{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:29:43Z","timestamp":1789738183889,"version":"4.0.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007417","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000}}],"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI135820"],"award-info":[{"award-number":["R21AI135820"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007417","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T18:29:31Z","timestamp":1543861771000},"page":"e1007417","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine"],"prefix":"10.1371","volume":"14","author":[{"given":"Xiaojian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6035-3313","authenticated-orcid":true,"given":"Fred L.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-5199","authenticated-orcid":true,"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-938X","authenticated-orcid":true,"given":"Katie","family":"Hanson-Dorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-6153","authenticated-orcid":true,"given":"Matthew W.","family":"Hopken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Cooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-4622","authenticated-orcid":true,"given":"John A.","family":"Baroch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-7558","authenticated-orcid":true,"given":"Brandon S.","family":"Schmit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia K.","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Jarman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-1472","authenticated-orcid":true,"given":"Thomas J.","family":"DeLiberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-9234","authenticated-orcid":true,"given":"Xiu-Feng","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1073\/pnas.1116200109","article-title":"A distinct lineage of influenza A virus from bats","volume":"109","author":"S Tong","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"e1003657","DOI":"10.1371\/journal.ppat.1003657","article-title":"New world bats harbor diverse influenza A viruses","volume":"9","author":"S Tong","year":"2013","journal-title":"PLoS Pathog"},{"issue":"5772","key":"ref3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1122438","article-title":"Global patterns of influenza a virus in wild birds","volume":"312","author":"B Olsen","year":"2006","journal-title":"Science"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/MMBR.56.1.152-179.1992","article-title":"Evolution and ecology of influenza A viruses","volume":"56","author":"RG Webster","year":"1992","journal-title":"Microbiol Rev"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1574-695X.1997.tb01056.x","article-title":"Influenza: interspecies transmission and emergence of new pandemics","volume":"18","author":"RG Webster","year":"1997","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"25","key":"ref6","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1056\/NEJMoa0903812","article-title":"Triple-reassortant swine influenza A (H1) in humans in the United States, 2005\u20132009","volume":"360","author":"V Shinde","year":"2009","journal-title":"N Engl J Med"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41598-017-01512-x","article-title":"A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine","volume":"7","author":"JC Mancera Gracia","year":"2017","journal-title":"Sci Rep"},{"issue":"16","key":"ref8","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1128\/JVI.00534-09","article-title":"Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessment","volume":"83","author":"S Jackson","year":"2009","journal-title":"J Virol"},{"issue":"32","key":"ref9","doi-asserted-by":"crossref","first-page":"12121","DOI":"10.1073\/pnas.0605134103","article-title":"Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model","volume":"103","author":"TR Maines","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1073\/pnas.0912807107","article-title":"Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence","volume":"107","author":"C Li","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"e59889","DOI":"10.1371\/journal.pone.0059889","article-title":"Reassortment between Avian H5N1 and human influenza viruses is mainly restricted to the matrix and neuraminidase gene segments","volume":"8","author":"EJ Schrauwen","year":"2013","journal-title":"PLoS One"},{"issue":"16","key":"ref12","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1128\/JVI.00534-09","article-title":"Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessment","volume":"83","author":"S Jackson","year":"2009","journal-title":"Journal of virology"},{"issue":"7403","key":"ref13","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature10831","article-title":"Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA\/H1N1 virus in ferrets","volume":"486","author":"M Imai","year":"2012","journal-title":"Nature"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev-virology-101416-041726","article-title":"Constraints, Drivers, and Implications of Influenza A Virus Reassortment","volume":"4","author":"AC Lowen","year":"2017","journal-title":"Annu Rev Virol"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"e1003421","DOI":"10.1371\/journal.ppat.1003421","article-title":"Influenza virus reassortment occurs with high frequency in the absence of segment mismatch","volume":"9","author":"N Marshall","year":"2013","journal-title":"PLoS Pathog"},{"issue":"16","key":"ref16","doi-asserted-by":"crossref","first-page":"8453","DOI":"10.1128\/JVI.01162-15","article-title":"Influenza A Virus Coinfection through Transmission Can Support High Levels of Reassortment","volume":"89","author":"H Tao","year":"2015","journal-title":"J Virol"},{"issue":"13","key":"ref17","doi-asserted-by":"crossref","first-page":"7485","DOI":"10.1128\/JVI.00715-14","article-title":"Intrahost dynamics of influenza virus reassortment","volume":"88","author":"H Tao","year":"2014","journal-title":"J Virol"},{"key":"ref18","article-title":"Influenza A virus reassortment is limited by anatomical compartmentalization following co-infection via distinct routes","author":"M Richard","year":"2017","journal-title":"J Virol"},{"issue":"2","key":"ref19","first-page":"e00919","article-title":"American triple reassortant and Eurasian H1N1 swine influenza viruses do not readily reassort to generate a 2009 pandemic H1N1-like virus","volume":"5","author":"W Ma","year":"2014","journal-title":"MBio"},{"issue":"Pt 9","key":"ref20","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1099\/0022-1317-75-9-2183","article-title":"Potential for transmission of avian influenza viruses to pigs","volume":"75","author":"H Kida","year":"1994","journal-title":"J Gen Virol"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1099\/jgv.0.000225","article-title":"Dynamics of virus shedding and antibody responses in influenza A virus-infected feral swine","volume":"96","author":"H Sun","year":"2015","journal-title":"J Gen Virol"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jcv.2009.09.013","article-title":"Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses","volume":"46","author":"IW Li","year":"2009","journal-title":"J Clin Virol"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"6427","DOI":"10.1128\/JVI.00341-12","article-title":"Oct4+ stem\/progenitor swine lung epithelial cells are targets for influenza virus replication","volume":"86","author":"M Khatri","year":"2012","journal-title":"J Virol"},{"issue":"Suppl 1","key":"ref24","first-page":"436","article-title":"The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection","volume":"5","author":"CF Hui","year":"2011","journal-title":"Influenza Other Respir Viruses"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/1743-422X-8-434","article-title":"Distribution of sialic acid receptors and influenza A virus of avian and swine origin in experimentally infected pigs","volume":"8","author":"R Trebbien","year":"2011","journal-title":"Virol J"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/infdis\/jis739","article-title":"Increased severity of 2009 pandemic influenza A virus subtype H1N1 infection in alveolar type II cells from patients with pulmonary fibrosis","volume":"207","author":"N Fujino","year":"2013","journal-title":"J Infect Dis"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/infdis\/jis455","article-title":"Influenza A viruses target type II pneumocytes in the human lung","volume":"206","author":"VK Weinheimer","year":"2012","journal-title":"J Infect Dis"},{"issue":"52","key":"ref28","doi-asserted-by":"crossref","first-page":"20949","DOI":"10.1073\/pnas.0710286104","article-title":"Identification of H2N3 influenza A viruses from swine in the United States","volume":"104","author":"W Ma","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"16","key":"ref29","doi-asserted-by":"crossref","first-page":"8204","DOI":"10.1128\/JVI.00718-08","article-title":"Amino acid 226 in the hemagglutinin of H4N6 influenza virus determines binding affinity for alpha2,6-linked sialic acid and infectivity levels in primary swine and human respiratory epithelial cells","volume":"82","author":"AC Bateman","year":"2008","journal-title":"J Virol"},{"issue":"1","key":"ref30","first-page":"75","article-title":"Evidence for the natural transmission of influenza A virus from wild ducts to swine and its potential importance for man","volume":"59","author":"M Pensaert","year":"1981","journal-title":"Bulletin of the World Health Organization"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"8041","DOI":"10.1128\/JVI.70.11.8041-8046.1996","article-title":"Emergence of avian H1N1 influenza viruses in pigs in China","volume":"70","author":"Y Guan","year":"1996","journal-title":"Journal of virology"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1128\/JCM.38.6.2453-2456.2000","article-title":"Genetic characterization of an H1N2 influenza virus isolated from a pig in Indiana","volume":"38","author":"AI Karasin","year":"2000","journal-title":"Journal of clinical microbiology"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1128\/JCM.42.9.4349-4354.2004","article-title":"Characterization of avian H3N3 and H1N1 influenza A viruses isolated from pigs in Canada","volume":"42","author":"AI Karasin","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"16","key":"ref34","doi-asserted-by":"crossref","first-page":"10821","DOI":"10.1128\/JVI.79.16.10821-10825.2005","article-title":"Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004","volume":"79","author":"YK Choi","year":"2005","journal-title":"Journal of virology"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.meegid.2011.02.023","article-title":"Identification of an H6N6 swine influenza virus in southern China","volume":"11","author":"G Zhang","year":"2011","journal-title":"Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases"},{"issue":"20","key":"ref36","doi-asserted-by":"crossref","first-page":"9679","DOI":"10.1128\/JVI.75.20.9679-9686.2001","article-title":"Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment?","volume":"75","author":"JS Peiris","year":"2001","journal-title":"Journal of virology"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.micinf.2004.04.015","article-title":"Isolation and identification of swine influenza recombinant A\/Swine\/Shandong\/1\/2003(H9N2) virus","volume":"6","author":"C Xu","year":"2004","journal-title":"Microbes Infect"},{"issue":"Pt 9","key":"ref38","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1099\/vir.0.021402-0","article-title":"Viral reassortment and transmission after co-infection of pigs with classical H1N1 and triple-reassortant H3N2 swine influenza viruses","volume":"91","author":"W Ma","year":"2010","journal-title":"J Gen Virol"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.1019109108","article-title":"High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1\/2009 influenza viruses","volume":"108","author":"Y Sun","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"29","key":"ref40","doi-asserted-by":"crossref","first-page":"12084","DOI":"10.1073\/pnas.1108058108","article-title":"Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model","volume":"108","author":"JB Kimble","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"e1000072","DOI":"10.1371\/journal.ppat.1000072","article-title":"Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses","volume":"4","author":"LM Chen","year":"2008","journal-title":"PLoS Pathog"},{"issue":"20","key":"ref42","doi-asserted-by":"crossref","first-page":"10918","DOI":"10.1128\/JVI.01140-10","article-title":"High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses","volume":"84","author":"CP Octaviani","year":"2010","journal-title":"J Virol"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/embj.201387442","article-title":"Role of receptor binding specificity in influenza A virus transmission and pathogenesis","volume":"33","author":"M de Graaf","year":"2014","journal-title":"EMBO J"},{"issue":"51","key":"ref44","doi-asserted-by":"crossref","first-page":"18590","DOI":"10.1073\/pnas.0507415102","article-title":"The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host","volume":"102","author":"G Gabriel","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"ref45","doi-asserted-by":"crossref","first-page":"9469","DOI":"10.1128\/JVI.00989-07","article-title":"The RNA binding domain of influenza A virus NS1 protein affects secretion of tumor necrosis factor alpha, interleukin-6, and interferon in primary murine tracheal epithelial cells","volume":"81","author":"CM Newby","year":"2007","journal-title":"J Virol"},{"key":"ref46","first-page":"00804","article-title":"Antigenic characterization of H3N2 influenza A viruses from Ohio agricultural fairs","author":"Z Feng","year":"2013","journal-title":"Journal of virology"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"11886","DOI":"10.1038\/s41598-017-11272-3","article-title":"Multiple Genome Constellations of Similar and Distinct Influenza A Viruses Co-Circulate in Pigs During Epidemic Events","volume":"7","author":"A Diaz","year":"2017","journal-title":"Scientific reports"},{"issue":"7","key":"ref48","doi-asserted-by":"crossref","first-page":"e1002791","DOI":"10.1371\/journal.ppat.1002791","article-title":"Pathogenicity and transmissibility of North American triple reassortant swine influenza A viruses in ferrets","volume":"8","author":"S Barman","year":"2012","journal-title":"PLoS Pathog"},{"issue":"11","key":"ref49","article-title":"Antigenically Diverse Swine Origin H1N1 Variant Influenza Viruses Exhibit Differential Ferret Pathogenesis and Transmission Phenotypes","volume":"92","author":"JA Pulit-Penaloza","year":"2018","journal-title":"J Virol"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1128\/JVI.03355-14","article-title":"Pathogenicity and transmissibility of novel reassortant H3N2 influenza viruses with 2009 pandemic H1N1 genes in pigs","volume":"89","author":"J Ma","year":"2015","journal-title":"J Virol"},{"issue":"7600","key":"ref51","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature17655","article-title":"Normalizing the environment recapitulates adult human immune traits in laboratory mice","volume":"532","author":"LK Beura","year":"2016","journal-title":"Nature"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3201\/eid2005.131578","article-title":"Influenza A subtype H3 viruses in feral swine, United States, 2011\u20132012","volume":"20","author":"Z Feng","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"422","DOI":"10.7589\/0090-3558-45.2.422","article-title":"Feral swine contact with domestic swine: a serologic survey and assessment of potential for disease transmission","volume":"45","author":"AC Wyckoff","year":"2009","journal-title":"J Wildl Dis"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"362","DOI":"10.7589\/0090-3558-44.2.362","article-title":"Influenza exposure in United States feral swine populations","volume":"44","author":"JS Hall","year":"2008","journal-title":"J Wildl Dis"},{"issue":"10","key":"ref55","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3201\/eid1610.100665","article-title":"Pandemic (H1N1) 2009 virus on commercial swine farm, Thailand","volume":"16","author":"D Sreta","year":"2010","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3201\/eid1602.091114","article-title":"Pandemic (H1N1) 2009 cases, Buenos Aires, Argentina","volume":"16","author":"M Echavarria","year":"2010","journal-title":"Emerg Infect Dis"},{"issue":"5","key":"ref57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/zph.12006","article-title":"Identification and analysis of the first 2009 pandemic H1N1 influenza virus from U.S. feral swine","volume":"60","author":"A Clavijo","year":"2013","journal-title":"Zoonoses Public Health"},{"issue":"4","key":"ref58","article-title":"Using sequence data to infer the antigenicity of influenza virus","volume":"4","author":"H Sun","year":"2013","journal-title":"MBio"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.vetmic.2014.12.011","article-title":"Hemagglutinin glycosylation modulates the pathogenicity and antigenicity of the H5N1 avian influenza virus","volume":"175","author":"X Zhang","year":"2015","journal-title":"Veterinary microbiology"},{"key":"ref60","article-title":"Limited antigenic diversity in contemporary H7 avian-origin influenza A viruses from North America","volume":"6","author":"Y Xu","year":"2016","journal-title":"Scientific reports"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.vetmic.2009.10.012","article-title":"Temperature sensitivity on growth and\/or replication of H1N1, H1N2 and H3N2 influenza A viruses isolated from pigs and birds in mammalian cells","volume":"142","author":"P Massin","year":"2010","journal-title":"Veterinary microbiology"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"e1000424","DOI":"10.1371\/journal.ppat.1000424","article-title":"Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways","volume":"5","author":"MA Scull","year":"2009","journal-title":"PLoS pathogens"},{"issue":"52","key":"ref63","doi-asserted-by":"crossref","first-page":"21474","DOI":"10.1073\/pnas.1218841110","article-title":"Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin","volume":"109","author":"YP Lin","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref64","first-page":"e01621","article-title":"A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells","volume":"92","author":"F Wen","year":"2018","journal-title":"J Virol"},{"issue":"7459","key":"ref65","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nature12372","article-title":"Receptor binding by an H7N9 influenza virus from humans","volume":"499","author":"X Xiong","year":"2013","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007417","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T17:15:19Z","timestamp":1605546919000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007417"}},"subtitle":[],"editor":[{"given":"Anice C.","family":"Lowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":65,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007417","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007417","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]}}}