{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:04:19Z","timestamp":1790622259329,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007430","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000}}],"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u00c9cole Normale Sup\u00e9rieure (FR)"},{"name":"Fondation pour l'innovation en infectiologie"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007430","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T18:44:48Z","timestamp":1542048288000},"page":"e1007430","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-3294","authenticated-orcid":true,"given":"Justine","family":"Schaeffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Carnec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8508-5167","authenticated-orcid":true,"given":"St\u00e9phanie","family":"Reynard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-0245","authenticated-orcid":true,"given":"Mathieu","family":"Mateo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Pietrosemoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Agn\u00e8s","family":"Dillies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3234-7477","authenticated-orcid":true,"given":"Sylvain","family":"Baize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Lassa fever in West African sub-region: an overview","volume":"44","author":"O Ogbu","year":"2007","journal-title":"J Vector Borne Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21977","DOI":"10.1038\/srep21977","article-title":"Spatial and temporal evolution of Lassa virus in the natural host population in Upper Guinea","volume":"6","author":"E Fichet-Calvet","year":"2016","journal-title":"Sci Rep"},{"key":"ref3","unstructured":"WHO. WHO publishes list of top emerging diseases likely to cause major epidemics. In: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/medicines\/ebola-treatment\/WHO-list-of-top-emerging-diseases\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/medicines\/ebola-treatment\/WHO-list-of-top-emerging-diseases\/en\/<\/ext-link>. 2015."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2217\/fvl.15.41","article-title":"Current and emerging strategies for the diagnosis, prevention and treatment of Lassa fever","volume":"10","author":"JN Hartnett","year":"2015","journal-title":"Future Virol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-017-0637-x","article-title":"Molecular pathogenesis of viral hemorrhagic fever","volume":"39","author":"CF Basler","year":"2017","journal-title":"Semin Immunopathol"},{"key":"ref6","first-page":"349","article-title":"Pathologic and virologic study of fatal Lassa fever in man","volume":"107","author":"DH Walker","year":"1982","journal-title":"Am J Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.3390\/v4091802","article-title":"Animal Models, Prophylaxis, and Therapeutics for Arenavirus Infections","volume":"4","author":"E Vela","year":"2012","journal-title":"Viruses"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.3390\/v4112766","article-title":"Immune responses and Lassa virus infection","volume":"4","author":"M Russier","year":"2012","journal-title":"Viruses"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1128\/JVI.01948-08","article-title":"Early and strong immune responses are associated with control of viral replication and recovery in lassa virus-infected cynomolgus monkeys","volume":"83","author":"S Baize","year":"2009","journal-title":"J Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.4049\/jimmunol.172.5.2861","article-title":"Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells","volume":"172","author":"S Baize","year":"2004","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/1743-422X-8-205","article-title":"Pathogenesis of Lassa fever in cynomolgus macaques","volume":"8","author":"LE Hensley","year":"2011","journal-title":"Virol J"},{"key":"ref12","first-page":"253","article-title":"Plasmacytoid dendritic cells\u2014virus experts of innate immunity. Semin Immunol","volume":"17","author":"W Barchet","year":"2005"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/imm.12117","article-title":"Human dendritic cell subsets","volume":"140","author":"M Collin","year":"2013","journal-title":"Immunology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6466","DOI":"10.4049\/jimmunol.171.12.6466","article-title":"Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody","volume":"171","author":"C Asselin-Paturel","year":"2003","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.1301440","article-title":"Conventional but Not Plasmacytoid Dendritic Cells Foster the Systemic Virus-Induced Type I IFN Response Needed for Efficient CD8 T Cell Priming","volume":"193","author":"S Hervas-Stubbs","year":"2014","journal-title":"J Immunol"},{"key":"ref16","first-page":"441","article-title":"Isolation of an arenavirus closely related to Lassa virus from Mastomys natalensis in south-east Africa","volume":"55","author":"H Wulff","year":"1977","journal-title":"Bull World Health Organ"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/mpev.1997.0436","article-title":"Phylogenetic Analysis of the Arenaviridae: Patterns of Virus Evolution and Evidence for Cospeciation between Arenaviruses and Their Rodent Hosts","volume":"8","author":"MD Bowen","year":"1997","journal-title":"Mol Phylogenet Evol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1128\/JVI.74.15.6777-6783.2000","article-title":"Effective Vaccine for Lassa Fever","volume":"74","author":"SP Fisher-Hoch","year":"2000","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"10516","DOI":"10.1128\/JVI.78.19.10516-10524.2004","article-title":"Human Macrophages, but Not Dendritic Cells, Are Activated and Produce Alpha \/ Beta Interferons in Response to Mopeia Virus Infection","volume":"78","author":"D Pannetier","year":"2004","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8293","DOI":"10.1128\/JVI.02120-10","article-title":"Human dendritic cells infected with the nonpathogenic Mopeia virus induce stronger T-cell responses than those infected with Lassa virus","volume":"85","author":"D Pannetier","year":"2011","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.immuni.2017.11.001","article-title":"High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization","volume":"47","author":"M Alc\u00e1ntara-Hern\u00e1ndez","year":"2017","journal-title":"Immunity"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.4049\/jimmunol.1402671","article-title":"Protection of human myeloid dendritic cell subsets against influenza A virus infection is differentially regulated upon TLR stimulation","volume":"194","author":"F Baharom","year":"2015","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.micinf.2006.02.002","article-title":"Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages","volume":"8","author":"S Baize","year":"2006","journal-title":"Microbes Infect"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"12093","DOI":"10.1128\/JVI.00429-11","article-title":"Lassa virus nucleoprotein mutants generated by reverse genetics induce a robust type I interferon response in human dendritic cells and macrophages","volume":"85","author":"X Carnec","year":"2011","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"13923","DOI":"10.1128\/JVI.01923-14","article-title":"Exonuclease domain of the Lassa virus nucleoprotein is critical to avoid RIG-I signaling and to inhibit the innate immune response","volume":"88","author":"S Reynard","year":"2014","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1038\/nm1142","article-title":"Exotic emerging viral diseases: progress and challenges","volume":"10","author":"TW Geisbert","year":"2004","journal-title":"Nat Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.coi.2005.05.001","article-title":"Pathogenesis of viral hemorrhagic fever","volume":"17","author":"M. Bray","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jmv.24312","article-title":"Cytokines as biomarkers of Crimean-Congo hemorrhagic fever","volume":"88","author":"A Papa","year":"2016","journal-title":"J Med Virol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12967-017-1226-4","article-title":"Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease","volume":"15","author":"YK Yong","year":"2017","journal-title":"J Transl Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1186\/s12864-016-3060-0","article-title":"In vivo Ebola virus infection leads to a strong innate response in circulating immune cells","volume":"17","author":"IS Caballero","year":"2016","journal-title":"BMC Genomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e0005943","DOI":"10.1371\/journal.pntd.0005943","article-title":"Metabolomics analyses identify platelet activating factors and heme breakdown products as Lassa fever biomarkers","volume":"11","author":"T V Gale","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1006220","DOI":"10.1371\/journal.ppat.1006220","article-title":"OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans","volume":"13","author":"B Sierra","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/JVI.74.5.2186-2192.2000","article-title":"Characterization of human CD4(+) T-cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein","volume":"74","author":"J ter Meulen","year":"2000","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.4049\/jimmunol.177.3.1981","article-title":"Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progression","volume":"177","author":"Y Meng","year":"2006","journal-title":"J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/intimm\/dxf028","article-title":"The genes for perforin, granzymes A-C and IFN-gamma are differentially expressed in single CD8(+) T cells during primary activation","volume":"14","author":"A Kelso","year":"2002","journal-title":"Int Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0042-6822(91)90068-M","article-title":"Sequence analysis of the S RNA of the African arenavirus Mopeia: an unusual secondary structure feature in the intergenic region","volume":"180","author":"SM Wilson","year":"1991","journal-title":"Virology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1128\/JVI.01362-09","article-title":"Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction","volume":"84","author":"L Fan","year":"2010","journal-title":"J Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1128\/JVI.03349-14","article-title":"The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production","volume":"89","author":"J Xing","year":"2015","journal-title":"J Virol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1126\/science.1252480","article-title":"Virus entry. Lassa virus entry requires a trigger-induced receptor switch","volume":"344","author":"LT Jae","year":"2014","journal-title":"Science"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e44211","DOI":"10.1371\/journal.pone.0044211","article-title":"Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease","volume":"7","author":"KM Hastie","year":"2012","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"12696","DOI":"10.1128\/JVI.00882-07","article-title":"Differential inhibition of type I interferon induction by arenavirus nucleoproteins","volume":"81","author":"L Mart\u00ednez-Sobrido","year":"2007","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/pathogens4020283","article-title":"Human Hemorrhagic Fever Causing Arenaviruses: Molecular Mechanisms Contributing to Virus Virulence and Disease Pathogenesis","volume":"4","author":"J Shao","year":"2015","journal-title":"Pathogens"},{"key":"ref43","article-title":"A vaccine platform against arenaviruses based on a recombinant hyper-attenuated Mopeia virus expressing heterologous glycoproteins","author":"X Carnec","year":"2018","journal-title":"J Virol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7728","DOI":"10.1128\/JVI.00187-12","article-title":"Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK\u03b5","volume":"86","author":"C Pythoud","year":"2012","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-4939-6981-4_16","article-title":"Roles of Arenavirus Z Protein in Mediating Virion Budding, Viral Transcription-Inhibition and Interferon-Beta Suppression","author":"J Shao","year":"2018","journal-title":"Hemorrhagic Fever Viruses Methods in Molecular Biology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e1007125","DOI":"10.1371\/journal.ppat.1007125","article-title":"DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection","volume":"14","author":"ME Loureiro","year":"2018","journal-title":"PLOS Pathog"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3201\/eid0605.000504","article-title":"Imported lassa fever in Germany: molecular characterization of a new lassa virus strain","volume":"6","author":"S G\u00fcnther","year":"2000","journal-title":"Emerg Infect Dis"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007430","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:07:00Z","timestamp":1589022420000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007430"}},"subtitle":[],"editor":[{"given":"Stefan","family":"Kunz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007430","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007430","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]}}}