{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:28:31Z","timestamp":1790411311289,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007881","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000}}],"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01-AI097576"],"award-info":[{"award-number":["R01-AI097576"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21-AI096277"],"award-info":[{"award-number":["R21-AI096277"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01-AI133749"],"award-info":[{"award-number":["R01-AI133749"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01-AI115691"],"award-info":[{"award-number":["R01-AI115691"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P50-AI098507"],"award-info":[{"award-number":["P50-AI098507"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["HQNTD1206356"],"award-info":[{"award-number":["HQNTD1206356"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000928","name":"Robert A. Welch Foundation","doi-asserted-by":"crossref","award":["AQ-1399"],"award-info":[{"award-number":["AQ-1399"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"crossref"}]},{"name":"FP6 STREP from the European Commission","award":["032203"],"award-info":[{"award-number":["032203"]}]},{"name":"Georgia Research Foundation Inc.","award":["50816"],"award-info":[{"award-number":["50816"]}]},{"DOI":"10.13039\/501100004351","name":"Sultan Qaboos University","doi-asserted-by":"crossref","award":["IG\/MED\/MICR\/00\/01"],"award-info":[{"award-number":["IG\/MED\/MICR\/00\/01"]}],"id":[{"id":"10.13039\/501100004351","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French Ministry of Foreign Affairs","award":["402419B"],"award-info":[{"award-number":["402419B"]}]},{"name":"French Ministry of Foreign Affairs","award":["402415K"],"award-info":[{"award-number":["402415K"]}]},{"name":"French Ministry of Foreign Affairs","award":["339660F"],"award-info":[{"award-number":["339660F"]}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","award":["01N92\/0745\/1"],"award-info":[{"award-number":["01N92\/0745\/1"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","award":["02N60\/1340"],"award-info":[{"award-number":["02N60\/1340"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"crossref","award":["01N92\/0745"],"award-info":[{"award-number":["01N92\/0745"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Projet International de Coop\u00e9ration Scientifique","award":["06249"],"award-info":[{"award-number":["06249"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007881","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T14:54:47Z","timestamp":1572015287000},"page":"e1007881","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-8106","authenticated-orcid":true,"given":"Fr\u00e9d\u00e9ric D.","family":"Chevalier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winka","family":"Le Clec\u2019h","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"McDew-White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan A.","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-6033","authenticated-orcid":true,"given":"Alexander B.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safari","family":"Kinung'hi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7857-4309","authenticated-orcid":true,"given":"Anouk N.","family":"Gouvras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-9314","authenticated-orcid":true,"given":"Bonnie L.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8616-4919","authenticated-orcid":true,"given":"Joanne P.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9028-8586","authenticated-orcid":true,"given":"Aidan M.","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rollinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amadou","family":"Garba Djirmay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid M.","family":"Al Mashikhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"Al Yafae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Idris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-344X","authenticated-orcid":true,"given":"H\u00e9l\u00e8ne","family":"Mon\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-5081","authenticated-orcid":true,"given":"Gabriel","family":"Mouahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. John","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip T.","family":"LoVerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-0204","authenticated-orcid":true,"given":"Timothy J. C.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"ppat.1007881.ref001","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tree.2007.09.008","article-title":"Adaptation from standing genetic variation","volume":"23","author":"RDH Barrett","year":"2008","journal-title":"Trends in ecology & evolution"},{"key":"ppat.1007881.ref002","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1534\/genetics.104.036947","article-title":"Soft sweeps: molecular population genetics of adaptation from standing genetic variation","volume":"169","author":"J Hermisson","year":"2005","journal-title":"Genetics"},{"key":"ppat.1007881.ref003","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tree.2013.08.003","article-title":"Population genomics of rapid adaptation by soft selective sweeps","volume":"28","author":"PW Messer","year":"2013","journal-title":"Trends Ecol Evol"},{"key":"ppat.1007881.ref004","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/genetics\/157.2.875","article-title":"Haldane\u2019s sieve and adaptation from the standing genetic variation","volume":"157","author":"HA Orr","year":"2001","journal-title":"Genetics"},{"key":"ppat.1007881.ref005","article-title":"The evolutionary origins of pesticide resistance","author":"NJ Hawkins","year":"2018","journal-title":"Biological reviews of the Cambridge Philosophical Society"},{"key":"ppat.1007881.ref006","doi-asserted-by":"crossref","first-page":"e0005816","DOI":"10.1371\/journal.pntd.0005816","article-title":"Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity","volume":"11","author":"SR Doyle","year":"2017","journal-title":"PLoS neglected tropical diseases"},{"key":"ppat.1007881.ref007","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.4269\/ajtmh.12-0484","article-title":"Molecular and biological diagnostic tests for monitoring benzimidazole resistance in human soil-transmitted helminths","volume":"88","author":"A Diawara","year":"2013","journal-title":"The American journal of tropical medicine and hygiene"},{"key":"ppat.1007881.ref008","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-3305-7-37","article-title":"Global numbers of infection and disease burden of soil transmitted helminth infections in 2010","volume":"7","author":"RL Pullan","year":"2014","journal-title":"Parasites & vectors"},{"key":"ppat.1007881.ref009","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s004360050320","article-title":"Enzymatic basis for the lack of oxamniquine activity in Schistosoma haematobium infections","volume":"83","author":"L Pica-Mattoccia","year":"1997","journal-title":"Parasitol Res"},{"key":"ppat.1007881.ref010","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1126\/science.1243106","article-title":"Genetic and molecular basis of drug resistance and species-specific drug action in Schistosome parasites","volume":"342","author":"CLL Valentim","year":"2013","journal-title":"Science"},{"key":"ppat.1007881.ref011","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.172.3987.1057","article-title":"Hycanthone resistance: development in Schistosoma mansoni","volume":"172","author":"SH Rogers","year":"1971","journal-title":"Science"},{"issue":"Suppl 4","key":"ppat.1007881.ref012","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0074-02761992000800032","article-title":"Genetic complementation analysis of two independently isolated hycanthone-resistant strains of Schistosoma mansoni","volume":"87","author":"L Pica-Mattoccia","year":"1992","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ppat.1007881.ref013","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ijpara.2016.03.006","article-title":"Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population","volume":"46","author":"FD Chevalier","year":"2016","journal-title":"Int J Parasitol"},{"key":"ppat.1007881.ref014","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1590\/S0074-02762004000900003","article-title":"Epidemiological and control aspects of schistosomiasis in Brazilian endemic areas","volume":"99","author":"JR Coura","year":"2004","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ppat.1007881.ref015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0035-9203(87)90282-3","article-title":"A review of clinical experience with oxamniquine","volume":"81","author":"R. Foster","year":"1987","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"ppat.1007881.ref016","first-page":"467","author":"PJ Hotez","year":"2006"},{"key":"ppat.1007881.ref017","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1756-3305-5-185","article-title":"Schistosomiasis collection at NHM (SCAN)","volume":"5","author":"AM Emery","year":"2012","journal-title":"Parasit Vectors"},{"key":"ppat.1007881.ref018","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0014-4894(92)90255-9","article-title":"Schistosoma mansoni: hycanthone\/oxamniquine resistance is controlled by a single autosomal recessive gene","volume":"75","author":"D Cioli","year":"1992","journal-title":"Exp Parasitol"},{"key":"ppat.1007881.ref019","author":"D Eltis","year":"2010"},{"key":"ppat.1007881.ref020","first-page":"25","article-title":"Preliminary clinical trials with oxamniquine, a new antischistosomal agent","volume":"15","author":"N Katz","year":"1973","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ppat.1007881.ref021","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1590\/S0037-86821973000600008","article-title":"Estudo de uma cepa humana de Schistosoma mansoni resistente a agentes esquistossomicidas","volume":"7","author":"N Katz","year":"1973","journal-title":"Rev Soc Bras Med Trop"},{"key":"ppat.1007881.ref022","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1590\/S0034-89101978000100013","article-title":"Linhagem humana de Schistosoma mansoni resistente a esquistossomicidas","volume":"12","author":"L. C. de S Dias","year":"1978","journal-title":"Revista de Sa\u00fade P\u00fablica"},{"key":"ppat.1007881.ref023","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0035-9203(87)90032-0","article-title":"Tolerance of Kenyan Schistosoma mansoni to oxamniquine","volume":"81","author":"GC Coles","year":"1987","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"ppat.1007881.ref024","first-page":"641","article-title":"Schistosoma mansoni treatment with oral oxamniquine in Zambia","volume":"61","author":"KK Gupta","year":"1984","journal-title":"East African medical journal"},{"key":"ppat.1007881.ref025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/bmj.2.6131.163","article-title":"Oxamniquine for treating Schistosoma mansoni infection in Sudan","volume":"2","author":"AH Omer","year":"1978","journal-title":"British medical journal"},{"key":"ppat.1007881.ref026","first-page":"505","article-title":"Oxamniquine (UK 4271): a potential antischistosomal drug in the treatment of Schistosoma mansoni infections in Uganda","volume":"53","author":"VL Ongom","year":"1976","journal-title":"The East African medical journal"},{"key":"ppat.1007881.ref027","first-page":"677","article-title":"Oxamniquine in the treatment of various schistosome infections in South Africa","volume":"53","author":"RJ Pitchford","year":"1978","journal-title":"S Afr Med J"},{"key":"ppat.1007881.ref028","author":"World Health Organization","year":"1995"},{"key":"ppat.1007881.ref029","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jac\/19.1.87","article-title":"Oxamniquine pharmacokinetics in hepatosplenic schistosomiasis in the Sudan","volume":"19","author":"TK Daneshmend","year":"1987","journal-title":"The Journal of antimicrobial chemotherapy"},{"key":"ppat.1007881.ref030","first-page":"359","article-title":"Oxamniquine pharmacokinetics in healthy Kenyan African volunteers","volume":"68","author":"GO Kokwaro","year":"1991","journal-title":"East African medical journal"},{"key":"ppat.1007881.ref031","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1021\/acsmedchemlett.8b00257","article-title":"Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents","volume":"9","author":"A Rugel","year":"2018","journal-title":"ACS medicinal chemistry letters"},{"key":"ppat.1007881.ref032","doi-asserted-by":"crossref","first-page":"e1007226","DOI":"10.1371\/journal.ppat.1007226","article-title":"Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles","volume":"14","author":"SR Hahnel","year":"2018","journal-title":"PLoS pathogens"},{"key":"ppat.1007881.ref033","doi-asserted-by":"crossref","first-page":"e75117","DOI":"10.1371\/journal.pone.0075117","article-title":"DNA analysis of herbarium Specimens of the grass weed Alopecurus myosuroides reveals herbicide resistance pre-dated herbicides","volume":"8","author":"C D\u00e9lye","year":"2013","journal-title":"PloS one"},{"key":"ppat.1007881.ref034","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10388","article-title":"Antibiotic resistance is ancient","volume":"477","author":"VM D\u2019Costa","year":"2011","journal-title":"Nature"},{"key":"ppat.1007881.ref035","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025197","article-title":"The Prehistory of Antibiotic Resistance","volume":"6","author":"J Perry","year":"2016","journal-title":"Cold Spring Harbor perspectives in medicine"},{"key":"ppat.1007881.ref036","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0020-7519(02)00032-2","article-title":"Diversity of benzimidazole-resistance alleles in populations of small ruminant parasites","volume":"32","author":"A Silvestre","year":"2002","journal-title":"Int J Parasitol"},{"key":"ppat.1007881.ref037","doi-asserted-by":"crossref","first-page":"e0003494","DOI":"10.1371\/journal.pntd.0003494","article-title":"The emergence of resistance to the benzimidazole anthlemintics in parasitic nematodes of livestock is characterised by multiple independent hard and soft selective sweeps","volume":"9","author":"E Redman","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ppat.1007881.ref038","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/CMR.13.2.207","article-title":"Drug resistance in human helminths: current situation and lessons from livestock","volume":"13","author":"S Geerts","year":"2000","journal-title":"Clinical microbiology reviews"},{"key":"ppat.1007881.ref039","doi-asserted-by":"crossref","first-page":"20954","DOI":"10.1038\/srep20954","article-title":"Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection","volume":"6","author":"T Crellen","year":"2016","journal-title":"Scientific Reports"},{"key":"ppat.1007881.ref040","author":"Organization WH","year":"2018"},{"key":"ppat.1007881.ref041","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/molbev\/msg162","article-title":"A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites","volume":"20","author":"S Nair","year":"2003","journal-title":"Molecular biology and evolution"},{"key":"ppat.1007881.ref042","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/molbev\/msw228","article-title":"Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites","volume":"34","author":"TJC Anderson","year":"2017","journal-title":"Molecular biology and evolution"},{"key":"ppat.1007881.ref043","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/abbi.2001.2368","article-title":"Structure and function of sulfotransferases","volume":"390","author":"M Negishi","year":"2001","journal-title":"Archives of biochemistry and biophysics"},{"key":"ppat.1007881.ref044","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.chembiol.2015.06.025","article-title":"Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression","volume":"22","author":"DM Rothman","year":"2015","journal-title":"Chemistry & Biology"},{"issue":"Suppl 1","key":"ppat.1007881.ref045","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1590\/S0074-02762006000900048","article-title":"The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase","volume":"101","author":"L Pica-Mattoccia","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ppat.1007881.ref046","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12936-018-2185-9","article-title":"Tools for surveillance of anti-malarial drug resistance: an assessment of the current landscape","volume":"17","author":"C Nsanzabana","year":"2018","journal-title":"Malaria journal"},{"key":"ppat.1007881.ref047","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2017.22.49.17-00269","article-title":"Assessment of HIV molecular surveillance capacity in the European Union, 2016","volume":"22","author":"P Keating","year":"2017","journal-title":"Eurosurveillance"},{"key":"ppat.1007881.ref048","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4155\/fmc.15.16","article-title":"Praziquantel: do we need another antischistosoma treatment?","volume":"7","author":"A. Fenwick","year":"2015","journal-title":"Future medicinal chemistry"},{"key":"ppat.1007881.ref049","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","article-title":"Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific","volume":"51","author":"PG Fallon","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"ppat.1007881.ref050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/S0074-02762011000200006","article-title":"Schistosoma mansoni: a method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails","volume":"106","author":"FFB Couto","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ppat.1007881.ref051","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3109\/13880209.2014.970289","article-title":"Evaluation of a method for induction of praziquantel resistance in Schistosoma mansoni","volume":"53","author":"WM Lotfy","year":"2015","journal-title":"Pharmaceutical biology"},{"key":"ppat.1007881.ref052","doi-asserted-by":"crossref","first-page":"e0140147","DOI":"10.1371\/journal.pone.0140147","article-title":"The Role of Efflux Pumps in Schistosoma mansoni Praziquantel Resistant Phenotype","volume":"10","author":"A Pinto-Almeida","year":"2015","journal-title":"PloS one"},{"key":"ppat.1007881.ref053","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s40249-017-0324-0","article-title":"Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment: evidence from a laboratory life-history trade-offs selection study","volume":"6","author":"PHL Lamberton","year":"2017","journal-title":"Infectious diseases of poverty"},{"key":"ppat.1007881.ref054","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.molbiopara.2018.12.005","article-title":"Transcriptomic analysis of reduced sensitivity to praziquantel in Schistosoma mansoni","volume":"228","author":"MC Sanchez","year":"2019","journal-title":"Molecular and biochemical parasitology"},{"key":"ppat.1007881.ref055","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2307\/3281829","article-title":"Large-scale laboratory maintenance of Schistosoma mansoni, with observations on three schistosome\/snail host combinations","volume":"72","author":"FA Lewis","year":"1986","journal-title":"J Parasitol"},{"key":"ppat.1007881.ref056","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.actatropica.2013.08.011","article-title":"Schistosomiasis research in Africa: how the CONTRAST alliance made it happen","volume":"128","author":"J Utzinger","year":"2013","journal-title":"Acta Tropica"},{"key":"ppat.1007881.ref057","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.actatropica.2012.08.009","article-title":"DNA \u201cbarcoding\u201d of Schistosoma mansoni across sub-Saharan Africa supports substantial within locality diversity and geographical separation of genotypes","volume":"128","author":"BL Webster","year":"2013","journal-title":"Acta Trop"},{"key":"ppat.1007881.ref058","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.actatropica.2012.09.014","article-title":"Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: Implications for epidemiology, evolution and control","volume":"128","author":"CM Gower","year":"2013","journal-title":"Acta Trop"},{"key":"ppat.1007881.ref059","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12879-016-1575-2","article-title":"Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries","volume":"16","author":"AE Ezeamama","year":"2016","journal-title":"BMC Infect Dis"},{"key":"ppat.1007881.ref060","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1017\/S0031182006001685","article-title":"Development and application of an ethically and epidemiologically advantageous assay for the multi-locus microsatellite analysis of Schistosoma mansoni","volume":"134","author":"CM Gower","year":"2007","journal-title":"Parasitology"},{"key":"ppat.1007881.ref061","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1007\/s00436-015-4643-4","article-title":"Introgressive hybridizations of Schistosoma haematobium by Schistosoma bovis at the origin of the first case report of schistosomiasis in Corsica (France, Europe)","volume":"114","author":"H Mon\u00e9","year":"2015","journal-title":"Parasitology research"},{"key":"ppat.1007881.ref062","article-title":"Host-parasite life-histories of the diurnal vs. nocturnal chronotypes of Schistosoma mansoni: adaptive significance","author":"G Mouahid","year":"2019","journal-title":"Tropical medicine & international health: TM & IH"},{"key":"ppat.1007881.ref063","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"RH Duvall","year":"1967","journal-title":"Am J Trop Med Hyg"},{"key":"ppat.1007881.ref064","first-page":"1","article-title":"Whole genome amplification and exome sequencing of archived schistosome miracidia","author":"W Le Clec\u2019h","year":"2018","journal-title":"Parasitology"},{"key":"ppat.1007881.ref065","article-title":"Haplotype-based variant detection from short-read sequencing","author":"E Garrison","year":"2012"},{"key":"ppat.1007881.ref066","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"P Danecek","year":"2011","journal-title":"Bioinformatics"},{"key":"ppat.1007881.ref067","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1093\/bioinformatics\/btv112","article-title":"Unified representation of genetic variants","volume":"31","author":"A Tan","year":"2015","journal-title":"Bioinformatics (Oxford, England)"},{"key":"ppat.1007881.ref068","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/521987","article-title":"Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering","volume":"81","author":"SR Browning","year":"2007","journal-title":"American journal of human genetics"},{"key":"ppat.1007881.ref069","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing [Internet]. Vienna, Austria; 2015. Available: http:\/\/www.R-project.org\/"},{"key":"ppat.1007881.ref070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/1755-0998.12549","article-title":"VCFR: a package to manipulate and visualize variant call format data in R","volume":"17","author":"BJ Knaus","year":"2017","journal-title":"Molecular ecology resources"},{"key":"ppat.1007881.ref071","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.7717\/peerj.281","article-title":"Poppr: an R package for genetic analysis of populations with clonal, partially clonal, and\/or sexual reproduction","volume":"2","author":"ZN Kamvar","year":"2014","journal-title":"PeerJ"},{"key":"ppat.1007881.ref072","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fgene.2015.00208","article-title":"Novel R tools for analysis of genome-wide population genetic data with emphasis on clonality","volume":"6","author":"ZN Kamvar","year":"2015","journal-title":"Frontiers in genetics"},{"key":"ppat.1007881.ref073","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/bioinformatics\/btr509","article-title":"A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data","volume":"27","author":"H. Li","year":"2011","journal-title":"Bioinformatics"},{"key":"ppat.1007881.ref074","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"F Sievers","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ppat.1007881.ref075","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/molbev\/msx248","article-title":"DnaSP 6: DNA Sequence Polymorphism Analysis of Large Data Sets","volume":"34","author":"J Rozas","year":"2017","journal-title":"Molecular Biology and Evolution"},{"key":"ppat.1007881.ref076","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: An open chemical toolbox","volume":"3","author":"NM O\u2019Boyle","year":"2011","journal-title":"Journal of Cheminformatics"},{"key":"ppat.1007881.ref077","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/prot.22921","article-title":"Role of conformational sampling in computing mutation-induced changes in protein structure and stability","volume":"79","author":"EH Kellogg","year":"2011","journal-title":"Proteins"},{"key":"ppat.1007881.ref078","unstructured":"Battey C. Cjbattey\/Driftr: Driftr_V1.3 [Internet]. Zenodo; 2017. doi: 10.5281\/zenodo.345172"},{"key":"ppat.1007881.ref079","first-page":"1","article-title":"Association for Molecular Patholpogy Training, Committtee E. Standard mutation nomenclature in molecular diagnostics: practical and educational challenges","volume":"9","author":"S Ogino","year":"2007","journal-title":"J Mol Diagn"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007881","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T13:18:38Z","timestamp":1664716718000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007881"}},"subtitle":[],"editor":[{"given":"James J.","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,10,25]]},"references-count":79,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007881","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/657056","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,25]]}}}