{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:21:21Z","timestamp":1790389281895,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007847","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000}}],"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI101221"],"award-info":[{"award-number":["AI101221"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI128372"],"award-info":[{"award-number":["AI128372"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI140002"],"award-info":[{"award-number":["AI140002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Saint George's University, School of Veterinary Medicine","award":["Postdoctoral Scholars Program Training Grant"],"award-info":[{"award-number":["Postdoctoral Scholars Program Training Grant"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007847","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T17:44:18Z","timestamp":1563212658000},"page":"e1007847","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Inflammatory monocytes provide a niche for Salmonella expansion in the lumen of the inflamed intestine"],"prefix":"10.1371","volume":"15","author":[{"given":"Patrick A.","family":"McLaughlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Bettke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Leeds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Bliska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-2997","authenticated-orcid":true,"given":"Brian P.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3006-0306","authenticated-orcid":true,"given":"Adrianus W. M.","family":"van der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1086\/649541","article-title":"Global trends in typhoid and paratyphoid Fever. Clinical infectious diseases: an official publication of the","volume":"50","author":"JA Crump","year":"2010","journal-title":"Infectious Diseases Society of America"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/QCO.0b013e32834a9980","article-title":"Invasive nontyphoidal Salmonella disease: epidemiology, pathogenesis and diagnosis","volume":"24","author":"MA Gordon","year":"2011","journal-title":"Current opinion in infectious diseases"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrmicro3428","article-title":"Now you see me, now you don't: the interaction of Salmonella with innate immune receptors","volume":"13","author":"AM Keestra-Gounder","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1086\/650733","article-title":"The global burden of nontyphoidal Salmonella gastroenteritis. Clinical infectious diseases: an official publication of the","volume":"50","author":"SE Majowicz","year":"2010","journal-title":"Infectious Diseases Society of America"},{"key":"ref5","first-page":"2887","article-title":"Mandell, Douglas and Bennett's Principles and Practice of Infectious Diseases","author":"DA Pegues","year":"2010"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","article-title":"Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host","volume":"71","author":"M Barthel","year":"2003","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fimmu.2014.00252","article-title":"Pathobiology of salmonella, intestinal microbiota, and the host innate immune response","volume":"5","author":"RL Santos","year":"2014","journal-title":"Front Immunol"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1128\/IAI.01369-10","article-title":"How to become a top model: impact of animal experimentation on human Salmonella disease research","volume":"79","author":"RM Tsolis","year":"2011","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-micro-091014-104108","article-title":"The Pyromaniac Inside You: Salmonella Metabolism in the Host Gut","volume":"69","author":"F Rivera-Chavez","year":"2015","journal-title":"Annu Rev Microbiol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.chom.2017.03.009","article-title":"Salmonella Typhimurium Diarrhea Reveals Basic Principles of Enteropathogen Infection and Disease-Promoted DNA Exchange","volume":"21","author":"SY Wotzka","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.immuni.2014.01.003","article-title":"The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria","volume":"40","author":"J Behnsen","year":"2014","journal-title":"Immunity"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.chom.2007.08.002","article-title":"Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae","volume":"2","author":"C Lupp","year":"2007","journal-title":"Cell Host Microbe"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1371\/journal.pbio.0050244","article-title":"Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota","volume":"5","author":"B Stecher","year":"2007","journal-title":"PLoS Biol"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1128\/IAI.00351-15","article-title":"The Periplasmic Nitrate Reductase NapABC Supports Luminal Growth of Salmonella enterica Serovar Typhimurium during Colitis","volume":"83","author":"CA Lopez","year":"2015","journal-title":"Infect Immun"},{"issue":"7314","key":"ref15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature09415","article-title":"Gut inflammation provides a respiratory electron acceptor for Salmonella","volume":"467","author":"SE Winter","year":"2010","journal-title":"Nature"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/embor.2013.27","article-title":"The dynamics of gut-associated microbial communities during inflammation","volume":"14","author":"SE Winter","year":"2013","journal-title":"EMBO Rep"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"e00226","DOI":"10.1128\/mBio.00226-12","article-title":"Salmonella "sops" up a preferred electron receptor in the inflamed intestine","volume":"3","author":"JB Bliska","year":"2012","journal-title":"MBio"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00143-12","article-title":"Phage-mediated acquisition of a type III secreted effector protein boosts growth of salmonella by nitrate respiration","volume":"3","author":"CA Lopez","year":"2012","journal-title":"MBio"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00430-13","article-title":"Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration","volume":"4","author":"AM Spees","year":"2013","journal-title":"MBio"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1128\/IAI.01590-13","article-title":"CD11b+ Ly6Chi Ly6G- immature myeloid cells recruited in response to Salmonella enterica serovar Typhimurium infection exhibit protective and immunosuppressive properties","volume":"82","author":"JW Tam","year":"2014","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-micro-092412-155725","article-title":"Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells","volume":"68","author":"JE Galan","year":"2014","journal-title":"Annu Rev Microbiol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mib.2012.11.006","article-title":"Salmonella T3SSs: successful mission of the secret(ion) agents","volume":"16","author":"TP Moest","year":"2013","journal-title":"Curr Opin Microbiol"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.chom.2009.03.011","article-title":"Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine","volume":"5","author":"M Raffatellu","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4161\/gmic.1.1.10950","article-title":"Salmonella SPI-1-mediated neutrophil recruitment during enteric colitis is associated with reduction and alteration in intestinal microbiota","volume":"1","author":"I Sekirov","year":"2010","journal-title":"Gut Microbes"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"NV Serbina","year":"2006","journal-title":"Nat Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/B978-0-12-394590-7.00003-8","article-title":"Monocyte-mediated immune defense against murine Listeria monocytogenes infection","volume":"113","author":"NV Serbina","year":"2012","journal-title":"Adv Immunol"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/nprot.2006.341","article-title":"Fluorometric measurement of nitrite\/nitrate by 2,3-diaminonaphthalene","volume":"1","author":"AK Nussler","year":"2006","journal-title":"Nat Protoc"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/mi.2017.9","article-title":"Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer","volume":"10","author":"C Wang","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"22","key":"ref29","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1074\/jbc.M611040200","article-title":"The interleukin-22\/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells","volume":"282","author":"E Ziesche","year":"2007","journal-title":"J Biol Chem"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/gut.44.5.659","article-title":"Acquired interferon gamma responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression","volume":"44","author":"AM Chavez","year":"1999","journal-title":"Gut"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1172\/JCI119522","article-title":"Epithelial cells as sensors for microbial infection","volume":"100","author":"MF Kagnoff","year":"1997","journal-title":"J Clin Invest"},{"issue":"6351","key":"ref32","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.aam9949","article-title":"Microbiota-activated PPAR-gamma signaling inhibits dysbiotic Enterobacteriaceae expansion","volume":"357","author":"MX Byndloss","year":"2017","journal-title":"Science"},{"key":"ref33","article-title":"Guide for the care and use of laboratory animals","year":"2011"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1128\/jb.177.5.1357-1366.1995","article-title":"Ethanolamine utilization in Salmonella typhimurium: nucleotide sequence, protein expression, and mutational analysis of the cchA cchB eutE eutJ eutG eutH gene cluster","volume":"177","author":"I Stojiljkovic","year":"1995","journal-title":"J Bacteriol"},{"issue":"5812","key":"ref35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/291238a0","article-title":"Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines","volume":"291","author":"SK Hoiseth","year":"1981","journal-title":"Nature"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1365-2958.1999.01244.x","article-title":"Salmonella SirA is a global regulator of genes mediating enteropathogenesis","volume":"31","author":"BM Ahmer","year":"1999","journal-title":"Mol Microbiol"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1128\/IAI.68.10.5702-5709.2000","article-title":"Salmonella pathogenicity island 1-independent induction of apoptosis in infected macrophages by Salmonella enterica serotype typhimurium","volume":"68","author":"AW van der Velden","year":"2000","journal-title":"Infect Immun"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"KA Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"e1000477","DOI":"10.1371\/journal.ppat.1000477","article-title":"Analysis of pools of targeted Salmonella deletion mutants identifies novel genes affecting fitness during competitive infection in mice","volume":"5","author":"CA Santiviago","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.micro.53.1.129","article-title":"In vivo genetic analysis of bacterial virulence","volume":"53","author":"SL Chiang","year":"1999","journal-title":"Annu Rev Microbiol"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nprot.2006.4","article-title":"Tricine-SDS-PAGE","volume":"1","author":"H. Schagger","year":"2006","journal-title":"Nat Protoc"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007847","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:35:58Z","timestamp":1589002558000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007847"}},"subtitle":[],"editor":[{"given":"Andreas J.","family":"Baumler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007847","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1007847","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,15]]}}}