{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:40:22Z","timestamp":1772257222682,"version":"3.50.1"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","award":["Pediatric Ophthalmology Career-Starter Research Grant"],"award-info":[{"award-number":["Pediatric Ophthalmology Career-Starter Research Grant"]}],"id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["the COBRE pilot grant (P20GM109094)"],"award-info":[{"award-number":["the COBRE pilot grant (P20GM109094)"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006498","name":"Clemson University","doi-asserted-by":"publisher","award":["Startup fund"],"award-info":[{"award-number":["Startup fund"]}],"id":[{"id":"10.13039\/100006498","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI111962"],"award-info":[{"award-number":["R01AI111962"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI056312"],"award-info":[{"award-number":["R01AI056312"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI096836"],"award-info":[{"award-number":["R01AI096836"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01AI120627"],"award-info":[{"award-number":["R01AI120627"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32AI060546"],"award-info":[{"award-number":["T32AI060546"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007775","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T13:47:36Z","timestamp":1559828856000},"page":"e1007775","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion"],"prefix":"10.1371","volume":"15","author":[{"given":"L. Brock","family":"Thornton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-6366","authenticated-orcid":true,"given":"Paige","family":"Teehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-090X","authenticated-orcid":true,"given":"Katherine","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Cochrane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-9671","authenticated-orcid":true,"given":"Bryce","family":"Riegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-6302","authenticated-orcid":true,"given":"Andrew J.","family":"Stasic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4154-5210","authenticated-orcid":true,"given":"Manlio","family":"Di Cristina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-6295","authenticated-orcid":true,"given":"Silvia N. J.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Roepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-1181","authenticated-orcid":true,"given":"Zhicheng","family":"Dou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1007\/s00018-008-7556-x","article-title":"Host cell manipulation by the human pathogen <italic>Toxoplasma gondii<\/italic>","volume":"65","author":"J Lalibert\u00e9","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-0-387-78267-6_2","article-title":"Microneme proteins in apicomplexans","volume":"47","author":"VB Carruthers","year":"2008","journal-title":"Subcell Biochem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1111\/j.1462-5822.2010.01509.x","article-title":"<italic>Toxoplasma gondii<\/italic> protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites","volume":"12","author":"V Lagal","year":"2010","journal-title":"Cell Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1365-2958.2010.07181.x","article-title":"Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo\/exocytic system of <italic>Toxoplasma gondii<\/italic>","volume":"76","author":"F Parussini","year":"2010","journal-title":"Mol Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.7554\/eLife.27480","article-title":"A druggable secretory protein maturase of Toxoplasma essential for invasion and egress","volume":"6","author":"SK Dogga","year":"2017","journal-title":"Elife"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1000858","DOI":"10.1371\/journal.ppat.1000858","article-title":"Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by <italic>Toxoplasma gondii<\/italic>","volume":"6","author":"JS Buguliskis","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.1199284","article-title":"Intramembrane cleavage of AMA1 triggers <italic>Toxoplasma<\/italic> to switch from an invasive to a replicative mode","volume":"331","author":"JM Santos","year":"2011","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1073\/pnas.1114661109","article-title":"Intramembrane proteolysis of <italic>Toxoplasma<\/italic> apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication","volume":"109","author":"F Parussini","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4419-8414-2_4","article-title":"Cathepsin proteases in <italic>Toxoplasma gondii<\/italic>","volume":"712","author":"Z Dou","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1365-2958.2010.07165.x","article-title":"Characterization of a novel organelle in <italic>Toxoplasma gondii<\/italic> with similar composition and function to the plant vacuole","volume":"76","author":"K Miranda","year":"2010","journal-title":"Mol Microbiol"},{"key":"ref11","first-page":"e01188","article-title":"<italic>Toxoplasma gondii<\/italic> ingests and digests host cytosolic proteins","volume":"5","author":"Z Dou","year":"2014","journal-title":"MBio"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"45341","DOI":"10.1074\/jbc.M106665200","article-title":"A conserved subtilisin-like protein TgSUB1 in microneme organelles of <italic>Toxoplasma gondii<\/italic>","volume":"276","author":"SA Miller","year":"2001","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"17096","DOI":"10.1038\/nmicrobiol.2017.96","article-title":"<italic>Toxoplasma<\/italic> depends on lysosomal consumption of autophagosomes for persistent infection","volume":"2","author":"M Di Cristina","year":"2017","journal-title":"Nat Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1074\/jbc.M112.443697","article-title":"Non-canonical maturation of two papain-family proteases in <italic>Toxoplasma gondii<\/italic>","volume":"288","author":"Z Dou","year":"2013","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/EC.00027-14","article-title":"Characterization of the chloroquine resistance transporter homologue in <italic>Toxoplasma gondii<\/italic>","volume":"13","author":"SD Warring","year":"2014","journal-title":"Euk Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/mmi.12685","article-title":"A vacuolar-H<sup>+<\/sup>-pyrophosphatase (TgVP1) is required for microneme secretion, host cell invasion, and extracellular survival of <italic>Toxoplasma gondii<\/italic>","volume":"93","author":"J Liu","year":"2014","journal-title":"Mol Microbiol"},{"key":"ref17","first-page":"515296","article-title":"The <italic>Toxoplasma<\/italic> Vacuolar H+-ATPase regulates intracellular pH","author":"AJ Stasic","year":"2019","journal-title":"and impacts the maturation of essential secretory proteins. bioRxiv"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"12411","DOI":"10.1021\/bi0610348","article-title":"Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria","volume":"45","author":"B Gligorijevic","year":"2006","journal-title":"Biochemistry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13578","DOI":"10.1038\/s41598-018-31715-9","article-title":"Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the <italic>Plasmodium falciparum<\/italic> Chloroquine Resistance Transporter","volume":"8","author":"AH Lee","year":"2018","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1021\/bi901035j","article-title":"Chloroquine transport in <italic>Plasmodium falciparum<\/italic>. 2. Analysis of PfCRT-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe","volume":"48","author":"MF Paguio","year":"2009","journal-title":"Biochemistry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1073\/pnas.1417102112","article-title":"<italic>Plasmodium falciparum<\/italic> chloroquine resistance transporter is a H<sup>+<\/sup>-coupled polyspecific nutrient and drug exporter","volume":"112","author":"N Juge","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1021\/acs.biochem.5b00412","article-title":"Functional Comparison of 45 Naturally Occurring Isoforms of the <italic>Plasmodium falciparum<\/italic> Chloroquine Resistance Transporter (PfCRT)","volume":"54","author":"PS Callaghan","year":"2015","journal-title":"Biochemistry"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"33593","DOI":"10.1074\/jbc.M302215200","article-title":"Chloroquine resistance modulated in vitro by expression levels of the <italic>Plasmodium falciparum<\/italic> chloroquine resistance transporter","volume":"278","author":"KL Waller","year":"2003","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1128\/EC.00358-08","article-title":"Tagging of endogenous genes in a <italic>Toxoplasma gondii<\/italic> strain lacking Ku80","volume":"8","author":"M-H Huynh","year":"2009","journal-title":"Euk Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"26839","DOI":"10.1074\/jbc.M109.003780","article-title":"<italic>Toxoplasma gondii<\/italic> cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl","volume":"284","author":"ET Larson","year":"2009","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/tra.12556","article-title":"Intersection of endocytic and exocytic systems in <italic>Toxoplasma gondii<\/italic>","volume":"19","author":"OL McGovern","year":"2018","journal-title":"Traffic"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.yexcr.2011.03.020","article-title":"A <italic>Toxoplasma gondii<\/italic> protein with homology to intracellular type Na\u207a\/H\u207a exchangers is important for osmoregulation and invasion","volume":"317","author":"ME Francia","year":"2011","journal-title":"Exp Cell Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev-micro-091014-104100","article-title":"Lytic Cycle of <italic>Toxoplasma gondii<\/italic>: 15 Years Later","volume":"69","author":"IJ Blader","year":"2015","journal-title":"Annu Rev Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pt.2007.10.008","article-title":"MARveling at parasite invasion","volume":"24","author":"KM Hager","year":"2008","journal-title":"Trends Parasitol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1462-5822.2007.00909.x","article-title":"Rhoptries are major players in <italic>Toxoplasma gondii<\/italic> invasion and host cell interaction","volume":"9","author":"J-F Dubremetz","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e00557","DOI":"10.1128\/mBio.00557-15","article-title":"<italic>Toxoplasma<\/italic> Actin Is Required for Efficient Host Cell Invasion.","volume":"6","author":"LL Drewry","year":"2015","journal-title":"MBio"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e01795","DOI":"10.1128\/mBio.01795-14","article-title":"Functional analysis of rhomboid proteases during <italic>Toxoplasma<\/italic> invasion","volume":"5","author":"B Shen","year":"2014","journal-title":"MBio"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.chom.2012.03.006","article-title":"<italic>Toxoplasma<\/italic> Sortilin-like Receptor Regulates Protein Transport and Is Essential for Apical Secretory Organelle Biogenesis and Host Infection.","volume":"11","author":"P-J Sloves","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"36029","DOI":"10.1074\/jbc.M112.389825","article-title":"Microneme protein 5 regulates the activity of <italic>Toxoplasma<\/italic> subtilisin 1 by mimicking a subtilisin prodomain","volume":"287","author":"S Saouros","year":"2012","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1111\/j.1600-0854.2008.00774.x","article-title":"The Prodomain of <italic>Toxoplasma gondii<\/italic> GPI-Anchored Subtilase TgSUB1 Mediates its Targeting to Micronemes","volume":"9","author":"EM Binder","year":"2008","journal-title":"Traffic"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"49767","DOI":"10.1074\/jbc.M204005200","article-title":"Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast","volume":"277","author":"H Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1021\/bi200922g","article-title":"Analysis of chloroquine resistance transporter (CRT) isoforms and orthologues in <italic>S<\/italic>. <italic>cerevisiae<\/italic> yeast","volume":"50","author":"NK Baro","year":"2011","journal-title":"Biochemistry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12936-016-1238-1","article-title":"<italic>Plasmodium falciparum<\/italic> chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology.","volume":"15","author":"PS Callaghan","year":"2016","journal-title":"Malar J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1021\/bi400557x","article-title":"Function of resistance conferring <italic>Plasmodium falciparum<\/italic> chloroquine resistance transporter isoforms","volume":"52","author":"NK Baro","year":"2013","journal-title":"Biochemistry"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1074045","article-title":"Chloroquine resistance in <italic>Plasmodium falciparum<\/italic> malaria parasites conferred by pfcrt mutations","volume":"298","author":"ABS Sidhu","year":"2002","journal-title":"Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1126\/science.1175667","article-title":"Chloroquine transport via the malaria parasite&apos;s chloroquine resistance transporter","volume":"325","author":"RE Martin","year":"2009","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.1204592","article-title":"TFEB links autophagy to lysosomal biogenesis","volume":"332","author":"C Settembre","year":"2011","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nri.2016.129","article-title":"RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins","volume":"17","author":"M Fu","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.281.5379.1001","article-title":"Feedback Inhibition of Macrophage Tumor Necrosis Factor-\u03b1 Production by Tristetraprolin","volume":"281","author":"E Carballo","year":"1998","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1004085","DOI":"10.1371\/journal.pgen.1004085","article-title":"Metabolic QTL analysis links chloroquine resistance in <italic>Plasmodium falciparum<\/italic> to impaired hemoglobin catabolism","volume":"10","author":"IA Lewis","year":"2014","journal-title":"PLoS Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1073\/pnas.0307720101","article-title":"Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by <italic>Plasmodium falciparum<\/italic>","volume":"101","author":"PS Sijwali","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/MCB.21.1.51-60.2001","article-title":"Ptc1, a type 2C Ser\/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1","volume":"21","author":"J Warmka","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/sj.emboj.7600036","article-title":"Nbp2 targets the Ptc1-type 2C Ser\/Thr phosphatase to the HOG MAPK pathway","volume":"23","author":"J Mapes","year":"2004","journal-title":"EMBO J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"35057","DOI":"10.1074\/jbc.M607919200","article-title":"Transcriptional profiling of the protein phosphatase 2C family in yeast provides insights into the unique functional roles of Ptc1","volume":"281","author":"A Gonz\u00e1lez","year":"2006","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e01114","DOI":"10.1128\/mBio.01114-14","article-title":"Efficient Gene Disruption in Diverse Strains of <italic>Toxoplasma gondii<\/italic> Using CRISPR\/CAS9","volume":"5","author":"B Shen","year":"2014","journal-title":"MBio"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e100450","DOI":"10.1371\/journal.pone.0100450","article-title":"Efficient Genome Engineering of <italic>Toxoplasma gondii<\/italic> Using CRISPR\/Cas9","volume":"9","author":"SM Sidik","year":"2014","journal-title":"PLoS ONE"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Meth"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4236\/abb.2011.23021","article-title":"pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent protein","volume":"2","author":"MJ Mahon","year":"2011","journal-title":"Adv Biosci Biotechnol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vascn.2015.02.001","article-title":"An optimized lactate dehydrogenase release assay for screening of drug candidates in neuroscience","volume":"73","author":"S Kaja","year":"2015","journal-title":"J Pharmacol Toxicol Methods"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"19637","DOI":"10.1074\/jbc.M114.565390","article-title":"Calcium entry in <italic>Toxoplasma gondii<\/italic> and its enhancing effect of invasion-linked traits","volume":"289","author":"DA Pace","year":"2014","journal-title":"J Biol Chem"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:56:37Z","timestamp":1588967797000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007775"}},"subtitle":[],"editor":[{"given":"Dominique","family":"Soldati-Favre","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,6]]},"references-count":55,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007775","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/409904","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,6]]}}}