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Sequential appearance of successive variant antigenic types","volume":"165","author":"SM Handunnetti","year":"1987","journal-title":"J Exp Med"},{"issue":"5017","key":"ref63","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/2081286a0","article-title":"Immunity to malaria: antigenic variation in chronic infections of <italic>Plasmodium knowlesi<\/italic>","volume":"208","author":"KN Brown","year":"1965","journal-title":"Nature"},{"issue":"4","key":"ref64","first-page":"503","article-title":"Antigenic variation and protective immunity in <italic>Plasmodium knowlesi<\/italic> malaria","volume":"23","author":"GA Butcher","year":"1972","journal-title":"Immunology"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"e1001306","DOI":"10.1371\/journal.ppat.1001306","article-title":"Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching pattern","volume":"7","author":"M Recker","year":"2011","journal-title":"PLoS 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<italic>Plasmodium falciparum<\/italic>-infected erythrocyte surface","volume":"109","author":"AG Maier","year":"2007","journal-title":"Blood"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"e2004328","DOI":"10.1371\/journal.pbio.2004328","article-title":"The <italic>Plasmodium falciparum<\/italic> transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes","volume":"16","author":"GQ Tonkin-Hill","year":"2018","journal-title":"PLoS Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"16044","DOI":"10.1038\/ncomms16044","article-title":"An exported protein-interacting complex involved in the trafficking of virulence determinants in <italic>Plasmodium<\/italic>-infected erythrocytes","volume":"8","author":"S Batinovic","year":"2017","journal-title":"Nat Commun"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1475-2875-7-108","article-title":"A semi-automated multiplex high-throughput assay for measuring IgG antibodies against <italic>Plasmodium falciparum<\/italic> erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma","volume":"7","author":"GK Cham","year":"2008","journal-title":"Malar J"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007906","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000}},{"DOI":"10.1371\/journal.ppat.1014177","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000}}],"container-title":["PLOS 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