{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:57:12Z","timestamp":1790773032633,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008101","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T00:00:00Z","timestamp":1577318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M02623X\/1"],"award-info":[{"award-number":["BB\/M02623X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/N002776\/1"],"award-info":[{"award-number":["BB\/N002776\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R012504\/1"],"award-info":[{"award-number":["BB\/R012504\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008101","type":"journal-article","created":{"date-parts":[[2019,12,26]],"date-time":"2019-12-26T13:41:01Z","timestamp":1577367661000},"page":"e1008101","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance"],"prefix":"10.1371","volume":"15","author":[{"given":"Helen E.","family":"McNeil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7212-3371","authenticated-orcid":true,"given":"Ilyas","family":"Alav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-1997","authenticated-orcid":true,"given":"Ricardo Corona","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda E.","family":"Rossiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Laycock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Legood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-3493","authenticated-orcid":true,"given":"Inderpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-8869","authenticated-orcid":true,"given":"Matthew","family":"Wand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-7592","authenticated-orcid":true,"given":"Mark A.","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-8924","authenticated-orcid":true,"given":"Vassiliy N.","family":"Bavro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-4253","authenticated-orcid":true,"given":"Jessica M. A.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,12,26]]},"reference":[{"issue":"10","key":"ppat.1008101.ref001","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2217\/fmb.14.66","article-title":"Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance","volume":"9","author":"JM Blair","year":"2014","journal-title":"Future Microbiol"},{"key":"ppat.1008101.ref002","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fmicb.2015.00513","article-title":"Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies","volume":"6","author":"MF Symmons","year":"2015","journal-title":"Front Microbiol"},{"key":"ppat.1008101.ref003","article-title":"Multidrug efflux pumps: structure, function and regulation","author":"D Du","year":"2018","journal-title":"Nat Rev Microbiol"},{"issue":"10","key":"ppat.1008101.ref004","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1128\/AAC.48.10.3729-3735.2004","article-title":"AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104","volume":"48","author":"S Baucheron","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ppat.1008101.ref005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jac\/dkh331","article-title":"Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibiotic-resistant Campylobacter jejuni","volume":"54","author":"L Pumbwe","year":"2004","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"23","key":"ppat.1008101.ref006","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1128\/AEM.01310-08","article-title":"Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation","volume":"74","author":"M Kvist","year":"2008","journal-title":"Applied and Environmental Microbiology"},{"issue":"10","key":"ppat.1008101.ref007","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/jac\/dks228","article-title":"Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm","volume":"67","author":"S Baugh","year":"2012","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"1","key":"ppat.1008101.ref008","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2958.2005.04940.x","article-title":"Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium","volume":"59","author":"K Nishino","year":"2006","journal-title":"Mol Microbiol"},{"issue":"5","key":"ppat.1008101.ref009","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1462-5822.2005.00671.x","article-title":"The AcrAB\u2013TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis","volume":"8","author":"AM Buckley","year":"2006","journal-title":"Cell Microbiol"},{"issue":"2","key":"ppat.1008101.ref010","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/jac\/dku380","article-title":"Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design","volume":"70","author":"JMA Blair","year":"2015","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"6","key":"ppat.1008101.ref011","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01916-16","article-title":"Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology","volume":"7","author":"MM Buckner","year":"2016","journal-title":"MBio"},{"issue":"11","key":"ppat.1008101.ref012","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1128\/IAI.00653-15","article-title":"MdsABC-Mediated Pathway for Pathogenicity in Salmonella enterica Serovar Typhimurium","volume":"83","author":"S Song","year":"2015","journal-title":"Infect Immun"},{"issue":"6","key":"ppat.1008101.ref013","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1128\/JB.182.6.1754-1756.2000","article-title":"AcrD of Escherichia coli is an aminoglycoside efflux pump","volume":"182","author":"EY Rosenberg","year":"2000","journal-title":"J Bacteriol"},{"issue":"1","key":"ppat.1008101.ref014","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1038\/s41598-017-08747-8","article-title":"Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters","volume":"7","author":"VK Ramaswamy","year":"2017","journal-title":"Sci Rep"},{"issue":"9","key":"ppat.1008101.ref015","doi-asserted-by":"crossref","first-page":"e108642","DOI":"10.1371\/journal.pone.0108642","article-title":"AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli","volume":"9","author":"T Horiyama","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"ppat.1008101.ref016","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1128\/JB.183.8.2646-2653.2001","article-title":"Suppression of hypersensitivity of Escherichia coli acrB mutant to organic solvents by integrational activation of the acrEF operon with the IS1 or IS2 element","volume":"183","author":"K Kobayashi","year":"2001","journal-title":"J Bacteriol"},{"issue":"6","key":"ppat.1008101.ref017","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ja.2011.28","article-title":"AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium","volume":"64","author":"S Yamasaki","year":"2011","journal-title":"J Antibiot (Tokyo)"},{"key":"ppat.1008101.ref018","article-title":"Redundancy in the periplasmic adaptor proteins AcrA and AcrE provides resilience and an ability to export substrates of multidrug efflux","author":"HE Smith","year":"2014","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"22","key":"ppat.1008101.ref019","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1128\/JB.187.22.7815-7825.2005","article-title":"Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC","volume":"187","author":"SY Lau","year":"2005","journal-title":"J Bacteriol"},{"issue":"7","key":"ppat.1008101.ref020","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/jac\/dkq160","article-title":"TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium","volume":"65","author":"T Horiyama","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"ppat.1008101.ref021","article-title":"Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump","author":"N Abdali","year":"2016","journal-title":"ACS Infect Dis"},{"issue":"9","key":"ppat.1008101.ref022","doi-asserted-by":"crossref","first-page":"e1002552","DOI":"10.1371\/journal.pbio.1002552","article-title":"Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy","volume":"14","author":"DH Ayhan","year":"2016","journal-title":"PLoS Biol"},{"issue":"7501","key":"ppat.1008101.ref023","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature13205","article-title":"Structure of the AcrAB-TolC multidrug efflux pump","volume":"509","author":"D Du","year":"2014","journal-title":"Nature"},{"key":"ppat.1008101.ref024","first-page":"6","article-title":"An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump","author":"Z Wang","year":"2017","journal-title":"Elife"},{"key":"ppat.1008101.ref025","doi-asserted-by":"crossref","first-page":"17070","DOI":"10.1038\/nmicrobiol.2017.70","article-title":"Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump","volume":"2","author":"AWP Fitzpatrick","year":"2017","journal-title":"Nat Microbiol"},{"key":"ppat.1008101.ref026","doi-asserted-by":"crossref","first-page":"10731","DOI":"10.1038\/ncomms10731","article-title":"Tripartite assembly of RND multidrug efflux pumps","volume":"7","author":"L Daury","year":"2016","journal-title":"Nat Commun"},{"issue":"4","key":"ppat.1008101.ref027","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.chembiol.2011.02.011","article-title":"Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC","volume":"18","author":"EB Tikhonova","year":"2011","journal-title":"Chem Biol"},{"issue":"7335","key":"ppat.1008101.ref028","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nature09743","article-title":"Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli","volume":"470","author":"CC Su","year":"2011","journal-title":"Nature"},{"issue":"3","key":"ppat.1008101.ref029","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.jmb.2003.10.069","article-title":"Identification of protein-protein interaction sites from docking energy landscapes","volume":"335","author":"J Fernandez-Recio","year":"2004","journal-title":"J Mol Biol"},{"issue":"17","key":"ppat.1008101.ref030","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1073\/pnas.0900693106","article-title":"The assembled structure of a complete tripartite bacterial multidrug efflux pump","volume":"106","author":"MF Symmons","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"ppat.1008101.ref031","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1128\/JB.00535-16","article-title":"Opening the Channel: the Two Functional Interfaces of Pseudomonas aeruginosa OpmH with the Triclosan Efflux Pump TriABC","volume":"198","author":"AT Ntreh","year":"2016","journal-title":"J Bacteriol"},{"issue":"3","key":"ppat.1008101.ref032","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.str.2005.11.015","article-title":"Conformational flexibility in the multidrug efflux system protein AcrA","volume":"14","author":"J Mikolosko","year":"2006","journal-title":"Structure"},{"issue":"24","key":"ppat.1008101.ref033","doi-asserted-by":"crossref","first-page":"11038","DOI":"10.1073\/pnas.1003908107","article-title":"Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems","volume":"107","author":"F De Angelis","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ppat.1008101.ref034","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.jmb.2009.02.048","article-title":"Crystal structure of the periplasmic component of a tripartite macrolide-specific efflux pump","volume":"387","author":"S Yum","year":"2009","journal-title":"J Mol Biol"},{"issue":"21","key":"ppat.1008101.ref035","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1128\/JB.00756-13","article-title":"MacA, a periplasmic membrane fusion protein of the macrolide transporter MacAB-TolC, binds lipopolysaccharide core specifically and with high affinity","volume":"195","author":"S Lu","year":"2013","journal-title":"J Bacteriol"},{"issue":"4","key":"ppat.1008101.ref036","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1365-2958.2011.07744.x","article-title":"The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter","volume":"81","author":"SD Modali","year":"2011","journal-title":"Mol Microbiol"},{"issue":"2","key":"ppat.1008101.ref037","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.str.2015.12.007","article-title":"Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC","volume":"24","author":"H Jeong","year":"2016","journal-title":"Structure"},{"issue":"5791","key":"ppat.1008101.ref038","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.1131542","article-title":"Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism","volume":"313","author":"MA Seeger","year":"2006","journal-title":"Science"},{"issue":"7108","key":"ppat.1008101.ref039","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature05076","article-title":"Crystal structures of a multidrug transporter reveal a functionally rotating mechanism","volume":"443","author":"S Murakami","year":"2006","journal-title":"Nature"},{"issue":"23","key":"ppat.1008101.ref040","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1016\/j.febslet.2015.10.003","article-title":"Computational prediction of protein interfaces: A review of data driven methods","volume":"589","author":"LC Xue","year":"2015","journal-title":"FEBS Lett"},{"issue":"7","key":"ppat.1008101.ref041","doi-asserted-by":"crossref","first-page":"e40460","DOI":"10.1371\/journal.pone.0040460","article-title":"Membrane fusion proteins of type I secretion system and tripartite efflux pumps share a binding motif for TolC in gram-negative bacteria","volume":"7","author":"M Lee","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"ppat.1008101.ref042","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbapap.2008.10.010","article-title":"Structural and functional diversity of bacterial membrane fusion proteins","volume":"1794","author":"HI Zgurskaya","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ppat.1008101.ref043","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/jac\/dkp234","article-title":"Only for substrate antibiotics are a functional AcrAB-TolC efflux pump and RamA required to select multidrug-resistant Salmonella Typhimurium","volume":"64","author":"V Ricci","year":"2009","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"ppat.1008101.ref044","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1128\/AAC.50.1.38-42.2006","article-title":"Ciprofloxacin-Resistant Salmonella enterica Serovar Typhimurium Strains Are Difficult To Select in the Absence of AcrB and TolC","volume":"50","author":"V Ricci","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"8","key":"ppat.1008101.ref045","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro1464","article-title":"Multidrug-resistance efflux pumps\u2014not just for resistance","volume":"4","author":"LJ Piddock","year":"2006","journal-title":"Nat Rev Microbiol"},{"issue":"8","key":"ppat.1008101.ref046","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tim.2014.04.007","article-title":"Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success","volume":"22","author":"LS Redgrave","year":"2014","journal-title":"Trends Microbiol"},{"issue":"5","key":"ppat.1008101.ref047","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/jac\/dkp311","article-title":"Periplasmic adaptor protein AcrA has a distinct role in the antibiotic resistance and virulence of Salmonella enterica serovar Typhimurium","volume":"64","author":"JM Blair","year":"2009","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"ppat.1008101.ref048","doi-asserted-by":"crossref","first-page":"702","DOI":"10.2174\/1389450116666151001103948","article-title":"Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria","volume":"17","author":"Y Wang","year":"2016","journal-title":"Curr Drug Targets"},{"issue":"1","key":"ppat.1008101.ref049","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41467-019-09463-9","article-title":"Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism","volume":"10","author":"K Tsutsumi","year":"2019","journal-title":"Nat Commun"},{"issue":"23","key":"ppat.1008101.ref050","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1128\/JB.184.23.6499-6507.2002","article-title":"Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria","volume":"184","author":"EB Tikhonova","year":"2002","journal-title":"J Bacteriol"},{"issue":"2","key":"ppat.1008101.ref051","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1128\/JB.01276-07","article-title":"Fitting periplasmic membrane fusion proteins to inner membrane transporters: mutations that enable Escherichia coli AcrA to function with Pseudomonas aeruginosa MexB","volume":"190","author":"G Krishnamoorthy","year":"2008","journal-title":"J Bacteriol"},{"issue":"7460","key":"ppat.1008101.ref052","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature12300","article-title":"Structural basis for the inhibition of bacterial multidrug exporters","volume":"500","author":"R Nakashima","year":"2013","journal-title":"Nature"},{"issue":"5","key":"ppat.1008101.ref053","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/mmi.12508","article-title":"Genetic assessment of the role of AcrB beta-hairpins in the assembly of the TolC-AcrAB multidrug efflux pump of Escherichia coli","volume":"91","author":"JW Weeks","year":"2014","journal-title":"Mol Microbiol"},{"issue":"13","key":"ppat.1008101.ref054","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1128\/JB.00204-09","article-title":"The C-terminal domain of AcrA is essential for the assembly and function of the multidrug efflux pump AcrAB-TolC","volume":"191","author":"Q Ge","year":"2009","journal-title":"J Bacteriol"},{"issue":"2","key":"ppat.1008101.ref055","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/jac\/dku380","article-title":"Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design","volume":"70","author":"JM Blair","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"ppat.1008101.ref056","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00968-17","article-title":"Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium","volume":"8","author":"X Wang-Kan","year":"2017","journal-title":"MBio"},{"issue":"1","key":"ppat.1008101.ref057","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1089\/mdr.2016.0207","article-title":"Upregulation of AcrEF in Quinolone Resistance Development in Escherichia coli When AcrAB-TolC Function Is Impaired","volume":"24","author":"CZ Zhang","year":"2018","journal-title":"Microb Drug Resist"},{"issue":"13","key":"ppat.1008101.ref058","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1093\/nar\/gkg556","article-title":"ESPript\/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteins","volume":"31","author":"P Gouet","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"24","key":"ppat.1008101.ref059","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1093\/bioinformatics\/btm474","article-title":"InterProSurf: a web server for predicting interacting sites on protein surfaces","volume":"23","author":"SS Negi","year":"2007","journal-title":"Bioinformatics"},{"issue":"Pt 4","key":"ppat.1008101.ref060","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"P Emsley","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"issue":"W1","key":"ppat.1008101.ref061","doi-asserted-by":"crossref","first-page":"W344","DOI":"10.1093\/nar\/gkw408","article-title":"ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules","volume":"44","author":"H Ashkenazy","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ppat.1008101.ref062","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"J Yang","year":"2015","journal-title":"Nat Methods"},{"issue":"2","key":"ppat.1008101.ref063","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0034-5288(18)32968-0","article-title":"Experimental Salmonella typhimurium infection in calves","volume":"25","author":"C Wray","year":"1978","journal-title":"Res Vet Sci"},{"issue":"12","key":"ppat.1008101.ref064","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"KA Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ppat.1008101.ref065","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/jac\/dkq169","article-title":"A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli","volume":"65","author":"NG Coldham","year":"2010","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"ppat.1008101.ref066","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/jac\/48.6.787","article-title":"Accumulation of five fluoroquinolones by Mycobacterium tuberculosis H37Rv","volume":"48","author":"LJ Piddock","year":"2001","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"ppat.1008101.ref067","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2180-11-11","article-title":"Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis","volume":"11","author":"ME Wand","year":"2011","journal-title":"BMC Microbiol"},{"issue":"6907","key":"ppat.1008101.ref068","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nature01050","article-title":"Crystal structure of bacterial multidrug efflux transporter AcrB","volume":"419","author":"S Murakami","year":"2002","journal-title":"Nature"},{"key":"ppat.1008101.ref069","first-page":"3","article-title":"Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB","author":"T Eicher","year":"2014","journal-title":"Elife"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008101","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T13:35:49Z","timestamp":1579700149000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008101"}},"subtitle":[],"editor":[{"given":"David S.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,26]]},"references-count":69,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008101","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,26]]}}}