{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:07:37Z","timestamp":1793308057643,"version":"4.5.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"crossref","award":["31425010"],"award-info":[{"award-number":["31425010"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"crossref","award":["XDB29010302"],"award-info":[{"award-number":["XDB29010302"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31621061"],"award-info":[{"award-number":["31621061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2015CB554302"],"award-info":[{"award-number":["2015CB554302"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research Programs of Frontier Sciences funded by the Chinese Academy of Sciences"},{"DOI":"10.13039\/501100005952","name":"Ministry of Human Resources and Social Security","doi-asserted-by":"publisher","award":["BX201700277"],"award-info":[{"award-number":["BX201700277"]}],"id":[{"id":"10.13039\/501100005952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800732"],"award-info":[{"award-number":["31800732"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M630894"],"award-info":[{"award-number":["2018M630894"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007691","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T17:25:06Z","timestamp":1558373106000},"page":"e1007691","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":58,"title":["Human cytomegalovirus protein UL42 antagonizes cGAS\/MITA-mediated innate antiviral response"],"prefix":"10.1371","volume":"15","author":[{"given":"Yu-Zhi","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9352-0643","authenticated-orcid":true,"given":"Min-Hua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9316-2417","authenticated-orcid":true,"given":"Yan-Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"S Akira","year":"2006","journal-title":"Cell"},{"issue":"7164","key":"ref2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"R. Medzhitov","year":"2007","journal-title":"Nature"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.immuni.2013.05.004","article-title":"Immune sensing of DNA","volume":"38","author":"SR Paludan","year":"2013","journal-title":"Immunity"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nri3682","article-title":"Post-transcriptional regulation of gene expression in innate immunity","volume":"14","author":"S Carpenter","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"6121","key":"ref5","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway","volume":"339","author":"LJ Sun","year":"2013","journal-title":"Science"},{"issue":"6152","key":"ref6","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1244040","article-title":"Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects","volume":"341","author":"XD Li","year":"2013","journal-title":"Science"},{"issue":"6121","key":"ref7","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA","volume":"339","author":"JX Wu","year":"2013","journal-title":"Science"},{"issue":"4","key":"ref8","first-page":"538","article-title":"The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3","volume":"29","author":"B Zhong","year":"2008","journal-title":"Transcription Factor Activation. Immunity"},{"issue":"7219","key":"ref9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nature07432","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling (vol 455, pg 674, 2008).","volume":"456","author":"H Ishikawa","year":"2008","journal-title":"Nature"},{"issue":"7265","key":"ref10","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"H Ishikawa","year":"2009","journal-title":"Nature"},{"issue":"21","key":"ref11","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.1073\/pnas.0900850106","article-title":"ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization","volume":"106","author":"WX Sun","year":"2009","journal-title":"P Natl Acad Sci USA"},{"issue":"16","key":"ref12","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1128\/MCB.00640-08","article-title":"MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals","volume":"28","author":"L Jin","year":"2008","journal-title":"Mol Cell Biol"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ni.3510","article-title":"iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING","volume":"17","author":"WW Luo","year":"2016","journal-title":"Nat Immunol"},{"issue":"7213","key":"ref14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"H Ishikawa","year":"2008","journal-title":"Nature"},{"issue":"2","key":"ref15","first-page":"231","article-title":"Human Cytomegalovirus Tegument Protein UL82","volume":"21","author":"YZ Fu","year":"2017","journal-title":"Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Cell Host Microbe"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-cellbio-100617-062903","article-title":"Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids","volume":"34","author":"MM Hu","year":"2018","journal-title":"Annual review of cell and developmental biology"},{"issue":"6227","key":"ref17","first-page":"1217","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"SQ Liu","year":"2015","journal-title":"Science"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.immuni.2010.10.013","article-title":"The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA","volume":"33","author":"T Tsuchida","year":"2010","journal-title":"Immunity"},{"issue":"34","key":"ref19","doi-asserted-by":"crossref","first-page":"28646","DOI":"10.1074\/jbc.M112.362608","article-title":"TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA\/STING Protein for K63-linked Ubiquitination","volume":"287","author":"J Zhang","year":"2012","journal-title":"J Biol Chem"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.immuni.2014.11.011","article-title":"The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING","volume":"41","author":"Q Wang","year":"2014","journal-title":"Immunity"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.immuni.2009.01.008","article-title":"The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA","volume":"30","author":"B Zhong","year":"2009","journal-title":"Immunity"},{"issue":"6110","key":"ref22","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1126\/science.1227919","article-title":"Decoding Human Cytomegalovirus.","volume":"338","author":"N Stern-Ginossar","year":"2012","journal-title":"Science"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/CMR.00023-08","article-title":"Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention.","volume":"22","author":"MCJ Cheeran","year":"2009","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2796.2006.01618.x","article-title":"Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer?","volume":"259","author":"C. Soderberg-Naucler","year":"2006","journal-title":"Journal of internal medicine"},{"issue":"2\u20133","key":"ref25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.antiviral.2006.05.002","article-title":"Antiviral drugs for cytomegalovirus diseases","volume":"71","author":"KK Biron","year":"2006","journal-title":"Antiviral research"},{"issue":"24","key":"ref26","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.jmb.2013.08.023","article-title":"The tiers and dimensions of evasion of the type I interferon response by human cytomegalovirus","volume":"425","author":"L Amsler","year":"2013","journal-title":"Journal of molecular biology"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.virusres.2010.10.031","article-title":"Human cytomegalovirus immunity and immune evasion","volume":"157","author":"SE Jackson","year":"2011","journal-title":"Virus Res"},{"issue":"4","key":"ref28","article-title":"cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. Plos Pathog","volume":"12","author":"J Paijo","year":"2016"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-biochem-061516-044813","article-title":"Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA","volume":"86","author":"K Kato","year":"2017","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chom.2016.01.010","article-title":"The cGAS-STING Defense Pathway and Its Counteraction by Viruses","volume":"19","author":"Z Ma","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.chom.2017.07.012","article-title":"Ten Strategies of Interferon Evasion by Viruses","volume":"22","author":"A. Garcia-Sastre","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.chom.2018.05.007","article-title":"Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion.","volume":"24","author":"ZF Huang","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.chom.2013.10.007","article-title":"Human Cytomegalovirus Tegument Protein pUL83 Inhibits IFI16-Mediated DNA Sensing for Immune Evasion","volume":"14","author":"T Li","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01774-17","article-title":"Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING","volume":"92","author":"M Biolatti","year":"2018","journal-title":"Journal of virology"},{"issue":"24","key":"ref35","doi-asserted-by":"crossref","first-page":"14223","DOI":"10.1073\/pnas.2334032100","article-title":"Functional profiling of a human cytomegalovirus genome","volume":"100","author":"W Dunn","year":"2003","journal-title":"P Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1099\/jgv.0.000336","article-title":"Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42","volume":"97","author":"T Koshizuka","year":"2016","journal-title":"J Gen Virol"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1128\/JVI.79.6.3873-3877.2005","article-title":"Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production","volume":"79","author":"RT Taylor","year":"2005","journal-title":"Journal of virology"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.immuni.2016.08.014","article-title":"Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus","volume":"45","author":"MM Hu","year":"2016","journal-title":"Immunity"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2013.09.049","article-title":"Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling","volume":"155","author":"H Konno","year":"2013","journal-title":"Cell"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"e1004783","DOI":"10.1371\/journal.ppat.1004783","article-title":"PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation","volume":"11","author":"Z Li","year":"2015","journal-title":"Plos Pathog"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"e1007336","DOI":"10.1371\/journal.ppat.1007336","article-title":"SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA","volume":"14","author":"J Wei","year":"2018","journal-title":"Plos Pathog"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1128\/jvi.76.5.2316-2328.2002","article-title":"Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL\/IRL13 gene","volume":"76","author":"D Yu","year":"2002","journal-title":"Journal of virology"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2014.12.002","article-title":"Adding to the STING.","volume":"41","author":"HB Shu","year":"2014","journal-title":"Immunity"},{"issue":"7672","key":"ref44","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature23890","article-title":"cGAS senses long and HMGB\/TFAM-bound U-turn DNA by forming protein-DNA ladders","volume":"549","author":"L Andreeva","year":"2017","journal-title":"Nature"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1038\/s41467-018-05559-w","article-title":"ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response","volume":"9","author":"H Lian","year":"2018","journal-title":"Nature communications"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.chom.2014.09.006","article-title":"The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA\/STING-Dependent Innate Immune Signaling","volume":"16","author":"Q Zhou","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"F McNab","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nri2436","article-title":"Viral evasion and subversion of pattern-recognition receptor signalling","volume":"8","author":"AG Bowie","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chom.2018.07.004","article-title":"Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication","volume":"24","author":"J Zhang","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"6","key":"ref50","article-title":"Herpes Simplex Virus 1 Abrogates the cGAS\/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41","volume":"91","author":"CH Su","year":"2017","journal-title":"Journal of virology"},{"issue":"13","key":"ref51","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.15252\/embj.201593458","article-title":"HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression","volume":"35","author":"MH Christensen","year":"2016","journal-title":"Embo J"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.chom.2015.07.015","article-title":"Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein.","volume":"18","author":"JJ Wu","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"8","key":"ref53","doi-asserted-by":"crossref","first-page":"E1034","DOI":"10.1073\/pnas.1516812113","article-title":"Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS","volume":"113","author":"GG Zhang","year":"2016","journal-title":"P Natl Acad Sci USA"},{"issue":"31","key":"ref54","doi-asserted-by":"crossref","first-page":"E4306","DOI":"10.1073\/pnas.1503831112","article-title":"Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses","volume":"112","author":"Z Ma","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"ref55","article-title":"TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3\/4-mediated innate immune responses. Plos Pathog","volume":"13","author":"Q Yang","year":"2017"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/jmcb\/mjv068","article-title":"Autoubiquitination of TRIM26 links TBK1 to NEMO in RLR-mediated innate antiviral immune response","volume":"8","author":"Y Ran","year":"2016","journal-title":"J Mol Cell Biol"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/cr.2016.16","article-title":"The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response","volume":"26","author":"Y Yang","year":"2016","journal-title":"Cell Res"},{"issue":"9","key":"ref58","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1128\/JVI.00060-16","article-title":"Highly Efficient CRISPR\/Cas9-Mediated Cloning and Functional Characterization of Gastric Cancer-Derived Epstein-Barr Virus Strains","volume":"90","author":"T Kanda","year":"2016","journal-title":"Journal of virology"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"e1005701","DOI":"10.1371\/journal.ppat.1005701","article-title":"CRISPR\/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections","volume":"12","author":"FR van Diemen","year":"2016","journal-title":"Plos Pathog"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"11770","DOI":"10.1073\/pnas.1203405109","article-title":"LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection","volume":"109","author":"Y Li","year":"2012","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:01:03Z","timestamp":1588989663000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007691"}},"subtitle":[],"editor":[{"given":"Victor Robert","family":"DeFilippis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,5,20]]},"references-count":60,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007691","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,20]]}}}