{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:16:39Z","timestamp":1790640999673,"version":"4.1.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673234, 41476161"],"award-info":[{"award-number":["81673234, 41476161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bijzonder Onderzoeksfonds KU Leuven","award":["OT\/14\/115"],"award-info":[{"award-number":["OT\/14\/115"]}]},{"name":"VIROGENESIS","award":["634650"],"award-info":[{"award-number":["634650"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2016YFA0600104"],"award-info":[{"award-number":["2016YFA0600104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Union\u2019s Seventh Framework Programme","award":["614725-PATHPHYLODYN"],"award-info":[{"award-number":["614725-PATHPHYLODYN"]}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["FWO"],"award-info":[{"award-number":["FWO"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["FWO"],"award-info":[{"award-number":["FWO"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002661","name":"Fonds De La Recherche Scientifique - FNRS","doi-asserted-by":"publisher","award":["FNRS"],"award-info":[{"award-number":["FNRS"]}],"id":[{"id":"10.13039\/501100002661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["725422-ReservoirDOCS"],"award-info":[{"award-number":["725422-ReservoirDOCS"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007392","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T18:30:33Z","timestamp":1544121033000},"page":"e1007392","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Transmission dynamics of re-emerging rabies in domestic dogs of rural China"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4466-0858","authenticated-orcid":true,"given":"Huaiyu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6547-5283","authenticated-orcid":true,"given":"Bram","family":"Vrancken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-361X","authenticated-orcid":true,"given":"Bernard","family":"Cazelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7818-1081","authenticated-orcid":true,"given":"Mandev S.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lemey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver G.","family":"Pybus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Chr.","family":"Stenseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-1052","authenticated-orcid":true,"given":"Simon","family":"Dellicour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(13)62707-5","article-title":"Current status of rabies and prospects for elimination","volume":"384","author":"AR Fooks","year":"2014","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e982","DOI":"10.1371\/journal.pntd.0000982","article-title":"Evaluation of cost-effective strategies for rabies post-exposure vaccination in low-income countries","volume":"5","author":"K Hampson","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref3","first-page":"360","article-title":"Re-evaluating the burden of rabies in Africa and Asia","volume":"83","author":"DL Knobel","year":"2005","journal-title":"Bull World Health Organ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e0004874","DOI":"10.1371\/journal.pntd.0004874","article-title":"Human rabies in China, 1960\u20132014: A descriptive epidemiological study","volume":"10","author":"H Zhou","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref5","article-title":"Re\u2010emerging of rabies in Shaanxi Province, China, 2009 to 2015","author":"C Ma","year":"2017","journal-title":"J Med Virol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3201\/eid1112.050271","article-title":"Pivotal role of dogs in rabies transmission, China","volume":"11","author":"X Tang","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref7","first-page":"1251","article-title":"Factors related to rabies prevalence in Kunming City from 1981 to 2010","volume":"11","author":"Z Deng","year":"2011","journal-title":"China Tropical Medicine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/vbz.2008.0046","article-title":"Rabies in China: an update","volume":"9","author":"R Hu","year":"2009","journal-title":"Vector Borne Zoonotic Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.vetmic.2006.04.009","article-title":"Canine vaccination\u2014providing broader benefits for disease control","volume":"117","author":"S Cleaveland","year":"2006","journal-title":"Vet Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/289765a0","article-title":"Population dynamics of fox rabies in Europe","volume":"289","author":"R Anderson","year":"1981","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1073\/pnas.0609122104","article-title":"Synchronous cycles of domestic dog rabies in sub-Saharan Africa and the impact of control efforts","volume":"104","author":"K Hampson","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1098\/rspb.1986.0078","article-title":"On the spatial spread of rabies among foxes","volume":"229","author":"J Murray","year":"1986","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13666","DOI":"10.1073\/pnas.240326697","article-title":"Predicting the local dynamics of epizootic rabies among raccoons in the United States","volume":"97","author":"JE Childs","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1098\/rspb.2003.2559","article-title":"A priori prediction of disease invasion dynamics in a novel environment","volume":"271","author":"CA Russell","year":"2004","journal-title":"Proc Biol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1073\/pnas.042400799","article-title":"Predicting the spatial dynamics of rabies epidemics on heterogeneous landscapes","volume":"99","author":"DL Smith","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1000053","DOI":"10.1371\/journal.pbio.1000053","article-title":"Transmission dynamics and prospects for the elimination of canine rabies","volume":"7","author":"K Hampson","year":"2009","journal-title":"PLoS Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1073\/pnas.0700741104","article-title":"A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus","volume":"104","author":"R Biek","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"12107","DOI":"10.1073\/pnas.0500057102","article-title":"Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus","volume":"102","author":"LA Real","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e1001166","DOI":"10.1371\/journal.ppat.1001166","article-title":"Phylodynamics and human-mediated dispersal of a zoonotic virus","volume":"6","author":"C Talbi","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e0003502","DOI":"10.1371\/journal.pntd.0003502","article-title":"The spatiotemporal expansion of human rabies and its probable explanation in mainland China, 2004\u20132013","volume":"9","author":"H-W Yao","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3201\/eid1508.081551","article-title":"Molecular epidemiology of rabies in Southern People\u2019s Republic of China","volume":"15","author":"X Tao","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1005525","DOI":"10.1371\/journal.ppat.1005525","article-title":"Revealing the micro-scale signature of endemic zoonotic disease transmission in an African urban setting","volume":"12","author":"H Bourhy","year":"2016","journal-title":"PLoS Pathog"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"20120194","DOI":"10.1098\/rstb.2012.0194","article-title":"Molecular evolutionary signatures reveal the role of host ecological dynamics in viral disease emergence and spread","volume":"368","author":"SM Duke-Sylvester","year":"2013","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"vev011","DOI":"10.1093\/ve\/vev011","article-title":"Elucidating the phylodynamics of endemic rabies virus in eastern Africa using whole-genome sequencing","volume":"1","author":"K Brunker","year":"2015","journal-title":"Virus Evol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3201\/eid2009.130440","article-title":"Molecular epidemiology of reemergent rabies in Yunnan Province, southwestern China","volume":"20","author":"H Zhang","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1093\/molbev\/msq067","article-title":"Phylogeography takes a relaxed random walk in continuous space and time","volume":"27","author":"P Lemey","year":"2010","journal-title":"Mol Biol Evol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"15066","DOI":"10.1073\/pnas.1206598109","article-title":"Unifying the spatial epidemiology and molecular evolution of emerging epidemics","volume":"109","author":"OG Pybus","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref28","article-title":"Using viral gene sequences to compare and explain the heterogeneous spatial dynamics of virus epidemics","author":"S Dellicour","year":"2017","journal-title":"Mol Biol Evol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12859-016-0924-x","article-title":"Explaining the geographic spread of emerging epidemics: a framework for comparing viral phylogenies and environmental landscape data","volume":"17","author":"S Dellicour","year":"2016","journal-title":"BMC bioinformatics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1093\/bioinformatics\/btw384","article-title":"SERAPHIM: studying environmental rasters and phylogenetically-informed movements","volume":"32","author":"S Dellicour","year":"2016","journal-title":"Bioinformatics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1000898","DOI":"10.1371\/journal.pcbi.1000898","article-title":"Forcing versus feedback: epidemic malaria and monsoon rains in northwest India","volume":"6","author":"K Laneri","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"ref32","first-page":"32","article-title":"Current situation and control of rabies in Yunnan Province","author":"G Dong","year":"2011","journal-title":"Modern Journal of Animal Husbandry and Veterinary Medicine"},{"key":"ref33","first-page":"44","article-title":"Some thoughts on rabies disease prevention in Yunnan Province","author":"Y Lv","year":"2012","journal-title":"Yunnan Journal of Animal Science and Veterinary Medicine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"14996","DOI":"10.1073\/pnas.0904740106","article-title":"Transmission dynamics and economics of rabies control in dogs and humans in an African city","volume":"106","author":"J Zinsstag","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref35","article-title":"Yunan statistical yearbook","year":"2015"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"eaaf6984","DOI":"10.1126\/scitranslmed.aaf6984","article-title":"Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure","volume":"9","author":"J Zinsstag","year":"2017","journal-title":"Sci Transl Med"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0001-706X(01)00082-1","article-title":"Dog ecology and demography information to support the planning of rabies control in Machakos District, Kenya","volume":"78","author":"P Kitala","year":"2001","journal-title":"Acta Trop"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-5877(99)00114-2","article-title":"Community-based active surveillance for rabies in Machakos District, Kenya","volume":"44","author":"P Kitala","year":"2000","journal-title":"Prev Vet Med"},{"key":"ref39","first-page":"1005","article-title":"Analysis of a surveillance system based on aggressive dog attack incidents in chuxiong prefecture","volume":"32","author":"Q Hu","year":"2016","journal-title":"J Med Pest Control"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"14574","DOI":"10.1073\/pnas.1604975113","article-title":"One Health approach to cost-effective rabies control in India","volume":"113","author":"MC Fitzpatrick","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref41","author":"DR Gwatkin","year":"2007"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e1640","DOI":"10.1371\/journal.pntd.0001640","article-title":"The spatial and temporal dynamics of rabies in China","volume":"6","author":"J Yu","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"K Katoh","year":"2013","journal-title":"Mol Biol Evol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/molbev\/mss075","article-title":"Bayesian phylogenetics with BEAUti and the BEAST 1.7","volume":"29","author":"AJ Drummond","year":"2012","journal-title":"Mol Biol Evol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1000520","DOI":"10.1371\/journal.pcbi.1000520","article-title":"Bayesian phylogeography finds its roots","volume":"5","author":"P Lemey","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/BF00160154","article-title":"Maximum likelihood phylogenetic estimation from DNA sequences with variable rates over sites: approximate methods","volume":"39","author":"Z Yang","year":"1994","journal-title":"J Mol Evol"},{"key":"ref47","first-page":"57","article-title":"Some Mathematical Questions in Biology\u2014DNA Sequence Analysis","author":"S Tavar\u00e9","year":"1986"},{"key":"ref48","first-page":"270","article-title":"Evidence from nuclear sequences that invariable sites should be considered when sequence divergence is calculated","volume":"6","author":"J Shoemaker","year":"1989","journal-title":"Mol Biol Evol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/molbev\/mss265","article-title":"Improving Bayesian population dynamics inference: a coalescent-based model for multiple loci","volume":"30","author":"MS Gill","year":"2013","journal-title":"Mol Biol Evol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1371\/journal.pbio.0040088","article-title":"Relaxed phylogenetics and dating with confidence","volume":"4","author":"AJ Drummond","year":"2006","journal-title":"PLoS Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"vew007","DOI":"10.1093\/ve\/vew007","article-title":"Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen)","volume":"2","author":"A Rambaut","year":"2016","journal-title":"Virus Evol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12985-017-0769-6","article-title":"Cross-border spread, lineage displacement and evolutionary rate estimation of rabies virus in Yunnan Province, China","volume":"14","author":"Y Zhang","year":"2017","journal-title":"Virol J"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/sysbio\/syw050","article-title":"Understanding past population dynamics: Bayesian coalescent-based modeling with covariates","volume":"65","author":"MS Gill","year":"2016","journal-title":"Syst Biol"},{"key":"ref54","first-page":"3264","article-title":"Bayesian inference reveals host-specific contributions to the epidemic expansion of Influenza A H5N1","volume":"32","author":"NS Trov\u00e3o","year":"2015","journal-title":"Mol Biol Evol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5994","DOI":"10.1111\/mec.13887","article-title":"Spatio\u2010temporal analysis of Nova virus, a divergent hantavirus circulating in the European mole in Belgium","volume":"25","author":"L Laenen","year":"2016","journal-title":"Mol Ecol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"20170919","DOI":"10.1098\/rspb.2017.0919","article-title":"Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference","volume":"284","author":"M Jacquot","year":"2017","journal-title":"Proc Biol Sci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/00031305.1995.10476177","article-title":"Understanding the metropolis-hastings algorithm","volume":"49","author":"S Chib","year":"1995","journal-title":"Am Stat"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11222-006-9438-0","article-title":"DRAM: efficient adaptive MCMC","volume":"16","author":"H Haario","year":"2006","journal-title":"Stat Comput"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1017\/S0031182000075806","article-title":"Maintenance of a microparasite infecting several host species: rabies in the Serengeti","volume":"111","author":"S Cleaveland","year":"1995","journal-title":"Parasitology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1017\/S0950268802006957","article-title":"Comparison of vaccination strategies for the control of dog rabies in Machakos District, Kenya","volume":"129","author":"P Kitala","year":"2002","journal-title":"Epidemiol Infect"},{"key":"ref61","first-page":"853","article-title":"Rabies virus carriage in domestic dogs and distribution of positive dogs in Lufenng, Yunnan","volume":"28","author":"M Hua","year":"2013","journal-title":"Disease Surveillance"},{"key":"ref62","first-page":"229","article-title":"Sensitivity and uncertainty analysis of complex models of disease transmission: an HIV model, as an example","volume":"62","author":"SM Blower","year":"1994","journal-title":"International Statistical Review\/Revue Internationale de Statistique"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtbi.2008.04.011","article-title":"A methodology for performing global uncertainty and sensitivity analysis in systems biology","volume":"254","author":"S Marino","year":"2008","journal-title":"J Theor Biol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T02:47:52Z","timestamp":1720838872000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007392"}},"subtitle":[],"editor":[{"given":"Matthias Johannes","family":"Schnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":63,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007392","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,6]]}}}