{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:18:27Z","timestamp":1791839907902,"version":"4.3.4"},"reference-count":103,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K08 AI130366"],"award-info":[{"award-number":["K08 AI130366"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003442","name":"Stony Wold-Herbert Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003442","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["RO1 AI093808"],"award-info":[{"award-number":["RO1 AI093808"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007627","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T17:27:02Z","timestamp":1553189222000},"page":"e1007627","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-575X","authenticated-orcid":true,"given":"Lena J.","family":"Heung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-5412","authenticated-orcid":true,"given":"Tobias M.","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"ref1","author":"J Heitman","year":"2010"},{"issue":"14","key":"ref2","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1056\/NEJMoa1110404","article-title":"Combination antifungal therapy for cryptococcal meningitis","volume":"368","author":"JN Day","year":"2013","journal-title":"N Engl J Med"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"e43582","DOI":"10.1371\/journal.pone.0043582","article-title":"Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative\/non-transplant","volume":"7","author":"EW Bratton","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"e1003940","DOI":"10.1371\/journal.ppat.1003940","article-title":"Inflammatory monocytes orchestrate innate antifungal immunity in the lung","volume":"10","author":"V Espinosa","year":"2014","journal-title":"PLoS Pathog"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.chom.2009.10.007","article-title":"Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection","volume":"6","author":"TM Hohl","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.immuni.2012.02.015","article-title":"Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes","volume":"36","author":"M Wuthrich","year":"2012","journal-title":"Immunity"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/infdis\/jit413","article-title":"Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis","volume":"209","author":"LY Ngo","year":"2014","journal-title":"J Infect Dis"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.4049\/jimmunol.0901316","article-title":"The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity","volume":"183","author":"WA Szymczak","year":"2009","journal-title":"J Immunol"},{"issue":"6","key":"ref9","first-page":"1517","article-title":"Pulmonary cryptococcosis","volume":"141","author":"GB Huffnagle","year":"1992","journal-title":"Am J Pathol"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1128\/IAI.01143-07","article-title":"Inheritance of immune polarization patterns is linked to resistance versus susceptibility to <italic>Cryptococcus neoformans<\/italic> in a mouse model","volume":"76","author":"GH Chen","year":"2008","journal-title":"Infect Immun"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4049\/jimmunol.181.1.610","article-title":"CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with <italic>Cryptococcus neoformans<\/italic>","volume":"181","author":"JJ Osterholzer","year":"2008","journal-title":"J Immunol"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"8044","DOI":"10.4049\/jimmunol.0902823","article-title":"Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes","volume":"183","author":"JJ Osterholzer","year":"2009","journal-title":"J Immunol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ajpath.2010.11.006","article-title":"Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection","volume":"178","author":"JJ Osterholzer","year":"2011","journal-title":"Am J Pathol"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.4049\/jimmunol.164.4.2021","article-title":"CCR2 expression determines T1 versus T2 polarization during pulmonary <italic>Cryptococcus neoformans<\/italic> infection","volume":"164","author":"TR Traynor","year":"2000","journal-title":"J Immunol"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.4049\/jimmunol.168.9.4659","article-title":"Differential roles of CC chemokine ligand 2\/monocyte chemotactic protein-1 and CCR2 in the development of T1 immunity","volume":"168","author":"TR Traynor","year":"2002","journal-title":"J Immunol"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.4049\/jimmunol.1103455","article-title":"Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation","volume":"189","author":"SE Hardison","year":"2012","journal-title":"J Immunol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1128\/IAI.00935-15","article-title":"STAT1 signaling within macrophages is required for antifungal activity against <italic>Cryptococcus neoformans<\/italic>","volume":"83","author":"CM Leopold Wager","year":"2015","journal-title":"Infect Immun"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"e1007358","DOI":"10.1371\/journal.ppat.1007358","article-title":"IFN-gamma immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against <italic>Cryptococcus neoformans<\/italic>","volume":"14","author":"CM Leopold Wager","year":"2018","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"e01828","DOI":"10.1128\/mBio.01828-17","article-title":"The F-Box protein Fbp1 shapes the immunogenic potential of <italic>Cryptococcus neoformans<\/italic>","volume":"9","author":"J Masso-Silva","year":"2018","journal-title":"MBio"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"e1004701","DOI":"10.1371\/journal.ppat.1004701","article-title":"Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection","volume":"11","author":"DL Wiesner","year":"2015","journal-title":"PLoS Pathog"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1128\/IAI.68.7.4225-4237.2000","article-title":"<italic>Cryptococcus neoformans<\/italic> is a facultative intracellular pathogen in murine pulmonary infection","volume":"68","author":"M Feldmesser","year":"2000","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2180-9-51","article-title":"The outcome of <italic>Cryptococcus neoformans<\/italic> intracellular pathogenesis in human monocytes","volume":"9","author":"M Alvarez","year":"2009","journal-title":"BMC Microbiol"},{"issue":"21","key":"ref23","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.cub.2006.09.061","article-title":"Phagosome extrusion and host-cell survival after <italic>Cryptococcus neoformans<\/italic> phagocytosis by macrophages","volume":"16","author":"M Alvarez","year":"2006","journal-title":"Curr Biol"},{"issue":"21","key":"ref24","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.cub.2006.09.032","article-title":"Expulsion of live pathogenic yeast by macrophages","volume":"16","author":"H Ma","year":"2006","journal-title":"Curr Biol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by <italic>Cryptococcus neoformans<\/italic>","volume":"77","author":"C Charlier","year":"2009","journal-title":"Infect Immun"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1172\/JCI72950","article-title":"Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis","volume":"124","author":"W Sabiiti","year":"2014","journal-title":"J Clin Invest"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.4049\/jimmunol.175.5.3244","article-title":"An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia","volume":"175","author":"XP Shao","year":"2005","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fimmu.2017.00093","article-title":"Arginine metabolism in myeloid cells shapes innate and adaptive immunity","volume":"8","author":"PC Rodriguez","year":"2017","journal-title":"Front Immunol"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.4049\/jimmunol.166.4.2173","article-title":"Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production","volume":"166","author":"R Rutschman","year":"2001","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages","volume":"5","author":"M Rath","year":"2014","journal-title":"Front Immunol"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"e00264","DOI":"10.1128\/mBio.00264-13","article-title":"Macrophage M1\/M2 polarization dynamically adapts to changes in cytokine microenvironments in <italic>Cryptococcus neoformans<\/italic> infection","volume":"4","author":"MJ Davis","year":"2013","journal-title":"MBio"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.4049\/jimmunol.172.12.7565","article-title":"Enhancer-mediated control of macrophage-specific arginase I expression","volume":"172","author":"AL Pauleau","year":"2004","journal-title":"J Immunol"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.gene.2005.04.004","article-title":"Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C\/EBPbeta","volume":"353","author":"MJ Gray","year":"2005","journal-title":"Gene"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"L Boring","year":"1997","journal-title":"J Clin Invest"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"NV Serbina","year":"2006","journal-title":"Nat Immunol"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/eji.200636745","article-title":"Faithful activation of an extra-bright red fluorescent protein in &quot;knock-in&quot; Cre-reporter mice ideally suited for lineage tracing studies","volume":"37","author":"H Luche","year":"2007","journal-title":"Eur J Immunol"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.166.7.4697","article-title":"Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice","volume":"166","author":"M Mack","year":"2001","journal-title":"J Immunol"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1084\/jem.20170832","article-title":"Development and differentiation of early innate lymphoid progenitors","volume":"215","author":"C Harly","year":"2018","journal-title":"J Exp Med"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1097\/00006454-199512000-00015","article-title":"Hypereosinophilia in disseminated cryptococcal disease","volume":"14","author":"RK Marwaha","year":"1995","journal-title":"Pediatr Infect Dis J"},{"issue":"12","key":"ref40","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1136\/thx.2010.140350","article-title":"Eosinophilia, meningitis and pulmonary nodules in a young woman","volume":"65","author":"PE Pfeffer","year":"2010","journal-title":"Thorax"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10156-008-0618-Z","article-title":"Disseminated cryptococcal infection with eosinophilia in a healthy person","volume":"14","author":"H Yamaguchi","year":"2008","journal-title":"J Infect Chemother"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1378\/chest.61.3.296","article-title":"Pleural effusion secondary to pulmonary cryptococcosis","volume":"61","author":"R Epstein","year":"1972","journal-title":"Chest"},{"issue":"1","key":"ref43","first-page":"189","article-title":"Serologic diagnosis of focal pneumonia caused by <italic>Cryptococcus neoformans<\/italic>","volume":"132","author":"WA Jensen","year":"1985","journal-title":"Am Rev Respir Dis"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/00000658-190812000-00012","article-title":"XII. Blastomycosis of the Spine: Double Lesion: Two Operations: Recovery","volume":"48","author":"GE Brewer","year":"1908","journal-title":"Ann Surg"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.160.5.2393","article-title":"IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment during a pulmonary <italic>Cryptococcus neoformans<\/italic> infection in genetically susceptible mice (C57BL\/6)","volume":"160","author":"GB Huffnagle","year":"1998","journal-title":"J Immunol"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1128\/IAI.65.5.1899-1907.1997","article-title":"Eosinophil-<italic>Cryptococcus neoformans<\/italic> interactions <italic>in vivo<\/italic> and <italic>in vitro<\/italic>","volume":"65","author":"M Feldmesser","year":"1997","journal-title":"Infect Immun"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1128\/IAI.00809-09","article-title":"Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary <italic>Cryptococcus neoformans<\/italic> infection","volume":"77","author":"AV Jain","year":"2009","journal-title":"Infect Immun"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"8017","DOI":"10.4049\/jimmunol.174.12.8017","article-title":"Mouse genetic background is a major determinant of isotype-related differences for antibody-mediated protective efficacy against <italic>Cryptococcus neoformans<\/italic>","volume":"174","author":"J Rivera","year":"2005","journal-title":"J Immunol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1128\/IAI.00855-13","article-title":"Impact of surfactant protein D, interleukin-5, and eosinophilia on cryptococcosis","volume":"82","author":"SM Holmer","year":"2014","journal-title":"Infect Immun"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1084\/jem.20020656","article-title":"Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo","volume":"195","author":"C Yu","year":"2002","journal-title":"J Exp Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2172-3-7","article-title":"IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype","volume":"3","author":"P Loke","year":"2002","journal-title":"BMC Immunol"},{"issue":"5","key":"ref52","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1189\/jlb.1110644","article-title":"Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function","volume":"90","author":"CS Whyte","year":"2011","journal-title":"J Leukoc Biol"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1086\/599090","article-title":"Alternatively activated and immunoregulatory monocytes in human filarial infections","volume":"199","author":"S Babu","year":"2009","journal-title":"J Infect Dis"},{"issue":"7","key":"ref54","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1182\/blood-2004-04-1448","article-title":"Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate","volume":"105","author":"Y Bakri","year":"2005","journal-title":"Blood"},{"issue":"5","key":"ref55","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"S Gordon","year":"2010","journal-title":"Immunity"},{"issue":"11","key":"ref56","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nri3088","article-title":"Transcriptional regulation of macrophage polarization: enabling diversity with identity","volume":"11","author":"T Lawrence","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/IAI.01477-13","article-title":"Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production","volume":"82","author":"BJ Murdock","year":"2014","journal-title":"Infect Immun"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.immuni.2015.08.010","article-title":"The cytokine GM-CSF drives the inflammatory signature of CCR2+ monocytes and licenses autoimmunity","volume":"43","author":"AL Croxford","year":"2015","journal-title":"Immunity"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2016.03.017","article-title":"Innate lymphocyte\/Ly6C(hi) monocyte crosstalk promotes <italic>Klebsiella pneumoniae<\/italic> clearance","volume":"165","author":"H Xiong","year":"2016","journal-title":"Cell"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"NV Serbina","year":"2008","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"ref61","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/ni1008-1091","article-title":"The Immunological Genome Project: networks of gene expression in immune cells","volume":"9","author":"TS Heng","year":"2008","journal-title":"Nat Immunol"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4049\/jimmunol.1101270","article-title":"Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity","volume":"188","author":"M Ikutani","year":"2012","journal-title":"J Immunol"},{"issue":"7470","key":"ref63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"JC Nussbaum","year":"2013","journal-title":"Nature"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.4049\/jimmunol.1600821","article-title":"Different lymphocyte populations direct dichotomous eosinophil or neutrophil responses to pulmonary <italic>Cryptococcus<\/italic> infection","volume":"198","author":"DL Wiesner","year":"2017","journal-title":"J Immunol"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2567.2011.03479.x","article-title":"Eosinophils elicit proliferation of naive and fungal-specific cells <italic>in vivo<\/italic> so enhancing a T helper type 1 cytokine profile in favour of a protective immune response against <italic>Cryptococcus neoformans<\/italic> infection","volume":"134","author":"AP Garro","year":"2011","journal-title":"Immunology"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2567.2010.03351.x","article-title":"Rat eosinophils stimulate the expansion of <italic>Cryptococcus neoformans<\/italic>-specific CD4(+) and CD8(+) T cells with a T-helper 1 profile","volume":"132","author":"AP Garro","year":"2011","journal-title":"Immunology"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.4049\/jimmunol.181.4.2907","article-title":"Innate antifungal immunity of human eosinophils mediated by a beta 2 integrin, CD11b","volume":"181","author":"J Yoon","year":"2008","journal-title":"J Immunol"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1128\/IAI.01172-13","article-title":"Eosinophil deficiency compromises lung defense against <italic>Aspergillus fumigatus<\/italic>","volume":"82","author":"LM Lilly","year":"2014","journal-title":"Infect Immun"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"e1006175","DOI":"10.1371\/journal.ppat.1006175","article-title":"Central role of IL-23 and IL-17 producing eosinophils as immunomodulatory effector cells in acute pulmonary aspergillosis and allergic asthma","volume":"13","author":"ES Guerra","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-2776(08)01003-1","article-title":"Biology of the eosinophil","volume":"101","author":"C Blanchard","year":"2009","journal-title":"Adv Immunol"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"PJ Murray","year":"2014","journal-title":"Immunity"},{"issue":"6","key":"ref72","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.chom.2010.05.010","article-title":"Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi","volume":"7","author":"K Ersland","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"e01086","DOI":"10.7554\/eLife.01086","article-title":"Essential yet limited role for CCR2(+) inflammatory monocytes during <italic>Mycobacterium tuberculosis<\/italic>-specific T cell priming","volume":"2","author":"M Samstein","year":"2013","journal-title":"Elife"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"e01820","DOI":"10.1128\/mBio.01820-16","article-title":"<italic>Candida albicans<\/italic> chitin increases arginase-1 activity in human macrophages, with an impact on macrophage antimicrobial functions","volume":"8","author":"J Wagener","year":"2017","journal-title":"MBio"},{"issue":"3","key":"ref75","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1046\/j.1365-2249.1999.00822.x","article-title":"<italic>Candida albicans<\/italic> suppresses nitric oxide (NO) production by interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS)-stimulated murine peritoneal macrophages","volume":"115","author":"T Chinen","year":"1999","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"e96203","DOI":"10.1371\/journal.pone.0096203","article-title":"<italic>Candida albicans<\/italic> suppresses nitric oxide generation from macrophages via a secreted molecule","volume":"9","author":"JR Collette","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"ref77","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1438-4221(01)80003-5","article-title":"Suppression of type 2 NO-synthase activity in macrophages by <italic>Candida albicans<\/italic>","volume":"290","author":"K Schroppel","year":"2001","journal-title":"Int J Med Microbiol"},{"issue":"9","key":"ref78","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1440-1681.2007.04638.x","article-title":"Arginase: a critical regulator of nitric oxide synthesis and vascular function","volume":"34","author":"W Durante","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"4","key":"ref79","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/eji.1830250436","article-title":"Reciprocal regulation of the nitric oxide synthase\/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines","volume":"25","author":"M Modolell","year":"1995","journal-title":"Eur J Immunol"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"e61961","DOI":"10.1371\/journal.pone.0061961","article-title":"Role of arginase 1 from myeloid cells in Th2-dominated lung inflammation","volume":"8","author":"L Barron","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref81","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2353\/ajpath.2009.080598","article-title":"IL-4\/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis","volume":"174","author":"W Stenzel","year":"2009","journal-title":"Am J Pathol"},{"issue":"8","key":"ref82","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.4049\/jimmunol.179.8.5367","article-title":"IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with <italic>Cryptococcus neoformans<\/italic>","volume":"179","author":"U Muller","year":"2007","journal-title":"J Immunol"},{"issue":"8","key":"ref83","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/intimm\/dxt003","article-title":"Abrogation of IL-4 receptor-alpha-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response","volume":"25","author":"U Muller","year":"2013","journal-title":"Int Immunol"},{"issue":"6","key":"ref84","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1128\/IAI.00222-16","article-title":"DAP12 inhibits pulmonary immune responses to <italic>Cryptococcus neoformans<\/italic>","volume":"84","author":"LJ Heung","year":"2016","journal-title":"Infect Immun"},{"issue":"3","key":"ref85","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/jof3030035","article-title":"Innate immune responses to <italic>Cryptococcus<\/italic>","volume":"3","author":"LJ Heung","year":"2017","journal-title":"J Fungi (Basel)"},{"issue":"4","key":"ref86","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.chom.2018.02.011","article-title":"Lung epithelial cells coordinate innate lymphocytes and immunity against pulmonary fungal infection","volume":"23","author":"N Hernandez-Santos","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"11","key":"ref87","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1128\/IAI.00507-12","article-title":"Titan cell production enhances the virulence of <italic>Cryptococcus neoformans<\/italic>","volume":"80","author":"JN Crabtree","year":"2012","journal-title":"Infect Immun"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tcsw.2017.12.001","article-title":"Titan cell production in <italic>Cryptococcus neoformans<\/italic> reshapes the cell wall and capsule composition during infection","volume":"1","author":"L Mukaremera","year":"2018","journal-title":"Cell Surf"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/gene.10056","article-title":"A conditional null allele of the major histocompatibility IA-beta chain gene","volume":"32","author":"K Hashimoto","year":"2002","journal-title":"Genesis"},{"issue":"12","key":"ref90","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ni.1671","article-title":"Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens","volume":"9","author":"KC El Kasmi","year":"2008","journal-title":"Nat Immunol"},{"issue":"1","key":"ref91","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2014.08.026","article-title":"The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells","volume":"159","author":"JM Karo","year":"2014","journal-title":"Cell"},{"issue":"2","key":"ref92","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/immu.200310005","article-title":"Transgenic mice with hematopoietic and lymphoid specific expression of Cre","volume":"33","author":"J de Boer","year":"2003","journal-title":"Eur J Immunol"},{"issue":"5","key":"ref93","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement","volume":"68","author":"Y Shinkai","year":"1992","journal-title":"Cell"},{"issue":"3","key":"ref94","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","article-title":"Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain","volume":"2","author":"X Cao","year":"1995","journal-title":"Immunity"},{"issue":"3","key":"ref95","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.4049\/jimmunol.0900612","article-title":"Selective expansion of the monocytic lineage directed by bacterial infection","volume":"183","author":"NV Serbina","year":"2009","journal-title":"J Immunol"},{"issue":"12","key":"ref96","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1101\/gr.476202","article-title":"Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replication","volume":"12","author":"S Gong","year":"2002","journal-title":"Genome Res"},{"key":"ref97","article-title":"Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice","author":"S Gong","year":"2005","journal-title":"Curr Protoc Neurosci"},{"issue":"4","key":"ref98","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/dvg.20612","article-title":"Building a zoo of mice for genetic analyses: a comprehensive protocol for the rapid generation of BAC transgenic mice","volume":"48","author":"T Johansson","year":"2010","journal-title":"Genesis"},{"issue":"3","key":"ref99","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1074-7613(00)80439-2","article-title":"Stat6 is required for mediating responses to IL-4 and for development of Th2 cells","volume":"4","author":"MH Kaplan","year":"1996","journal-title":"Immunity"},{"issue":"18","key":"ref100","doi-asserted-by":"crossref","first-page":"e1927","DOI":"10.21769\/BioProtoc.1927","article-title":"Flow cytometry of lung and bronchoalveolar lavage fluid cells from mice challenged with Fluorescent Aspergillus Reporter (FLARE) conidia","volume":"6","author":"A Jhingran","year":"2016","journal-title":"Bio Protoc"},{"issue":"1","key":"ref101","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"R Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref102","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"12","key":"ref103","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nmeth.2722","article-title":"Systematic evaluation of spliced alignment programs for RNA-seq data","volume":"10","author":"PG Engstrom","year":"2013","journal-title":"Nat Methods"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:59:36Z","timestamp":1721091576000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007627"}},"subtitle":[],"editor":[{"given":"Robin Charles","family":"May","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,21]]},"references-count":103,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007627","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,21]]}}}