{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:11:40Z","timestamp":1778825500563,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008017","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000}}],"reference-count":129,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["GM081498"],"award-info":[{"award-number":["GM081498"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008017","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T17:33:26Z","timestamp":1566236006000},"page":"e1008017","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Adenovirus early region 3 RID\u03b1 protein limits NF\u03baB signaling through stress-activated EGF receptors"],"prefix":"10.1371","volume":"15","author":[{"given":"Xuehuo","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3569-4247","authenticated-orcid":true,"given":"Cathleen R.","family":"Carlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"ppat.1008017.ref001","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.coviro.2015.03.017","article-title":"Old foes, new understandings: nuclear entry of small non-enveloped DNA viruses","volume":"12","author":"N Fay","year":"2015","journal-title":"Curr Opin Virol"},{"key":"ppat.1008017.ref002","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/cmi.12053","article-title":"Adenovirus signalling in entry","volume":"15","author":"N Wolfrum","year":"2012","journal-title":"Cell Micro"},{"key":"ppat.1008017.ref003","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/hum.2014.001","article-title":"Innate immunity to adenovirus","volume":"25","author":"R Hendrickx","year":"2014","journal-title":"Hum Gene Ther"},{"key":"ppat.1008017.ref004","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/hum.2004.15.1157","article-title":"The innate immune response to adenovirus vectors","volume":"15","author":"DA Muruve","year":"2004","journal-title":"Hum Gene Ther"},{"key":"ppat.1008017.ref005","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.virol.2008.10.016","article-title":"Insights into adenovirus host cell interactions from structural studies","volume":"384","author":"GR Nemerow","year":"2009","journal-title":"Virology"},{"key":"ppat.1008017.ref006","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/cas.13228","article-title":"Recent advances in genetic modification of adenovirus vectors for cancer treatment","volume":"108","author":"Y Yamamoto","year":"2017","journal-title":"Cancer Sci"},{"key":"ppat.1008017.ref007","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1126\/science.1233028","article-title":"Cellular self-defense: How cell-autonomous immunity protects against pathogens","volume":"340","author":"F Randow","year":"2013","journal-title":"Science"},{"key":"ppat.1008017.ref008","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1073\/pnas.86.10.3823","article-title":"Role of early region 3 (E3) in pathogenesis of adenovirus disease","volume":"86","author":"HS Ginsberg","year":"1989","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1008017.ref009","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13073-014-0115-1","article-title":"Virus-host interactomics: new insights and opportunities for antiviral drug discovery","volume":"6","author":"B de Chassey","year":"2016","journal-title":"Genome Medicine"},{"key":"ppat.1008017.ref010","first-page":"229","article-title":"Immune evasion by adenovirus E3 proteins: exploitation of intracellular trafficking pathways","volume":"273","author":"M Windheim","year":"2004","journal-title":"Curr Top Microbiol Immunol"},{"key":"ppat.1008017.ref011","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1002\/jgm.495","article-title":"Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins","volume":"1","author":"MS Horwitz","year":"2004","journal-title":"J Gene Med 6 Suppl"},{"key":"ppat.1008017.ref012","doi-asserted-by":"crossref","first-page":"9","DOI":"10.29245\/2578-3009\/2018\/1.1112","article-title":"Human adenoviruses, cholesterol trafficking, and NF-\u03baB signaling","volume":"2","author":"N Cianciola","year":"2018","journal-title":"J Immunol Sci"},{"key":"ppat.1008017.ref013","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1093\/nar\/13.14.5389","article-title":"Adenovirus E3-early promoter: sequences required for activation by E1A","volume":"13","author":"DL Weeks","year":"1985","journal-title":"Nucleic Acids Res"},{"key":"ppat.1008017.ref014","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1128\/JVI.72.5.4049-4056.1998","article-title":"Control of adenovirus early gene expression during the late phase of infection","volume":"72","author":"SP Fessler","year":"1998","journal-title":"J Virol"},{"key":"ppat.1008017.ref015","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1128\/JVI.77.2.1112-1119.2003","article-title":"The adenovirus E3 promoter is sensitive to activation signals in human T cells","volume":"77","author":"JA Mahr","year":"2003","journal-title":"J Virol"},{"key":"ppat.1008017.ref016","first-page":"113","article-title":"Mechanisms of E3 modulation of immune and inflammatory responses","volume":"273","author":"S Fessler","year":"2004","journal-title":"Curr Top Microbiol Immunol"},{"key":"ppat.1008017.ref017","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/08830180490265556","article-title":"Functions and mechanisms of action of the adenovirus E3 proteins","volume":"23","author":"D Lichtenstein","year":"2004","journal-title":"Int Rev Immunol"},{"key":"ppat.1008017.ref018","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1008135928310","article-title":"Immunomodulatory functions encoded by the E3 transcription unit of adenoviruses","volume":"21","author":"H Burgert","year":"2000","journal-title":"Virus Genes"},{"key":"ppat.1008017.ref019","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1128\/MCB.14.6.3695","article-title":"Adenovirus E3 protein causes constitutively internalized EGF receptors to accumulate in a prelysosomal compartment, resulting in enhanced degradation","volume":"14","author":"P Hoffman","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ppat.1008017.ref020","first-page":"1723","volume-title":"Field's Virology","author":"MS Horwitz","year":"1995"},{"key":"ppat.1008017.ref021","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.bmt.1705003","article-title":"Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery","volume":"36","author":"MJ Tol","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"ppat.1008017.ref022","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bmt.1702508","article-title":"Adenovirus infections following haematopoietic cell transplantation: is there a role for adoptive immunotherapy?","volume":"26","author":"S Chakrabarti","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"ppat.1008017.ref023","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1086\/313514","article-title":"Adenovirus infections in hematopoietic stem cell transplant recipients","volume":"29","author":"DS Howard","year":"1999","journal-title":"Clin Infect Dis"},{"key":"ppat.1008017.ref024","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/MOT.0b013e3283324e1b","article-title":"Adenovirus infections in solid organ transplant recipients","volume":"14","author":"JA Hoffman","year":"2009","journal-title":"Curr Opin Organ Transplantation"},{"key":"ppat.1008017.ref025","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1080\/10428190310001628176","article-title":"Adenovirus infections in stem cell transplant recipients: recent developments in understanding of pathogenesis, diagnosis and management","volume":"45","author":"S Chakrabarti","year":"2004","journal-title":"Leukemia Lymphoma"},{"key":"ppat.1008017.ref026","doi-asserted-by":"crossref","first-page":"90","DOI":"10.12688\/f1000research.10152.1","article-title":"Mechanisms of pathogenesis of emerging adenoviruses","volume":"6","author":"J Cook","year":"2017","journal-title":"F1000Research"},{"key":"ppat.1008017.ref027","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3201\/eid1803.111238","article-title":"Adenovirus-associated deaths in US military during postvaccination period, 1999\u20132010","volume":"18","author":"R Potter","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"ppat.1008017.ref028","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3201\/eid2402.171407","article-title":"Adenovirus type 4 respiratory infections among civilian adults, northeastern United States, 2011\u20132015","volume":"24","author":"AE Kajon","year":"2018","journal-title":"Emerging Infect Dis"},{"key":"ppat.1008017.ref029","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.cmet.2014.03.009","article-title":"Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication","volume":"19","author":"M Thai","year":"2014","journal-title":"Cell Metab"},{"key":"ppat.1008017.ref030","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/sj.mt.6300032","article-title":"Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver","volume":"15","author":"AY Wang","year":"2007","journal-title":"Mol Therapy"},{"key":"ppat.1008017.ref031","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/sj.gt.3302036","article-title":"Molecular basis of the inflammatory response to adenovirus vectors","volume":"10","author":"Q Liu","year":"2003","journal-title":"Gene Therapy"},{"key":"ppat.1008017.ref032","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nri2655","article-title":"Regulation of tissue homeostasis by NF-kB signalling: implications for inflammatory diseases","volume":"9","author":"M Pasparakis","year":"2009","journal-title":"Nat Rev Immunology"},{"key":"ppat.1008017.ref033","doi-asserted-by":"crossref","first-page":"14507","DOI":"10.1128\/JVI.79.23.14507-14515.2005","article-title":"Akt\/protein kinase B activation by adenovirus vectors contributes to NFkB-dependent CXCL10 expression","volume":"79","author":"Q Liu","year":"2005","journal-title":"J Virol"},{"key":"ppat.1008017.ref034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.2000.0468","article-title":"Cell receptors involved in adenovirus entry","volume":"274","author":"G Nemerow","year":"2000","journal-title":"Virology"},{"key":"ppat.1008017.ref035","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1128\/JVI.71.1.398-404.1997","article-title":"Adenovirus infection stimulates the Raf\/MAPK signaling pathway and induces interleukin-8 expression","volume":"71","author":"JT Bruder","year":"1997","journal-title":"J Virol"},{"key":"ppat.1008017.ref036","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1089\/10430340252792503","article-title":"Adenovirus vector-induced inflammation: Capsid-dependent induction of the C-C chemokine RANTES requires NF-kB","volume":"13","author":"GP Bowen","year":"2002","journal-title":"Hum Gene Ther"},{"key":"ppat.1008017.ref037","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1128\/JVI.74.9.3941-3947.2000","article-title":"Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-kB","volume":"74","author":"SL Borgland","year":"2000","journal-title":"J Virol"},{"key":"ppat.1008017.ref038","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.4049\/jimmunol.170.8.4226","article-title":"Modulation of human b-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production","volume":"170","author":"Y Tsutsumi-Ishii","year":"2003","journal-title":"J Immunology"},{"key":"ppat.1008017.ref039","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1083\/jcb.132.4.511","article-title":"Activation of transcription factor NF-kappaB by the adenovirus E3\/19K protein requires its ER retention","volume":"132","author":"HL Pahl","year":"1996","journal-title":"J Cell Biol"},{"key":"ppat.1008017.ref040","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","article-title":"Molecular basis of NF-kB signaling","volume":"42","author":"J Napetschnig","year":"2013","journal-title":"Annu Rev Biophys"},{"key":"ppat.1008017.ref041","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-3-0348-9088-5_23","volume-title":"Stress-Inducible Cellular Responses","author":"MG Santoro","year":"1996"},{"key":"ppat.1008017.ref042","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tcb.2013.11.002","article-title":"EGF receptor trafficking: consequences for signaling and cancer","volume":"24","author":"A Tomas","year":"2014","journal-title":"Trends Cell Biol"},{"key":"ppat.1008017.ref043","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.tcb.2015.12.006","article-title":"Stress-induced EGFR trafficking: mechanisms, functions, and therapeutic implications","volume":"26","author":"X Tan","year":"2016","journal-title":"Trends Cell Biol"},{"key":"ppat.1008017.ref044","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1038\/ncomms8324","article-title":"WASH and Tsg101\/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway","volume":"6","author":"A Tomas","year":"2015","journal-title":"Nat Commun"},{"key":"ppat.1008017.ref045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tcb.2013.10.009","article-title":"ALIX and the multivesicular endosome: ALIX in Wonderland","volume":"24","author":"C Bissig","year":"2013","journal-title":"Trends Cell Biol"},{"key":"ppat.1008017.ref046","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.molmed.2015.04.001","article-title":"EGFR and NF-kB: partners in cancer","volume":"21","author":"K Shostak","year":"2015","journal-title":"Trends Mol Med"},{"key":"ppat.1008017.ref047","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1083\/jcb.120.5.1271","article-title":"Structurally related class I and class II receptor protein tyrosine kinases are down-regulated by the same E3 protein coded by human group C adenoviruses","volume":"120","author":"E Kuivinen","year":"1993","journal-title":"J Cell Biol"},{"key":"ppat.1008017.ref048","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0092-8674(89)90179-7","article-title":"Epidermal growth factor receptor is down-regulated by a 10,400 MW protein encoded by the E3 region of adenovirus","volume":"57","author":"CR Carlin","year":"1989","journal-title":"Cell"},{"key":"ppat.1008017.ref049","doi-asserted-by":"crossref","first-page":"13480","DOI":"10.1016\/S0021-9258(18)42237-5","article-title":"Characterization of the adenovirus E3 protein that down-regulates the epidermal growth factor receptor","volume":"267","author":"P Hoffman","year":"1992","journal-title":"J Biol Chem"},{"key":"ppat.1008017.ref050","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1128\/JVI.66.1.197-203.1992","article-title":"Evidence for intracellular down-regulation of the epidermal growth factor receptor during adenovirus infection by an EGF-independent mechanism","volume":"66","author":"PH Hoffman","year":"1992","journal-title":"J Virol"},{"key":"ppat.1008017.ref051","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1091\/mbc.11.10.3559","article-title":"7 integral membrane proteins encoded by human adenoviruses alter epidermal growth factor receptor trafficking by interacting directly with receptors in early endosomes","volume":"11","author":"D Crooks","year":"2000","journal-title":"Mol Biol Cell"},{"key":"ppat.1008017.ref052","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1128\/JVI.00399-07","article-title":"A tyrosine-based signal plays a critical role in the targeting and function of adenovirus RID{alpha} protein","volume":"81","author":"NL Cianciola","year":"2007","journal-title":"J Virol"},{"key":"ppat.1008017.ref053","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1242\/jcs.02527","article-title":"A novel dileucine lysosomal-sorting-signal mediates intracellular EGF-receptor retention independently of protein ubiquitylation","volume":"118","author":"A Tsacoumangos","year":"2005","journal-title":"J Cell Sci"},{"key":"ppat.1008017.ref054","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S1097-2765(03)00490-8","article-title":"Regulation of NF-kB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65\/RelA","volume":"12","author":"A Ryo","year":"2003","journal-title":"Mol Cell"},{"key":"ppat.1008017.ref055","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1038\/ncomms8999","article-title":"Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells","volume":"6","author":"F Capuani","year":"2015","journal-title":"Nat Commun"},{"key":"ppat.1008017.ref056","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.107.2.801","article-title":"Anomolous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system","volume":"107","author":"HS Wiley","year":"1988","journal-title":"J Cell Biol"},{"key":"ppat.1008017.ref057","doi-asserted-by":"crossref","first-page":"15749","DOI":"10.1016\/S0021-9258(17)40744-7","article-title":"Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions","volume":"269","author":"AR French","year":"1994","journal-title":"J Biol Chem"},{"key":"ppat.1008017.ref058","doi-asserted-by":"crossref","first-page":"20517","DOI":"10.1016\/S0021-9258(17)30533-1","article-title":"Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation","volume":"265","author":"KA Lund","year":"1990","journal-title":"J Biol Chem"},{"key":"ppat.1008017.ref059","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4161\/cbt.7.4.5533","article-title":"Differential sensitivity of A549 non small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors","volume":"7","author":"ML Jaramillo","year":"2008","journal-title":"Canc Biol Therapy"},{"key":"ppat.1008017.ref060","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1128\/JVI.02014-12","article-title":"Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells","volume":"87","author":"X Zeng","year":"2013","journal-title":"J Virol"},{"key":"ppat.1008017.ref061","doi-asserted-by":"crossref","first-page":"L393","DOI":"10.1152\/ajplung.00359.2003","article-title":"Adenovirus vectors activate survival pathways in lung epithelial cells","volume":"287","author":"DM Flaherty","year":"2004","journal-title":"Am J Physiol\u2014Lung Cell Mol Physiol"},{"key":"ppat.1008017.ref062","first-page":"1","article-title":"Characterization of transgene expression in adenoviral vector-based HIV-1 vaccine candidates","volume":"7","author":"M-N Takahashi","year":"2010","journal-title":"Virology J"},{"key":"ppat.1008017.ref063","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb1514s46","article-title":"Quantitative analysis of endocytosis and turnover of epidermal growth factor (EGF) and EGF receptor","author":"A Sorkin","year":"2010","journal-title":"Curr Protocols Cell Biol"},{"key":"ppat.1008017.ref064","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/1097-4652(200010)185:1<47::AID-JCP4>3.0.CO;2-O","article-title":"EGF receptor residues Leu679, Leu680 mediate selective sorting of ligand-receptor complexes in early endocytic compartments","volume":"185","author":"S Kil","year":"2000","journal-title":"J Cell Physiol"},{"key":"ppat.1008017.ref065","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1128\/MCB.8.8.3291","article-title":"Competition between splicing and polyadenylation reactions determines which adenovirus region E3 mRNAs are synthesized","volume":"8","author":"HA Brady","year":"1988","journal-title":"Mol Cell Biol"},{"key":"ppat.1008017.ref066","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.tcb.2006.08.003","article-title":"Intra-endosomal membrane traffic","volume":"16","author":"FG van der Goot","year":"2006","journal-title":"Trends Cell Biol"},{"key":"ppat.1008017.ref067","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature07961","article-title":"The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins","volume":"458","author":"C Raiborg","year":"2009","journal-title":"Nature"},{"key":"ppat.1008017.ref068","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature08849","article-title":"Molecular mechanism of multivesicular body biogenesis by ESCRT complexes","volume":"464","author":"T Wollert","year":"2010","journal-title":"Nature"},{"key":"ppat.1008017.ref069","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nature07836","article-title":"Membrane scission by the ESCRT-III complex","volume":"458","author":"T Wollert","year":"2009","journal-title":"Nature"},{"key":"ppat.1008017.ref070","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.yexcr.2007.10.014","article-title":"Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking","volume":"314","author":"C Raiborg","year":"2008","journal-title":"Exp Cell Res"},{"key":"ppat.1008017.ref071","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201110031","article-title":"ALIX binds a YPX3L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III\/MVB sorting","volume":"197","author":"MR Dores","year":"2012","journal-title":"J Cell Biol"},{"key":"ppat.1008017.ref072","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1074\/jbc.M508632200","article-title":"Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII","volume":"281","author":"K Bowers","year":"2006","journal-title":"J Biol Chem"},{"key":"ppat.1008017.ref073","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1242\/jcs.02382","article-title":"Alix regulates cortical actin and the spatial distribution of endosomes","volume":"118","author":"A Cabezas","year":"2005","journal-title":"J Cell Sci"},{"key":"ppat.1008017.ref074","doi-asserted-by":"crossref","first-page":"8981","DOI":"10.1128\/MCB.24.20.8981-8993.2004","article-title":"Alix\/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA\/CIN85 complex","volume":"24","author":"MHH Schmidt","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ppat.1008017.ref075","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1073\/pnas.0707601105","article-title":"The Bro1-related protein HD-PTP\/PTPN23 is required for endosomal cargo sorting and multivesicular body morphogenesis","volume":"105","author":"A Doyotte","year":"2008","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1008017.ref076","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-0854.2008.00820.x","article-title":"The ESCRT-I subunit TSG101 controls endosome-to-cytosol release of viral RNA","volume":"9","author":"P-P Luyet","year":"2008","journal-title":"Traffic"},{"key":"ppat.1008017.ref077","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1083\/jcb.200702187","article-title":"Adenovirus RIDa regulates endosome maturation by mimicking GTP-Rab7","volume":"179","author":"AH Shah","year":"2007","journal-title":"J Cell Biol"},{"key":"ppat.1008017.ref078","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1038\/sj.emboj.7601297","article-title":"p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy","volume":"25","author":"Y Zwang","year":"2006","journal-title":"EMBO J"},{"key":"ppat.1008017.ref079","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1432-1033.1979.tb12956.x","article-title":"Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin","volume":"95","author":"PO Seglin","year":"1979","journal-title":"Eur J Biochem"},{"key":"ppat.1008017.ref080","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/cells5010012","article-title":"The regulation of NF-kB subunits by phosphorylation","volume":"5","author":"F Christian","year":"2016","journal-title":"Cells"},{"key":"ppat.1008017.ref081","doi-asserted-by":"crossref","first-page":"e24021","DOI":"10.1371\/journal.pone.0024021","article-title":"O-GlcNAc modification of NFkB p65 inhibits TNF-a-induced inflammatory mediator expression in rat aortic smooth muscle cells","volume":"6","author":"D Xing","year":"2011","journal-title":"PLoS ONE"},{"key":"ppat.1008017.ref082","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1165\/ajrcmb.19.2.3149","article-title":"Inhibition of TNF-a-induced NF-kB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132","volume":"19","author":"MA Fiedler","year":"1998","journal-title":"Am J Res Cell Mol Biol"},{"key":"ppat.1008017.ref083","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/emboj\/20.6.1310","article-title":"Adenovirus-activated PKA and p38\/MAPK pathways boost microtubule-mediated nuclear targeting of virus","volume":"20","author":"M Suomalainen","year":"2001","journal-title":"EMBO J"},{"key":"ppat.1008017.ref084","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.abb.2012.11.006","article-title":"Phosphorylation of epidermal growth factor receptor at serine 1047 by MAP kinase-activated protein kinase-2 in cultured lung epithelial cells treated with flagellin","volume":"529","author":"N Noguchi","year":"2013","journal-title":"Arch Biochem Biophys"},{"key":"ppat.1008017.ref085","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1038\/sj.onc.1209337","article-title":"MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer","volume":"25","author":"L Xu","year":"2006","journal-title":"Oncogene"},{"key":"ppat.1008017.ref086","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1600-0854.2011.01322.x","article-title":"Differential roles of Grb2 and AP-2 in p38MAPK- and EGF-Induced EGFR internalization","volume":"13","author":"MV Grandal","year":"2012","journal-title":"Traffic"},{"key":"ppat.1008017.ref087","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1097-2765(00)80066-0","article-title":"Phosphorylation of NF-kB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP\/p300","volume":"1","author":"H Zhong","year":"1998","journal-title":"Mol Cell"},{"key":"ppat.1008017.ref088","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1091\/mbc.e12-10-0760","article-title":"Adenovirus RIDa uncovers a novel pathway requiring ORP1L for lipid droplet formation independent of NPC1","volume":"24","author":"NL Cianciola","year":"2013","journal-title":"Mol Biol Cell"},{"key":"ppat.1008017.ref089","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1083\/jcb.200903039","article-title":"Adenovirus RID-a activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C","volume":"187","author":"NL Cianciola","year":"2009","journal-title":"J Cell Biol"},{"key":"ppat.1008017.ref090","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1128\/JVI.75.14.6450-6459.2001","article-title":"Adenovirus type 7 induces Interleukin-8 production via activation of extracellular regulated kinase 1\/2","volume":"75","author":"MJ Alcorn","year":"2001","journal-title":"J Virol"},{"key":"ppat.1008017.ref091","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0962-8924(00)01847-X","article-title":"Jamming the endosomal system: lipid rafts and lysosomal storage diseases","volume":"10","author":"K Simons","year":"2000","journal-title":"Trends in Cell Biology"},{"key":"ppat.1008017.ref092","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1152\/physiol.00032.2006","article-title":"Lipid rafts, detergent-resistant membranes, and raft targeting signals","volume":"21","author":"DA Brown","year":"2006","journal-title":"Physiology"},{"key":"ppat.1008017.ref093","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Y Kabeya","year":"2000","journal-title":"EMBO J"},{"key":"ppat.1008017.ref094","first-page":"503","article-title":"Maturation of autophagosomes and endosomes: A key role for Rab7","volume":"1833","author":"JMT Hyttinen","year":"2013","journal-title":"BBA\u2014Mol Cell Res"},{"key":"ppat.1008017.ref095","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1242\/jcs.01370","article-title":"Role for Rab7 in maturation of late autophagic vacuoles","volume":"117","author":"S Jager","year":"2004","journal-title":"J Cell Sci"},{"key":"ppat.1008017.ref096","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1242\/jcs.01114","article-title":"Rab7 is required for the normal progression of the autophagic pathway in mammalian cells","volume":"117","author":"MG Gutierrez","year":"2004","journal-title":"J Cell Sci"},{"key":"ppat.1008017.ref097","doi-asserted-by":"crossref","first-page":"12110","DOI":"10.1074\/jbc.M809277200","article-title":"Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration","volume":"284","author":"PA Vanlandingham","year":"2009","journal-title":"J Biol Chem"},{"key":"ppat.1008017.ref098","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.4161\/auto.6826","article-title":"Selective turnover of p62\/A170\/SQSTM1 by autophagy","volume":"4","author":"Y Ichimura","year":"2008","journal-title":"Autophagy"},{"key":"ppat.1008017.ref099","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"JM Bergelson","year":"1997","journal-title":"Science"},{"key":"ppat.1008017.ref100","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nm952","article-title":"CD46 is a cellular receptor for group B adenoviruses","volume":"9","author":"DMS Anuj Gaggar","year":"2003","journal-title":"Nat Med"},{"key":"ppat.1008017.ref101","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90231-E","article-title":"Integrins avb3 and avb5 promote adenovirus internalization but not virus attachment","volume":"73","author":"TJ Wickham","year":"1993","journal-title":"Cell"},{"key":"ppat.1008017.ref102","doi-asserted-by":"crossref","first-page":"15458","DOI":"10.1074\/jbc.M110.191924","article-title":"Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting","volume":"286","author":"Y Amano","year":"2011","journal-title":"J Biol Chem"},{"key":"ppat.1008017.ref103","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ncb1269","article-title":"Endosome-to-cytosol transport of viral nucleocapsids","volume":"7","author":"I Le Blanc","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ppat.1008017.ref104","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1002\/ijc.24748","article-title":"Akt-mediated regulation of NFkB and the essentialness of NFkB for the oncogenicity of PI3K and Akt","volume":"125","author":"D Bai","year":"2009","journal-title":"Int J Cancer"},{"key":"ppat.1008017.ref105","first-page":"a000034","article-title":"The NF-kB family of transcription factors and its regulation","volume":"1","author":"A Oeckinghaus","year":"2009","journal-title":"CSH Perspectives Biol"},{"key":"ppat.1008017.ref106","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.biocel.2014.01.009","article-title":"Met endosomal signalling: In the right place, at the right time","volume":"49","author":"R Barrow-McGee","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"ppat.1008017.ref107","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1038\/sj.onc.1209675","article-title":"Gab1 signaling is regulated by EGF receptor sorting in early endosomes","volume":"25","author":"O Kostenko","year":"2006","journal-title":"Oncogene"},{"key":"ppat.1008017.ref108","doi-asserted-by":"crossref","first-page":"24380","DOI":"10.1074\/jbc.M010275200","article-title":"Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2","volume":"276","author":"JM Cunnick","year":"2001","journal-title":"J Biol Chem"},{"key":"ppat.1008017.ref109","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1091\/mbc.e07-09-0957","article-title":"Regulation of Tsg101 expression by the steadiness box: A role of Tsg101-associated ligase","volume":"19","author":"B McDonald","year":"2007","journal-title":"Mol Biol Cell"},{"key":"ppat.1008017.ref110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1078\/0171-9335-00160","article-title":"Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF","volume":"80","author":"MP Oksvold","year":"2001","journal-title":"Eur J Cell Biol"},{"key":"ppat.1008017.ref111","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1038\/srep07282","article-title":"RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking","volume":"4","author":"X Lin","year":"2015","journal-title":"Sci Rep"},{"key":"ppat.1008017.ref112","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molcel.2014.11.006","article-title":"PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3\/GABARAP proteins","volume":"57","author":"David G McEwan","year":"2015","journal-title":"Mol Cell"},{"key":"ppat.1008017.ref113","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1513\/pats.200909-101JS","article-title":"Autophagy in the lung","volume":"7","author":"SW Ryter","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"ppat.1008017.ref114","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4161\/auto.8792","article-title":"Cancer cell death by design: Apoptosis, autophagy and glioma virotherapy","volume":"5","author":"MA Tyler","year":"2009","journal-title":"Autophagy"},{"key":"ppat.1008017.ref115","doi-asserted-by":"crossref","first-page":"e29467","DOI":"10.1371\/journal.pone.0029467","article-title":"The E1B19K oncoprotein complexes with Beclin 1 to regulate autophagy in adenovirus-infected cells","volume":"6","author":"S Piya","year":"2011","journal-title":"PLoS ONE"},{"key":"ppat.1008017.ref116","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virol.2011.04.017","article-title":"Adenoviruses induce autophagy to promote virus replication and oncolysis","volume":"416","author":"H Rodriguez-Rocha","year":"2011","journal-title":"Virology"},{"key":"ppat.1008017.ref117","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3390\/ijms18071479","article-title":"Impact of autophagy in oncolytic adenoviral therapy for cancer","volume":"18","author":"H Tazawa","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ppat.1008017.ref118","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1128\/JVI.02032-10","article-title":"Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity","volume":"85","author":"H Jiang","year":"2011","journal-title":"J Virol"},{"key":"ppat.1008017.ref119","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1365-2567.2005.02277.x","article-title":"A novel mechanism of nuclear factor-kappaB regulation by adenoviral protein 14.7K","volume":"117","author":"RJ Carmody","year":"2006","journal-title":"Immunology"},{"key":"ppat.1008017.ref120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1172\/JCI11918","article-title":"Hostile takeovers: viral appropriation of the NF-kB pathway","volume":"107","author":"J Hiscott","year":"2001","journal-title":"J Clin Invest"},{"key":"ppat.1008017.ref121","doi-asserted-by":"crossref","first-page":"e1004696","DOI":"10.1371\/journal.ppat.1004696","article-title":"Adenovirus entry from the apical surface of polarized epithelia is facilitated by the host innate immune response","volume":"11","author":"PLN Kotha","year":"2015","journal-title":"PLOS Pathogens"},{"key":"ppat.1008017.ref122","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.virol.2006.07.001","article-title":"Calcium-dependent viral internalization is required for adenovirus type 7 induction of IL-8 protein","volume":"355","author":"W Wu","year":"2006","journal-title":"Virology"},{"key":"ppat.1008017.ref123","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/rmv.1796","article-title":"Viruses exploit the function of epidermal growth factor receptor","volume":"24","author":"K Zheng","year":"2014","journal-title":"Rev Med Virol"},{"key":"ppat.1008017.ref124","first-page":"223","volume-title":"Methods in Molecular Medicine","author":"AE Tollefson","year":"2007"},{"key":"ppat.1008017.ref125","volume-title":"Principles of Virology","author":"SJ Flint","year":"2009","edition":"3rd ed."},{"key":"ppat.1008017.ref126","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.bbrc.2006.07.007","article-title":"RILP interacts with the VPS22 component of the ESCRT-II complex","volume":"347","author":"C Progida","year":"2006","journal-title":"Biochem Biophys Res Comm"},{"key":"ppat.1008017.ref127","first-page":"87","article-title":"A new method of preparing gold probes for multiple-labelling cytochemistry","volume":"38","author":"J Slot","year":"1985","journal-title":"Eur J Cell Biol"},{"key":"ppat.1008017.ref128","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-biophys-042910-155404","article-title":"Molecular mechanisms of ubiquitin-dependent membrane traffic","volume":"40","author":"JH Hurley","year":"2011","journal-title":"Ann Rev Biophysics"},{"key":"ppat.1008017.ref129","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1242\/jcs.129270","article-title":"Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L","volume":"126","author":"R van der Kant","year":"2013","journal-title":"J Cell Sci"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008017","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T00:00:00Z","timestamp":1567036800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.ppat.1008017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T22:27:42Z","timestamp":1664144862000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008017"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Hearing","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,19]]},"references-count":129,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008017","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1008017","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,19]]}}}