{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:47:08Z","timestamp":1790646428369,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007228","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T00:00:00Z","timestamp":1533254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000040","name":"Agriculture and Agri-Food Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000040","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"the Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007228","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T16:02:27Z","timestamp":1533312147000},"page":"e1007228","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":87,"title":["RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors"],"prefix":"10.1371","volume":"14","author":[{"given":"Fangfang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-0652","authenticated-orcid":true,"given":"Aiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature02874","article-title":"RNA silencing in plants","volume":"431","author":"D Baulcombe","year":"2004","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nri2824","article-title":"RNA-based antiviral immunity","volume":"10","author":"SW Ding","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nrmicro3120","article-title":"RNA silencing suppression by plant pathogens: defence, counter-defence and counter-counter-defence","volume":"11","author":"N Pumplin","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coviro.2015.12.002","article-title":"The dual edge of RNA silencing suppressors in the virus-host interactions","volume":"17","author":"JH Zhao","year":"2016","journal-title":"Curr Opin Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.virol.2015.02.028","article-title":"Viral silencing suppressors: tools forged to fine-tune host-pathogen coexistence","volume":"479","author":"T Csorba","year":"2015","journal-title":"Virology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pbi.2016.12.003","article-title":"mRNA decay in plants: both quantity and quality matter","volume":"35","author":"X Zhang","year":"2017","journal-title":"Curr Opin Plant Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10265-017-0906-8","article-title":"Interconnections between mRNA degradation and RDR-dependent siRNA production in mRNA turnover in plants","volume":"130","author":"M Tsuzuki","year":"2017","journal-title":"J Plant Res"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/wrna.1221","article-title":"Deadenylation: enzymes, regulation, and functional implications","volume":"5","author":"YB Yan","year":"2014","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/cr.2008.317","article-title":"The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses","volume":"19","author":"W Liang","year":"2009","journal-title":"Cell Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1261\/rna.7540204","article-title":"mRNA deadenylation by PARN is essential for embryogenesis in higher plants","volume":"10","author":"SV Reverdatto","year":"2004","journal-title":"RNA"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1105\/tpc.106.047605","article-title":"Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development","volume":"18","author":"J Xu","year":"2006","journal-title":"Plant Cell"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbagrm.2013.03.005","article-title":"XRN 5\u2032\u2192 3\u2032 exoribonucleases: structure, mechanisms and functions","volume":"1829","author":"VK Nagarajan","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"e1003762","DOI":"10.1371\/journal.ppat.1003762","article-title":"Cytoplasmic viruses: rage against the (cellular RNA decay) machine","volume":"9","author":"SL Moon","year":"2013","journal-title":"PLoS Pathog"},{"issue":"20","key":"ref14","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1073\/pnas.0502604102","article-title":"Yeast genome-wide screen reveals dissimilar sets of host genes affecting replication of RNA viruses","volume":"102","author":"T Panavas","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.virol.2007.07.001","article-title":"Expression of the Arabidopsis Xrn4p 5\u2032\u20133\u2032 exoribonuclease facilitates degradation of tombusvirus RNA and promotes rapid emergence of viral variants in plants","volume":"368","author":"CP Cheng","year":"2007","journal-title":"Virology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.virol.2009.01.015","article-title":"Silencing of <italic>Nicotiana benthamiana<\/italic> Xrn4p exoribonuclease promotes tombusvirus RNA accumulation and recombination","volume":"386","author":"HM Jaag","year":"2009","journal-title":"Virology"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.virusres.2011.03.004","article-title":"Silencing of NbXrn4 facilitates the systemic infection of Tobacco mosaic virus in <italic>Nicotiana benthamiana<\/italic>","volume":"158","author":"J Peng","year":"2011","journal-title":"Virus Res"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jxb\/eru447","article-title":"Different roles for RNA silencing and RNA processing components in virus recovery and virus-induced gene silencing in plants","volume":"66","author":"X Ma","year":"2015","journal-title":"J Exp Bot"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.gene.2017.10.004","article-title":"Over-expression of <italic>Oryza sativa<\/italic> Xrn4 confers plant resistance to virus infection","volume":"639","author":"S Jiang","year":"2018","journal-title":"Gene"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1128\/JVI.07167-11","article-title":"Hepatitis C virus infection alters P-body composition but is independent of P-body granules","volume":"86","author":"G Perez-Vilaro","year":"2012","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"6882","DOI":"10.1128\/JVI.02418-10","article-title":"Hepatitis C virus hijacks P-body and stress granule components around lipid droplets","volume":"85","author":"Y Ariumi","year":"2011","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1128\/JVI.00397-10","article-title":"DDX6 (Rck\/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation","volume":"84","author":"RK Jangra","year":"2010","journal-title":"J Virol"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1128\/JVI.01657-10","article-title":"Poliovirus-mediated disruption of cytoplasmic processing bodies","volume":"85","author":"JD Dougherty","year":"2011","journal-title":"J Virol"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"e13431","DOI":"10.1128\/mBio.00431-12","article-title":"Picornavirus modification of a host mRNA decay protein","volume":"3","author":"JM Rozovics","year":"2012","journal-title":"MBio"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nbt816","article-title":"Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis","volume":"21","author":"CD Hu","year":"2003","journal-title":"Nat Biotechnol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.virol.2017.07.016","article-title":"The C-terminal region of the Turnip mosaic virus P3 protein is essential for viral infection via targeting P3 to the viral replication complex","volume":"510","author":"X Cui","year":"2017","journal-title":"Virology"},{"issue":"6","key":"ref27","first-page":"e1130962","article-title":"Formation of complexes at plasmodesmata for potyvirus intercellular movement is mediated by the viral protein P3N-PIPO","volume":"6","author":"T Wei","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1105\/tpc.107.055319","article-title":"<italic>Arabidopsis<\/italic> FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors","volume":"19","author":"I Gy","year":"2007","journal-title":"Plant Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1365-313X.2012.05066.x","article-title":"The <italic>Arabidopsis<\/italic> DCP2 gene is required for proper mRNA turnover and prevents transgene silencing in <italic>Arabidopsis<\/italic>","volume":"72","author":"M Thran","year":"2012","journal-title":"Plant J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1093\/nar\/gkt152","article-title":"Cytoplasmic and nuclear quality control and turnover of single-stranded RNA modulate post-transcriptional gene silencing in plants","volume":"41","author":"AB Moreno","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.aaa2618","article-title":"Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis","volume":"348","author":"X Zhang","year":"2015","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1003921","DOI":"10.1371\/journal.ppat.1003921","article-title":"Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression","volume":"10","author":"F Li","year":"2014","journal-title":"PLoS Pathog"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-313X.2008.03623.x","article-title":"Plant stress granules and mRNA processing bodies are distinct from heat stress granules","volume":"56","author":"C Weber","year":"2008","journal-title":"Plant J"},{"issue":"20","key":"ref34","doi-asserted-by":"crossref","first-page":"10460","DOI":"10.1128\/JVI.00819-09","article-title":"Turnip mosaic virus RNA replication complex vesicles are mobile, align with microfilaments, and are each derived from a single viral genome","volume":"83","author":"S Cotton","year":"2009","journal-title":"J Virol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.virol.2015.08.023","article-title":"Visualizing double-stranded RNA distribution and dynamics in living cells by dsRNA binding-dependent fluorescence complementation","volume":"485","author":"X Cheng","year":"2015","journal-title":"Virology"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"e01478","DOI":"10.1128\/JVI.01478-16","article-title":"The potyvirus silencing suppressor protein VPg mediates degradation of SGS3 via ubiquitination and autophagy pathways","volume":"91","author":"X Cheng","year":"2017","journal-title":"J Virol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.molcel.2004.06.006","article-title":"AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets","volume":"15","author":"FF Souret","year":"2004","journal-title":"Mol Cell"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"17036","DOI":"10.1038\/nplants.2017.36","article-title":"The poly (A) tail blocks RDR6 from converting self mRNAs into substrates for gene silencing","volume":"3","author":"K Baeg","year":"2017","journal-title":"Nature plants"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1093\/nar\/gkv119","article-title":"In plants, decapping prevents RDR6-dependent production of small interfering RNAs from endogenous mRNAs","volume":"43","author":"AE Mart\u00ednez de Alba","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1261\/rna.2467911","article-title":"Evidence that XRN4, an Arabidopsis homolog of exoribonuclease XRN1, preferentially impacts transcripts with certain sequences or in particular functional categories","volume":"17","author":"LA Rymarquis","year":"2011","journal-title":"RNA"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"E247","DOI":"10.3390\/v9090247","article-title":"SGS3 Cooperates with RDR6 in Triggering Geminivirus-Induced Gene Silencing and in Suppressing Geminivirus Infection in Nicotiana Benthamiana","volume":"9","author":"F Li","year":"2017","journal-title":"Viruses"},{"issue":"18","key":"ref42","doi-asserted-by":"crossref","first-page":"9759","DOI":"10.1128\/JVI.00844-07","article-title":"Interactions between brome mosaic virus RNAs and cytoplasmic processing bodies","volume":"81","author":"CJ Beckham","year":"2007","journal-title":"J Virol"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1534-5807(03)00025-X","article-title":"P1\/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA function","volume":"4","author":"KD Kasschau","year":"2003","journal-title":"Dev Cell"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"e1000729","DOI":"10.1371\/journal.ppat.1000729","article-title":"Two plant viral suppressors of silencing require the ethylene-inducible host transcription factor RAV2 to block RNA silencing","volume":"6","author":"MW Endres","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1101\/gad.1201204","article-title":"Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step","volume":"18","author":"EJ Chapman","year":"2004","journal-title":"Genes Dev"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1105\/tpc.105.036608","article-title":"Ectopic DICER-LIKE1 expression in P1\/HC-Pro Arabidopsis rescues phenotypic anomalies but not defects in microRNA and silencing pathways","volume":"17","author":"S Mlotshwa","year":"2005","journal-title":"Plant Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.aivir.2014.11.006","article-title":"Molecular biology of potyviruses","volume":"92","author":"F Revers","year":"2015","journal-title":"Adv Virus Res"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.virusres.2004.01.020","article-title":"Plant viral suppressors of RNA silencing","volume":"102","author":"BM Roth","year":"2004","journal-title":"Virus Res"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tplants.2011.02.010","article-title":"Viral suppressors of RNA silencing","volume":"16","author":"J Burgy\u00e1n","year":"2011","journal-title":"Trends Plant Sci"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","article-title":"Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana","volume":"16","author":"SJ Clough","year":"1998","journal-title":"Plant J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-313X.2009.04048.x","article-title":"Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin","volume":"61","author":"Q Lu","year":"2010","journal-title":"Plant J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1365-313X.2005.02617.x","article-title":"Gateway-compatible vectors for plant functional genomics and proteomics","volume":"45","author":"KW Earley","year":"2006","journal-title":"Plant J"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2011.03.024","article-title":"Arabidopsis Argonaute10 specifically sequesters miR166\/165 to regulate shoot apical meristem development","volume":"145","author":"H Zhu","year":"2011","journal-title":"Cell"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1128\/JVI.01824-09","article-title":"Sequential recruitment of the endoplasmic reticulum and chloroplasts for plant potyvirus replication","volume":"84","author":"T Wei","year":"2010","journal-title":"J Virol"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/s41467-018-03658-2","article-title":"Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase","volume":"9","author":"F Li","year":"2018","journal-title":"Nat Commun"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1365-313X.2002.01394.x","article-title":"Virus-induced gene silencing in tomato","volume":"31","author":"Y Liu","year":"2002","journal-title":"Plant J"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/nph.13473","article-title":"The AC5 protein encoded by Mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing-based antiviral defenses","volume":"208","author":"F Li","year":"2015","journal-title":"New Phytol"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"e1006213","DOI":"10.1371\/journal.ppat.1006213","article-title":"A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in <italic>Nicotiana benthamiana<\/italic>","volume":"13","author":"F Li","year":"2017","journal-title":"PLoS Pathogens"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/tpj.13723","article-title":"NbEXPA1, an \u03b1-expansin, is plasmodesmata-specific and a novel host factor for potyviral infection","volume":"92","author":"S Park","year":"2018","journal-title":"Plant J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.virol.2009.01.045","article-title":"Characterization and subcellular localization of an RNA silencing suppressor encoded by Rice stripe tenuivirus","volume":"387","author":"R Xiong","year":"2009","journal-title":"Virology"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007228","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T04:11:51Z","timestamp":1540354311000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007228"}},"subtitle":[],"editor":[{"given":"John","family":"Carr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,8,3]]},"references-count":60,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,8,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007228","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007228","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,3]]}}}