{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:02:43Z","timestamp":1790182963191,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007717","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000}}],"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21DE023632"],"award-info":[{"award-number":["R21DE023632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1-DE013986"],"award-info":[{"award-number":["RO1-DE013986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007717","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T13:36:51Z","timestamp":1555940211000},"page":"e1007717","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":156,"title":["Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3619-6618","authenticated-orcid":true,"given":"Martinna","family":"Bertolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-1145","authenticated-orcid":true,"given":"Patricia I.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-7275","authenticated-orcid":true,"given":"Kendra","family":"Maas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dongari-Bagtzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00520-010-0892-z","article-title":"A systematic review of oral fungal infections in patients receiving cancer therapy","volume":"18","author":"RV Lalla","year":"2010","journal-title":"Support Care Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"v139","DOI":"10.1093\/annonc\/mdv202","article-title":"Management of oral and gastrointestinal mucosal injury: ESMO Clinical Practice Guidelines for diagnosis, treatment, and follow-up","volume":"26","author":"DE Peterson","year":"2015","journal-title":"Ann Oncol"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1093\/clinids\/22.Supplement_2.S73","article-title":"The role of the gastrointestinal tract in hematogenous candidiasis: from the laboratory to the bedside","volume":"22","author":"GT Cole","year":"1996","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/clinids\/20.6.1526","article-title":"Epidemiology of nosocomial fungal infections, with emphasis on Candida species. Clinical infectious diseases: an official publication of the","volume":"20","author":"WR Jarvis","year":"1995","journal-title":"Infectious Diseases Society of America"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3390\/pathogens5010006","article-title":"How Chemotherapy Increases the Risk of Systemic Candidiasis in Cancer Patients: Current Paradigm and Future Directions","volume":"5","author":"F Teoh","year":"2016","journal-title":"Pathogens"},{"issue":"56","key":"ref6","doi-asserted-by":"crossref","first-page":"30919","DOI":"10.18632\/oncotarget.25778","article-title":"Protection from chemotherapy- and antibiotic-mediated dysbiosis of the gut microbiota by a probiotic with digestive enzymes supplement","volume":"9","author":"TE Ichim","year":"2018","journal-title":"Oncotarget"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mib.2015.06.002","article-title":"Shaping the oral mycobiota: interactions of opportunistic fungi with oral bacteria and the host","volume":"26","author":"H Xu","year":"2015","journal-title":"Current opinion in microbiology"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/infdis\/jiw201","article-title":"Streptococcus oralis and Candida albicans Synergistically Activate mu-Calpain to Degrade E-cadherin From Oral Epithelial Junctions","volume":"214","author":"H Xu","year":"2016","journal-title":"The Journal of infectious diseases"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/cmi.12216","article-title":"Streptococcal co-infection augments Candida pathogenicity by amplifying the mucosal inflammatory response","volume":"16","author":"H Xu","year":"2014","journal-title":"Cellular microbiology"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1080\/21505594.2017.1326438","article-title":"oralis activates the Efg1 filamentation pathway in C. albicans to promote cross-kingdom interactions and mucosal biofilms","volume":"8","author":"H Xu","year":"2017","journal-title":"Virulence"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-4939-3052-4_10","article-title":"Experimental Models of C. albicans-Streptococcal Co-infection","volume":"1356","author":"T Sobue","year":"2016","journal-title":"Methods in molecular biology"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/IAI.05162-11","article-title":"Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis","volume":"80","author":"KL Mason","year":"2012","journal-title":"Infection and immunity"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/IAI.00449-12","article-title":"Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy","volume":"80","author":"KL Mason","year":"2012","journal-title":"Infection and immunity"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"8131","DOI":"10.1038\/srep08131","article-title":"Using Bayesian modelling to investigate factors governing antibiotic-induced Candida albicans colonization of the GI tract","volume":"5","author":"J Shankar","year":"2015","journal-title":"Scientific reports"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/02681219280000281","article-title":"Fatal systemic candidiasis of gastrointestinal origin: an experimental model in mice compromised by anti-cancer treatment","volume":"30","author":"H Sandovsky-Losica","year":"1992","journal-title":"J Med Vet Mycol"},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1128\/AAC.00366-11","article-title":"Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis","volume":"55","author":"K Hata","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1371\/journal.ppat.0040035","article-title":"Mucosal damage and neutropenia are required for Candida albicans dissemination","volume":"4","author":"AY Koh","year":"2008","journal-title":"PLoS Pathog"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1128\/AAC.00530-06","article-title":"Development of an orogastrointestinal mucosal model of candidiasis with dissemination to visceral organs","volume":"50","author":"KV Clemons","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.tranon.2017.05.001","article-title":"Chemotherapy Induces Oral Mucositis in Mice Without Additional Noxious Stimuli","volume":"10","author":"M Bertolini","year":"2017","journal-title":"Transl Oncol"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1365-2354.2006.00684.x","article-title":"The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review","volume":"15","author":"CM Potting","year":"2006","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"e1005882","DOI":"10.1371\/journal.ppat.1005882","article-title":"IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa","volume":"12","author":"S Altmeier","year":"2016","journal-title":"PLoS Pathog"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s150100070007","article-title":"Clinical infections and bloodstream isolates associated with fever in patients undergoing chemotherapy for acute myeloid leukemia","volume":"28","author":"TA Madani","year":"2000","journal-title":"Infection"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/IAI.00449-12","article-title":"Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy","volume":"80","author":"KL Mason","year":"2012","journal-title":"Infect Immun"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.micinf.2007.01.012","article-title":"Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactions","volume":"9","author":"D Rahman","year":"2007","journal-title":"Microbes Infect"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1128\/IAI.02604-14","article-title":"CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans","volume":"83","author":"TJ Break","year":"2015","journal-title":"Infect Immun"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/omi.12214","article-title":"Chemotherapy-induced oral mucositis and associated infections in a novel organotypic model","volume":"33","author":"T Sobue","year":"2018","journal-title":"Mol Oral Microbiol"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nprot.2012.011","article-title":"Mouse model of oropharyngeal candidiasis","volume":"7","author":"NV Solis","year":"2012","journal-title":"Nat Protoc"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4161\/viru.25199","article-title":"Recent mouse and rat methods for the study of experimental oral candidiasis","volume":"4","author":"AC Costa","year":"2013","journal-title":"Virulence"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1128\/IAI.00054-07","article-title":"Mucosal tissue invasion by Candida albicans is associated with E-cadherin degradation, mediated by transcription factor Rim101p and protease Sap5p","volume":"75","author":"CC Villar","year":"2007","journal-title":"Infect Immun"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1053\/j.gastro.2011.05.035","article-title":"Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation","volume":"141","author":"N Steck","year":"2011","journal-title":"Gastroenterology"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/IAI.00425-15","article-title":"Enterococcus faecalis Gelatinase Mediates Intestinal Permeability via Protease-Activated Receptor 2","volume":"83","author":"N Maharshak","year":"2015","journal-title":"Infect Immun"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/AEM.00756-10","article-title":"Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operon","volume":"77","author":"JR Galloway-Pe\u00f1a","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00436059","article-title":"The relative contribution of resident pulmonary alveolar macrophage and inflammatory polymorphonuclear neutrophils in host resistance to pulmonary infection by Candida albicans","volume":"108","author":"RT Sawyer","year":"1989","journal-title":"Mycopathologia"},{"issue":"3\u20134","key":"ref34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1439-0507.1991.tb00630.x","article-title":"Protective effect of human granulocyte colony stimulating factor (hG-CSF) on Candida infections in normal and immunosuppressed mice","volume":"34","author":"A. Polak-Wyss","year":"1991","journal-title":"Mycoses"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1128\/IAI.00863-08","article-title":"Neutrophils are essential for rapid clearance of Enterococcus faecium in mice","volume":"77","author":"M Leendertse","year":"2009","journal-title":"Infect Immun"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"6219","DOI":"10.1038\/s41598-018-24342-x","article-title":"Fecal microbiota transplantation reverses antibiotic and chemotherapy-induced gut dysbiosis in mice","volume":"8","author":"Q Le Bastard","year":"2018","journal-title":"Sci Rep"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/02681219080000371","article-title":"Interaction of Candida albicans with murine gastrointestinal mucosa from methotrexate and 5-fluorouracil treated animals: in vitro adhesion and prevention","volume":"28","author":"H Sandovsky-Losica","year":"1990","journal-title":"J Med Vet Mycol"},{"key":"ref38","article-title":"Pathogen colonization of the gastrointestinal microbiome at intensive care unit admission and risk for subsequent death or infection","author":"DE Freedberg","year":"2018","journal-title":"Intensive care medicine"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ccell.2006.10.005","article-title":"Vancomycin-resistant enterococcus in critical care areas","volume":"19","author":"S Bryant","year":"2007","journal-title":"Critical care nursing clinics of North America"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.iccn.2008.01.004","article-title":"Oral care and the risk of bloodstream infections in mechanically ventilated adults: A review","volume":"24","author":"DJ Jones","year":"2008","journal-title":"Intensive & critical care nursing"},{"issue":"2","key":"ref41","first-page":"177","article-title":"[Occurrence of oral subclinical infections in insulin treated diabetics]","volume":"50","author":"L Chomicz","year":"2004","journal-title":"Wiadomosci parazytologiczne"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"e0163001","DOI":"10.1371\/journal.pone.0163001","article-title":"Enterococcus Species in the Oral Cavity: Prevalence, Virulence Factors and Antimicrobial Susceptibility","volume":"11","author":"EY Komiyama","year":"2016","journal-title":"PloS one"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v4i0.10855","article-title":"Virulence factors and antibiotic susceptibility in enterococci isolated from oral mucosal and deep infections","volume":"4","author":"G Dahlen","year":"2012","journal-title":"Journal of oral microbiology"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-0714.1992.tb01016.x","article-title":"Oral carriage of yeasts, coliforms and staphylococci in patients with advanced malignant disease","volume":"21","author":"J Jobbins","year":"1992","journal-title":"Journal of oral pathology & medicine: official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bbmt.2014.01.030","article-title":"Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease","volume":"20","author":"E Holler","year":"2014","journal-title":"Biology of blood and marrow transplantation: journal of the American Society for Blood and Marrow Transplantation"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1177\/154405910508401101","article-title":"The host cytokine responses and protective immunity in oropharyngeal candidiasis","volume":"84","author":"A Dongari-Bagtzoglou","year":"2005","journal-title":"Journal of dental research"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4161\/gmic.26040","article-title":"Candida albicans and Enterococcus faecalis in the gut: synergy in commensalism?","volume":"4","author":"DA Garsin","year":"2013","journal-title":"Gut microbes"},{"issue":"11\u201312","key":"ref48","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1046\/j.1439-0507.1999.00519.x","article-title":"Bacterial flora accompanying Candida yeasts in clinical specimens","volume":"42","author":"C Hermann","year":"1999","journal-title":"Mycoses"},{"issue":"12","key":"ref49","first-page":"716","article-title":"Enterococcus faecalis and Candida albicans in the dental root canal and periapical infections","volume":"114","author":"J Kovac","year":"2013","journal-title":"Bratislavske lekarske listy"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v4i0.10855","article-title":"Virulence factors and antibiotic susceptibility in enterococci isolated from oral mucosal and deep infections","volume":"4","author":"G Dahlen","year":"2012","journal-title":"Journal of oral microbiology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/978-1-61779-539-8_41","article-title":"Orogastrointestinal model of mucosal and disseminated candidiasis","volume":"845","author":"KV Clemons","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/lam.12201","article-title":"Intestinal dysbacteriosis contributes to decreased intestinal mucosal barrier function and increased bacterial translocation","volume":"58","author":"H Wang","year":"2014","journal-title":"Lett Appl Microbiol"},{"issue":"29","key":"ref53","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"SM Jandhyala","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.2741\/4031","article-title":"Soluble E-cadherin: more than a symptom of disease","volume":"17","author":"MM Grabowska","year":"2012","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"11","key":"ref55","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1097\/01.CCM.0000145579.66001.05","article-title":"Exacerbation of intestinal permeability in rats after a two-hit injury: burn and Enterococcus faecalis infection","volume":"32","author":"VA Samonte","year":"2004","journal-title":"Crit Care Med"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"e1004911","DOI":"10.1371\/journal.ppat.1004911","article-title":"Surface-Associated Lipoproteins Link Enterococcus faecalis Virulence to Colitogenic Activity in IL-10-Deficient Mice Independent of Their Expression Levels","volume":"11","author":"S Ocvirk","year":"2015","journal-title":"PLoS Pathog"},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.immuni.2015.03.014","article-title":"Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis","volume":"42","author":"T Kobayashi","year":"2015","journal-title":"Immunity"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/carcin\/23.3.529","article-title":"Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA","volume":"23","author":"MM Huycke","year":"2002","journal-title":"Carcinogenesis"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.4049\/jimmunol.174.5.2990","article-title":"IL-10 gene-deficient mice lack TGF-beta\/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis","volume":"174","author":"PA Ruiz","year":"2005","journal-title":"J Immunol"},{"issue":"16","key":"ref60","doi-asserted-by":"crossref","first-page":"13170","DOI":"10.1074\/jbc.M111.292235","article-title":"Novel bacterial lipoprotein structures conserved in low-GC content gram-positive bacteria are recognized by Toll-like receptor 2","volume":"287","author":"K Kurokawa","year":"2012","journal-title":"J Biol Chem"},{"issue":"5","key":"ref61","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/mnfr.201000361","article-title":"Impact of a probiotic Enterococcus faecalis in a gnotobiotic mouse model of experimental colitis","volume":"55","author":"M Hoffmann","year":"2011","journal-title":"Mol Nutr Food Res"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1365-2567.2005.02200.x","article-title":"Macfarlane GT; Microbiology & Gut Biology Group; Tayside Tissue & Tumour Bank. Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria","volume":"115","author":"E Furrie","year":"2005","journal-title":"Immunology"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00328721","article-title":"Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations","volume":"198","author":"AM Gillum","year":"1984","journal-title":"Mol Gen Genet"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1399-302X.2004.00150.x","article-title":"Role of Candida albicans polymorphism in interactions with oral epithelial cells","volume":"19","author":"CC Villar","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ctrv.2016.08.002","article-title":"Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity\u2014Ready for clinical practice?","volume":"50","author":"D Meulendijks","year":"2016","journal-title":"Cancer Treat Rev"},{"issue":"3","key":"ref66","article-title":"Interkingdom cooperation between Candida albicans, Streptococcus oralis and Actinomyces oris modulates early biofilm development on denture material","volume":"74","author":"IM Cavalcanti","year":"2016","journal-title":"Pathog Dis"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1128\/JCM.00193-14","article-title":"Routine testing for anaerobic bacteria in cerebrospinal fluid cultures improves recovery of clinically significant pathogens","volume":"52","author":"ME Pittman","year":"2014","journal-title":"J Clin Microbiol"},{"issue":"24","key":"ref68","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2655","article-title":"Oral Microbiome Characterization in Murine Models","volume":"7","author":"L Abusleme","year":"2017","journal-title":"Bio Protoc"},{"issue":"Pt 1","key":"ref69","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1099\/00221287-148-1-257","article-title":"Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set","volume":"148","author":"MA Nadkarni","year":"2002","journal-title":"Microbiology"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1128\/AEM.02802-12","article-title":"Development of quantitative PCR assays targeting the 16S rRNA genes of Enterococcus spp. and their application to the identification of enterococcus species in environmental samples","volume":"79","author":"H Ryu","year":"2013","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"ref71","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"JG Caporaso","year":"2012","journal-title":"ISME J"},{"issue":"17","key":"ref72","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1128\/AEM.01043-13","article-title":"Development of a dual-index sequencing strategy and curation pipeline for analyzing amplicon sequence data on the MiSeq Illumina sequencing platform","volume":"79","author":"JJ Kozich","year":"2013","journal-title":"Appl Environ Microbiol"},{"issue":"16","key":"ref73","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"ref74","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1128\/JCM.42.8.3558-3565.2004","article-title":"Use of a genus- and species-specific multiplex PCR for identification of enterococci","volume":"42","author":"CR Jackson","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"11","key":"ref75","doi-asserted-by":"crossref","first-page":"e7967","DOI":"10.1371\/journal.pone.0007967","article-title":"Characterization of mucosal Candida albicans biofilms","volume":"4","author":"A Dongari-Bagtzoglou","year":"2009","journal-title":"PLoS One"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1128\/AEM.56.6.1919-1925.1990","article-title":"Combination of 16S ribosomal RNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations","volume":"56","author":"RI Amann","year":"1990","journal-title":"Appl Env Microbiol"},{"issue":"Pt10","key":"ref77","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1099\/jmm.0.46022-0","article-title":"Fluorescent in situ hybridization with specific DNA probes offers adequate detection of Enterococcus faecalis and Enterococcus faecium in clinical samples","volume":"54","author":"K Waar","year":"2005","journal-title":"J Med Microbiol"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/nprot.2006.323","article-title":"Development of a highly reproducible three-dimensional organotypic model of the oral mucosa","volume":"1","author":"A Dongari-Bagtzoglou","year":"2006","journal-title":"Nat Protoc"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.3389\/fmicb.2015.01521","article-title":"Global Regulation of Gene Expression by the MafR Protein of Enterococcus faecalis","volume":"6","author":"S Ruiz-Cruz","year":"2016","journal-title":"Front Microbiol"},{"issue":"8","key":"ref80","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1128\/IAI.70.8.4344-4352.2002","article-title":"Differential expression of virulence-related genes in Enterococcus faecalis in response to biological cues in serum and urine","volume":"70","author":"BD Shepard","year":"2002","journal-title":"Infect Immun"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007717","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T18:54:08Z","timestamp":1694804048000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007717"}},"subtitle":[],"editor":[{"given":"Mairi C.","family":"Noverr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":80,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007717","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735597340.793584817","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.735597340.793559661","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]}}}