{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:28:58Z","timestamp":1790724538850,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008525","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000}}],"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008525","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T17:32:57Z","timestamp":1587403977000},"page":"e1008525","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-7644","authenticated-orcid":true,"given":"So Ri","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Ashhurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip K.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-3060","authenticated-orcid":true,"given":"Barney","family":"Viengkhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-9772","authenticated-orcid":true,"given":"Nicholas J. C.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5111-3978","authenticated-orcid":true,"given":"Markus J.","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"issue":"8","key":"ppat.1008525.ref001","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1002\/ijc.29945","article-title":"Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human","volume":"138","author":"L Andzinski","year":"2016","journal-title":"Int J Cancer"},{"issue":"9","key":"ppat.1008525.ref002","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1182\/blood.V99.9.3263","article-title":"Type I interferons produced by dendritic cells promote their phenotypic and functional activation","volume":"99","author":"M Montoya","year":"2002","journal-title":"Blood"},{"issue":"1","key":"ppat.1008525.ref003","doi-asserted-by":"crossref","first-page":"e1001759","DOI":"10.1371\/journal.pbio.1001759","article-title":"Direct type I IFN but not MDA5\/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation","volume":"12","author":"A Pantel","year":"2014","journal-title":"PLoS Biol"},{"issue":"7","key":"ppat.1008525.ref004","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.4049\/jimmunol.1101313","article-title":"Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing","volume":"188","author":"DP Simmons","year":"2012","journal-title":"J Immunol"},{"issue":"2","key":"ppat.1008525.ref005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12016-011-8296-5","article-title":"Type I interferons: beneficial in Th1 and detrimental in Th17 autoimmunity","volume":"44","author":"RC Axtell","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"issue":"5","key":"ppat.1008525.ref006","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.178.5.1655","article-title":"Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells","volume":"178","author":"V Brinkmann","year":"1993","journal-title":"J Exp Med"},{"issue":"8","key":"ppat.1008525.ref007","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.4049\/jimmunol.174.8.4465","article-title":"Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation","volume":"174","author":"JM Curtsinger","year":"2005","journal-title":"J Immunol"},{"issue":"24","key":"ppat.1008525.ref008","doi-asserted-by":"crossref","first-page":"11706","DOI":"10.1073\/pnas.89.24.11706","article-title":"Identification of a functionally important sequence in the C terminus of the interferon-gamma receptor","volume":"89","author":"MA Farrar","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"31","key":"ppat.1008525.ref009","doi-asserted-by":"crossref","first-page":"32269","DOI":"10.1074\/jbc.M404789200","article-title":"Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29\/interferon-lambda 1: similarities with type I interferon signaling.","volume":"279","author":"L Dumoutier","year":"2004","journal-title":"J Biol Chem"},{"issue":"5071","key":"ppat.1008525.ref010","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.1496401","article-title":"Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor","volume":"257","author":"C Schindler","year":"1992","journal-title":"Science"},{"issue":"11","key":"ppat.1008525.ref011","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1073\/pnas.91.11.4776","article-title":"Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein","volume":"91","author":"T Improta","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ppat.1008525.ref012","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0092-8674(94)90154-6","article-title":"The human interferon alpha\/beta receptor: characterization and molecular cloning","volume":"77","author":"D Novick","year":"1994","journal-title":"Cell"},{"issue":"1","key":"ppat.1008525.ref013","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0168-1702(85)90058-9","article-title":"Conserved sequences and coding of two strains of lymphocytic choriomeningitis virus (WE and ARM) and Pichinde arenavirus.","volume":"2","author":"V Romanowski","year":"1985","journal-title":"Virus Res"},{"issue":"1","key":"ppat.1008525.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0042-6822(89)90216-X","article-title":"The completed sequence of lymphocytic choriomeningitis virus reveals a unique RNA structure and a gene for a zinc finger protein","volume":"173","author":"MS Salvato","year":"1989","journal-title":"Virology"},{"issue":"1","key":"ppat.1008525.ref015","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/oxfordjournals.bmb.a072029","article-title":"Virus and immune responses: lymphocytic choriomeningitis virus as a prototype model of viral pathogenesis","volume":"41","author":"MB Oldstone","year":"1985","journal-title":"Br Med Bull"},{"issue":"2","key":"ppat.1008525.ref016","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.3390\/v11020172","article-title":"Complexities of Type I Interferon Biology: Lessons from LCMV","volume":"11","author":"T Suprunenko","year":"2019","journal-title":"Viruses"},{"key":"ppat.1008525.ref017","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0065-2776(08)60197-2","article-title":"The virology and immunobiology of lymphocytic choriomeningitis virus infection","volume":"30","author":"MJ Buchmeier","year":"1980","journal-title":"Adv Immunol"},{"issue":"1","key":"ppat.1008525.ref018","doi-asserted-by":"crossref","first-page":"R3: 1","DOI":"10.1186\/ar3221","article-title":"Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts.","volume":"13","author":"SK Agarwal","year":"2011","journal-title":"Arthritis Res Ther."},{"issue":"22","key":"ppat.1008525.ref019","doi-asserted-by":"crossref","first-page":"e01219","DOI":"10.1128\/JVI.01219-17","article-title":"IRF9 prevents CD8(+) T cell exhaustion in an extrinsic manner during acute lymphocytic choriomeningitis virus infection.","volume":"91","author":"M Huber","year":"2017","journal-title":"J Virol"},{"issue":"7","key":"ppat.1008525.ref020","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.4049\/jimmunol.138.7.2278","article-title":"Functional analysis of T lymphocyte subsets in antiviral host defense","volume":"138","author":"TP Leist","year":"1987","journal-title":"J Immunol"},{"issue":"6","key":"ppat.1008525.ref021","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1128\/JVI.61.6.1867-1874.1987","article-title":"Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response","volume":"61","author":"D Moskophidis","year":"1987","journal-title":"J Virol"},{"issue":"13","key":"ppat.1008525.ref022","doi-asserted-by":"crossref","first-page":"7578","DOI":"10.1128\/JVI.03117-13","article-title":"IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus","volume":"88","author":"W Li","year":"2014","journal-title":"J Virol"},{"issue":"12","key":"ppat.1008525.ref023","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1128\/JVI.07147-11","article-title":"Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus","volume":"86","author":"MJ Hofer","year":"2012","journal-title":"J Virol"},{"issue":"5","key":"ppat.1008525.ref024","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature lymphocytes-B and lymphocytes-T","volume":"68","author":"P Mombaerts","year":"1992","journal-title":"Cell"},{"issue":"1","key":"ppat.1008525.ref025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1586\/eri.10.142","article-title":"Pathogenesis of arenavirus hemorrhagic fevers.","volume":"9","author":"ML Moraz","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"13","key":"ppat.1008525.ref026","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1084\/jem.20121015","article-title":"Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice","volume":"209","author":"H Frebel","year":"2012","journal-title":"J Exp Med"},{"issue":"24","key":"ppat.1008525.ref027","doi-asserted-by":"crossref","first-page":"8925","DOI":"10.1073\/pnas.1408148111","article-title":"Type I interferon is a therapeutic target for virus-induced lethal vascular damage","volume":"111","author":"R Baccala","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ppat.1008525.ref028","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.celrep.2019.04.004","article-title":"Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection","volume":"27","author":"I Misumi","year":"2019","journal-title":"Cell Rep"},{"issue":"5","key":"ppat.1008525.ref029","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.4049\/jimmunol.177.5.3266","article-title":"Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection","volume":"177","author":"J Louten","year":"2006","journal-title":"J Immunol"},{"issue":"5","key":"ppat.1008525.ref030","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1128\/jvi.76.5.2375-2383.2002","article-title":"Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production","volume":"76","author":"S Muller","year":"2002","journal-title":"J Virol"},{"issue":"4","key":"ppat.1008525.ref031","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.4049\/jimmunol.180.4.2158","article-title":"STAT1 signaling in CD8 T cells is required for their clonal expansion and memory formation following viral infection in vivo","volume":"180","author":"M Quigley","year":"2008","journal-title":"J Immunol"},{"issue":"1","key":"ppat.1008525.ref032","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4049\/jimmunol.170.1.503","article-title":"Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression","volume":"170","author":"NC Riedemann","year":"2003","journal-title":"J Immunol"},{"issue":"2","key":"ppat.1008525.ref033","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1165\/ajrcmb.23.2.3999","article-title":"Airway subepithelial fibrosis in a murine model of atopic asthma: suppression by dexamethasone or anti-interleukin-5 antibody","volume":"23","author":"DI Blyth","year":"2000","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"ppat.1008525.ref034","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1160\/TH14-11-0951","article-title":"Poly (I:C) downregulates platelet production and function through type I interferon.","volume":"114","author":"L Rivadeneyra","year":"2015","journal-title":"Thromb Haemost"},{"issue":"3","key":"ppat.1008525.ref035","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2007-12-125906","article-title":"Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes","volume":"112","author":"A Yamane","year":"2008","journal-title":"Blood"},{"issue":"8","key":"ppat.1008525.ref036","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.it.2010.05.006","article-title":"Neutrophil kinetics in health and disease","volume":"31","author":"C Summers","year":"2010","journal-title":"Trends Immunol"},{"issue":"3","key":"ppat.1008525.ref037","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0092-8674(00)81289-1","article-title":"Targeted disruption of the mouse STAT1 results in compromised innate immunity to viral disease","volume":"84","author":"JE Durbin","year":"1996","journal-title":"Cell"},{"issue":"Pt 8","key":"ppat.1008525.ref038","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1099\/0022-1317-64-8-1689","article-title":"Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains","volume":"64","author":"FJ Dutko","year":"1983","journal-title":"J Gen Virol"},{"issue":"1","key":"ppat.1008525.ref039","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4049\/jimmunol.153.1.220","article-title":"Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha\/beta","volume":"153","author":"K Sandberg","year":"1994","journal-title":"J Immunol"},{"issue":"10","key":"ppat.1008525.ref040","doi-asserted-by":"crossref","first-page":"7832","DOI":"10.1128\/JVI.71.10.7832-7840.1997","article-title":"Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis","volume":"71","author":"VC Asensio","year":"1997","journal-title":"J Virol"},{"issue":"1","key":"ppat.1008525.ref041","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/13550289909029747","article-title":"Chemokines and the inflammatory response to viral infection in the central nervous system with a focus on lymphocytic choriomeningitis virus","volume":"5","author":"VC Asensio","year":"1999","journal-title":"J Neurovirol"},{"issue":"7","key":"ppat.1008525.ref042","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis.","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods."},{"issue":"2\u20133","key":"ppat.1008525.ref043","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0168-1656(99)00163-7","article-title":"Housekeeping genes as internal standards: use and limits","volume":"75","author":"O Thellin","year":"1999","journal-title":"J Biotechnol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008525","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T04:16:49Z","timestamp":1696047409000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008525"}},"subtitle":[],"editor":[{"given":"Mehul","family":"Suthar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008525","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1008525","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]}}}