{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:14:29Z","timestamp":1772226869718,"version":"3.50.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008055","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T13:28:35Z","timestamp":1573133315000},"page":"e1008055","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chlamydia trachomatis and human herpesvirus 6 infections in ovarian cancer\u2014Casual or causal?"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8511-1065","authenticated-orcid":true,"given":"Nitish","family":"Gulve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-6991","authenticated-orcid":true,"given":"Thomas","family":"Rudel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"issue":"22","key":"ppat.1008055.ref001","doi-asserted-by":"crossref","first-page":"36225","DOI":"10.18632\/oncotarget.16717","article-title":"The ovarian cancer oncobiome","volume":"8","author":"S Banerjee","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"ppat.1008055.ref002","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1007\/s10096-012-1570-5","article-title":"Viral and bacterial aetiologies of epithelial ovarian cancer","volume":"31","author":"S Shanmughapriya","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"3","key":"ppat.1008055.ref003","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/OLQ.0b013e318286bb53","article-title":"Sexually transmitted infections among US women and men: prevalence and incidence estimates, 2008","volume":"40","author":"CL Satterwhite","year":"2013","journal-title":"Sex Transm Dis"},{"issue":"6","key":"ppat.1008055.ref004","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro.2016.30","article-title":"Chlamydia cell biology and pathogenesis","volume":"14","author":"C Elwell","year":"2016","journal-title":"Nature Reviews Microbiology"},{"issue":"53","key":"ppat.1008055.ref005","doi-asserted-by":"crossref","first-page":"41637","DOI":"10.1074\/jbc.M110.137885","article-title":"Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1","volume":"285","author":"AA Abdul-Sater","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"ppat.1008055.ref006","doi-asserted-by":"crossref","first-page":"e12986","DOI":"10.1111\/cmi.12986","article-title":"Chlamydia trachomatis impairs host base excision repair by downregulating polymerase beta","volume":"21","author":"N Gulve","year":"2019","journal-title":"Cell Microbiol"},{"issue":"7","key":"ppat.1008055.ref007","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1093\/nar\/gkv222","article-title":"Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability","volume":"43","author":"E Markkanen","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"ppat.1008055.ref008","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1073\/pnas.131009198","article-title":"Single-strand interruptions in replicating chromosomes cause double-strand breaks","volume":"98","author":"A Kuzminov","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ppat.1008055.ref009","doi-asserted-by":"crossref","first-page":"e1004033","DOI":"10.1371\/journal.pgen.1004033","article-title":"Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation","volume":"9","author":"BK Prusty","year":"2013","journal-title":"PLoS Genet"},{"issue":"6","key":"ppat.1008055.ref010","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.chom.2013.05.010","article-title":"Chlamydia Infection Promotes Host DNA Damage and Proliferation but Impairs the DNA Damage Response","volume":"13","author":"C Chumduri","year":"2013","journal-title":"Cell Host & Microbe"},{"issue":"6","key":"ppat.1008055.ref011","article-title":"Chlamydia trachomatis Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling","volume":"9","author":"Y Mi","year":"2018","journal-title":"MBio"},{"issue":"8","key":"ppat.1008055.ref012","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ijmm.2013.06.001","article-title":"Chlamydia trachomatis inhibits telomeric DNA damage signaling via transient hTERT upregulation","volume":"303","author":"I Padberg","year":"2013","journal-title":"Int J Med Microbiol"},{"issue":"12","key":"ppat.1008055.ref013","doi-asserted-by":"crossref","first-page":"5563","DOI":"10.1073\/pnas.0913586107","article-title":"The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro","volume":"107","author":"JH Arbuckle","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"ppat.1008055.ref014","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1542\/peds.2007-2838","article-title":"Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection","volume":"122","author":"CB Hall","year":"2008","journal-title":"Pediatrics"},{"issue":"1","key":"ppat.1008055.ref015","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neurobiolaging.2013.06.024","article-title":"Herpes virus in Alzheimer's disease: relation to progression of the disease","volume":"35","author":"I Carbone","year":"2014","journal-title":"Neurobiology of Aging"},{"issue":"26","key":"ppat.1008055.ref016","doi-asserted-by":"crossref","first-page":"8058","DOI":"10.1073\/pnas.1502741112","article-title":"Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris","volume":"112","author":"A Gravel","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ppat.1008055.ref017","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/cid\/cit358","article-title":"Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study","volume":"57","author":"M Ogata","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ppat.1008055.ref018","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41598-017-00658-y","article-title":"Chromosomal integration of HHV-6A during non-productive viral infection","volume":"7","author":"N Gulve","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"ppat.1008055.ref019","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1086\/510915","article-title":"Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy","volume":"195","author":"T Ikeda","year":"2007","journal-title":"J Infect Dis"},{"key":"ppat.1008055.ref020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41525-018-0064-5","article-title":"HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation","volume":"3","author":"BK Prusty","year":"2018","journal-title":"NPJ Genom Med"},{"issue":"19","key":"ppat.1008055.ref021","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1158\/1078-0432.CCR-10-0470","article-title":"Involvement of human herpesvirus-6 variant B in classic Hodgkin's lymphoma via DR7 oncoprotein","volume":"16","author":"A Lacroix","year":"2010","journal-title":"Clin Cancer Res"},{"issue":"10","key":"ppat.1008055.ref022","doi-asserted-by":"crossref","first-page":"e47427","DOI":"10.1371\/journal.pone.0047427","article-title":"Imbalanced oxidative stress causes chlamydial persistence during non-productive human herpes virus co-infection","volume":"7","author":"BK Prusty","year":"2012","journal-title":"PLoS ONE"},{"issue":"7","key":"ppat.1008055.ref023","article-title":"Chlamydia infection and ovarian cancer risk","volume":"19","author":"M Das","year":"2018","journal-title":"The Lancet Oncology"},{"issue":"6","key":"ppat.1008055.ref024","doi-asserted-by":"crossref","first-page":"753 e1","DOI":"10.1016\/j.ajog.2016.07.003","article-title":"Prevalence and factors associated with coinfection of human papillomavirus and Chlamydia trachomatis in adolescents and young women","volume":"215","author":"DR Nonato","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"ppat.1008055.ref025","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1099\/jmm.0.000245","article-title":"HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy","volume":"65","author":"S Seraceni","year":"2016","journal-title":"J Med Microbiol"},{"key":"ppat.1008055.ref026","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.ypmed.2011.08.017","article-title":"Epidemiology and burden of HPV infection and related diseases: Implications for prevention strategies","volume":"53","author":"JE Tota","year":"2011","journal-title":"Preventive Medicine"},{"issue":"5","key":"ppat.1008055.ref027","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/QCO.0b013e328349ac4f","article-title":"The company malaria keeps","volume":"24","author":"AM Moormann","year":"2011","journal-title":"Current Opinion in Infectious Diseases"},{"issue":"1","key":"ppat.1008055.ref028","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1016\/j.ejim.2013.04.005","article-title":"Additional data on Helicobacter pylori and hepatitis C virus infections and lymphoma association","volume":"25","author":"J Kountouras","year":"2014","journal-title":"Eur J Intern Med"},{"issue":"10","key":"ppat.1008055.ref029","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/MEG.0000000000000928","article-title":"Helicobacter pylori infection among patients with liver cirrhosis","volume":"29","author":"J Pogorzelska","year":"2017","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ppat.1008055.ref030","first-page":"147","article-title":"Prevalence of Helicobacter pylori and hepatitis C virus infections among non-Hodgkin\u2019s lymphoma patients in Southern Switzerland","volume":"85","author":"E Zucca","year":"2000","journal-title":"Haematologica"},{"issue":"1","key":"ppat.1008055.ref031","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6201","article-title":"Chlamydia infection depends on a functional MDM2-p53 axis","volume":"5","author":"E Gonz\u00e1lez","year":"2014","journal-title":"Nature Communications"},{"issue":"3","key":"ppat.1008055.ref032","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.celrep.2014.10.004","article-title":"Tumor suppressor p53 alters host cell metabolism to limit Chlamydia trachomatis infection","volume":"9","author":"C Siegl","year":"2014","journal-title":"Cell Rep"},{"issue":"4","key":"ppat.1008055.ref033","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.201608063","article-title":"Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission","volume":"216","author":"SR Chowdhury","year":"2017","journal-title":"The Journal of Cell Biology"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T13:28:46Z","timestamp":1573133326000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008055"}},"subtitle":[],"editor":[{"given":"June L.","family":"Round","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,7]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008055","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737173411.793569353","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,7]]}}}