{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:36:25Z","timestamp":1791333385614,"version":"4.3.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008371","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000}}],"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS043097"],"award-info":[{"award-number":["R01NS043097"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P01NS065719"],"award-info":[{"award-number":["P01NS065719"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008371","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T18:37:47Z","timestamp":1583347067000},"page":"e1008371","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-5159","authenticated-orcid":true,"given":"Bethany A.","family":"O\u2019Hara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Morris-Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0403-3240","authenticated-orcid":true,"given":"Gretchen V.","family":"Gee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-5668","authenticated-orcid":true,"given":"Sheila A.","family":"Haley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-9073","authenticated-orcid":true,"given":"Walter J.","family":"Atwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"issue":"1","key":"ppat.1008371.ref001","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-virology-101416-041439","article-title":"Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain Disease","volume":"4","author":"SA Haley","year":"2017","journal-title":"Annu Rev Virol"},{"issue":"10","key":"ppat.1008371.ref002","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1473-3099(09)70226-9","article-title":"Progressive multifocal leukoencephalopathy in HIV-1 infection","volume":"9","author":"P Cinque","year":"2009","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"ppat.1008371.ref003","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1056\/NEJMp0906248","article-title":"Reemergence of PML in natalizumab-treated patients\u2014new cases, same concerns","volume":"361","author":"EO Major","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"ppat.1008371.ref004","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/JVI.51.2.458-469.1984","article-title":"Human polyomavirus JC virus genome","volume":"51","author":"RJ Frisque","year":"1984","journal-title":"J Virol"},{"issue":"3","key":"ppat.1008371.ref005","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1128\/CMR.05031-11","article-title":"Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain","volume":"25","author":"MW Ferenczy","year":"2012","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"ppat.1008371.ref006","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJMc055235","article-title":"Natalizumab and progressive multifocal leukoencephalopathy","volume":"353","author":"B Adelman","year":"2005","journal-title":"N Engl J Med"},{"issue":"6","key":"ppat.1008371.ref007","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s13365-015-0392-5","article-title":"2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment","volume":"21","author":"AC Patera","year":"2015","journal-title":"J Neurovirol"},{"issue":"4","key":"ppat.1008371.ref008","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s13365-016-0427-6","article-title":"Reassessing the risk of natalizumab-associated PML","volume":"22","author":"JR Berger","year":"2016","journal-title":"J Neurovirol"},{"issue":"3","key":"ppat.1008371.ref009","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1212\/NXI.0000000000000235","article-title":"A link between long-term natalizumab dosing in MS and PML: Putting the puzzle together","volume":"3","author":"EO Major","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"ppat.1008371.ref010","first-page":"1577","article-title":"Central Nervous System Infections With Immunomodulatory Therapies","volume":"21","author":"EM Williamson","year":"2015","journal-title":"Continuum (Minneap Minn)"},{"issue":"3","key":"ppat.1008371.ref011","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s40263-015-0226-2","article-title":"Infection risk in patients on multiple sclerosis therapeutics","volume":"29","author":"EM Williamson","year":"2015","journal-title":"CNS Drugs"},{"issue":"12","key":"ppat.1008371.ref012","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1128\/JVI.00489-15","article-title":"The Greater Affinity of JC Polyomavirus Capsid for alpha2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity","volume":"89","author":"LJ Stroh","year":"2015","journal-title":"J Virol"},{"issue":"24","key":"ppat.1008371.ref013","doi-asserted-by":"crossref","first-page":"13490","DOI":"10.1128\/JVI.02252-13","article-title":"5-HT2 receptors facilitate JC polyomavirus entry","volume":"87","author":"B Assetta","year":"2013","journal-title":"J Virol"},{"issue":"5700","key":"ppat.1008371.ref014","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1126\/science.1103492","article-title":"The human polyomavirus, JCV, uses serotonin receptors to infect cells","volume":"306","author":"GF Elphick","year":"2004","journal-title":"Science"},{"issue":"4","key":"ppat.1008371.ref015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.chom.2010.09.004","article-title":"Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif","volume":"8","author":"U Neu","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"7","key":"ppat.1008371.ref016","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.celrep.2019.04.067","article-title":"Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus","volume":"27","author":"B Assetta","year":"2019","journal-title":"Cell Rep"},{"issue":"8","key":"ppat.1008371.ref017","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1016\/j.ajpath.2015.04.003","article-title":"Human polyomavirus receptor distribution in brain parenchyma contrasts with receptor distribution in kidney and choroid plexus","volume":"185","author":"SA Haley","year":"2015","journal-title":"Am J Pathol"},{"issue":"2","key":"ppat.1008371.ref018","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/infdis\/jir256","article-title":"Sequencing and analysis of JC virus DNA from natalizumab-treated PML patients","volume":"204","author":"CE Reid","year":"2011","journal-title":"J Infect Dis"},{"issue":"1","key":"ppat.1008371.ref019","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/infdis\/jir198","article-title":"Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity","volume":"204","author":"L Gorelik","year":"2011","journal-title":"J Infect Dis"},{"issue":"2","key":"ppat.1008371.ref020","doi-asserted-by":"crossref","first-page":"e1000368","DOI":"10.1371\/journal.pgen.1000368","article-title":"Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML)","volume":"5","author":"SR Sunyaev","year":"2009","journal-title":"PLoS Genet"},{"key":"ppat.1008371.ref021","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-60761-938-3_4","article-title":"The blood-cerebrospinal fluid barrier: structure and functional significance","volume":"686","author":"CE Johanson","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"10","key":"ppat.1008371.ref022","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.15252\/emmm.201606271","article-title":"Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles","volume":"8","author":"S Balusu","year":"2016","journal-title":"EMBO Mol Med"},{"issue":"6","key":"ppat.1008371.ref023","doi-asserted-by":"crossref","first-page":"e1001874","DOI":"10.1371\/journal.pbio.1001874","article-title":"Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation","volume":"12","author":"K Ridder","year":"2014","journal-title":"PLoS Biol"},{"issue":"1","key":"ppat.1008371.ref024","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12974-017-1038-8","article-title":"In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation","volume":"15","author":"JJ Li","year":"2018","journal-title":"J Neuroinflammation"},{"issue":"2","key":"ppat.1008371.ref025","doi-asserted-by":"crossref","first-page":"e00437","DOI":"10.1128\/mBio.00437-16","article-title":"The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis","volume":"7","author":"DR Wilcox","year":"2016","journal-title":"MBio"},{"key":"ppat.1008371.ref026","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/ncomms3123","article-title":"Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma","volume":"4","author":"M Grapp","year":"2013","journal-title":"Nat Commun"},{"issue":"8","key":"ppat.1008371.ref027","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00105-18","article-title":"Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus","volume":"92","author":"BA O'Hara","year":"2018","journal-title":"J Virol"},{"issue":"1","key":"ppat.1008371.ref028","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/ana.24192","article-title":"A fatal case of JC virus meningitis presenting with hydrocephalus in a human immunodeficiency virus-seronegative patient","volume":"76","author":"SP Agnihotri","year":"2014","journal-title":"Ann Neurol"},{"issue":"4","key":"ppat.1008371.ref029","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s13365-019-00753-y","article-title":"JC virus infection of meningeal and choroid plexus cells in patients with progressive multifocal leukoencephalopathy","volume":"25","author":"SM Corbridge","year":"2019","journal-title":"J Neurovirol"},{"issue":"4","key":"ppat.1008371.ref030","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4103\/1673-5374.180372","article-title":"The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier","volume":"11","author":"S Balusu","year":"2016","journal-title":"Neural Regen Res"},{"issue":"1","key":"ppat.1008371.ref031","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2009.07.031","article-title":"The blood-brain barrier and immune function and dysfunction","volume":"37","author":"WA Banks","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"2","key":"ppat.1008371.ref032","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00379-19","article-title":"JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells","volume":"10","author":"J Morris-Love","year":"2019","journal-title":"MBio"},{"key":"ppat.1008371.ref033","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fimmu.2015.00159","article-title":"Immune System Involvement in the Pathogenesis of JC Virus Induced PML: What is Learned from Studies of Patients with Underlying Diseases and Therapies as Risk Factors","volume":"6","author":"MC Monaco","year":"2015","journal-title":"Front Immunol"},{"issue":"5","key":"ppat.1008371.ref034","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.celrep.2017.10.027","article-title":"Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses","volume":"21","author":"EM Geoghegan","year":"2017","journal-title":"Cell Rep"},{"issue":"306","key":"ppat.1008371.ref035","doi-asserted-by":"crossref","first-page":"306ra151","DOI":"10.1126\/scitranslmed.aab1720","article-title":"JC polyomavirus mutants escape antibody-mediated neutralization","volume":"7","author":"U Ray","year":"2015","journal-title":"Sci Transl Med"},{"issue":"2","key":"ppat.1008371.ref036","doi-asserted-by":"crossref","first-page":"e1007594","DOI":"10.1371\/journal.ppat.1007594","article-title":"Picornavirus infection induces temporal release of multiple extracellular vesicle subsets that differ in molecular composition and infectious potential","volume":"15","author":"SG van der Grein","year":"2019","journal-title":"PLoS Pathog"},{"key":"ppat.1008371.ref037","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.semcdb.2017.03.005","article-title":"Herpesviruses hijack host exosomes for viral pathogenesis","volume":"67","author":"S Sadeghipour","year":"2017","journal-title":"Semin Cell Dev Biol"},{"issue":"7445","key":"ppat.1008371.ref038","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature12029","article-title":"A pathogenic picornavirus acquires an envelope by hijacking cellular membranes","volume":"496","author":"Z Feng","year":"2013","journal-title":"Nature"},{"issue":"1","key":"ppat.1008371.ref039","doi-asserted-by":"crossref","first-page":"14787","DOI":"10.1038\/s41598-017-14817-8","article-title":"Exosomes Derived from HIV-1 Infected DCs Mediate Viral trans-Infection via Fibronectin and Galectin-3","volume":"7","author":"R Kulkarni","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"ppat.1008371.ref040","doi-asserted-by":"crossref","first-page":"e1006764","DOI":"10.1371\/journal.ppat.1006764","article-title":"Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells","volume":"14","author":"W Zhou","year":"2018","journal-title":"PLoS Pathog"},{"issue":"3","key":"ppat.1008371.ref041","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.chom.2009.06.009","article-title":"Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells","volume":"6","author":"C Muratori","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ppat.1008371.ref042","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.chom.2018.07.006","article-title":"Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission","volume":"24","author":"M Santiana","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ppat.1008371.ref043","article-title":"JC Virus Infects Neurons and Glial Cells in the Hippocampus","author":"C Wuthrich","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"issue":"7","key":"ppat.1008371.ref044","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1089\/dna.2015.2884","article-title":"Modulation of cellular function through immune-activated exosomes","volume":"34","author":"L Pulliam","year":"2015","journal-title":"DNA Cell Biol"},{"key":"ppat.1008371.ref045","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.omtn.2018.09.019","article-title":"Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration","volume":"13","author":"G Hu","year":"2018","journal-title":"Mol Ther Nucleic Acids"},{"issue":"9","key":"ppat.1008371.ref046","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nrmicro.2017.60","article-title":"Viral effects on the content and function of extracellular vesicles","volume":"15","author":"N Raab-Traub","year":"2017","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"ppat.1008371.ref047","doi-asserted-by":"crossref","first-page":"e1927","DOI":"10.1002\/rmv.1927","article-title":"Polyomavirus microRNAs circulating in biological fluids during viral persistence","volume":"27","author":"F Martelli","year":"2017","journal-title":"Rev Med Virol"},{"issue":"9","key":"ppat.1008371.ref048","doi-asserted-by":"crossref","DOI":"10.3390\/v10090466","article-title":"BK Polyomavirus MicroRNA Levels in Exosomes Are Modulated by Non-Coding Control Region Activity and Down-Regulate Viral Replication When Delivered to Non-Infected Cells Prior to Infection","volume":"10","author":"F Martelli","year":"2018","journal-title":"Viruses"},{"key":"ppat.1008371.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcv.2015.06.104","article-title":"The JCPYV DNA load inversely correlates with the viral microrna expression in blood and cerebrospinal fluid of patients at risk of PML","volume":"70","author":"A Rocca","year":"2015","journal-title":"J Clin Virol"},{"key":"ppat.1008371.ref050","article-title":"HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture","author":"G Hu","year":"2019","journal-title":"J Neuroimmune Pharmacol"},{"key":"ppat.1008371.ref051","article-title":"Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease","author":"L Pulliam","year":"2019","journal-title":"J Neurovirol"},{"key":"ppat.1008371.ref052","doi-asserted-by":"crossref","DOI":"10.1007\/7854_2019_100","article-title":"Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV\/AIDS","author":"N Fernandes","year":"2019","journal-title":"Curr Top Behav Neurosci"},{"key":"ppat.1008371.ref053","article-title":"Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics","author":"S Sil","year":"2019","journal-title":"J Neuroimmune Pharmacol"},{"issue":"4","key":"ppat.1008371.ref054","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1073\/pnas.82.4.1257","article-title":"Establishment of a line of human fetal glial cells that supports JC virus multiplication","volume":"82","author":"EO Major","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ppat.1008371.ref055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0042-6822(89)90425-X","article-title":"Extension of JC virus host range to monkey cells by insertion of a simian virus 40 enhancer into the JC virus regulatory region","volume":"170","author":"DA Vacante","year":"1989","journal-title":"Virology"},{"key":"ppat.1008371.ref056","first-page":"9","article-title":"Propagation and assay of the JC virus","volume":"165","author":"CK Liu","year":"2001","journal-title":"Methods Mol Biol"},{"issue":"6","key":"ppat.1008371.ref057","doi-asserted-by":"crossref","first-page":"e00729","DOI":"10.1128\/mBio.00729-13","article-title":"A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses","volume":"4","author":"CD Nelson","year":"2013","journal-title":"MBio"},{"key":"ppat.1008371.ref058","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","author":"C Thery","year":"2006","journal-title":"Curr Protoc Cell Biol"},{"issue":"5","key":"ppat.1008371.ref059","doi-asserted-by":"crossref","first-page":"F1365","DOI":"10.1152\/ajprenal.90405.2008","article-title":"hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics","volume":"295","author":"M Wieser","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"ppat.1008371.ref060","doi-asserted-by":"crossref","first-page":"26913","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles","volume":"3","author":"J Lotvall","year":"2014","journal-title":"J Extracell Vesicles"},{"issue":"1","key":"ppat.1008371.ref061","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/13550289509111009","article-title":"Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells","volume":"1","author":"WJ Atwood","year":"1995","journal-title":"J Neurovirol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008371","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T17:38:13Z","timestamp":1584380293000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008371"}},"subtitle":[],"editor":[{"given":"David","family":"Ornelles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,4]]},"references-count":61,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008371","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1008371","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,4]]}}}