{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:00:14Z","timestamp":1790766014688,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007413","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Basic Research Program of China","award":["2015CB554203"],"award-info":[{"award-number":["2015CB554203"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371763"],"award-info":[{"award-number":["81371763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Fundamental Research Funds for the Central Universities","award":["KYZ201741"],"award-info":[{"award-number":["KYZ201741"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI120489"],"award-info":[{"award-number":["R01AI120489"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007413","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T17:31:55Z","timestamp":1540920715000},"page":"e1007413","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hypermutation-induced in vivo oxidative stress resistance enhances Vibrio cholerae host adaptation"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-3599","authenticated-orcid":true,"given":"Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jipeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Larios-Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saijun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijuan","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-9276","authenticated-orcid":true,"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-5224","authenticated-orcid":true,"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nrmicro2204","article-title":"Cholera transmission: the host, pathogen and bacteriophage dynamic","volume":"7","author":"EJ Nelson","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"39","key":"ref2","doi-asserted-by":"crossref","first-page":"14542","DOI":"10.1073\/pnas.0604650103","article-title":"Vibrio cholerae virulence regulator-coordinated evasion of host immunity","volume":"103","author":"A Hsiao","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"28","key":"ref3","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1073\/pnas.0802241105","article-title":"Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing","volume":"105","author":"Z Liu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1073\/pnas.1218039110","article-title":"Bile salt-induced intermolecular disulfide bond formation activates Vibrio cholerae virulence","volume":"110","author":"M Yang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"E2376","DOI":"10.1073\/pnas.1716973115","article-title":"In vivo repressed genes of Vibrio cholerae reveal inverse requirements of an H(+)\/Cl(-) transporter along the gastrointestinal passage","volume":"115","author":"F Cakar","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"e1003800","DOI":"10.1371\/journal.ppat.1003800","article-title":"Gene fitness landscapes of Vibrio cholerae at important stages of its life cycle","volume":"9","author":"HD Kamp","year":"2013","journal-title":"PLoS Pathog"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.chom.2007.09.004","article-title":"Genes induced late in infection increase fitness of Vibrio cholerae after release into the environment","volume":"2","author":"S Schild","year":"2007","journal-title":"Cell Host Microbe"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrmicro3433","article-title":"Living in the matrix: assembly and control of Vibrio cholerae biofilms","volume":"13","author":"JK Teschler","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1534-5807(03)00295-8","article-title":"Quorum sensing-dependent biofilms enhance colonization in Vibrio cholerae","volume":"5","author":"J Zhu","year":"2003","journal-title":"Dev Cell"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1128\/IAI.00048-10","article-title":"Growth in a biofilm induces a hyperinfectious phenotype in Vibrio cholerae","volume":"78","author":"R Tamayo","year":"2010","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.physiol.68.040104.110001","article-title":"Oxidative stress in marine environments: biochemistry and physiological ecology","volume":"68","author":"MP Lesser","year":"2006","journal-title":"Annual review of physiology"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbagen.2003.10.016","article-title":"Role of the W07-toxin on Vibrio cholerae-induced diarrhoea","volume":"1670","author":"S Bhattacharyya","year":"2004","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1128\/IAI.02765-14","article-title":"Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera","volume":"83","author":"CN Ellis","year":"2015","journal-title":"Infect Immun"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"e53383","DOI":"10.1371\/journal.pone.0053383","article-title":"Catalases promote resistance of oxidative stress in Vibrio cholerae","volume":"7","author":"H Wang","year":"2012","journal-title":"PloS one"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/mmi.13524","article-title":"Thiol-based switch mechanism of virulence regulator AphB modulates oxidative stress response in Vibrio cholerae","volume":"102","author":"Z Liu","year":"2016","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"e0171201","DOI":"10.1371\/journal.pone.0171201","article-title":"OxyR-activated expression of Dps is important for Vibrio cholerae oxidative stress resistance and pathogenesis","volume":"12","author":"X Xia","year":"2017","journal-title":"PloS one"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1365-2958.2012.07982.x","article-title":"Hsp33 confers bleach resistance by protecting elongation factor Tu against oxidative degradation in Vibrio cholerae","volume":"83","author":"WY Wholey","year":"2012","journal-title":"Molecular microbiology"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00929-16","article-title":"OxyR2 Modulates OxyR1 Activity and Vibrio cholerae Oxidative Stress Response","volume":"85","author":"H Wang","year":"2017","journal-title":"Infect Immun"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1073\/pnas.052694299","article-title":"Quorum-sensing regulators control virulence gene expression in Vibrio cholerae","volume":"99","author":"J Zhu","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1099\/mic.0.000364","article-title":"Catalases and PhoB\/PhoR system independently contribute to oxidative stress resistance in Vibrio cholerae O1","volume":"162","author":"CL Goulart","year":"2016","journal-title":"Microbiology"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/AEM.02804-06","article-title":"Quorum sensing enhances the stress response in Vibrio cholerae","volume":"73","author":"A Joelsson","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1146\/annurev.biochem.74.082803.133243","article-title":"DNA mismatch repair","volume":"74","author":"TA Kunkel","year":"2005","journal-title":"Annual review of biochemistry"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.femsim.2005.01.003","article-title":"Mutator phenotype confers advantage in Escherichia coli chronic urinary tract infection pathogenesis","volume":"44","author":"F Labat","year":"2005","journal-title":"FEMS immunology and medical microbiology"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1534\/genetics.104.030304","article-title":"Experimental adaptation of Salmonella typhimurium to mice","volume":"168","author":"AI Nilsson","year":"2004","journal-title":"Genetics"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1128\/JB.00120-07","article-title":"Inactivation of the mismatch repair system in Pseudomonas aeruginosa attenuates virulence but favors persistence of oropharyngeal colonization in cystic fibrosis mice","volume":"189","author":"A Mena","year":"2007","journal-title":"Journal of bacteriology"},{"issue":"5513","key":"ref26","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1126\/science.1056421","article-title":"Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut","volume":"291","author":"A Giraud","year":"2001","journal-title":"Science"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"e00013","DOI":"10.1128\/mBio.00013-12","article-title":"The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines","volume":"3","author":"AM Stern","year":"2012","journal-title":"mBio"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"e00430","DOI":"10.1128\/mBio.00430-13","article-title":"Streptomycin-Induced Inflammation Enhances Escherichia coli Gut Colonization Through Nitrate Respiration","volume":"4","author":"AM Spees","year":"2013","journal-title":"mBio"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions","volume":"60","author":"M Zafarullah","year":"2003","journal-title":"Cellular and molecular life sciences: CMLS"},{"issue":"1\u20133","key":"ref30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejphar.2012.06.014","article-title":"N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice","volume":"691","author":"I Amrouche-Mekkioui","year":"2012","journal-title":"European journal of pharmacology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.dnarep.2015.11.016","article-title":"Evolution of the methyl directed mismatch repair system in Escherichia coli","volume":"38","author":"CD Putnam","year":"2016","journal-title":"DNA Repair (Amst)"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.genet.34.1.359","article-title":"DNA mismatch repair and genetic instability","volume":"34","author":"BD Harfe","year":"2000","journal-title":"Annual review of genetics"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1128\/IAI.00736-07","article-title":"Decreased potency of the Vibrio cholerae sheathed flagellum to trigger host innate immunity","volume":"76","author":"SS Yoon","year":"2008","journal-title":"Infect Immun"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1073\/pnas.0915164107","article-title":"Reactogenicity of live-attenuated Vibrio cholerae vaccines is dependent on flagellins","volume":"107","author":"H Rui","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri3423","article-title":"Beyond oxidative stress: an immunologist&apos;s guide to reactive oxygen species","volume":"13","author":"C Nathan","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ni1200","article-title":"ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity","volume":"6","author":"A Matsuzawa","year":"2005","journal-title":"Nature immunology"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/j.1348-0421.1986.tb03037.x","article-title":"Culture conditions for stimulating cholera toxin production by Vibrio cholerae O1 El Tor","volume":"30","author":"M Iwanaga","year":"1986","journal-title":"Microbiol Immunol"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1073\/pnas.96.7.4028","article-title":"Vibrio cholerae O1 El Tor: identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation","volume":"96","author":"FH Yildiz","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1128\/AEM.68.11.5773-5778.2002","article-title":"High-frequency rugose exopolysaccharide production by Vibrio cholerae","volume":"68","author":"A Ali","year":"2002","journal-title":"Appl Environ Microbiol"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.1128\/AEM.64.10.3648-3655.1998","article-title":"Vibrio cholerae O1 strain TSI-4 produces the exopolysaccharide materials that determine colony morphology, stress resistance, and biofilm formation","volume":"64","author":"SN Wai","year":"1998","journal-title":"Appl Environ Microbiol"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tim.2008.12.004","article-title":"Vibrio biofilms: so much the same yet so different","volume":"17","author":"FH Yildiz","year":"2009","journal-title":"Trends Microbiol"},{"issue":"Pt 9","key":"ref42","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1099\/mic.0.040196-0","article-title":"Role of Vibrio polysaccharide (vps) genes in VPS production, biofilm formation and Vibrio cholerae pathogenesis","volume":"156","author":"JC Fong","year":"2010","journal-title":"Microbiology"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1128\/AAC.49.6.2276-2282.2005","article-title":"Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammation","volume":"49","author":"O Ciofu","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"issue":"1757","key":"ref44","doi-asserted-by":"crossref","first-page":"20130007","DOI":"10.1098\/rspb.2013.0007","article-title":"A trade-off between oxidative stress resistance and DNA repair plays a role in the evolution of elevated mutation rates in bacteria","volume":"280","author":"C Torres-Barcelo","year":"2013","journal-title":"Proceedings Biological sciences \/ The Royal Society"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"e1001295","DOI":"10.1371\/journal.ppat.1001295","article-title":"DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine","volume":"7","author":"BW Davies","year":"2011","journal-title":"PLoS Pathog"},{"issue":"Pt 5","key":"ref46","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1099\/jmm.0.024083-0","article-title":"Bacterial hypermutation: clinical implications","volume":"60","author":"A Jolivet-Gougeon","year":"2011","journal-title":"Journal of medical microbiology"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1469-0691.2010.03250.x","article-title":"Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistance","volume":"16","author":"A Oliver","year":"2010","journal-title":"Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0966-842X(97)01157-8","article-title":"To be a mutator, or how pathogenic and commensal bacteria can evolve rapidly","volume":"5","author":"F Taddei","year":"1997","journal-title":"Trends Microbiol"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"e1005072","DOI":"10.1371\/journal.pgen.1005072","article-title":"The role of China in the global spread of the current cholera pandemic","volume":"11","author":"X Didelot","year":"2015","journal-title":"PLoS genetics"},{"issue":"1","key":"ref50","article-title":"A Mobile Element in mutS Drives Hypermutation in a Marine Vibrio","volume":"8","author":"ND Chu","year":"2017","journal-title":"mBio"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0923-2508(00)01163-3","article-title":"Second-order selection in bacterial evolution: selection acting on mutation and recombination rates in the course of adaptation","volume":"152","author":"O Tenaillon","year":"2001","journal-title":"Research in microbiology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/ncomms2607","article-title":"beta-Lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity","volume":"4","author":"A Gutierrez","year":"2013","journal-title":"Nature communications"},{"issue":"19","key":"ref53","doi-asserted-by":"crossref","first-page":"6290","DOI":"10.1128\/JB.01569-07","article-title":"Phage-associated mutator phenotype in group A streptococcus","volume":"190","author":"J Scott","year":"2008","journal-title":"Journal of bacteriology"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1462-2920.2008.01853.x","article-title":"Inactivation of mismatch repair increases the diversity of Vibrio parahaemolyticus","volume":"11","author":"TH Hazen","year":"2009","journal-title":"Environ Microbiol"},{"issue":"Pt 5","key":"ref55","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1099\/mic.0.27777-0","article-title":"Role of RpoS and MutS in phase variation of Pseudomonas sp. PCL1171","volume":"151","author":"D van den Broek","year":"2005","journal-title":"Microbiology"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1097-2765(00)80471-2","article-title":"Hypermutation in pathogenic bacteria: frequent phase variation in meningococci is a phenotypic trait of a specialized mutator biotype","volume":"3","author":"C Bucci","year":"1999","journal-title":"Molecular cell"},{"issue":"10","key":"ref57","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1128\/JB.02594-14","article-title":"Neisseria gonorrhoeae MutS Affects Pilin Antigenic Variation through Mismatch Correction and Not by pilE Guanine Quartet Binding","volume":"197","author":"E Rotman","year":"2015","journal-title":"Journal of bacteriology"},{"key":"ref58","article-title":"Bistability and phase variation in Salmonella enterica","author":"L Garcia-Pastor","year":"2018","journal-title":"Biochim Biophys Acta"},{"issue":"20","key":"ref59","doi-asserted-by":"crossref","first-page":"13929","DOI":"10.1074\/jbc.R113.472274","article-title":"Programmed heterogeneity: epigenetic mechanisms in bacteria","volume":"288","author":"J Casadesus","year":"2013","journal-title":"J Biol Chem"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1128\/IAI.74.2.1141-1147.2006","article-title":"Genetic and phenotypic diversity of quorum-sensing systems in clinical and environmental isolates of Vibrio cholerae","volume":"74","author":"A Joelsson","year":"2006","journal-title":"Infect Immun"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/plas.1996.0001","article-title":"Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria","volume":"35","author":"WW Metcalf","year":"1996","journal-title":"Plasmid"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1128\/IAI.02841-14","article-title":"Vibrio cholerae represses polysaccharide synthesis to promote motility in mucosa","volume":"83","author":"Z Liu","year":"2015","journal-title":"Infect Immun"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0378-1119(95)00584-1","article-title":"Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes","volume":"166","author":"ME Kovach","year":"1995","journal-title":"Gene"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1073\/pnas.1014640108","article-title":"Vibrio cholerae anaerobic induction of virulence gene expression is controlled by thiol-based switches of virulence regulator AphB","volume":"108","author":"Z Liu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0076-6879(94)35167-8","article-title":"Regulation of cholera toxin by temperature, pH, and osmolarity","volume":"235","author":"CL Gardel","year":"1994","journal-title":"Methods Enzymol"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00203-002-0442-2","article-title":"Genetic analysis of pigment biosynthesis in Xanthobacter autotrophicus Py2 using a new, highly efficient transposon mutagenesis system that is functional in a wide variety of bacteria","volume":"178","author":"RA Larsen","year":"2002","journal-title":"Archives of microbiology"},{"issue":"2","key":"ref67","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.celrep.2015.12.038","article-title":"Differential Thiol-Based Switches Jump-Start Vibrio cholerae Pathogenesis","volume":"14","author":"Z Liu","year":"2016","journal-title":"Cell reports"},{"issue":"4","key":"ref68","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1365-2958.1993.tb01737.x","article-title":"Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence","volume":"9","author":"BL Bassler","year":"1993","journal-title":"Molecular microbiology"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007413","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T10:07:06Z","timestamp":1605348426000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007413"}},"subtitle":[],"editor":[{"given":"Karla J.F.","family":"Satchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,30]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007413","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007413","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,30]]}}}