{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:21:12Z","timestamp":1791908472560,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007541","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000}}],"reference-count":96,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15DE027314"],"award-info":[{"award-number":["R15DE027314"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007541","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T13:42:17Z","timestamp":1556113337000},"page":"e1007541","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress"],"prefix":"10.1371","volume":"15","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E. A.","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9284-8663","authenticated-orcid":true,"given":"Ayrianna","family":"Sparks-Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camri A.","family":"Nicksic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa","family":"Kohne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton H.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6102-6541","authenticated-orcid":true,"given":"Jonathan P.","family":"Moorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Q.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5484-5779","authenticated-orcid":true,"given":"Shunbin","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cell.2016.09.030","article-title":"p62 in Cancer: Signaling Adaptor Beyond Autophagy","volume":"167","author":"J Moscat","year":"2016","journal-title":"Cell"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1007\/s11357-014-9626-3","article-title":"p62\/SQSTM1 at the interface of aging, autophagy, and disease","volume":"36","author":"A Bitto","year":"2014","journal-title":"AGE"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568009618666181016164920","article-title":"The Multifunctional Protein p62 and Its Mechanistic Roles in Cancers","volume":"19","author":"S Ning","year":"2019","journal-title":"Current Cancer Drug Targets"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1042\/BCJ20170847","article-title":"Autophagy in cancer: a complex relationship","volume":"475","author":"L Wilde","year":"2018","journal-title":"Biochemical Journal"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/s41388-017-0046-6","article-title":"Dual role of autophagy in hallmarks of cancer","volume":"37","author":"SS Singh","year":"2018","journal-title":"Oncogene"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41556-018-0042-2","article-title":"The autophagic network and cancer","volume":"20","author":"MD Rybstein","year":"2018","journal-title":"Nature Cell Biology"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrm.2016.74","article-title":"Mechanistic insights into selective autophagy pathways: lessons from yeast","volume":"17","author":"J-C Farre","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.jmb.2016.02.004","article-title":"Mechanisms of Selective Autophagy","volume":"428","author":"G Zaffagnini","year":"2016","journal-title":"Journal of Molecular Biology"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"e1006787","DOI":"10.1371\/journal.ppat.1006787","article-title":"TRIM proteins: New players in virus-induced autophagy","volume":"14","author":"KMJ Sparrer","year":"2018","journal-title":"PLOS Pathogens"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"7527","DOI":"10.1038\/ncomms8527","article-title":"Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation","volume":"6","author":"T Murakawa","year":"2015","journal-title":"Nature Communications"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1155\/2016\/1245049","article-title":"Role of ROS and RNS Sources in Physiological and Pathological Conditions","volume":"2016","author":"S Di Meo","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2008.03.036","article-title":"Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair","volume":"270","author":"A Sallmyr","year":"2008","journal-title":"Cancer Letters"},{"issue":"22","key":"ref13","doi-asserted-by":"crossref","first-page":"12871","DOI":"10.1073\/pnas.2135498100","article-title":"Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer","volume":"100","author":"MM Vilenchik","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"HHY Chang","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cell.2017.01.002","article-title":"Endogenous DNA Damage as a Source of Genomic Instability in Cancer","volume":"168","author":"A Tubbs","year":"2017","journal-title":"Cell"},{"issue":"29","key":"ref16","doi-asserted-by":"crossref","first-page":"22576","DOI":"10.1074\/jbc.M110.118976","article-title":"p62\/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription","volume":"285","author":"A Jain","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1080\/15548627.2016.1210368","article-title":"SQSTM1\/p62 mediates crosstalk between autophagy and the UPS in DNA repair","volume":"12","author":"G Hewitt","year":"2016","journal-title":"Autophagy"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molcel.2016.05.027","article-title":"Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1\/p62","volume":"63","author":"Y Wang","year":"2016","journal-title":"Molecular Cell"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrm.2016.58","article-title":"Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers","volume":"17","author":"P Schwertman","year":"2016","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-cancerbio-041816-122338","article-title":"The Role of Autophagy in Cancer","volume":"1","author":"N Santana-Codina","year":"2017","journal-title":"Annual Review of Cancer Biology"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.molcel.2015.10.040","article-title":"Targeting the DNA Damage Response in Cancer","volume":"60","author":"J O\u2019Connor Mark","year":"2015","journal-title":"Molecular Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1101\/sqb.2012.76.011015","article-title":"Autophagy, Stress, and Cancer Metabolism: What Doesn't Kill You Makes You Stronger","volume":"76","author":"R Mathew","year":"2011","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"e838","DOI":"10.1038\/cddis.2013.350","article-title":"Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment","volume":"4","author":"X Sui","year":"2013","journal-title":"Cell Death & Disease"},{"issue":"20","key":"ref24","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1038\/sj.onc.1210946","article-title":"The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy","volume":"27","author":"DY Lee","year":"2008","journal-title":"Oncogene"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.molcel.2008.09.025","article-title":"Inactivation of effector caspases through nondegradative polyubiquitylation","volume":"32","author":"M Ditzel","year":"2008","journal-title":"Mol Cell"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3390\/v2010314","article-title":"Herpesviruses and Autophagy: Catch Me If You Can!","volume":"2","author":"Y Cavignac","year":"2010","journal-title":"Viruses"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/cells1030617","article-title":"How human tumor viruses make use of autophagy","volume":"1","author":"ZL Pratt","year":"2012","journal-title":"Cells"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3390\/v9110341","article-title":"Epstein\u2013Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle","volume":"9","author":"P Hau","year":"2017","journal-title":"Viruses"},{"issue":"15","key":"ref29","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1128\/JVI.00588-12","article-title":"Epstein-Barr Virus BPLF1 Deubiquitinates PCNA and Attenuates Polymerase \u03b7 Recruitment to DNA Damage Sites","volume":"86","author":"CB Whitehurst","year":"2012","journal-title":"Journal of Virology"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3390\/v9120366","article-title":"Characterization of the EBV-Induced Persistent DNA Damage Response","volume":"9","author":"A Hafez","year":"2017","journal-title":"Viruses"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e1876","DOI":"10.1038\/cddis.2015.156","article-title":"Inhibition of autophagy in EBV-positive Burkitt\u2019s lymphoma cells enhances EBV lytic genes expression and replication","volume":"6","author":"A De Leo","year":"2015","journal-title":"Cell Death &Amp; Disease"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1080\/15548627.2015.1115939","article-title":"Constitutive autophagy contributes to resistance to TP53-mediated apoptosis in Epstein-Barr virus-positive latency III B-cell lymphoproliferations","volume":"11","author":"A Pujals","year":"2015","journal-title":"Autophagy"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1038\/sj.onc.1207372","article-title":"Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system","volume":"23","author":"MG Masucci","year":"2004","journal-title":"Oncogene"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1044-579X(02)00101-3","article-title":"The ubiquitin\/proteasome system in Epstein-Barr virus latency and associated malignancies","volume":"13","author":"NP Dantuma","year":"2003","journal-title":"Sem Cancer Biol"},{"issue":"Suppl 1","key":"ref35","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1471-2091-8-S1-S8","article-title":"Role of the ubiquitin system and tumor viruses in AIDS-related cancer","volume":"8","author":"J Shackelford","year":"2007","journal-title":"BMC Biochem"},{"issue":"4","key":"ref36","first-page":"e1138","article-title":"LUBAC modulates LMP1 activation of NF\u03baB and IRF7","volume":"91","author":"L Wang","year":"2017","journal-title":"Journal of Virology"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.18632\/oncotarget.23676","article-title":"LIMD1 Is Induced by and Required for LMP1 Signaling, and Protects EBV-Transformed Cells from DNA Damage-Induced Cell Death","volume":"9","author":"L Wang","year":"2018","journal-title":"Oncotarget"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3390\/v9120372","article-title":"Herpesvirus and Autophagy: \u201cAll Right, Everybody Be Cool, This Is a Robbery!\u201d","volume":"9","author":"M Lussignol","year":"2017","journal-title":"Viruses"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/path.2694","article-title":"Autophagy: assays and artifacts","volume":"221","author":"S Barth","year":"2010","journal-title":"The Journal of pathology"},{"key":"ref40","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2011.07.039","article-title":"Serine 403 phosphorylation of p62\/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins","volume":"44","author":"G Matsumoto","year":"2011","journal-title":"Mol Cell"},{"key":"ref41","first-page":"53","article-title":"Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy","author":"V Rogov","year":"2014","journal-title":"Mol Cell"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)","volume":"12","author":"DJ Klionsky","year":"2016","journal-title":"Autophagy"},{"issue":"34","key":"ref43","doi-asserted-by":"crossref","first-page":"13561","DOI":"10.1073\/pnas.1121572109","article-title":"Keap1 degradation by autophagy for the maintenance of redox homeostasis","volume":"109","author":"K Taguchi","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"24","key":"ref44","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1128\/MCB.24.24.10941-10953.2004","article-title":"Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex","volume":"24","author":"DD Zhang","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"ref45","article-title":"HACE1, an E3 ubiquitin-protein ligase, Mitigates KSHV Infection Induced Oxidative Stress by Promoting Nrf2 Activity","author":"B Kumar","year":"2019","journal-title":"Journal of Virology"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1128\/JVI.02742-14","article-title":"KSHV Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1","volume":"89","author":"O Gjyshi","year":"2015","journal-title":"Journal of Virology"},{"issue":"51","key":"ref47","doi-asserted-by":"crossref","first-page":"53272","DOI":"10.1074\/jbc.M406879200","article-title":"Doxorubicin Activates ATM-dependent Phosphorylation of Multiple Downstream Targets in Part through the Generation of Reactive Oxygen Species","volume":"279","author":"EU Kurz","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"ref48","first-page":"75","article-title":"Lymphoblastoid Cell lines: a Continuous in Vitro Source of Cells to Study Carcinogen Sensitivity and DNA Repair","volume":"1","author":"T Hussain","year":"2012","journal-title":"International Journal of Molecular and Cellular Medicine"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1073\/pnas.1409563112","article-title":"Loss of autophagy causes a synthetic lethal deficiency in DNA repair","volume":"112","author":"EY Liu","year":"2015","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"43","key":"ref50","doi-asserted-by":"crossref","first-page":"E2949","DOI":"10.1073\/pnas.1207718109","article-title":"Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation","volume":"109","author":"SB Kim","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2353\/ajpath.2007.070188","article-title":"Linking of Autophagy to Ubiquitin-Proteasome System Is Important for the Regulation of Endoplasmic Reticulum Stress and Cell Viability","volume":"171","author":"W-X Ding","year":"2007","journal-title":"The American Journal of Pathology"},{"issue":"15","key":"ref52","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1158\/0008-5472.CAN-07-1015","article-title":"Proteasome Function Is Required for DNA Damage Response and Fanconi Anemia Pathway Activation","volume":"67","author":"C Jacquemont","year":"2007","journal-title":"Cancer Research"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4939-2404-2_3","article-title":"Autophagy and aging","volume":"847","author":"N Martinez-Lopez","year":"2015","journal-title":"Advances in experimental medicine and biology"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-immunol-042617-053253","article-title":"Autophagy and Inflammation","volume":"36","author":"Y Matsuzawa-Ishimoto","year":"2018","journal-title":"Annual Review of Immunology"},{"issue":"9","key":"ref55","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41580-018-0033-y","article-title":"Autophagy as a promoter of longevity: insights from model organisms","volume":"19","author":"M Hansen","year":"2018","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1155\/2018\/8023821","article-title":"Autophagy Modulation in Cancer: Current Knowledge on Action and Therapy","volume":"2018","author":"M Marinkovi\u0107","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrc3342","article-title":"The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance","volume":"12","author":"P Bouwman","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3390\/v10110599","article-title":"EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis","volume":"10","author":"M Cirone","year":"2018","journal-title":"Viruses"},{"issue":"21","key":"ref59","doi-asserted-by":"crossref","first-page":"12715","DOI":"10.1128\/JVI.02199-14","article-title":"Epstein-Barr Virus Blocks the Autophagic Flux and Appropriates the Autophagic Machinery To Enhance Viral Replication","volume":"88","author":"M Granato","year":"2014","journal-title":"Journal of Virology"},{"key":"ref60","first-page":"1","article-title":"EBV reduces autophagy, intracellular ROS and mitochondria to impair monocyte survival and differentiation","volume":"2018","author":"MS Gilardini Montani","journal-title":"Autophagy"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.aivir.2016.02.002","article-title":"Autophagy and Mammalian Viruses","volume":"95","author":"P Paul","year":"2016","journal-title":"Advances in Virus Research"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.semcancer.2013.05.005","article-title":"Modulation of the autophagy pathway by human tumor viruses","volume":"23","author":"LM Silva","year":"2013","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2042-4280-2-2","article-title":"Autophagy in herpesvirus immune control and immune escape","volume":"2","author":"G Taylor","year":"2011","journal-title":"Herpesviridae"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fimmu.2012.00170","article-title":"Autophagy and immunity\u2013insights from human herpesviruses","volume":"3","author":"LR Williams","year":"2012","journal-title":"Frontiers in Immunology"},{"issue":"9","key":"ref65","doi-asserted-by":"crossref","first-page":"e1876","DOI":"10.1038\/cddis.2015.156","article-title":"Inhibition of autophagy in EBV-positive Burkitt's lymphoma cells enhances EBV lytic genes expression and replication","volume":"6","author":"A De Leo","year":"2015","journal-title":"Cell death & disease"},{"issue":"6","key":"ref66","first-page":"605","article-title":"Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death &","volume":"9","author":"S Bhattacharjee","year":"2018","journal-title":"Disease"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"E782","DOI":"10.1073\/pnas.1517141113","article-title":"Metabolic stress is a barrier to Epstein\u2013Barr virus-mediated B-cell immortalization","volume":"113","author":"K McFadden","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"45","key":"ref68","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1038\/onc.2009.258","article-title":"Three Epstein-Barr virus latency proteins independently promote genomic instability by inducing DNA damage, inhibiting DNA repair and inactivating cell cycle checkpoints","volume":"28","author":"B Gruhne","year":"2009","journal-title":"Oncogene"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1073\/pnas.0408381102","article-title":"Reactive oxygen signaling and MAPK activation distinguish Epstein\u2013Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma","volume":"102","author":"F Cerimele","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"ref70","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1073\/pnas.0810619106","article-title":"The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species","volume":"106","author":"B Gruhne","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S1044579X0200086X","article-title":"Epstein-Barr virus in the pathogenesis of NPC","volume":"12","author":"N Raab-Traub","year":"2002","journal-title":"Seminars in Cancer Biology"},{"issue":"3\u20134","key":"ref72","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bbrc.2017.10.095","article-title":"EBV-encoded EBNA1 regulates cell viability by modulating miR34a-NOX2-ROS signaling in gastric cancer cells","volume":"494","author":"SM Kim","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"ref73","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ccr.2008.02.001","article-title":"The Signaling Adaptor p62 Is an Important NF-\u03baB Mediator in Tumorigenesis","volume":"13","author":"A Duran","year":"2008","journal-title":"Cancer Cell"},{"issue":"6","key":"ref74","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ccell.2016.04.006","article-title":"p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells","volume":"29","author":"A Umemura","year":"2016","journal-title":"Cancer Cell"},{"issue":"6","key":"ref75","first-page":"1072","article-title":"SQSTM1\/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination","volume":"14","author":"J Yang","year":"2018","journal-title":"Autophagy"},{"key":"ref76","article-title":"Autophagic cell death restricts chromosomal instability during replicative crisis","author":"J Nassour","year":"2019","journal-title":"Nature"},{"issue":"15","key":"ref77","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1038\/sj.onc.1206325","article-title":"p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells","volume":"22","author":"HGR Thompson","year":"2003","journal-title":"Oncogene"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.3816\/CLM.2009.s.004","article-title":"p62: A Potential Target for Blocking Microenvironmental Support of Myeloma","volume":"9","author":"GD Roodman","year":"2009","journal-title":"Clinical Lymphoma and Myeloma"},{"key":"ref79","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2013.08.003","article-title":"Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy","volume":"51","author":"Y Ichimura","year":"2013","journal-title":"Mol Cell"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","DOI":"10.1002\/cpmb.51","article-title":"CRISPR\/Cas9-Mediated Genome Editing in Epstein-Barr Virus-Transformed Lymphoblastoid B-Cell Lines","volume":"121","author":"S Jiang","year":"2018","journal-title":"Current Protocols in Molecular Biology"},{"issue":"2","key":"ref81","doi-asserted-by":"crossref","first-page":"e12694","DOI":"10.1111\/cmi.12694","article-title":"CRISPR\/Cas9, a powerful tool to target human herpesviruses","volume":"19","author":"FR van Diemen","year":"2017","journal-title":"Cellular Microbiology"},{"issue":"6","key":"ref82","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/v10060291","article-title":"Potential Application of the CRISPR\/Cas9 System against Herpesvirus Infections","volume":"10","author":"Y-C Chen","year":"2018","journal-title":"Viruses"},{"key":"ref83","doi-asserted-by":"crossref","DOI":"10.1002\/cpmb.51","article-title":"CRISPR\/Cas9-Mediated Genome Editing in Epstein-Barr Virus-Transformed Lymphoblastoid B-Cell Lines","volume":"121","author":"S Jiang","year":"2018","journal-title":"Curr Protoc Mol Biol"},{"issue":"16","key":"ref84","article-title":"Insufficiency of DNA repair enzyme ATM promotes na\u00efve CD4 T cell loss in chronic hepatitis C virus infection","volume":"4","author":"J Zhao","year":"2018","journal-title":"Cell Discovery"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41419-018-0897-y","article-title":"Inhibition of TRF2 accelerates telomere attrition and DNA damage in na\u00efve CD4 T cells during HCV infection","volume":"9","author":"LN Nguyen","year":"2018","journal-title":"Cell Death and Diseases"},{"issue":"8","key":"ref86","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.1074\/jbc.M109.039925","article-title":"Nucleocytoplasmic Shuttling of p62\/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies","volume":"285","author":"S Pankiv","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"9","key":"ref87","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/bies.20089","article-title":"PML nuclear bodies: dynamic sensors of DNA damage and cellular stress","volume":"26","author":"G Dellaire","year":"2004","journal-title":"BioEssays"},{"issue":"6","key":"ref88","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41580-018-0001-6","article-title":"The coming of age of chaperone-mediated autophagy","volume":"19","author":"S Kaushik","year":"2018","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1128\/MCB.01044-14","article-title":"RAD6 Promotes Homologous Recombination Repair by Activating the Autophagy-Mediated Degradation of Heterochromatin Protein HP1","volume":"35","author":"S Chen","year":"2015","journal-title":"Molecular and Cellular Biology"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1038\/ncomms7823","article-title":"Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage","volume":"6","author":"C Park","year":"2015","journal-title":"Nature Communications"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fgene.2016.00204","article-title":"DNA Damage Response and Autophagy: A Meaningful Partnership","volume":"7","author":"AG Eliopoulos","year":"2016","journal-title":"Frontiers in Genetics"},{"issue":"5","key":"ref92","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3390\/ijms19051405","article-title":"Autophagic Regulation of p62 is Critical for Cancer Therapy","volume":"19","author":"MA Islam","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"ref93","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1128\/JVI.1.5.1045-1051.1967","article-title":"Immunofluorescence and Herpes-Type Virus Particles in the P3HR-1 Burkitt Lymphoma Cell Line","volume":"1","author":"Y Hinuma","year":"1967","journal-title":"Journal of virology"},{"issue":"21","key":"ref94","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1073\/pnas.79.21.6651","article-title":"Human hybridomas constructed with antigen-specific Epstein-Barr virus-transformed cell lines","volume":"79","author":"D Kozbor","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"25","key":"ref95","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1073\/pnas.1322913111","article-title":"Regulation of cell proliferation and migration by p62 through stabilization of Twist1","volume":"111","author":"L Qiang","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"20","key":"ref96","first-page":"6536","article-title":"TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the Tumor Necrosis Factor Receptor family member Latent Membrane Protein 1","volume":"28","author":"S Ning","year":"2008","journal-title":"MolCellBiol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007541","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T12:24:29Z","timestamp":1607343869000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007541"}},"subtitle":[],"editor":[{"given":"Paul M.","family":"Lieberman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":96,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007541","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/502823","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]}}}