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Altamia","year":"2019","journal-title":"Int J Syst Evol Microbiol"},{"key":"ppat.1008600.ref066","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.219.4588.1077","article-title":"Dwarf males in the teredinidae (bivalvia, pholadacea)","volume":"219","author":"RD Turner","year":"1983","journal-title":"Science"},{"key":"ppat.1008600.ref067","doi-asserted-by":"crossref","first-page":"e0155269","DOI":"10.1371\/journal.pone.0155269","article-title":"Zachsia zenkewitschi (Teredinidae), a Rare and Unusual Seagrass Boring Bivalve Revisited and Redescribed","volume":"11","author":"JR Shipway","year":"2016","journal-title":"PLoS One"},{"key":"ppat.1008600.ref068","doi-asserted-by":"crossref","first-page":"20190434","DOI":"10.1098\/rspb.2019.0434","article-title":"A rock-boring and rock-ingesting freshwater bivalve (shipworm) from the Philippines","volume":"286","author":"JR Shipway","year":"2019","journal-title":"Proc Biol 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Parasitol"},{"key":"ppat.1008600.ref072","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0166-6851(93)90035-V","article-title":"Isolate-specific parasite antigens of the Babesia bovis-infected erythrocyte surface","volume":"60","author":"DR Allred","year":"1993","journal-title":"Molecular and Biochemical Parasitology"},{"key":"ppat.1008600.ref073","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molbiopara.2004.05.009","article-title":"Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method","volume":"137","author":"CJ Tonkin","year":"2004","journal-title":"Molecular and Biochemical Parasitology"},{"key":"ppat.1008600.ref074","doi-asserted-by":"crossref","first-page":"79","DOI":"10.12688\/wellcomeopenres.12251.1","article-title":"Quenching autofluorescence in tissue immunofluorescence","volume":"2","author":"J Yang","year":"2017","journal-title":"Wellcome Open Research"},{"key":"ppat.1008600.ref075","first-page":"28.21","volume-title":"Handbook of Experimental Immunology","author":"GD Johnson","year":"1986"},{"key":"ppat.1008600.ref076","unstructured":"Wendykier P (2009) Parallel Iterative Deconvolution. https:\/\/sites google com\/site\/piotrwendykier\/software\/deconvolution\/paralleliterativedeconvolution (ImageJ plug-in)."},{"key":"ppat.1008600.ref077","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0091-679X(08)61845-2","article-title":"Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii","volume":"45","author":"DS Roos","year":"1994","journal-title":"Methods Cell Biol"},{"key":"ppat.1008600.ref078","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/1471-2164-13-603","article-title":"Comparative genomic analysis and phylogenetic position of Theileria equi","volume":"13","author":"LS Kappmeyer","year":"2012","journal-title":"BMC Genomics"},{"key":"ppat.1008600.ref079","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1128\/AAC.48.5.1807-1810.2004","article-title":"Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy","volume":"48","author":"TN Bennett","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ppat.1008600.ref080","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1128\/AAC.01607-06","article-title":"Assessment and continued validation of the malaria SYBR Green I-based fluorescence assay for use in malaria drug screening","volume":"51","author":"JD Johnson","year":"2007","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ppat.1008600.ref081","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/AAC.48.5.1803-1806.2004","article-title":"Simple and inexpensive fluorescence-baseed technique for high-throughput antimalarial drug screening","volume":"48","author":"M Smilkstein","year":"2004","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ppat.1008600.ref082","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.7355284","article-title":"Babesia bovis: continuous cultivation in a microaerophilous stationary phase culture","volume":"207","author":"MG Levy","year":"1980","journal-title":"Science"},{"key":"ppat.1008600.ref083","first-page":"179","article-title":"A column purification procedure for the removal of leucocytes from parasite-infected bovine blood","volume":"53","author":"RE Ambrosio","year":"1986","journal-title":"Onderstepoort Journal of Veterinary Research"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008600","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000}}],"container-title":["PLOS 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