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Graf","year":"2019","journal-title":"DMM Dis Model Mech"},{"issue":"7","key":"ppat.1008478.ref124","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nm.3871","article-title":"Activation of HIF-1\u03b1 and LL-37 by commensal bacteria inhibits Candida albicans colonization","volume":"21","author":"D Fan","year":"2015","journal-title":"Nature Medicine"},{"issue":"8","key":"ppat.1008478.ref125","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1128\/IAI.00096-09","article-title":"The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells","volume":"77","author":"JA Gaddy","year":"2009","journal-title":"Infect Immun"},{"issue":"1","key":"ppat.1008478.ref126","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1128\/IAI.01059-15","article-title":"Morphology-independent virulence of Candida species during polymicrobial intra-abdominal infections with Staphylococcus aureus","volume":"84","author":"EE Nash","year":"2015","journal-title":"Infect Immun"},{"issue":"3","key":"ppat.1008478.ref127","first-page":"e00910","article-title":"Candida albicans augments Staphylococcus aureus virulence by engaging the staphylococcal agr quorum sensing system","volume":"10","author":"OA Todd","year":"2019","journal-title":"mBio"},{"issue":"Pt 1","key":"ppat.1008478.ref128","first-page":"168","article-title":"Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue","volume":"161","author":"LM Schlecht","year":"2015","journal-title":"Microbiol (United Kingdom)"},{"key":"ppat.1008478.ref129","volume-title":"Curr Top Microbiol Immunol","author":"DS Childers","year":"2019"},{"issue":"6","key":"ppat.1008478.ref130","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1439-0507.2008.01597.x","article-title":"Complement and fungal pathogens: An update","volume":"51","author":"C Speth","year":"2008","journal-title":"Mycoses"},{"issue":"12","key":"ppat.1008478.ref131","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1371\/journal.ppat.0020129","article-title":"Fungal invasion of normally non-phagocytic host cells","volume":"2","author":"SG Filler","year":"2006","journal-title":"PLoS Pathog"},{"issue":"4","key":"ppat.1008478.ref132","doi-asserted-by":"crossref","first-page":"e01334","DOI":"10.1128\/mBio.01334-14","article-title":"Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes","volume":"5","author":"D Kaloriti","year":"2014","journal-title":"mBio"},{"issue":"6","key":"ppat.1008478.ref133","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.4049\/jimmunol.1003730","article-title":"The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation","volume":"187","author":"K Seider","year":"2011","journal-title":"J Immunol"},{"issue":"10","key":"ppat.1008478.ref134","doi-asserted-by":"crossref","first-page":"e1003634","DOI":"10.1371\/journal.ppat.1003634","article-title":"NADPH Oxidase-Driven Phagocyte Recruitment Controls Candida albicans Filamentous Growth and Prevents Mortality","volume":"9","author":"KM Brothers","year":"2013","journal-title":"PLoS Pathog"},{"issue":"2","key":"ppat.1008478.ref135","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/biof.1150","article-title":"Peroxynitrite, a potent macrophage-derived oxidizing cytotoxin to combat invading pathogens","volume":"40","author":"C Prolo","year":"2014","journal-title":"BioFactors"},{"issue":"2","key":"ppat.1008478.ref136","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1091\/mbc.e05-06-0501","article-title":"Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen 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Zhang","year":"2000","journal-title":"Mol Microbiol"},{"issue":"19","key":"ppat.1008478.ref143","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1128\/MCB.00313-10","article-title":"Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans","volume":"30","author":"A da Silva Dantas","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"2","key":"ppat.1008478.ref144","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1128\/EC.00240-07","article-title":"CTA4 transcription factor mediates induction of nitrosative stress response in Candida albicans","volume":"7","author":"W Chiranand","year":"2008","journal-title":"Eukaryot Cell"},{"issue":"4","key":"ppat.1008478.ref145","first-page":"1051","article-title":"Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model","volume":"6","author":"GM Chaves","year":"2007","journal-title":"Genetics and Molecular Research"},{"issue":"Pt 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