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and contributes to the virulence of Salmonella enterica","volume":"75","author":"S Ammendola","year":"2007","journal-title":"Infect Immun"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2180-11-36","article-title":"Role of ZnuABC and ZinT in Escherichia coli O157:H7 zinc acquisition and interaction with epithelial cells","volume":"11","author":"R Gabbianelli","year":"2011","journal-title":"BMC Microbiol"},{"issue":"10","key":"ref77","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1128\/IAI.00447-15","article-title":"Dual Zinc Transporter Systems in Vibrio cholerae Promote Competitive Advantages over Gut Microbiome","volume":"83","author":"Y Sheng","year":"2015","journal-title":"Infect Immun"},{"issue":"3","key":"ref78","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2012.01.017","article-title":"Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut","volume":"11","author":"JZ Liu","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/IAI.05208-11","article-title":"The Neisseria meningitidis ZnuD zinc receptor contributes to interactions with epithelial cells and supports heme utilization when expressed in Escherichia coli","volume":"80","author":"P Kumar","year":"2012","journal-title":"Infect Immun"},{"issue":"2","key":"ref80","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/jcp.36.2.213","article-title":"The pathogenic potential of commensal species of Neisseria","volume":"36","author":"AP Johnson","year":"1983","journal-title":"J Clin Pathol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1128\/jb.85.6.1274-1279.1963","article-title":"NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION","volume":"85","author":"DS KELLOGG","year":"1963","journal-title":"J Bacteriol"},{"issue":"6","key":"ref82","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.dci.2008.12.005","article-title":"The human antimicrobial protein psoriasin acts by permeabilization of bacterial membranes","volume":"33","author":"M Michalek","year":"2009","journal-title":"Dev Comp Immunol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/978-1-4939-9030-6_18","article-title":"S100 Proteins in the Innate Immune Response to Pathogens","volume":"1929","author":"N Kozlyuk","year":"2019","journal-title":"Methods Mol Biol"},{"key":"ref84","article-title":"Characterization of the Effects of Iron on Neisseria Gonorrhoeae Surface Protein Modulation and Host Cell Interactions","author":"A. 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