{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:35:30Z","timestamp":1792654530983,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1007940","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1007940","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T13:39:28Z","timestamp":1563802768000},"page":"e1007940","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Caspase-mediated cleavage of murine norovirus NS1\/2 potentiates apoptosis and is required for persistent infection of intestinal epithelial cells"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-9510","authenticated-orcid":true,"given":"Bridget A.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-4175","authenticated-orcid":true,"given":"Jacob A.","family":"Van Winkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-5316","authenticated-orcid":true,"given":"Broc T.","family":"McCune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Mack","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-7666","authenticated-orcid":true,"given":"Timothy J.","family":"Nice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S1473-3099(14)70767-4","article-title":"Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis","volume":"14","author":"SM Ahmed","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1056\/NEJMra0804575","article-title":"Norovirus gastroenteritis","volume":"361","author":"RI Glass","year":"2009","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/cid\/cit763","article-title":"Multiple Norovirus Infections in a Birth Cohort in a Peruvian Periurban Community","volume":"58","author":"M Saito","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1017\/S095026881400274X","article-title":"Shedding of norovirus in symptomatic and asymptomatic infections","volume":"143","author":"PFM Teunis","year":"2015","journal-title":"Epidemiol Infect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.aaf5211","article-title":"Replication of human noroviruses in stem cell-derived human enteroids","volume":"353","author":"K Ettayebi","year":"2016","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1126\/science.1257147","article-title":"Enteric bacteria promote human and mouse norovirus infection of B cells","volume":"346","author":"MK Jones","year":"2014","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e1004626","DOI":"10.1371\/journal.ppat.1004626","article-title":"A Working Model of How Noroviruses Infect the Intestine","volume":"11","author":"SM Karst","year":"2015","journal-title":"LOS Pathog"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.tim.2017.10.010","article-title":"The Role of Interferon in Persistent Viral Infection: Insights from Murine Norovirus","volume":"26","author":"TJ Nice","year":"2018","journal-title":"Trends Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.molmed.2016.10.003","article-title":"Norovirus Regulation by Host and Microbe","volume":"22","author":"MT Baldridge","year":"2016","journal-title":"Trends Mol Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1126\/science.1077905","article-title":"STAT1-dependent innate immunity to a Norwalk-like virus","volume":"299","author":"SM Karst","year":"2003","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.8380940","article-title":"Sequence and genome organization of a human small round-structured (Norwalk-like) virus","volume":"259","author":"PR Lambden","year":"1993","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1128\/JVI.00532-06","article-title":"Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells","volume":"80","author":"V Sosnovtsev S","year":"2006","journal-title":"J Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1128\/JVI.77.12.7150-7155.2003","article-title":"trans activity of the norovirus Camberwell proteinase and cleavage of the N-terminal protein encoded by ORF1","volume":"77","author":"EL Seah","year":"2003","journal-title":"J Virol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1128\/JVI.70.4.2605-2610.1996","article-title":"Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis","volume":"70","author":"B Liu","year":"1996","journal-title":"J Virol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9709","DOI":"10.1128\/JVI.00600-09","article-title":"Mouse Norovirus Replication Is Associated with Virus-Induced Vesicle Clusters Originating from Membranes Derived from the Secretory Pathway","volume":"83","author":"JL Hyde","year":"2009","journal-title":"J Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.virol.2010.06.047","article-title":"Subcellular localization of the MNV-1 ORF1 proteins and their potential roles in the formation of the MNV-1 replication complex","volume":"406","author":"JL Hyde","year":"2010","journal-title":"Virology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1006705","DOI":"10.1371\/journal.ppat.1006705","article-title":"Membrane alterations induced by nonstructural proteins of human norovirus","volume":"13","author":"SY Doerflinger","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11790","DOI":"10.1128\/JVI.77.21.11790-11797.2003","article-title":"Norwalk Virus Nonstructural Protein p48 Forms a Complex with the SNARE Regulator VAP-A and Prevents Cell Surface Expression of Vesicular Stomatitis Virus G Protein","volume":"77","author":"K Ettayebi","year":"2003","journal-title":"J Virol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1099\/vir.0.059634-0","article-title":"Norovirus gene expression and replication","volume":"95","author":"LG Thorne","year":"2014","journal-title":"J Gen Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1128\/JVI.01864-12","article-title":"A single-amino-acid change in murine norovirus NS1\/2 is sufficient for colonic tropism and persistence","volume":"87","author":"TJ Nice","year":"2013","journal-title":"J Virol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.1128\/JVI.00237-08","article-title":"A Single Amino Acid Substitution in the Murine Norovirus Capsid Protein Is Sufficient for Attenuation In Vivo","volume":"82","author":"D Bailey","year":"2008","journal-title":"J Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1128\/JVI.07038-11","article-title":"Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo","volume":"86","author":"DW Strong","year":"2012","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/prot.24484","article-title":"Murine norovirus protein NS1\/2 aspartate to glutamate mutation, sufficient for persistence, reorients side chain of surface exposed tryptophan within a novel structured domain","volume":"82","author":"BN Borin","year":"2014","journal-title":"Proteins"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e432","DOI":"10.1371\/journal.pbio.0020432","article-title":"Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages","volume":"2","author":"CE Wobus","year":"2004","journal-title":"PLoS Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/s41564-017-0057-7","article-title":"The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue","volume":"2","author":"KR Grau","year":"2017","journal-title":"Nat Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aaf1220","article-title":"Discovery of a proteinaceous cellular receptor for a norovirus","volume":"353","author":"RC Orchard","year":"2016","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"E6248","DOI":"10.1073\/pnas.1605575113","article-title":"Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells","volume":"113","author":"K Haga","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1126\/science.aar3799","article-title":"Tropism for tuft cells determines immune promotion of norovirus pathogenesis","volume":"360","author":"CB Wilen","year":"2018","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.chom.2017.08.021","article-title":"Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine","volume":"22","author":"S Lee","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A single-cell survey of the small intestinal epithelium","volume":"551","author":"AL Haber","year":"2017","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.it.2015.01.004","article-title":"Interferons and viruses: an evolutionary arms race of molecular interactions","volume":"36","author":"H-H Hoffmann","year":"2015","journal-title":"Trends Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1005684","DOI":"10.1371\/journal.ppat.1005684","article-title":"Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity","volume":"12","author":"TJ Nice","year":"2016","journal-title":"PLoS Pathog"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"13515","DOI":"10.1128\/JVI.01824-12","article-title":"Critical Role for Interferon Regulatory Factor 3 (IRF-3) and IRF-7 in Type I Interferon-Mediated Control of Murine Norovirus Replication","volume":"86","author":"LB Thackray","year":"2012","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1126\/science.1258025","article-title":"Commensal microbes and interferon-\u03bb determine persistence of enteric murine norovirus infection","volume":"347","author":"MT Baldridge","year":"2015","journal-title":"Science"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1258100","article-title":"Interferon-\u03bb cures persistent murine norovirus infection in the absence of adaptive immunity","volume":"347","author":"TJ Nice","year":"2015","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrm2312","article-title":"Apoptosis: controlled demolition at the cellular level","volume":"9","author":"RC Taylor","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbamcr.2003.11.001","article-title":"Viral Bcl-2 homologs and their role in virus replication and associated diseases","volume":"1644","author":"BM Polster","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1000018","DOI":"10.1371\/journal.ppat.1000018","article-title":"Viral control of mitochondrial apoptosis","volume":"4","author":"L Galluzzi","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nrmicro3469","article-title":"Viral apoptotic mimicry","volume":"13","author":"A Amara","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1038\/cddis.2012.18","article-title":"Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis","volume":"3","author":"A Richard","year":"2012","journal-title":"Cell Death Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1165\/rcmb.2015-0133OC","article-title":"Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection","volume":"54","author":"YA Mebratu","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1099\/vir.0.18840-0","article-title":"Caspase-mediated cleavage of the feline calicivirus capsid protein","volume":"84","author":"N Al-Molawi","year":"2003","journal-title":"J Gen Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"10372","DOI":"10.1128\/JVI.00809-06","article-title":"Pathogenesis of a genogroup II human norovirus in gnotobiotic pigs","volume":"80","author":"S Cheetham","year":"2006","journal-title":"J Virol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/gut.2008.160150","article-title":"Structural and functional changes of the duodenum in human norovirus infection","volume":"58","author":"H Troeger","year":"2009","journal-title":"Gut"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1128\/JVI.02096-06","article-title":"Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses","volume":"81","author":"SM Mumphrey","year":"2007","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1128\/JVI.02028-08","article-title":"Apoptosis in Murine Norovirus-Infected RAW264.7 Cells Is Associated with Downregulation of Survivin","volume":"83","author":"K Bok","year":"2009","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1743-422X-6-139","article-title":"Cysteine protease activation and apoptosis in Murine norovirus infection","volume":"6","author":"LM Furman","year":"2009","journal-title":"Virol J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e90679","DOI":"10.1371\/journal.pone.0090679","article-title":"Expression of the Murine Norovirus (MNV) ORF1 Polyprotein Is Sufficient to Induce Apoptosis in a Virus-Free Cell Model","volume":"9","author":"MR Herod","year":"2014","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.chom.2018.10.003","article-title":"Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells","volume":"24","author":"JA Van Winkle","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.chom.2019.04.005","article-title":"A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis","volume":"25","author":"S Lee","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1128\/MMBR.64.4.821-846.2000","article-title":"Proteases for cell suicide: functions and regulation of caspases","volume":"64","author":"HY Chang","year":"2000","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.00668-17","article-title":"Noroviruses Co-opt the Function of Host Proteins VAPA and VAPB for Replication via a Phenylalanine-Phenylalanine-Acidic-Tract-Motif Mimic in Nonstructural Viral Protein NS1\/2","volume":"8","author":"BT McCune","year":"2017","journal-title":"MBio"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature12029","article-title":"A pathogenic picornavirus acquires an envelope by hijacking cellular membranes","volume":"496","author":"Z Feng","year":"2013","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.cell.2015.01.032","article-title":"Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses","volume":"160","author":"Y-H Chen","year":"2015","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chom.2013.07.005","article-title":"Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors","volume":"14","author":"S Bhattacharyya","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.chom.2018.07.006","article-title":"Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission","author":"M Santiana","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature16527","article-title":"Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites","volume":"529","author":"F Gerbe","year":"2016","journal-title":"Nature"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature16161","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit","volume":"529","author":"J Von Moltke","year":"2016","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1111\/febs.13575","article-title":"Cell death at the intestinal epithelial front line","volume":"283","author":"ME Delgado","year":"2016","journal-title":"FEBS J"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ncb1026","article-title":"Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis","volume":"5","author":"MJ Reginato","year":"2003","journal-title":"Nat Cell Biol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"26533","DOI":"10.1074\/jbc.M111.265322","article-title":"BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells","volume":"286","author":"M Hausmann","year":"2011","journal-title":"J Biol Chem"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"RJ Youle","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nri3607","article-title":"Apoptotic cell clearance: basic biology and therapeutic potential","volume":"14","author":"IKH Poon","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.immuni.2016.02.005","article-title":"Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo","volume":"44","author":"CS Lee","year":"2016","journal-title":"Immunity"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature11714","article-title":"Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation","volume":"493","author":"IJ Juncadella","year":"2013","journal-title":"Nature"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/sj.cdd.4401517","article-title":"Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release","volume":"12","author":"J Monks","year":"2005","journal-title":"Cell Death Differ"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","article-title":"Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus","volume":"27","author":"E Blasi","year":"1990","journal-title":"J Neuroimmunol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"770","DOI":"10.4049\/jimmunol.159.2.770","article-title":"Interleukin-10 prevents dendritic cell accumulation and vaccination with granulocyte-macrophage colony-stimulating factor gene-modified tumor cells","volume":"159","author":"Z Qin","year":"1997","journal-title":"J Immunol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1128\/JVI.00204-14","article-title":"Efficient Norovirus and Reovirus Replication in the Mouse Intestine Requires Microfold (M) Cells","volume":"88","author":"MB Gonzalez-Hernandez","year":"2014","journal-title":"J Virol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1007940","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1007940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T08:54:28Z","timestamp":1695027268000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1007940"}},"subtitle":[],"editor":[{"given":"Christiane E.","family":"Wobus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1007940","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/372615","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]}}}