{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:21:32Z","timestamp":1787872892653,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008807","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2554\/18"],"award-info":[{"award-number":["2554\/18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["1412-414.13\/2017"],"award-info":[{"award-number":["1412-414.13\/2017"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001698","name":"Israel Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israeli Science Foundation","doi-asserted-by":"crossref","award":["442-18"],"award-info":[{"award-number":["442-18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science Personal Medicine","award":["3-14764"],"award-info":[{"award-number":["3-14764"]}]},{"name":"DKFZ-MOST","award":["3-14931"],"award-info":[{"award-number":["3-14931"]}]},{"DOI":"10.13039\/501100003973","name":"Israel Academy of Sciences and Humanities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000618","name":"Foulkes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Natural killer (NK) cells are innate immune lymphocytes capable of killing target cells without prior sensitization. One pivotal activating NK receptor is NKG2D, which binds a family of eight ligands, including the major histocompatibility complex (MHC) class I-related chain A (MICA). Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus causing morbidity and mortality in immunosuppressed patients and congenitally infected infants. HCMV encodes multiple antagonists of NK cell activation, including many mechanisms targeting MICA. However, only one of these mechanisms, the HCMV protein US9, counters the most prevalent MICA allele, MICA*008. Here, we discover that a hitherto uncharacterized HCMV protein, UL147A, specifically downregulates MICA*008. UL147A primarily induces MICA*008 maturation arrest, and additionally targets it to proteasomal degradation, acting additively with US9 during HCMV infection. Thus, UL147A hinders NKG2D-mediated elimination of HCMV-infected cells by NK cells. Mechanistic analyses disclose that the non-canonical GPI anchoring pathway of immature MICA*008 constitutes the determinant of UL147A specificity for this MICA allele. These findings advance our understanding of the complex and rapidly evolving HCMV immune evasion mechanisms, which may facilitate the development of antiviral drugs and vaccines.<\/jats:p>","DOI":"10.1371\/journal.ppat.1008807","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T14:01:00Z","timestamp":1620050460000},"page":"e1008807","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The human cytomegalovirus protein UL147A downregulates the most prevalent MICA allele: MICA*008, to evade NK cell-mediated killing"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-0272","authenticated-orcid":true,"given":"Einat","family":"Seidel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7897-7282","authenticated-orcid":true,"given":"Liat","family":"Dassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1371-0779","authenticated-orcid":true,"given":"Corinna","family":"Schuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Oiknine-Djian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana G.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2733-3732","authenticated-orcid":true,"given":"Vu Thuy Khanh","family":"Le-Trilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-1855","authenticated-orcid":true,"given":"Ofer","family":"Mandelboim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"ppat.1008807.ref001","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/path.4437","article-title":"The pathogenesis of human cytomegalovirus","volume":"235","author":"P Griffiths","year":"2015","journal-title":"J Pathol"},{"key":"ppat.1008807.ref002","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1126\/science.1227919","article-title":"Decoding human cytomegalovirus","volume":"338","author":"N Stern-Ginossar","year":"2012","journal-title":"Science"},{"key":"ppat.1008807.ref003","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.cell.2014.04.028","article-title":"Quantitative temporal viromics: An approach to investigate host-pathogen interaction","volume":"157","author":"MP Weekes","year":"2014","journal-title":"Cell"},{"key":"ppat.1008807.ref004","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49894","article-title":"Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions","volume":"8","author":"L Nobre","year":"2019","journal-title":"Elife"},{"key":"ppat.1008807.ref005","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.chom.2018.07.011","article-title":"High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms","volume":"24","author":"K Nightingale","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ppat.1008807.ref006","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1099\/vir.0.013250-0","article-title":"High-throughput sequence analysis of variants of human cytomegalovirus strains Towne and AD169","volume":"90","author":"AJ Bradley","year":"2009","journal-title":"J Gen Virol"},{"key":"ppat.1008807.ref007","doi-asserted-by":"crossref","first-page":"19755","DOI":"10.1073\/pnas.1115861108","article-title":"High-resolution human cytomegalovirus transcriptome","volume":"108","author":"D Gatherer","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008807.ref008","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fmicb.2014.00218","article-title":"Functional annotation of human cytomegalovirus gene products: an update","volume":"5","author":"E Van Damme","year":"2014","journal-title":"Front Microbiol"},{"key":"ppat.1008807.ref009","article-title":"Modulation of innate 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Freud","year":"2017","journal-title":"Immunity"},{"key":"ppat.1008807.ref013","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/imr.12725","article-title":"Emerging insights into human health and NK cell biology from the study of NK cell deficiencies","volume":"287","author":"EM Mace","year":"2019","journal-title":"Immunol Rev"},{"key":"ppat.1008807.ref014","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0167-5699(00)01673-X","article-title":"Human NK-cell receptors","author":"L Moretta","year":"2000","journal-title":"Immunology Today. Elsevier Ltd"},{"key":"ppat.1008807.ref015","first-page":"1","article-title":"Natural killer cells: Development, maturation, and clinical utilization","author":"AM Abel","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"ppat.1008807.ref016","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","article-title":"NK cell recognition","volume":"23","author":"LL Lanier","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"ppat.1008807.ref017","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1158\/2326-6066.CIR-15-0098","article-title":"NKG2D receptor and its ligands in host defense","volume":"3","author":"LL Lanier","year":"2015","journal-title":"Cancer Immunol Res"},{"key":"ppat.1008807.ref018","article-title":"Regulation of ligands for the NKG2D activating receptor","author":"DH Raulet","year":"2013","journal-title":"Annual review of immunology"},{"key":"ppat.1008807.ref019","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BJ20130194","article-title":"A GPI anchor explains the unique biological features of the common NKG2D-ligand allele MICA*008","volume":"454","author":"O Ashiru","year":"2013","journal-title":"Biochem J"},{"key":"ppat.1008807.ref020","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fimmu.2012.00299","article-title":"Human NKG2D-ligands: cell biology strategies to ensure immune recognition","volume":"3","author":"L Fern\u00e1ndez-Messina","year":"2012","journal-title":"Front Immunol"},{"key":"ppat.1008807.ref021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/0008-5472.CAN-09-1688","article-title":"Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA* 008 that is shed by tumor cells in exosomes","volume":"70","author":"O Ashiru","year":"2010","journal-title":"Cancer Res"},{"key":"ppat.1008807.ref022","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0065-2776(06)92006-9","article-title":"Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions","volume":"92","author":"J Loureiro","year":"2006","journal-title":"Adv Immunol"},{"key":"ppat.1008807.ref023","first-page":"179","article-title":"MICA and NKG2D: Is there an impact on kidney transplant outcome? 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Cosman","year":"2001","journal-title":"Immunity"},{"key":"ppat.1008807.ref033","doi-asserted-by":"crossref","first-page":"12345","DOI":"10.1128\/JVI.01175-09","article-title":"NKG2D ligand MICA is retained in the cis-Golgi apparatus by human cytomegalovirus protein UL142","volume":"83","author":"O Ashiru","year":"2009","journal-title":"J Virol"},{"key":"ppat.1008807.ref034","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2006.05.092","article-title":"Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus glycoprotein UL142","volume":"346","author":"NJ Chalupny","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ppat.1008807.ref035","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.4049\/jimmunol.175.11.7457","article-title":"Human Cytomegalovirus Encodes an MHC Class I-Like Molecule (UL142) That Functions to Inhibit NK Cell Lysis","volume":"175","author":"MR Wills","year":"2005","journal-title":"J Immunol"},{"key":"ppat.1008807.ref036","doi-asserted-by":"crossref","first-page":"e1004058","DOI":"10.1371\/journal.ppat.1004058","article-title":"Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation","volume":"10","author":"CA Fielding","year":"2014","journal-title":"PLoS Pathog."},{"key":"ppat.1008807.ref037","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.22206","article-title":"Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation","volume":"6","author":"CA Fielding","year":"2017","journal-title":"Elife"},{"key":"ppat.1008807.ref038","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-08866-2","article-title":"Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20","volume":"7","author":"Y Charpak-Amikam","year":"2017","journal-title":"Sci Rep"},{"key":"ppat.1008807.ref039","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00162-18","article-title":"The Human Cytomegalovirus Protein UL148A Downregulates the NK Cell-Activating Ligand MICA To Avoid NK Cell Attack","volume":"92","author":"L Dassa","year":"2018","journal-title":"J Virol"},{"key":"ppat.1008807.ref040","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jcv.2007.10.027","article-title":"Modulation of natural killer cells by human cytomegalovirus","volume":"41","author":"GGWG Wilkinson","year":"2008","journal-title":"J Clin Virol"},{"key":"ppat.1008807.ref041","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.celrep.2015.01.029","article-title":"Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA*008 to Escape Elimination by NK Cells","volume":"10","author":"E Seidel","year":"2015","journal-title":"Cell Rep"},{"key":"ppat.1008807.ref042","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1743-422X-3-4","article-title":"Analysis of the human cytomegalovirus genomic region from UL146 through UL147A reveals sequence hypervariability, genotypic stability, and overlapping transcripts","volume":"3","author":"N Lurain","year":"2006","journal-title":"Virol J"},{"key":"ppat.1008807.ref043","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1099\/vir.0.18606-0","article-title":"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome","volume":"84","author":"AJ Davison","year":"2003","journal-title":"J Gen Virol"},{"key":"ppat.1008807.ref044","doi-asserted-by":"crossref","first-page":"D158","DOI":"10.1093\/nar\/gkw1099","article-title":"UniProt: The universal protein knowledgebase","volume":"45","author":"A Bateman","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"ppat.1008807.ref045","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00430-015-0411-4","article-title":"Human cytomegalovirus: taking the strain","author":"GWG Wilkinson","year":"2015","journal-title":"Medical Microbiology and Immunology"},{"key":"ppat.1008807.ref046","article-title":"HCMV-encoded NK modulators: Lessons from in vitro and in vivo genetic variation","author":"M Patel","year":"2018","journal-title":"Frontiers in Immunology."},{"key":"ppat.1008807.ref047","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chom.2013.02.003","article-title":"Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses","volume":"13","author":"W Smith","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ppat.1008807.ref048","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/ni1156","article-title":"Downregulation of natural killer cell-activating ligang CD155 by human 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Natl Acad Sci U S A"},{"key":"ppat.1008807.ref052","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.1073\/pnas.1230533100","article-title":"Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions\/deletions as the major path to genomic divergence","volume":"100","author":"T Anzai","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008807.ref053","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1099\/vir.0.79888-0","article-title":"Genetic content of wild-type human cytomegalovirus","volume":"85","author":"A Dolan","year":"2004","journal-title":"J Gen Virol"},{"key":"ppat.1008807.ref054","article-title":"Human Cytomegalovirus Clinical Isolates Carry at Least 19 Genes Not Found in Laboratory Strains Downloaded from","author":"T-A Cha","year":"1996","journal-title":"J Virol"},{"key":"ppat.1008807.ref055","doi-asserted-by":"crossref","first-page":"14976","DOI":"10.1073\/pnas.2136652100","article-title":"Coding potential of laboratory and clinical strains of human cytomegalovirus","volume":"100","author":"E Murphy","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008807.ref056","doi-asserted-by":"crossref","first-page":"13260","DOI":"10.1128\/JVI.06005-11","article-title":"The cytomegaloviral protein pUL138 acts as potentiator of tumor necrosis factor (TNF) receptor 1 surface density to enhance ULb\u2019-encoded modulation of TNF-\u03b1 signaling","volume":"85","author":"VTK Le","year":"2011","journal-title":"J Virol"},{"key":"ppat.1008807.ref057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-21983-x","article-title":"A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain","volume":"12","author":"E Seidel","year":"2021","journal-title":"Nat Commun"},{"key":"ppat.1008807.ref058","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.3390\/v4112448","article-title":"Human Cytomegalovirus Encoded Homologs of Cytokines, 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Viruses","author":"BP Johnston","year":"2019","journal-title":"MDPI AG"},{"key":"ppat.1008807.ref063","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1099\/vir.0.008466-0","article-title":"Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis","volume":"90","author":"L Mandic","year":"2009","journal-title":"J Gen Virol"},{"key":"ppat.1008807.ref064","article-title":"Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type i interferon immune responses","volume":"9","author":"HJ Choi","year":"2018","journal-title":"Nat Commun"},{"key":"ppat.1008807.ref065","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00251-012-0638-9","article-title":"Immunogenetics of the NKG2D ligand gene family","volume":"64","author":"M Kasahara","year":"2012","journal-title":"Immunogenetics"},{"key":"ppat.1008807.ref066","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1365-2370.1999.00146.x-i2","article-title":"MIC genes in non-human primates","volume":"26","author":"P Pellet","year":"1999","journal-title":"Eur J Immunogenet"},{"key":"ppat.1008807.ref067","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1128\/JVI.01132-12","article-title":"Reevaluation of the Coding Potential and Proteomic Analysis of the BAC-Derived Rhesus Cytomegalovirus Strain 68\u20131","volume":"86","author":"D Malouli","year":"2012","journal-title":"J Virol"},{"key":"ppat.1008807.ref068","first-page":"12","article-title":"Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus","author":"ER Sturgill","year":"2016","journal-title":"PLoS Pathog"},{"key":"ppat.1008807.ref069","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1099\/0022-1317-76-12-2987","article-title":"Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells","volume":"76","author":"H Hengel","year":"1995","journal-title":"J Gen Virol"},{"key":"ppat.1008807.ref070","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1084\/jem.184.3.913","article-title":"Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules","volume":"184","author":"O Mandelboim","year":"1996","journal-title":"J Exp Med"},{"key":"ppat.1008807.ref071","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2144\/000112096","article-title":"Two-step Red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli","volume":"40","author":"BK Tischer","year":"2006","journal-title":"Biotechniques"},{"key":"ppat.1008807.ref072","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20020811","article-title":"Major Histocompatibility Complex Class I Allele-specific Cooperative and Competitive Interactions between Immune Evasion Proteins of Cytomegalovirus","volume":"196","author":"M Wagner","year":"2002","journal-title":"J Exp Med"},{"key":"ppat.1008807.ref073","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1128\/JVI.76.17.8596-8608.2002","article-title":"Identification and Expression of Human Cytomegalovirus Transcription Units Coding for Two Distinct Fc Receptor Homologs","volume":"76","author":"R Atalay","year":"2002","journal-title":"J Virol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008807","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T02:05:52Z","timestamp":1698977152000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008807"}},"subtitle":[],"editor":[{"given":"Richard James","family":"Stanton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":73,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008807","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.17.208462","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]}}}