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Surve S","year":"2017","journal-title":"Mol Biochem Parasitol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.molbiopara.2007.03.012","article-title":"Functional genomics in Trypanosoma brucei: a collection of vectors for the expression of tagged proteins from endogenous and ectopic gene loci","volume":"154","author":"S Kelly","year":"2007","journal-title":"Mol Biochem Parasitol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molbiopara.2010.09.002","article-title":"Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters","volume":"175","author":"G Schumann Burkard","year":"2011","journal-title":"Mol Biochem Parasitol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"985","DOI":"10.2307\/3282883","article-title":"Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers","volume":"75","author":"H Hirumi","year":"1989","journal-title":"J Parasitol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.meegid.2005.08.002","article-title":"Characterization of Trypanosoma evansi type B","volume":"6","author":"ZK Njiru","year":"2006","journal-title":"Infect Genet Evol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0014-4894(76)90110-7","article-title":"Trypanosoma brucei: a rapid \u201cmatching\u201d method for estimating the host\u2019s parasitemia","volume":"40","author":"WJ Herbert","year":"1976","journal-title":"Exp Parasitol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/2181273a0","article-title":"Separation of trypanosomes from the blood of infected rats and mice by anion-exchangers","volume":"218","author":"SM Lanham","year":"1968","journal-title":"Nature"},{"key":"ref83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000946","article-title":"Quantitative analysis of immune response and erythropoiesis during rodent malarial infection","volume":"6","author":"MR Miller","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e1000416","DOI":"10.1371\/journal.pcbi.1000416","article-title":"Quantitative analysis of mechanisms that govern red blood cell age structure and dynamics during anaemia","volume":"5","author":"NJ Savill","year":"2009","journal-title":"PLoS Comput Biol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007195","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T16:53:41Z","timestamp":1661619221000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007195"}},"subtitle":[],"editor":[{"given":"Markus","family":"Engstler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,18]]},"references-count":84,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007195","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,18]]}}}