{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:44:53Z","timestamp":1789767893501,"version":"4.0.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008752","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1279, SPP 1923"],"award-info":[{"award-number":["CRC 1279, SPP 1923"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHM 3336-1-1"],"award-info":[{"award-number":["SCHM 3336-1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Germany\u2019s Excellence Strategy","award":["EXC2151"],"award-info":[{"award-number":["EXC2151"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008752","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T19:15:57Z","timestamp":1596741357000},"page":"e1008752","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells"],"prefix":"10.1371","volume":"16","author":[{"given":"Matteo","family":"Bosso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Prelli Bozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Hotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meta","family":"Volcic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"St\u00fcrzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rammelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3634-066X","authenticated-orcid":true,"given":"Miriam","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-583X","authenticated-orcid":true,"given":"Mario","family":"Schelhaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Wittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4778-3009","authenticated-orcid":true,"given":"Maria H.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9979-9769","authenticated-orcid":true,"given":"Florian I.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5507-6721","authenticated-orcid":true,"given":"Thomas","family":"Gramberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-1779","authenticated-orcid":true,"given":"Konstantin M. J.","family":"Sparrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7665-0040","authenticated-orcid":true,"given":"Daniel","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7052-2360","authenticated-orcid":true,"given":"Frank","family":"Kirchhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"ppat.1008752.ref001","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-065X.2011.01053.x","article-title":"The PYHIN protein family as mediators of host defenses","volume":"243","author":"SA Schattgen","year":"2011","journal-title":"Immunol Rev"},{"key":"ppat.1008752.ref002","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and Regulation of NLRP3 Inflammasome Activation","volume":"41","author":"Y He","year":"2016","journal-title":"Trends Biochem Sci"},{"key":"ppat.1008752.ref003","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1110\/ps.13801","article-title":"The PYRIN domain: a member of the death domain-fold superfamily","volume":"10","author":"WJ Fairbrother","year":"2001","journal-title":"Protein Sci"},{"key":"ppat.1008752.ref004","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/sj.cdd.4400774","article-title":"The PYRIN domain: a novel motif found in apoptosis and inflammation proteins","volume":"7","author":"J Bertin","year":"2000","journal-title":"Cell Death Differ"},{"key":"ppat.1008752.ref005","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/jmcb\/mjv053","article-title":"New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16","volume":"8","author":"X Ni","year":"2016","journal-title":"J Mol Cell Biol"},{"key":"ppat.1008752.ref006","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ni.2829","article-title":"The PYRIN domain\u2013only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses","volume":"15","author":"S Khare","year":"2014","journal-title":"Nat Immunol"},{"key":"ppat.1008752.ref007","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15556","article-title":"The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation","volume":"8","author":"RA Ratsimandresy","year":"2017","journal-title":"Nat Commun"},{"key":"ppat.1008752.ref008","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.molimm.2011.11.004","article-title":"Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: Regulation of subcellular localization","volume":"49","author":"S Veeranki","year":"2012","journal-title":"Mol Immunol"},{"key":"ppat.1008752.ref009","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1038\/sj.onc.1207592","article-title":"Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer","volume":"23","author":"Y Ding","year":"2004","journal-title":"Oncogene"},{"key":"ppat.1008752.ref010","doi-asserted-by":"crossref","first-page":"787","DOI":"10.15252\/msb.20145808","article-title":"The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA","volume":"11","author":"BA Diner","year":"2015","journal-title":"Mol Syst Biol"},{"key":"ppat.1008752.ref011","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cytogfr.2014.06.004","article-title":"IFI16: At the interphase between innate DNA sensing and genome regulation","volume":"25","author":"MR Jakobsen","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"ppat.1008752.ref012","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"L Franchi","year":"2009","journal-title":"Nat Immunol"},{"key":"ppat.1008752.ref013","doi-asserted-by":"crossref","first-page":"E4571","DOI":"10.1073\/pnas.1311669110","article-title":"IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication","volume":"110","author":"MR Jakobsen","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008752.ref014","doi-asserted-by":"crossref","first-page":"14391","DOI":"10.1038\/ncomms14391","article-title":"IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP","volume":"8","author":"KL J\u00f8nsson","year":"2017","journal-title":"Nat Commun"},{"key":"ppat.1008752.ref015","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/jcb.240560417","article-title":"Regulation and specificity of MNDA expression in monocytes, macrophages, and leukemia\/B lymophoma cell lines","volume":"56","author":"RC Briggs","year":"1994","journal-title":"J Cell Biochem"},{"key":"ppat.1008752.ref016","first-page":"1183","article-title":"cis-diamminedichloroplatinum(II) cross-linking of the human myeloid cell nuclear differentiation antigen to DNA in HL-60 cells following 1,25-dihydroxy vitamin D3-induced monocyte differentiation","volume":"50","author":"M Gaczynski","year":"1990","journal-title":"Cancer Res"},{"key":"ppat.1008752.ref017","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s10529-013-1432-y","article-title":"Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA)","volume":"36","author":"H Li","year":"2014","journal-title":"Biotechnol Lett"},{"key":"ppat.1008752.ref018","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/(SICI)1097-4644(19980915)70:4<489::AID-JCB6>3.0.CO;2-F","article-title":"Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding","volume":"70","author":"J Xie","year":"1998","journal-title":"J Cell Biochem"},{"key":"ppat.1008752.ref019","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1243640","article-title":"IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV","volume":"343","author":"KM Monroe","year":"2014","journal-title":"Science"},{"key":"ppat.1008752.ref020","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1074\/mcp.M116.064741","article-title":"Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation","volume":"16","author":"MS Crow","year":"2017","journal-title":"Mol Cell Proteomics"},{"key":"ppat.1008752.ref021","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/MCB.26.5.1979-1996.2006","article-title":"Interferon-Inducible Protein IFIX 1 Functions as a Negative Regulator of HDM2","volume":"26","author":"Y Ding","year":"2006","journal-title":"Mol Cell Biol"},{"key":"ppat.1008752.ref022","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/mc.20423","article-title":"Interferon-inducible protein IFIX\u03b1 inhibits cell invasion by upregulating the metastasis suppressor maspin","volume":"47","author":"H Yamaguchi","year":"2008","journal-title":"Mol Carcinog"},{"key":"ppat.1008752.ref023","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.chom.2011.04.008","article-title":"IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection","volume":"9","author":"N Kerur","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ppat.1008752.ref024","doi-asserted-by":"crossref","first-page":"E3008","DOI":"10.1073\/pnas.1211302109","article-title":"Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein","volume":"109","author":"MH Orzalli","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008752.ref025","doi-asserted-by":"crossref","first-page":"10558","DOI":"10.1073\/pnas.1203447109","article-title":"Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16","volume":"109","author":"T Li","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008752.ref026","doi-asserted-by":"crossref","first-page":"e1002498","DOI":"10.1371\/journal.ppat.1002498","article-title":"The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication","volume":"8","author":"GR Gariano","year":"2012","journal-title":"PLoS Pathog"},{"key":"ppat.1008752.ref027","doi-asserted-by":"crossref","first-page":"e1004503","DOI":"10.1371\/journal.ppat.1004503","article-title":"IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications","volume":"10","author":"KE Johnson","year":"2014","journal-title":"PLoS Pathog"},{"key":"ppat.1008752.ref028","doi-asserted-by":"crossref","first-page":"e01553","DOI":"10.1128\/mBio.01553-16","article-title":"Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection","volume":"7","author":"BA Diner","year":"2016","journal-title":"MBio"},{"key":"ppat.1008752.ref029","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1128\/JVI.00013-15","article-title":"The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters","volume":"89","author":"I Lo Cigno","year":"2015","journal-title":"J Virol"},{"key":"ppat.1008752.ref030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12977-015-0165-5","article-title":"Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses","volume":"12","author":"PJ McLaren","year":"2015","journal-title":"Retrovirology"},{"key":"ppat.1008752.ref031","article-title":"IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation2019","author":"D Hotter","journal-title":"Cell Host Microbe"},{"key":"ppat.1008752.ref032","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/ni.1932","article-title":"IFI16 is an innate immune sensor for intracellular DNA","volume":"11","author":"L Unterholzner","year":"2010","journal-title":"Nat Immunol"},{"key":"ppat.1008752.ref033","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature10429","article-title":"STING is a direct innate immune sensor of cyclic di-GMP","volume":"478","author":"DL Burdette","year":"2011","journal-title":"Nature"},{"key":"ppat.1008752.ref034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41596-018-0069-7","article-title":"CRISPR\u2013Cas9 genome engineering of primary CD4 + T cells for the interrogation of HIV\u2013host factor interactions","volume":"14","author":"JF Hultquist","year":"2019","journal-title":"Nat Protoc"},{"key":"ppat.1008752.ref035","doi-asserted-by":"crossref","first-page":"E62","DOI":"10.1073\/pnas.1313577111","article-title":"Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy","volume":"111","author":"SR Morrone","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008752.ref036","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","author":"V Hornung","year":"2009","journal-title":"Nature"},{"key":"ppat.1008752.ref037","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cell.2014.02.008","article-title":"Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes","volume":"156","author":"A Lu","year":"2014","journal-title":"Cell"},{"key":"ppat.1008752.ref038","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1084\/jem.20151790","article-title":"A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly","volume":"213","author":"FI Schmidt","year":"2016","journal-title":"J Exp Med"},{"key":"ppat.1008752.ref039","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12611","article-title":"The intra- and extracellular functions of ASC specks","volume":"281","author":"BS Franklin","year":"2018","journal-title":"Immunol Rev"},{"key":"ppat.1008752.ref040","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1128\/JVI.03282-12","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes","volume":"87","author":"VV Singh","year":"2013","journal-title":"J Virol"},{"key":"ppat.1008752.ref041","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1128\/JVI.00082-13","article-title":"Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes","volume":"87","author":"KE Johnson","year":"2013","journal-title":"J Virol"},{"key":"ppat.1008752.ref042","doi-asserted-by":"crossref","first-page":"e1005019","DOI":"10.1371\/journal.ppat.1005019","article-title":"Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-\u03b2 Responses","volume":"11","author":"MA Ansari","year":"2015","journal-title":"PLoS Pathog"},{"key":"ppat.1008752.ref043","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.chom.2010.11.007","article-title":"Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing","volume":"8","author":"P Broz","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ppat.1008752.ref044","doi-asserted-by":"crossref","first-page":"14.40.1","DOI":"10.1002\/cpim.13","article-title":"Assessment of Inflammasome Formation by Flow Cytometry","volume":"114","author":"DP Sester","year":"2016","journal-title":"Curr Protoc Immunol"},{"key":"ppat.1008752.ref045","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1128\/JVI.00013-15","article-title":"The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters. Ross SR, editor","volume":"89","author":"I Lo Cigno","year":"2015","journal-title":"J Virol"},{"key":"ppat.1008752.ref046","article-title":"Nuclear Sensor IFI 16 Inhibits the Function of HBV ccc DNA by Integrating Innate Immune Activation and Epigenetic Suppression","author":"Y Yang","year":"2019","journal-title":"Hepatology"},{"key":"ppat.1008752.ref047","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cld.2016.06.006","article-title":"Epidemiology of Hepatitis B Virus Infection and Impact of Vaccination on Disease","volume":"20","author":"NP Nelson","year":"2016","journal-title":"Clin Liver Dis"},{"key":"ppat.1008752.ref048","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13100-018-0116-5","article-title":"The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation","volume":"9","author":"A Herrmann","year":"2018","journal-title":"Mob DNA"},{"key":"ppat.1008752.ref049","first-page":"513","article-title":"The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease","volume":"89","author":"L O\u2019Connor","year":"2016","journal-title":"Yale J Biol Med"},{"key":"ppat.1008752.ref050","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.aanat.2010.07.010","article-title":"The role of Sp1 and Sp3 in normal and cancer cell biology","volume":"192","author":"L Li","year":"2010","journal-title":"Ann Anat"},{"key":"ppat.1008752.ref051","article-title":"Nuclear Sensor Interferon\u2010Inducible Protein 16 Inhibits the Function of Hepatitis B Virus Covalently Closed Circular DNA by Integrating Innate Immune Activation and Epigenetic Suppression","author":"Y Yang","year":"2019","journal-title":"Hepatology"},{"key":"ppat.1008752.ref052","doi-asserted-by":"crossref","first-page":"e11721","DOI":"10.7554\/eLife.11721","article-title":"The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex","volume":"4","author":"SA Stratmann","year":"2015","journal-title":"Elife"},{"key":"ppat.1008752.ref053","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.immuni.2012.02.014","article-title":"Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor","volume":"36","author":"T Jin","year":"2012","journal-title":"Immunity"},{"key":"ppat.1008752.ref054","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-2148-12-140","article-title":"The mammalian PYHIN gene family: phylogeny, evolution and expression","volume":"12","author":"JA Cridland","year":"2012","journal-title":"BMC Evol Biol"},{"key":"ppat.1008752.ref055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1471-2148-12-71","article-title":"An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals","volume":"12","author":"C M\u00fcnk","year":"2012","journal-title":"BMC Evol Biol"},{"key":"ppat.1008752.ref056","doi-asserted-by":"crossref","first-page":"e1005085","DOI":"10.1371\/journal.ppat.1005085","article-title":"Evolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid Interface","volume":"11","author":"KR McCarthy","year":"2015","journal-title":"PLOS Pathog"},{"key":"ppat.1008752.ref057","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1741-7007-7-7","article-title":"A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish","volume":"7","author":"LM van der Aa","year":"2009","journal-title":"BMC Biol"},{"key":"ppat.1008752.ref058","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10495-014-1065-1","article-title":"An updated view on the structure and function of PYRIN domains","volume":"20","author":"LH Chu","year":"2015","journal-title":"Apoptosis"},{"key":"ppat.1008752.ref059","doi-asserted-by":"crossref","first-page":"e1002384","DOI":"10.1371\/journal.pgen.1002384","article-title":"Repetitive elements may comprise over two-thirds of the human genome","volume":"7","author":"APJ de Koning","year":"2011","journal-title":"PLoS Genet"},{"key":"ppat.1008752.ref060","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.ajpath.2014.01.007","article-title":"Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers","volume":"184","author":"N Rodi\u0107","year":"2014","journal-title":"Am J Pathol"},{"key":"ppat.1008752.ref061","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ni.2872","article-title":"The enemy within: endogenous retroelements and autoimmune disease","volume":"15","author":"HE Volkman","year":"2014","journal-title":"Nat Immunol"},{"key":"ppat.1008752.ref062","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"M De Cecco","year":"2019","journal-title":"Nature"},{"key":"ppat.1008752.ref063","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bbrc.2005.12.040","article-title":"Podgornaya OI. Identification of the proteins specifically binding to the rat LINE1 promoter","volume":"340","author":"A V Fedorov","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ppat.1008752.ref064","doi-asserted-by":"crossref","first-page":"E4492","DOI":"10.1073\/pnas.1316194110","article-title":"Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA","volume":"110","author":"MH Orzalli","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1008752.ref065","doi-asserted-by":"crossref","first-page":"eaap9927","DOI":"10.1126\/scitranslmed.aap9927","article-title":"HIV latency in isolated patient CD4 + T cells may be due to blocks in HIV transcriptional elongation, completion, and splicing.","volume":"10","author":"SA Yukl","year":"2018","journal-title":"Sci Transl Med"},{"key":"ppat.1008752.ref066","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MCB.7.1.379","article-title":"Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system","volume":"7","author":"RB DuBridge","year":"1987","journal-title":"Mol Cell Biol"},{"key":"ppat.1008752.ref067","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1128\/JVI.72.4.2855-2864.1998","article-title":"Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1","volume":"72","author":"EJ Platt","year":"1998","journal-title":"J Virol"},{"key":"ppat.1008752.ref068","article-title":"Domains of interaction between alpha interferon and its receptor components","author":"G Uz\u00e9","year":"1994","journal-title":"J Mol Biol"},{"key":"ppat.1008752.ref069","article-title":"INFECTION OF HUMAN AND SIMIAN TISSUE CULTURES WITH ROUS SARCOMA VIRUS","author":"FC JENSEN","year":"1964","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008752.ref070","article-title":"Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line [15]","author":"DP Aden","year":"1979","journal-title":"Nature"},{"key":"ppat.1008752.ref071","article-title":"TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy","author":"T Liu","year":"2016","journal-title":"Cell Rep"},{"key":"ppat.1008752.ref072","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2019.05.002","article-title":"IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation","volume":"25","author":"D Hotter","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ppat.1008752.ref073","doi-asserted-by":"crossref","first-page":"E4311","DOI":"10.1073\/pnas.1605828113","article-title":"DNA damage tolerance pathway involving DNA polymerase? and the tumor suppressor p53 regulates DNA replication fork progression","volume":"113","author":"S Hampp","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"ppat.1008752.ref074","article-title":"Simian Virus 40 Depends on ER Protein Folding and Quality Control Factors for Entry into Host Cells","author":"M Schelhaas","year":"2007","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008752","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T18:38:25Z","timestamp":1597775905000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008752"}},"subtitle":[],"editor":[{"given":"Bryan R.","family":"Cullen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":74,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008752","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1008752","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]}}}