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Rowe","year":"1970","journal-title":"J Virol"},{"issue":"suppl_2","key":"ppat.1008100.ref080","first-page":"W362","article-title":"ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins","volume":"34","author":"A Gattiker","year":"2006","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"ppat.1008100.ref081","doi-asserted-by":"crossref","first-page":"D344","DOI":"10.1093\/nar\/gks1067","article-title":"New and continuing developments at PROSITE","volume":"41","author":"A Bridge","year":"2012","journal-title":"Nucleic Acids Research"},{"issue":"17","key":"ppat.1008100.ref082","first-page":"2795","article-title":"Molecular insights into the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1","volume":"586","author":"M Sudol","year":"2012"},{"issue":"11","key":"ppat.1008100.ref083","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.3390\/v4112973","article-title":"Multifunctional Nature of the 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(U.S.).","year":"2009"},{"issue":"19","key":"ppat.1008100.ref113","doi-asserted-by":"crossref","first-page":"10314","DOI":"10.1128\/JVI.00842-09","article-title":"Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein 2 Interacts with a Host Protein Complex Involved in Mitochondrial Biogenesis and Intracellular Signaling","volume":"83","author":"CT Cornillez-Ty","year":"2009","journal-title":"J Virol"},{"issue":"1","key":"ppat.1008100.ref114","doi-asserted-by":"crossref","first-page":"e87293","DOI":"10.1371\/journal.pone.0087293","article-title":"Evaluating Strategies to Normalise Biological Replicates of Western Blot Data","volume":"9","author":"A Degasperi","year":"2014","journal-title":"PLoS ONE"},{"issue":"2","key":"ppat.1008100.ref115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1099\/0022-1317-14-2-177","article-title":"Determinants of Lymphocytic Choriomeningitis Interference","volume":"14","author":"RM Welsh","year":"1972","journal-title":"J Gen 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