{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:23:49Z","timestamp":1790173429266,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007398","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-102712"],"award-info":[{"award-number":["MOP-102712"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["370954"],"award-info":[{"award-number":["370954"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-93770"],"award-info":[{"award-number":["MOP-93770"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["TCO-125276"],"award-info":[{"award-number":["TCO-125276"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007398","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T18:44:35Z","timestamp":1542048275000},"page":"e1007398","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["HIV-1 capsids from B27\/B57+ elite controllers escape Mx2 but are targeted by TRIM5\u03b1, leading to the induction of an antiviral state"],"prefix":"10.1371","volume":"14","author":[{"given":"Natacha","family":"Merindol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Far","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Sylla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Masroori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dufour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3984-4839","authenticated-orcid":true,"given":"Pearl","family":"Cherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lodie B.","family":"Plourde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Tremblay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-5058","authenticated-orcid":true,"given":"Lionel","family":"Berthoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1086\/605446","article-title":"Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters","volume":"200","author":"F Pereyra","year":"2009","journal-title":"The Journal of infectious diseases"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1093\/infdis\/jiu809","article-title":"Hospitalization Rates and Reasons Among HIV Elite Controllers and Persons With Medically Controlled HIV Infection","volume":"211","author":"TA Crowell","year":"2015","journal-title":"The Journal of infectious diseases"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/infdis\/jit581","article-title":"Evidence for innate immune system activation in HIV type 1-infected elite controllers","volume":"209","author":"S Krishnan","year":"2014","journal-title":"The Journal of infectious diseases"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1073\/pnas.050567397","article-title":"HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors","volume":"97","author":"SA Migueles","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nm0496-405","article-title":"Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection","volume":"2","author":"RA Kaslow","year":"1996","journal-title":"Nat Med"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm1333","article-title":"AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis","volume":"11","author":"X Gao","year":"2005","journal-title":"Nat Med"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"e1424","DOI":"10.1371\/journal.pone.0001424","article-title":"Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads","volume":"3","author":"M Rolland","year":"2008","journal-title":"PLoS One"},{"issue":"18","key":"ref8","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1097\/00002030-200212060-00004","article-title":"Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection","volume":"16","author":"C Chouquet","year":"2002","journal-title":"Aids"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2174\/1570162X13666150608104412","article-title":"Restriction Factors in HIV-1 Disease Progression","volume":"13","author":"N Merindol","year":"2015","journal-title":"Current HIV research"},{"key":"ref10","article-title":"Role of Innate Genes in HIV Replication","author":"K Schott","year":"2017","journal-title":"Curr Top Microbiol Immunol"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.tim.2017.04.004","article-title":"Capsid-Dependent Host Factors in HIV-1 Infection","volume":"25","author":"M Yamashita","year":"2017","journal-title":"Trends in microbiology"},{"issue":"7472","key":"ref12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12542","article-title":"Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection","volume":"502","author":"C Goujon","year":"2013","journal-title":"Nature"},{"issue":"7472","key":"ref13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nature12653","article-title":"MX2 is an interferon-induced inhibitor of HIV-1 infection","volume":"502","author":"M Kane","year":"2013","journal-title":"Nature"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.chom.2013.08.015","article-title":"The interferon-inducible MxB protein inhibits HIV-1 infection","volume":"14","author":"Z Liu","year":"2013","journal-title":"Cell host & microbe"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12977-014-0068-x","article-title":"MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1","volume":"11","author":"T Fricke","year":"2014","journal-title":"Retrovirology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12977-014-0090-z","article-title":"Host and viral determinants for MxB restriction of HIV-1 infection","volume":"11","author":"KA Matreyek","year":"2014","journal-title":"Retrovirology"},{"issue":"6977","key":"ref17","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nature02343","article-title":"The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys","volume":"427","author":"M Stremlau","year":"2004","journal-title":"Nature"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1093\/emboj\/20.9.2140","article-title":"The tripartite motif family identifies cell compartments","volume":"20","author":"A Reymond","year":"2001","journal-title":"The EMBO journal"},{"issue":"29","key":"ref19","doi-asserted-by":"crossref","first-page":"10774","DOI":"10.1073\/pnas.0402361101","article-title":"Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha","volume":"101","author":"T Hatziioannou","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"29","key":"ref20","doi-asserted-by":"crossref","first-page":"10780","DOI":"10.1073\/pnas.0402474101","article-title":"The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities","volume":"101","author":"Z Keckesova","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.0409853102","article-title":"Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain","volume":"102","author":"SL Sawyer","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nrmicro1248","article-title":"TRIM family proteins: retroviral restriction and antiviral defence","volume":"3","author":"S Nisole","year":"2005","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1128\/JVI.05811-11","article-title":"RING domain mutations uncouple TRIM5alpha restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating","volume":"86","author":"A Roa","year":"2012","journal-title":"Journal of virology"},{"issue":"14","key":"ref24","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1073\/pnas.0509996103","article-title":"Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor","volume":"103","author":"M Stremlau","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"e1003214","DOI":"10.1371\/journal.ppat.1003214","article-title":"Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection","volume":"9","author":"SB Kutluay","year":"2013","journal-title":"PLoS Pathog"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1089\/aid.2010.0367","article-title":"Recent insights into the mechanism and consequences of TRIM5alpha retroviral restriction","volume":"27","author":"J Sastri","year":"2011","journal-title":"AIDS research and human retroviruses"},{"issue":"14","key":"ref27","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1128\/JVI.00214-14","article-title":"Host and viral determinants of Mx2 antiretroviral activity","volume":"88","author":"I Busnadiego","year":"2014","journal-title":"Journal of virology"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.chom.2014.09.021","article-title":"Structural insight into HIV-1 restriction by MxB","volume":"16","author":"JL Fribourgh","year":"2014","journal-title":"Cell host & microbe"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12977-014-0129-1","article-title":"The highly polymorphic cyclophilin A-binding loop in HIV-1 capsid modulates viral resistance to MxB","volume":"12","author":"Z Liu","year":"2015","journal-title":"Retrovirology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1742-4690-4-68","article-title":"Both TRIM5alpha and TRIMCyp have only weak antiviral activity in canine D17 cells","volume":"4","author":"J B\u00e9rub\u00e9","year":"2007","journal-title":"Retrovirology"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"e1003352","DOI":"10.1371\/journal.ppat.1003352","article-title":"Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5alpha specificity","volume":"9","author":"KR McCarthy","year":"2013","journal-title":"PLoS Pathog"},{"issue":"15","key":"ref32","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.15252\/embj.201490361","article-title":"TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription","volume":"34","author":"AJ Fletcher","year":"2015","journal-title":"The EMBO journal"},{"issue":"7343","key":"ref33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature09976","article-title":"TRIM5 is an innate immune sensor for the retrovirus capsid lattice","volume":"472","author":"T Pertel","year":"2011","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.virusres.2014.02.013","article-title":"The conserved sumoylation consensus site in TRIM5alpha modulates its immune activation functions","volume":"184C","author":"ME Nepveu-Traversy","year":"2014","journal-title":"Virus research"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.celrep.2015.06.072","article-title":"RING Dimerization Links Higher-Order Assembly of TRIM5alpha to Synthesis of K63-Linked Polyubiquitin","volume":"12","author":"Z Yudina","year":"2015","journal-title":"Cell reports"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"e00056","DOI":"10.1016\/j.heliyon.2015.e00056","article-title":"A putative SUMO interacting motif in the B30.2\/SPRY domain of rhesus macaque TRIM5alpha important for NF-kappaB\/AP-1 signaling and HIV-1 restriction","volume":"2","author":"ME Nepveu-Traversy","year":"2016","journal-title":"Heliyon"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1128\/JVI.01804-12","article-title":"TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity","volume":"87","author":"PD Uchil","year":"2013","journal-title":"Journal of virology"},{"issue":"29","key":"ref38","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1073\/pnas.0402876101","article-title":"Trim5alpha protein restricts both HIV-1 and murine leukemia virus","volume":"101","author":"MW Yap","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"22","key":"ref39","doi-asserted-by":"crossref","first-page":"11846","DOI":"10.1128\/JVI.05201-11","article-title":"Gag cytotoxic T lymphocyte escape mutations can increase sensitivity of HIV-1 to human TRIM5alpha, linking intrinsic and acquired immunity","volume":"85","author":"E Battivelli","year":"2011","journal-title":"Journal of virology"},{"issue":"18","key":"ref40","doi-asserted-by":"crossref","first-page":"10368","DOI":"10.1128\/JVI.01313-13","article-title":"Pressure from TRIM5alpha contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles","volume":"87","author":"C Granier","year":"2013","journal-title":"Journal of virology"},{"key":"ref41","article-title":"Naturally occurring mutations in HIV-1 CRF01_AE capsid affect viral sensitivity to restriction factors","author":"EE Nakayama","year":"2018","journal-title":"AIDS research and human retroviruses"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2742648","DOI":"10.1155\/2016\/2742648","article-title":"Previously Unidentified Single Nucleotide Polymorphisms in HIV\/AIDS Cases Associate with Clinical Parameters and Disease Progression","volume":"2016","author":"VV Anokhin","year":"2016","journal-title":"Biomed Res Int"},{"issue":"5\u20136","key":"ref43","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s12026-016-8810-1","article-title":"TRIM5 gene polymorphisms in HIV-1-infected patients and healthy controls from Northeastern Brazil","volume":"64","author":"R Celerino da Silva","year":"2016","journal-title":"Immunol Res"},{"issue":"22","key":"ref44","doi-asserted-by":"crossref","first-page":"12608","DOI":"10.1128\/JVI.01369-07","article-title":"Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A","volume":"81","author":"MA Brockman","year":"2007","journal-title":"Journal of virology"},{"issue":"22","key":"ref45","doi-asserted-by":"crossref","first-page":"12382","DOI":"10.1128\/JVI.01543-07","article-title":"Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication","volume":"81","author":"A Schneidewind","year":"2007","journal-title":"Journal of virology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ebiom.2016.04.020","article-title":"Accumulation of MxB\/Mx2-resistant HIV-1 Capsid Variants During Expansion of the HIV-1 Epidemic in Human Populations","volume":"8","author":"W Wei","year":"2016","journal-title":"EBioMedicine"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"FA Ran","year":"2013","journal-title":"Nature protocols"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.clim.2008.01.007","article-title":"LPS reduces HIV-1 replication in primary human macrophages partly through an endogenous production of type I interferons","volume":"127","author":"S Simard","year":"2008","journal-title":"Clinical immunology"},{"issue":"7476","key":"ref49","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature12769","article-title":"HIV-1 evades innate immune recognition through specific cofactor recruitment","volume":"503","author":"J Rasaiyaah","year":"2013","journal-title":"Nature"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"7992","DOI":"10.1128\/JVI.72.10.7992-8001.1998","article-title":"Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins","volume":"72","author":"JL Rossio","year":"1998","journal-title":"Journal of virology"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ni1303","article-title":"Innate immune recognition of viral infection","volume":"7","author":"T Kawai","year":"2006","journal-title":"Nature immunology"},{"issue":"2","key":"ref52","first-page":"M57","article-title":"A new family of IKK-related kinases may function as I kappa B kinase kinases","volume":"1471","author":"RT Peters","year":"2001","journal-title":"Biochim Biophys Acta"},{"issue":"5339","key":"ref53","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1126\/science.278.5339.860","article-title":"IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation","volume":"278","author":"F Mercurio","year":"1997","journal-title":"Science"},{"issue":"357","key":"ref54","doi-asserted-by":"crossref","first-page":"re13","DOI":"10.1126\/stke.3572006re13","article-title":"Regulation and function of IKK and IKK-related kinases","volume":"2006","author":"H Hacker","year":"2006","journal-title":"Science's STKE: signal transduction knowledge environment"},{"issue":"36","key":"ref55","doi-asserted-by":"crossref","first-page":"22771","DOI":"10.1074\/jbc.272.36.22771","article-title":"Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction","volume":"272","author":"W Wang","year":"1997","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.coviro.2012.02.003","article-title":"TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling","volume":"2","author":"MG Grutter","year":"2012","journal-title":"Curr Opin Virol"},{"issue":"21","key":"ref57","doi-asserted-by":"crossref","first-page":"14136","DOI":"10.1074\/jbc.M109.000414","article-title":"Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation","volume":"284","author":"K Clark","year":"2009","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"ref58","first-page":"1530","article-title":"Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester","volume":"42","author":"S Tsuchiya","year":"1982","journal-title":"Cancer research"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"e1003461","DOI":"10.1371\/journal.ppat.1003461","article-title":"Extreme genetic fragility of the HIV-1 capsid","volume":"9","author":"SJ Rihn","year":"2013","journal-title":"PLoS pathogens"},{"issue":"16","key":"ref60","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1128\/JVI.00458-16","article-title":"Complex Interplay between HIV-1 Capsid and MX2-Independent Alpha Interferon-Induced Antiviral Factors","volume":"90","author":"L Bulli","year":"2016","journal-title":"Journal of virology"},{"issue":"10","key":"ref61","doi-asserted-by":"crossref","first-page":"e110480","DOI":"10.1371\/journal.pone.0110480","article-title":"Time to seroconversion in HIV-exposed subjects carrying protective versus non protective KIR3DS1\/L1 and HLA-B genotypes","volume":"9","author":"BJ Tallon","year":"2014","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"22902","DOI":"10.1038\/srep22902","article-title":"Proinflammatory isoforms of IL-32 as novel and robust biomarkers for control failure in HIV-infected slow progressors","volume":"6","author":"M El-Far","year":"2016","journal-title":"Scientific reports"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1128\/JVI.59.2.284-291.1986","article-title":"Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone","volume":"59","author":"A Adachi","year":"1986","journal-title":"Journal of virology"},{"issue":"6617","key":"ref64","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/385645a0","article-title":"CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia","volume":"385","author":"J He","year":"1997","journal-title":"Nature"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","DOI":"10.1128\/mSphereDirect.00233-17","article-title":"Gene Knockout Shows That PML (TRIM19) Does Not Restrict the Early Stages of HIV-1 Infection in Human Cell Lines","volume":"2","author":"N Masroori","year":"2017","journal-title":"mSphere"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12977-016-0253-1","article-title":"The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific, isoform-specific fashion","volume":"13","author":"N Masroori","year":"2016","journal-title":"Retrovirology"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/excr.1998.4175","article-title":"A composite CMV-IE enhancer\/beta-actin promoter is ubiquitously expressed in mouse cutaneous epithelium","volume":"244","author":"JA Sawicki","year":"1998","journal-title":"Experimental cell research"},{"issue":"22","key":"ref68","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1093\/nar\/gku936","article-title":"Easy quantitative assessment of genome editing by sequence trace decomposition","volume":"42","author":"EK Brinkman","year":"2014","journal-title":"Nucleic acids research"},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.virol.2010.06.021","article-title":"Murine double minute 2 as a modulator of retroviral restrictions mediated by TRIM5alpha","volume":"405","author":"M Malbec","year":"2010","journal-title":"Virology"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007398","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T03:37:16Z","timestamp":1605411436000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007398"}},"subtitle":[],"editor":[{"given":"Michael","family":"Emerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":69,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007398","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007398","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]}}}