{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:57:25Z","timestamp":1791511045638,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007574","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000}}],"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007574","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T18:42:00Z","timestamp":1549910520000},"page":"e1007574","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["TDP-43 proteinopathy in Theiler\u2019s murine encephalomyelitis virus infection"],"prefix":"10.1371","volume":"15","author":[{"given":"Katsuhisa","family":"Masaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Sonobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1232-462X","authenticated-orcid":true,"given":"Ghanashyam","family":"Ghadge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-4709","authenticated-orcid":true,"given":"Peter","family":"Pytel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-4048","authenticated-orcid":true,"given":"Raymond P.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"E10941","DOI":"10.1073\/pnas.1809821115","article-title":"Cell-autonomous requirement of TDP-43, an ALS\/FTD signature protein, for oligodendrocyte survival and myelination","volume":"115","author":"J Wang","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798684","article-title":"Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis","volume":"37","author":"P Fratta","year":"2018","journal-title":"EMBO J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"13318","DOI":"10.1073\/pnas.1008227107","article-title":"ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS\/TLS","volume":"107","author":"SC Ling","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nn.2779","article-title":"Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43","volume":"14","author":"M Polymenidou","year":"2011","journal-title":"Nat Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"T Arai","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2017.07.029","article-title":"Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases","volume":"96","author":"HJ Kim","year":"2017","journal-title":"Neuron"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"M Neumann","year":"2006","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ana.21425","article-title":"Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"64","author":"M Hasegawa","year":"2008","journal-title":"Ann Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2353\/ajpath.2008.080003","article-title":"Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"173","author":"LM Igaz","year":"2008","journal-title":"Am J Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00401-008-0477-9","article-title":"Phosphorylation of S409\/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies","volume":"117","author":"M Neumann","year":"2009","journal-title":"Acta Neuropathol"},{"key":"ref11","article-title":"Pathomechanisms of TDP-43 in neurodegeneration","author":"J Gao","year":"2018","journal-title":"J Neurochem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.virol.2015.06.004","article-title":"Three cardiovirus Leader proteins equivalently inhibit four different nucleocytoplasmic trafficking pathways","volume":"484","author":"JJ Ciomperlik","year":"2015","journal-title":"Virology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2015.10.001","article-title":"Cardiovirus Leader proteins bind exportins: Implications for virus replication and nucleocytoplasmic trafficking inhibition","volume":"487","author":"JJ Ciomperlik","year":"2016","journal-title":"Virology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nrm3461","article-title":"Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions","volume":"13","author":"M Raices","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref15","first-page":"427","article-title":"P","author":"RP Roos","year":"2002"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1128\/JVI.72.12.9553-9560.1998","article-title":"Interaction of Theiler's virus with intermediate filaments of infected cells","volume":"72","author":"P Nedellec","year":"1998","journal-title":"J Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/viro.2001.1101","article-title":"Association of L* protein of Theiler's murine encephalomyelitis virus with microtubules in infected cells","volume":"289","author":"M Obuchi","year":"2001","journal-title":"Virology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1101\/gad.14.16.2028","article-title":"A cell cycle-dependent protein serves as a template-specific translation initiation factor","volume":"14","author":"EV Pilipenko","year":"2000","journal-title":"Genes Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"22906","DOI":"10.3390\/ijms141122906","article-title":"New insights into functional roles of the polypyrimidine tract-binding protein","volume":"14","author":"MG Romanelli","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1083\/jcb.143.7.1883","article-title":"Aggresomes: a cellular response to misfolded proteins","volume":"143","author":"JA Johnston","year":"1998","journal-title":"J Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"885","DOI":"10.4049\/jimmunol.97.6.885","article-title":"Host dependence of GDVII virus: complete or abortive multiplication in various cell types","volume":"97","author":"LS Sturman","year":"1966","journal-title":"J Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"R397","DOI":"10.1016\/j.cub.2009.03.013","article-title":"Stress granules","volume":"19","author":"P Anderson","year":"2009","journal-title":"Curr Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev-virology-031413-085505","article-title":"Cytoplasmic RNA Granules and Viral Infection","volume":"1","author":"WC Tsai","year":"2014","journal-title":"Annu Rev Virol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9614","DOI":"10.1128\/JVI.00480-11","article-title":"The leader protein of cardioviruses inhibits stress granule assembly","volume":"85","author":"F Borghese","year":"2011","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1086\/420978","article-title":"Nuclear factor TDP-43 binds to the polymorphic TG repeats in CFTR intron 8 and causes skipping of exon 9: a functional link with disease penetrance","volume":"74","author":"E Buratti","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"37572","DOI":"10.1074\/jbc.M505557200","article-title":"TDP-43 binds heterogeneous nuclear ribonucleoprotein A\/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing","volume":"280","author":"E Buratti","year":"2005","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41593-017-0047-3","article-title":"TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS\/FTD","volume":"21","author":"CC Chou","year":"2018","journal-title":"Nat Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fnins.2018.00326","article-title":"Linking hnRNP Function to ALS and FTD Pathology","volume":"12","author":"MD Purice","year":"2018","journal-title":"Front Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"37754","DOI":"10.7554\/eLife.37754","article-title":"Unexpected similarities between C9ORF72 and sporadic forms of ALS\/FTD suggest a common disease mechanism","volume":"7","author":"EG Conlon","year":"2018","journal-title":"Elife"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1128\/JVI.78.8.4357-4362.2004","article-title":"The Leader Protein of Theiler's Virus Interferes with Nucleocytoplasmic Trafficking of Cellular Proteins","volume":"78","author":"S Delhaye","year":"2004","journal-title":"Journal of Virology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0168-1702(03)00165-5","article-title":"Inhibition of nucleo-cytoplasmic trafficking by RNA viruses: targeting the nuclear pore complex","volume":"95","author":"KE Gustin","year":"2003","journal-title":"Virus Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/cdd.2015.58","article-title":"Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis","volume":"22","author":"G Fung","year":"2015","journal-title":"Cell Death Differ"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.3389\/fmicb.2017.01986","article-title":"Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV Neuropathology","volume":"8","author":"RN Douville","year":"2017","journal-title":"Front Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1083\/jcb.153.3.449","article-title":"Aggresomes resemble sites specialized for virus assembly","volume":"153","author":"CM Heath","year":"2001","journal-title":"J Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.15252\/embj.201695957","article-title":"An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function","volume":"36","author":"D Mateju","year":"2017","journal-title":"EMBO J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1242\/jcs.140087","article-title":"Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species","volume":"127","author":"EL Scotter","year":"2014","journal-title":"J Cell Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/brain\/awt030","article-title":"RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis\/frontotemporal dementia disease continuum","volume":"136","author":"M Thomas","year":"2013","journal-title":"Brain"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/hmg\/ddg074","article-title":"Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein","volume":"12","author":"JP Taylor","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e0140248","DOI":"10.1371\/journal.pone.0140248","article-title":"Inflammation Induces TDP-43 Mislocalization and Aggregation","volume":"10","author":"AS Correia","year":"2015","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jneuroim.2018.08.015","article-title":"Dysfunctional RNA binding proteins and stress granules in multiple sclerosis","volume":"324","author":"HE Salapa","year":"2018","journal-title":"J Neuroimmunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1093\/emboj\/20.23.6899","article-title":"Cell-specific proteins regulate viral RNA translation and virus-induced disease","volume":"20","author":"EV Pilipenko","year":"2001","journal-title":"EMBO J"},{"key":"ref42","first-page":"30846","article-title":"ALS\/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS","volume":"17","author":"J Lopez-Erauskin","year":"2018","journal-title":"Neuron"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"15875","DOI":"10.1523\/JNEUROSCI.0882-15.2015","article-title":"Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development","volume":"35","author":"J Dai","year":"2015","journal-title":"J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"15057","DOI":"10.3390\/ijms160715057","article-title":"Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis?","volume":"16","author":"P Gottle","year":"2015","journal-title":"Int J Mol Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1523\/JNEUROSCI.1423-14.2015","article-title":"Oligodendroglial maturation is dependent on intracellular protein shuttling","volume":"35","author":"P Gottle","year":"2015","journal-title":"J Neurosci"},{"key":"ref46","first-page":"169","article-title":"Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis","volume":"119","author":"J Nakahara","year":"2009","journal-title":"J Clin Invest"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1128\/JVI.00603-10","article-title":"Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway","volume":"84","author":"S Stavrou","year":"2010","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"5544","DOI":"10.1128\/JVI.69.9.5544-5549.1995","article-title":"The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells","volume":"69","author":"MA Calenoff","year":"1995","journal-title":"J Virol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm0995-927","article-title":"A picornaviral protein synthesized out of frame with the polyprotein plays a key role in a virus-induced immune-mediated demyelinating disease","volume":"1","author":"HH Chen","year":"1995","journal-title":"Nat Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1128\/JVI.53.2.651-657.1985","article-title":"Neutralizing monoclonal antibodies to Theiler's murine encephalomyelitis viruses","volume":"53","author":"S Nitayaphan","year":"1985","journal-title":"J Virol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007574","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T15:13:45Z","timestamp":1694618025000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007574"}},"subtitle":[],"editor":[{"given":"Bert L.","family":"Semler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007574","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007574","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,11]]}}}