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Radoshevich","year":"2015","journal-title":"Elife"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fgene.2014.00423","article-title":"Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection","volume":"5","author":"Y Ariumi","year":"2014","journal-title":"Front Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1128\/MCB.00560-10","article-title":"DDX3 regulates cell growth through translational control of cyclin E1","volume":"30","author":"MC Lai","year":"2010","journal-title":"Mol Cell Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/sj.onc.1209239","article-title":"DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control","volume":"25","author":"PC 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Role in suppression of cytotoxic T lymphocyte response and viral persistence","volume":"160","author":"R Ahmed","year":"1984","journal-title":"J Exp Med"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"8451","DOI":"10.1128\/JVI.03382-12","article-title":"IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus","volume":"87","author":"R Mudhasani","year":"2013","journal-title":"J Virol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1073\/pnas.0900088106","article-title":"Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest","volume":"106","author":"SF Emonet","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"DG Gibson","year":"2009","journal-title":"Nat Methods"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"ME Sowa","year":"2009","journal-title":"Cell"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1261\/rna.7131604","article-title":"Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis","volume":"10","author":"RS Pillai","year":"2004","journal-title":"RNA"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"FA Ran","year":"2013","journal-title":"Nat Protoc"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/genetics\/120.3.621","article-title":"Genetic applications of an inverse polymerase chain reaction","volume":"120","author":"H Ochman","year":"1988","journal-title":"Genetics"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1128\/JVI.05503-11","article-title":"Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function","volume":"86","author":"E Ortiz-Riano","year":"2012","journal-title":"J Virol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/ac960799q","article-title":"Direct analysis and identification of proteins in mixtures by LC\/MS\/MS and database searching at the low-femtomole level","volume":"69","author":"AL McCormack","year":"1997","journal-title":"Anal Chem"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"18928","DOI":"10.1073\/pnas.0606379103","article-title":"Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors","volume":"103","author":"AC Paoletti","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref84","article-title":"Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals","author":"MD Daugherty","year":"2016","journal-title":"Elife"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1242\/jcs.199240","article-title":"Stress-specific differences in assembly and composition of stress granules and related foci","volume":"130","author":"A Aulas","year":"2017","journal-title":"J Cell Sci"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1109\/MC.1983.1654163","article-title":"Biomedical image processing","volume":"16","author":"S Sternberg","year":"1983","journal-title":"Computer"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","article-title":"A threshold selection method from gray-level histograms","volume":"9","author":"N Otsu","year":"1979","journal-title":"IEEE Transactions on Systems, Man, and Cybernetics"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","article-title":"A guided tour into subcellular colocalization analysis in light microscopy","volume":"224","author":"S Bolte","year":"2006","journal-title":"J Microsc"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-2818.1993.tb03313.x","article-title":"Measurement of co-localization of objects in dual-colour confocal images","volume":"169","author":"EM Manders","year":"1993","journal-title":"Journal of Microscopy"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/srep01365","article-title":"Bridging the gap between qualitative and quantitative colocalization results in fluorescence microscopy studies","volume":"3","author":"V Zinchuk","year":"2013","journal-title":"Sci Rep"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"10569","DOI":"10.1128\/JVI.00103-10","article-title":"Infectious Lassa virus, but not filoviruses, is restricted by BST-2\/tetherin","volume":"84","author":"SR Radoshitzky","year":"2010","journal-title":"J Virol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"7373","DOI":"10.1128\/JVI.00307-15","article-title":"Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines","volume":"89","author":"BY Cheng","year":"2015","journal-title":"J Virol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1099\/vir.0.051102-0","article-title":"Arenavirus reverse genetics for vaccine development","volume":"94","author":"E Ortiz-Riano","year":"2013","journal-title":"J Gen Virol"}],"container-title":["PLOS 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