{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:38:28Z","timestamp":1767980308921,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007289","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000}}],"reference-count":91,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Biotechnology, Govt of India","award":["BT\/PR10394\/MED\/29\/1128\/2016"],"award-info":[{"award-number":["BT\/PR10394\/MED\/29\/1128\/2016"]}]},{"name":"EC FP7 EURIPRED","award":["FP7-INFRA-2012 Grant Agreement No. 312661"],"award-info":[{"award-number":["FP7-INFRA-2012 Grant Agreement No. 312661"]}]},{"name":"EC HORIZON2020"},{"name":"TBVAC2020"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007289","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T14:56:55Z","timestamp":1537369015000},"page":"e1007289","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Circulating HLA-DR+CD4+ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis"],"prefix":"10.1371","volume":"14","author":[{"given":"Asma","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-4786","authenticated-orcid":true,"given":"Vasista","family":"Adiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumya","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Anto Jesuraj","family":"Uday Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirag","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravat Nalini","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharath K.","family":"Sundararaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4260-258X","authenticated-orcid":true,"given":"Annapurna","family":"Vyakarnam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"ref1","unstructured":"World Health Organisation Global Tuberculosis Report Executive Summary <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/tb\/publications\/global_report\/Exec_Summary_13Nov2017.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/tb\/publications\/global_report\/Exec_Summary_13Nov2017.pdf<\/ext-link>. 2016. Accessed on August 4, 2018"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature","volume":"271","author":"GA Colditz","year":"1994","journal-title":"JAMA"},{"key":"ref3","unstructured":"Revised National Tuberculosis Control Programme Annual Status report <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/tbcindia.gov.in\/showfile.php\" xlink:type=\"simple\">https:\/\/tbcindia.gov.in\/showfile.php<\/ext-link>. 2018. Accessed on August 4, 2018."},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12274","article-title":"T cells and adaptive immunity to <italic>Mycobacterium tuberculosis<\/italic> in humans","volume":"264","author":"LD Jasenosky","year":"2015","journal-title":"Immunol Rev"},{"issue":"Suppl 1","key":"ref5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/odi.12390","article-title":"HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection","volume":"22","author":"A Ahmed","year":"2016","journal-title":"Oral Dis"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1086\/301750","article-title":"A causative relationship between mutant IFNgR1 alleles and impaired cellular response to IFNgamma in a compound heterozygous child","volume":"62","author":"F Altare","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1172\/JCI4950","article-title":"Inherited interleukin 12 deficiency in a child with Bacille Calmette-Gu\u00e9rin and Salmonella enteritidis disseminated infection","volume":"102","author":"F Altare","year":"1998","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.25.022106.141623","article-title":"Regulatory T cells: mechanisms of differentiation and function","volume":"30","author":"SZ Josefowicz","year":"2012","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4049\/jimmunol.178.5.2661","article-title":"Cutting Edge: Regulatory T cells prevent efficient clearance of <italic>Mycobacterium tuberculosis<\/italic>","volume":"178","author":"M Kursar","year":"2007","journal-title":"J Immunol"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1084\/jem.20062105","article-title":"Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis","volume":"204","author":"JP Scott-Browne","year":"2007","journal-title":"J Exp Med"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.immuni.2013.06.003","article-title":"Pathogen-specific Treg cells expand early during <italic>Mycobacterium tuberculosis<\/italic> infection but are later eliminated in response to Interleukin-12","volume":"38","author":"S Shafiani","year":"2013","journal-title":"Immunity"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1164\/rccm.200508-1294OC","article-title":"Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis","volume":"173","author":"V Guyot-Revol","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2249.2006.03027.x","article-title":"A role for CD4<sup>+<\/sup>CD25<sup>+<\/sup> T cells in regulation of the immune response during human tuberculosis","volume":"144","author":"R Ribeiro-Rodrigues","year":"2006","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1164\/rccm.200701-084OC","article-title":"Regulatory T cells depress immune responses to protective antigens in active tuberculosis","volume":"176","author":"JM Hougardy","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.5588\/ijtld.15.0148","article-title":"Enrichment of regulatory T-cells in blood of patients with multidrug-resistant tuberculosis","volume":"19","author":"N Li","year":"2015","journal-title":"Int J Tuberc Lung Dis"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.tube.2010.05.003","article-title":"Regulatory T cell frequency and modulation of IFN-gamma and IL-17 in active and latent tuberculosis","volume":"90","author":"ND Marin","year":"2010","journal-title":"Tuberculosis (Edinb)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tube.2016.06.007","article-title":"<italic>Ex vivo<\/italic> characterization of regulatory T cells in pulmonary tuberculosis patients, latently infected persons, and healthy endemic controls","volume":"100","author":"M Zewdie","year":"2016","journal-title":"Tuberculosis (Edinb)"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"e17726","DOI":"10.5812\/jjm.8(4)2015.17726","article-title":"Evaluation of CD4<sup>+<\/sup>CD25<sup>+<\/sup> FoxP3<sup>+<\/sup> regulatory T cells and FoxP3 and CTLA-4 gene expression in patients with newly diagnosed tuberculosis in northeast of Iran","volume":"8","author":"R Ghazalsofala","year":"2015","journal-title":"Jundishapur J Microbiol"},{"issue":"7309","key":"ref19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"MP Berry","year":"2010","journal-title":"Nature"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"e10469","DOI":"10.1371\/journal.pone.0010469","article-title":"In mice, tuberculosis progression is associated with intensive inflammatory response and the accumulation of Gr-1 cells in the lungs","volume":"5","author":"IV Lyadova","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-3083.2010.02496.x","article-title":"T regulatory cells and immune activation in <italic>Mycobacterium tuberculosis<\/italic> infection and the effect of preventive therapy","volume":"73","author":"I Wergeland","year":"2011","journal-title":"Scand J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"11290","DOI":"10.1038\/ncomms11290","article-title":"T-cell activation is an immune correlate of risk in BCG vaccinated infants","volume":"7","author":"HA Fletcher","year":"2016","journal-title":"Nat Commun"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1172\/JCI72030","article-title":"CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis","volume":"124","author":"G Nouailles","year":"2014","journal-title":"J Clin Invest"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"e0166954","DOI":"10.1371\/journal.pone.0166954","article-title":"Immune activation at sites of HIV\/TB co-infection contributes to the pathogenesis of HIV-1 disease","volume":"11","author":"Q Meng","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ebiom.2015.03.005","article-title":"Latent and active tuberculosis infection increase immune activation in individuals co-infected with HIV","volume":"2","author":"ZA Sullivan","year":"2015","journal-title":"EBioMedicine"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/joim.12256","article-title":"Inflammation and tuberculosis: host-directed therapies","volume":"277","author":"A Zumla","year":"2015","journal-title":"J Intern Med"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1086\/654896","article-title":"CD4(+) regulatory T cells in a cynomolgus macaque model of <italic>Mycobacterium tuberculosis<\/italic> infection","volume":"202","author":"AM Green","year":"2010","journal-title":"J Infect Dis"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1128\/IAI.05552-11","article-title":"Failure to recruit anti-inflammatory CD103<sup>+<\/sup> dendritic cells and a diminished CD4<sup>+<\/sup>FoxP3<sup>+<\/sup> regulatory T cell pool in mice that display excessive lung inflammation and increased susceptibility to Mycobacterium tuberculosis","volume":"80","author":"C Leepiyasakulchai","year":"2012","journal-title":"Infect Immun"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.4049\/jimmunol.1101291","article-title":"-2 simultaneously expands Foxp3<sup>+<\/sup> T regulatory and T effector cells and confers resistance to severe tuberculosis (TB): implicative Treg-T effector co-operation immunity to TB","volume":"188","author":"CY Chen","year":"2012","journal-title":"J Immunol"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.4049\/jimmunol.1003224","article-title":"CD4<sup>+<\/sup>FOXP3<sup>+<\/sup> T regulatory cells in human autoimmunity: more than a numbers game","volume":"187","author":"SA Long","year":"2011","journal-title":"J Immunol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"e9254","DOI":"10.1371\/journal.pone.0009254","article-title":"Increased sensitivity of CD4<sup>+<\/sup> T-effector cells to CD4<sup>+<\/sup>CD25<sup>+<\/sup> Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection","volume":"5","author":"G Thorborn","year":"2010","journal-title":"PLoS One"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.4049\/jimmunol.181.10.7350","article-title":"The effector T cells of diabetic subjects are resistant to regulation via CD4<sup>+<\/sup>FoxP3<sup>+<\/sup> regulatory T cells","volume":"181","author":"A Schneider","year":"2008","journal-title":"J Immunol"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1172\/JCI83987","article-title":"T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression","volume":"126","author":"SJ Patterson","year":"2016","journal-title":"J Clin Invest"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.4049\/jimmunol.182.3.1746","article-title":"Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer","volume":"182","author":"MC Tan","year":"2009","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"38362","DOI":"10.1038\/srep38362","article-title":"PD-1\/PD-L pathway inhibits <italic>M<\/italic>.<italic>tb<\/italic>-specific CD4<sup>+<\/sup> T-cell functions and phagocytosis of macrophages in active tuberculosis","volume":"6","author":"L Shen","year":"2016","journal-title":"Sci Rep"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"e44728","DOI":"10.1371\/journal.pone.0044728","article-title":"Foxp3<sup>+<\/sup> regulatory T cells among tuberculosis patients: impact on prognosis and restoration of antigen specific IFN-\u03b3 producing T cells","volume":"7","author":"A Singh","year":"2012","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1084\/jem.20090847","article-title":"PD-L1 regulates the development, maintenance, and function of induced regulatory T cells","volume":"206","author":"LM Francisco","year":"2009","journal-title":"J Exp Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6309219","DOI":"10.1155\/2016\/6309219","article-title":"Balancing Inflammation: The Link between Th17 and Regulatory T Cells","volume":"2016","author":"ML Diller","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1172\/JCI81151","article-title":"Sodium chloride inhibits the suppressive function of FOXP3<sup>+<\/sup> regulatory T cells","volume":"125","author":"AL Hernandez","year":"2015","journal-title":"J Clin Invest"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s10753-012-9496-8","article-title":"CD4<sup>+<\/sup>CD25<sup>+<\/sup>CD127<sup>low\/-<\/sup> T cells: a more specific Treg population in human peripheral blood","volume":"35","author":"N Yu","year":"2012","journal-title":"Inflammation"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/eji.201141426","article-title":"Elevated effector cell sensitivity to Treg-cell suppression that is not associated with reduced Th17-cell expression distinguishes HIV+ asymptomatic subjects from progressors","volume":"42","author":"GS Thorborn","year":"2012","journal-title":"Eur J Immunol"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1002\/eji.200526065","article-title":"Reduced suppressive effect of CD4<sup>+<\/sup>CD25<sup>high<\/sup> regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis","volume":"35","author":"J Haas","year":"2005","journal-title":"Eur J Immunol"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2249.2008.03810.x","article-title":"Increased resistance to CD4<sup>+<\/sup>CD25<sup>hi<\/sup> regulatory T cell-mediated suppression in patients with type 1 diabetes","volume":"154","author":"JM Lawson","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fimmu.2016.00193","article-title":"Breaking free of control: how conventional T cells overcome regulatory T cell suppression","volume":"7","author":"ER Mercadante","year":"2016","journal-title":"Front Immunol"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1172\/JCI77990","article-title":"Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response","volume":"125","author":"T Adekambi","year":"2015","journal-title":"J Clin Invest"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.4049\/jimmunol.1003304","article-title":"CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition","volume":"186","author":"DL Barber","year":"2011","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tube.2016.10.001","article-title":"The characteristic profiles of PD-1 and PD-L1 expressions and dynamic changes during treatment in active tuberculosis","volume":"101","author":"L Shen","year":"2016","journal-title":"Tuberculosis (Edinb)"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tube.2015.11.008","article-title":"KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults","volume":"97","author":"MC Boer","year":"2016","journal-title":"Tuberculosis (Edinb)"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3109\/0284186X.2015.1125017","article-title":"Tuberculosis reactivation in a patient receiving anti-programmed death-1 (PD-1) inhibitor for relapsed Hodgkin&apos;s lymphoma","volume":"55","author":"JJ Lee","year":"2016","journal-title":"Acta Oncol"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"11948","DOI":"10.1038\/s41598-017-10773-5","article-title":"Circulating <italic>Mycobacterium tuberculosis<\/italic> DosR latency antigen-specific, polyfunctional, regulatory IL10(+) Th17 CD4 T-cells differentiate latent from active tuberculosis","volume":"7","author":"S Rakshit","year":"2017","journal-title":"Sci Rep"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3389\/fimmu.2017.00968","article-title":"Analysis of the phenotype of <italic>Mycobacterium tuberculosis<\/italic>-specific CD4<sup>+<\/sup> T cells to discriminate latent from active tuberculosis in HIV-uninfected and HIV-infected individuals","volume":"8","author":"C Riou","year":"2017","journal-title":"Front Immunol"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"e1000520","DOI":"10.1371\/journal.ppat.1000520","article-title":"Chemokine coreceptor signalling in HIV-1 infection and pathogenesis","volume":"5","author":"Y Wu","year":"2009","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.drudis.2015.07.003","article-title":"Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies","volume":"20","author":"TH Borch","year":"2015","journal-title":"Drug Discov Today"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.clim.2011.08.005","article-title":"Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus","volume":"141","author":"S Dolff","year":"2011","journal-title":"Clin Immunol"},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.20091885","article-title":"Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis","volume":"207","author":"S Shafiani","year":"2010","journal-title":"J Exp Med"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1440-1711.2006.01460.x","article-title":"Inactivation of CD4<sup>+<\/sup>CD25<sup>+<\/sup> regulatory T cells during early mycobacterial infection increases cytokine production but does not affect pathogen load","volume":"84","author":"KM Quinn","year":"2006","journal-title":"Immunol Cell Biol"},{"issue":"11","key":"ref57","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1164\/rccm.201210-1934OC","article-title":"Regulatory T cells attenuate mycobacterial stasis in alveolar and blood-derived macrophages from patients with tuberculosis","volume":"187","author":"PL Semple","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"ref58","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1164\/rccm.200804-529OC","article-title":"FoxP3<sup>+<\/sup> regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis","volume":"179","author":"PK Sharma","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"528","DOI":"10.4049\/jimmunol.1402990","article-title":"Polyfunctional, pathogenic CD161+ Th17 lineage cells are resistant to regulatory T cell-mediated suppression in the context of autoimmunity","volume":"195","author":"SA Basdeo","year":"2015","journal-title":"J Immunol"},{"issue":"8","key":"ref60","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.4049\/jimmunol.173.8.5008","article-title":"Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4<sup>+<\/sup>CD25<sup>+<\/sup> T cells","volume":"173","author":"GL Stephens","year":"2004","journal-title":"J Immunol"},{"issue":"10","key":"ref61","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1002\/art.30503","article-title":"Impaired suppression of synovial fluid CD4<sup>+<\/sup>CD25<sup>-<\/sup> T cells from patients with juvenile idiopathic arthritis by CD4<sup>+<\/sup>CD25<sup>+<\/sup> Treg cells","volume":"63","author":"S Haufe","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"6","key":"ref62","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.cytogfr.2010.10.004","article-title":"IL-17 and Th17 cells in tuberculosis","volume":"21","author":"E Torrado","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/imr.12027","article-title":"IL-22, not simply a Th17 cytokine","volume":"252","author":"S Rutz","year":"2013","journal-title":"Immunol Rev"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"e57379","DOI":"10.1371\/journal.pone.0057379","article-title":"IL-22 is mainly produced by IFN\u03b3-secreting cells but is dispensable for host protection against <italic>Mycobacterium tuberculosis<\/italic> infection","volume":"8","author":"J Behrends","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref65","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/art.20965","article-title":"Expression of Interleukin-22 in rheumatoid arthritis: potential role as a pro-inflammatory cytokine","volume":"52","author":"H Ikeuchi","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"12","key":"ref66","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.humimm.2013.08.003","article-title":"Altered Th17 cells and Th17\/regulatory T-cell ratios indicate the subsequent conversion from undifferentiated connective tissue disease to definitive systemic autoimmune disorders","volume":"74","author":"P Szodoray","year":"2013","journal-title":"Hum Immunol"},{"issue":"10","key":"ref67","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1128\/CVI.05214-11","article-title":"Imbalance of Th17 cells and regulatory T cells in tuberculous pleural effusion","volume":"18","author":"ZJ Ye","year":"2011","journal-title":"Clin Vaccine Immunol"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tube.2011.02.002","article-title":"Increased frequencies of T helper type 17 cells in tuberculous pleural effusion","volume":"91","author":"T Wang","year":"2011","journal-title":"Tuberculosis (Edinb)"},{"issue":"6","key":"ref69","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1189\/jlb.1211619","article-title":"IL-17 and IFN-\u03b3 expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease","volume":"91","author":"JO Jurado","year":"2012","journal-title":"J Leukoc Biol"},{"issue":"2","key":"ref70","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bjid.2016.10.011","article-title":"Imbalance of Th17 and Treg in peripheral blood mononuclear cells of active tuberculosis patients","volume":"21","author":"J Luo","year":"2017","journal-title":"Braz J Infect Dis"},{"issue":"29","key":"ref71","doi-asserted-by":"crossref","first-page":"10101","DOI":"10.1073\/pnas.0804286105","article-title":"CXCR4-CCR5: a couple modulating T cell functions","volume":"105","author":"RL Contento","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref72","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/jat.2744","article-title":"CCR5 plays an important role in resolving an inflammatory response to single-walled carbon nanotubes","volume":"33","author":"EJ Park","year":"2013","journal-title":"J Appl Toxicol"},{"issue":"4","key":"ref73","doi-asserted-by":"crossref","first-page":"H781","DOI":"10.1152\/ajpheart.00798.2016","article-title":"Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells","volume":"312","author":"T Kimura","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"ref74","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.2353\/ajpath.2010.090759","article-title":"CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells","volume":"176","author":"M Dobaczewski","year":"2010","journal-title":"Am J Pathol"},{"issue":"5","key":"ref75","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nri1349","article-title":"Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity","volume":"4","author":"L Chen","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"ref76","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"GJ Freeman","year":"2000","journal-title":"J Exp Med"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1074-7613(00)80089-8","article-title":"Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor","volume":"11","author":"H Nishimura","year":"1999","journal-title":"Immunity"},{"issue":"7","key":"ref78","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nri2356","article-title":"Colony-stimulating factors in inflammation and autoimmunity","volume":"8","author":"JA Hamilton","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"ref79","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/intimm\/dxh354","article-title":"TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45","volume":"18","author":"PJ Bryce","year":"2006","journal-title":"Int Immunol"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/s41598-017-02280-4","article-title":"TRAF3 enhances TCR signalling by regulating the inhibitors Csk and PTPN22","volume":"7","author":"AM Wallis","year":"2017","journal-title":"Sci Rep"},{"issue":"13","key":"ref81","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1074\/jbc.275.13.9767","article-title":"Expression of Fas ligand in activated T cells is regulated by c-Myc","volume":"275","author":"T Brunner","year":"2000","journal-title":"J Biol Chem"},{"issue":"12","key":"ref82","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1128\/IAI.00513-10","article-title":"CD46 engagement on human CD4+ T cells produces T regulatory type 1-like regulation of anti-mycobacterial T cell responses","volume":"78","author":"SM Truscott","year":"2010","journal-title":"Infect Immun"},{"issue":"9","key":"ref83","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.4049\/jimmunol.0902797","article-title":"Dual effects of TRAIL in suppression of autoimmunity: the inhibition of Th1 cells and the promotion of regulatory T cells","volume":"185","author":"T Ikeda","year":"2010","journal-title":"J Immunol"},{"issue":"20","key":"ref84","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1073\/pnas.1121072109","article-title":"Common patterns and disease-related signatures in tuberculosis and sarcoidosis","volume":"109","author":"J Maertzdorf","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"e45839","DOI":"10.1371\/journal.pone.0045839","article-title":"Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis","volume":"7","author":"TH Ottenhoff","year":"2012","journal-title":"PLoS One"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ebiom.2016.12.009","article-title":"Unbiased identification of blood-based biomarkers for pulmonary tuberculosis by modeling and mining molecular interaction networks","volume":"15","author":"A Sambarey","year":"2017","journal-title":"EBioMedicine"},{"issue":"6","key":"ref87","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon gamma in resistance to <italic>Mycobacterium tuberculosis<\/italic> infection","volume":"178","author":"JL Flynn","year":"1993","journal-title":"J Exp Med"},{"issue":"6","key":"ref88","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1172\/JCI80273","article-title":"STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection","volume":"125","author":"L Desvignes","year":"2015","journal-title":"J Clin Invest"},{"issue":"8","key":"ref89","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/eji.201344219","article-title":"Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics","volume":"44","author":"A Dorhoi","year":"2014","journal-title":"Eur J Immunol"},{"issue":"2","key":"ref90","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/infdis\/jit152","article-title":"Ibuprofen therapy resulted in significantly decreased tissue bacillary loads and increased survival in a new murine experimental model of active tuberculosis","volume":"208","author":"C Vilaplana","year":"2013","journal-title":"J Infect Dis"},{"issue":"5","key":"ref91","doi-asserted-by":"crossref","first-page":"e1005667","DOI":"10.1371\/journal.ppat.1005667","article-title":"CD4 T Cell-Derived IFN-\u03b3 plays a minimal role in control of pulmonary <italic>Mycobacterium tuberculosis<\/italic> infection and must be actively repressed by PD-1 to prevent lethal disease","volume":"12","author":"S Sakai","year":"2016","journal-title":"PLoS Pathog"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007289","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:17:48Z","timestamp":1588961868000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007289"}},"subtitle":[],"editor":[{"given":"David M.","family":"Lewinsohn","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":91,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007289","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007289","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]}}}