title":"Proteins"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"RA Laskowski","year":"1993","journal-title":"Journal of Applied Crystallography"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ijpara.2014.04.002","article-title":"Excreted\/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression","volume":"44","author":"TP Yoshino","year":"2014","journal-title":"International journal for parasitology"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"e0003920","DOI":"10.1371\/journal.pntd.0003920","article-title":"Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment","volume":"9","author":"IW Chalmers","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2144\/04365PT03","article-title":"Quantitative beta-galactosidase assay suitable for high-throughput applications in the yeast two-hybrid system","volume":"36","author":"N Mockli","year":"2004","journal-title":"Biotechniques"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"e543","DOI":"10.1371\/journal.pntd.0000543","article-title":"Anti-schistosomal Intervention Targets Identified by Lifecycle Transcriptomic Analyses","volume":"3","author":"JM Fitzpatrick","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"issue":"7438","key":"ref37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature11924","article-title":"Adult somatic stem cells in the human parasite Schistosoma mansoni","volume":"494","author":"JJ Collins 3rd","year":"2013","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-213X-13-8","article-title":"In situ hybridization protocol for enhanced detection of gene expression in the planarian Schmidtea mediterranea","volume":"13","author":"RS King","year":"2013","journal-title":"BMC Dev Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1186\/1471-2164-14-462","article-title":"Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes","volume":"14","author":"KK Geyer","year":"2013","journal-title":"BMC genomics"},{"issue":"25","key":"ref40","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1073\/pnas.0900604106","article-title":"Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs","volume":"106","author":"S Kosugi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","article-title":"WormBase ParaSite\u2014a comprehensive resource for helminth genomics","author":"KL Howe","year":"2016","journal-title":"Mol Biochem Parasitol"},{"issue":"24","key":"ref42","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1021\/bi0001271","article-title":"Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA","volume":"39","author":"E Ballestar","year":"2000","journal-title":"Biochemistry"},{"issue":"21","key":"ref43","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1093\/nar\/28.21.4172","article-title":"Functional consequences of Rett syndrome mutations on human MeCP2","volume":"28","author":"TM Yusufzai","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cell.2013.03.011","article-title":"Methylation-dependent and -independent genomic targeting principles of the MBD protein family","volume":"153","author":"T Baubec","year":"2013","journal-title":"Cell"},{"issue":"14","key":"ref45","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1093\/nar\/gkq228","article-title":"Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA","volume":"38","author":"T Clouaire","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"14","key":"ref46","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1128\/MCB.20.14.5107-5118.2000","article-title":"Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1","volume":"20","author":"N Fujita","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"23","key":"ref47","doi-asserted-by":"crossref","first-page":"6653","DOI":"10.1093\/emboj\/18.23.6653","article-title":"Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1","volume":"18","author":"I Ohki","year":"1999","journal-title":"EMBO J"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1093\/nar\/gkg249","article-title":"The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties","volume":"31","author":"MF Fraga","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"38","key":"ref49","doi-asserted-by":"crossref","first-page":"35434","DOI":"10.1074\/jbc.M203455200","article-title":"The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD\/Mi2 components HDAC1 and MTA2","volume":"277","author":"M Saito","year":"2002","journal-title":"J Biol Chem"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/15384047.2014.1001277","article-title":"Beyond the histone tale: HP1alpha deregulation in breast cancer epigenetics","volume":"16","author":"J Vad-Nielsen","year":"2015","journal-title":"Cancer Biol Ther"},{"issue":"16","key":"ref51","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1093\/nar\/gkm599","article-title":"MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation","volume":"35","author":"N Agarwal","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1631\/jzus.B1400077","article-title":"Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins","volume":"15","author":"RG Ma","year":"2014","journal-title":"J Zhejiang Univ Sci B"},{"issue":"5562","key":"ref53","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1126\/science.1069473","article-title":"Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail","volume":"295","author":"SA Jacobs","year":"2002","journal-title":"Science"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"e52977","DOI":"10.1371\/journal.pone.0052977","article-title":"Crystal structure of the human SUV39H1 chromodomain and its recognition of histone H3K9me2\/3","volume":"7","author":"T Wang","year":"2012","journal-title":"PLoS One"},{"issue":"17","key":"ref55","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1128\/MCB.20.17.6449-6465.2000","article-title":"3rd. Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential","volume":"20","author":"MS Lechner","year":"2000","journal-title":"Mol Cell Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gde.2016.05.018","article-title":"Phenotypic plasticity and developmental innovations in nematodes","volume":"39","author":"S Tandonnet","year":"2016","journal-title":"Curr Opin Genet Dev"},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pt.2016.12.002","article-title":"(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach","volume":"33","author":"C Cosseau","year":"2016","journal-title":"Trends Parasitol"},{"key":"ref58","first-page":"93","article-title":"Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation","volume":"7","author":"KH Wood","year":"2016","journal-title":"Front Genet"},{"issue":"8","key":"ref59","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1128\/MCB.24.8.3387-3395.2004","article-title":"Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains","volume":"24","author":"HF Jorgensen","year":"2004","journal-title":"Molecular and cellular biology"},{"issue":"17","key":"ref60","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1093\/nar\/gks628","article-title":"Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation","volume":"40","author":"H Hashimoto","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"ref61","doi-asserted-by":"crossref","first-page":"e11982","DOI":"10.1371\/journal.pone.0011982","article-title":"The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA","volume":"5","author":"S Laget","year":"2010","journal-title":"PLoS One"},{"issue":"8","key":"ref62","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-2443.2000.00359.x","article-title":"MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase","volume":"5","author":"KI Tatematsu","year":"2000","journal-title":"Genes Cells"},{"issue":"26","key":"ref63","doi-asserted-by":"crossref","first-page":"24132","DOI":"10.1074\/jbc.M302283200","article-title":"Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression","volume":"278","author":"N Fujita","year":"2003","journal-title":"J Biol Chem"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"A Barski","year":"2007","journal-title":"Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"e12473","DOI":"10.7554\/eLife.12473","article-title":"Stem cell progeny contribute to the schistosome host-parasite interface","volume":"5","author":"JJ Collins 3rd","year":"2016","journal-title":"Elife"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"170118","DOI":"10.1038\/sdata.2017.118","article-title":"A gene expression atlas of adult Schistosoma mansoni and their gonads","volume":"4","author":"Z Lu","year":"2017","journal-title":"Sci Data"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11626-013-9596-2","article-title":"Investigation of the relationship between chromobox homolog 8 and nucleus pulposus cells degeneration in rat intervertebral disc","volume":"49","author":"X Zhou","year":"2013","journal-title":"In Vitro Cell Dev Biol Anim"},{"issue":"13","key":"ref68","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1182\/blood-2012-08-451666","article-title":"Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem\/progenitor cells","volume":"121","author":"V van den Boom","year":"2013","journal-title":"Blood"},{"issue":"Suppl 3","key":"ref69","doi-asserted-by":"crossref","first-page":"S684","DOI":"10.1245\/s10434-013-3171-7","article-title":"Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma","volume":"20","author":"B Wang","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"ref70","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.292169.116","article-title":"Cbx3 maintains lineage specificity during neural differentiation","volume":"31","author":"C Huang","year":"2017","journal-title":"Genes Dev"},{"issue":"3","key":"ref71","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.stem.2008.07.002","article-title":"Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea","volume":"3","author":"GT Eisenhoffer","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"5","key":"ref72","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.devcel.2005.02.014","article-title":"Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria","volume":"8","author":"PW Reddien","year":"2005","journal-title":"Dev Cell"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T23:57:55Z","timestamp":1571529475000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007107"}},"subtitle":[],"editor":[{"given":"Michael H.","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":72,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007107","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,28]]}}}