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Stein","year":"2003","journal-title":"Traffic"},{"key":"ppat.1008482.ref075","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/S0076-6879(05)03055-7","article-title":"Interaction and functional analyses of human VPS34\/p150 phosphatidylinositol 3-kinase complex with Rab7","volume":"403","author":"MP Stein","year":"2005","journal-title":"Methods Enzymol"},{"key":"ppat.1008482.ref076","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.bbabio.2009.01.019","article-title":"Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells","volume":"1787","author":"EJ Griffiths","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ppat.1008482.ref077","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis","volume":"43","author":"C Wang","year":"2009","journal-title":"Annu Rev Genet"},{"key":"ppat.1008482.ref078","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tem.2014.06.007","article-title":"Stress-responsive regulation of mitochondria through the ER unfolded protein response","volume":"25","author":"TK Rainbolt","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"ppat.1008482.ref079","first-page":"201914732","article-title":"Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii","volume":"5","author":"A Rosenberg","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"ppat.1008482.ref080","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4269\/ajtmh.1993.49.485","article-title":"Morphologic effects of artemisinin in Plasmodium falciparum","volume":"49","author":"Y Maeno","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"ppat.1008482.ref081","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/infdis\/jiv048","article-title":"Mitochondrial membrane potential in a small subset of artemisinin-induced dormant Plasmodium falciparum parasites in vitro","volume":"212","author":"CL Peatey","year":"2015","journal-title":"J Infect Dis"},{"key":"ppat.1008482.ref082","doi-asserted-by":"crossref","first-page":"e9582","DOI":"10.1371\/journal.pone.0009582","article-title":"Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation.","volume":"5","author":"J Wang","year":"2010","journal-title":"PLoS One"},{"key":"ppat.1008482.ref083","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molbiopara.2015.11.002","article-title":"Comparison of methods probing the intracellular redox milieu in Plasmodium falciparum","volume":"206","author":"F Mohring","year":"2016","journal-title":"Mol Biochem Parasitol"},{"key":"ppat.1008482.ref084","doi-asserted-by":"crossref","first-page":"10449","DOI":"10.1038\/s41598-017-10093-8","article-title":"Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.","volume":"7","author":"M Rahbari","year":"2017","journal-title":"Sci Rep"},{"key":"ppat.1008482.ref085","doi-asserted-by":"crossref","first-page":"8716","DOI":"10.1073\/pnas.96.15.8716","article-title":"A set of independent selectable markers for transfection of the human malaria parasite Plasmodium falciparum","volume":"96","author":"CB Mamoun","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008482.ref086","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nmeth904","article-title":"Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase.","volume":"3","author":"LJ Nkrumah","year":"2006","journal-title":"Nat Methods."},{"key":"ppat.1008482.ref087","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1124\/mol.54.6.1140","article-title":"Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase","volume":"54","author":"DA Fidock","year":"1998","journal-title":"Mol Pharmacol"},{"key":"ppat.1008482.ref088","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1096\/fj.11-187401","article-title":"Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches","volume":"25","author":"EH Ekland","year":"2011","journal-title":"FASEB J"},{"key":"ppat.1008482.ref089","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1021\/acsinfecdis.8b00140","article-title":"Stable integration and comparison of hGrx1-roGFP2 and sfroGFP2 redox probes in the malaria parasite Plasmodium falciparum.","volume":"4","author":"AK Schuh","year":"2018","journal-title":"ACS Infect Dis"},{"key":"ppat.1008482.ref090","doi-asserted-by":"crossref","first-page":"E1214","DOI":"10.1073\/pnas.1112037108","article-title":"Quantitative assessment of Plasmodium falciparum sexual development 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