{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:27:58Z","timestamp":1790810878323,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008823","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000}}],"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K15380"],"award-info":[{"award-number":["15K15380"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K19661"],"award-info":[{"award-number":["17K19661"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03548"],"award-info":[{"award-number":["19H03548"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K1002900"],"award-info":[{"award-number":["16K1002900"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K08930"],"award-info":[{"award-number":["19K08930"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"a Cooperative Research Grant of the Institute for Enzyme Research, Tokushima University"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008823","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T17:37:19Z","timestamp":1598463439000},"page":"e1008823","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice"],"prefix":"10.1371","volume":"16","author":[{"given":"Junji","family":"Chida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5667-3509","authenticated-orcid":true,"given":"Keiji","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuhisa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironori","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Kosako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Tomioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-2594","authenticated-orcid":true,"given":"Toshihiro","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Horiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8824-3124","authenticated-orcid":true,"given":"Suehiro","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"ppat.1008823.ref001","doi-asserted-by":"crossref","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","article-title":"Prions.","volume":"95","author":"SB Prusiner","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008823.ref002","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0092-8674(85)90333-2","article-title":"A cellular gene encodes scrapie PrP 27\u201330 protein","volume":"40","author":"B Oesch","year":"1985","journal-title":"Cell"},{"key":"ppat.1008823.ref003","doi-asserted-by":"crossref","first-page":"e1007049","DOI":"10.1371\/journal.ppat.1007049","article-title":"Prion protein protects mice from lethal infection with influenza A viruses.","volume":"14","author":"J Chida","year":"2018","journal-title":"PLoS Pathog"},{"key":"ppat.1008823.ref004","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neulet.2004.09.030","article-title":"Upregulation of cellular prion protein (PrPc) after focal cerebral ischemia and influence of lesion severity.","volume":"372","author":"J Weise","year":"2004","journal-title":"Neurosci Lett"},{"key":"ppat.1008823.ref005","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0002-9440(10)63291-9","article-title":"Prion protein accumulation and neuroprotection in hypoxic brain damage","volume":"165","author":"NF McLennan","year":"2004","journal-title":"Am J Pathol"},{"key":"ppat.1008823.ref006","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neuroscience.2005.06.095","article-title":"Female-specific neuroprotection against transient brain ischemia observed in mice devoid of prion protein is abolished by ectopic expression of prion protein-like protein","volume":"136","author":"Y Sakurai-Yamashita","year":"2005","journal-title":"Neuroscience"},{"key":"ppat.1008823.ref007","doi-asserted-by":"crossref","first-page":"e0136923","DOI":"10.1371\/journal.pone.0136923","article-title":"Prion Protein Protects against Renal Ischemia\/Reperfusion Injury.","volume":"10","author":"B Zhang","year":"2015","journal-title":"PLoS ONE."},{"key":"ppat.1008823.ref008","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/cvr\/cvu194","article-title":"The cellular prion protein counteracts cardiac oxidative stress","volume":"104","author":"F Zanetti","year":"2014","journal-title":"Cardiovascular research"},{"key":"ppat.1008823.ref009","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1089\/dna.2018.4402","article-title":"Roles of Prion Protein in Virus Infections","volume":"37","author":"S Sakaguchi","year":"2018","journal-title":"DNA Cell Biol"},{"key":"ppat.1008823.ref010","first-page":"1","article-title":"Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2008.","volume":"57","author":"AE Fiore","year":"2008","journal-title":"MMWR Recommendations and reports: Morbidity and mortality weekly report Recommendations and reports \/ Centers for Disease Control."},{"key":"ppat.1008823.ref011","doi-asserted-by":"crossref","first-page":"10366","DOI":"10.1128\/JVI.01200-09","article-title":"Zanamivir-resistant influenza viruses with a novel neuraminidase mutation","volume":"83","author":"AC Hurt","year":"2009","journal-title":"J Virol"},{"key":"ppat.1008823.ref012","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1128\/JVI.72.3.2456-2462.1998","article-title":"Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors","volume":"72","author":"JL McKimm-Breschkin","year":"1998","journal-title":"J Virol"},{"key":"ppat.1008823.ref013","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1128\/AAC.49.11.4515-4520.2005","article-title":"Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors","volume":"49","author":"VP Mishin","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ppat.1008823.ref014","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/viro.1998.9529","article-title":"Characterization of the surface proteins of influenza A (H5N1) viruses isolated from humans in 1997\u20131998.","volume":"254","author":"C Bender","year":"1999","journal-title":"Virology"},{"key":"ppat.1008823.ref015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature02746","article-title":"Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia","volume":"430","author":"KS Li","year":"2004","journal-title":"Nature"},{"key":"ppat.1008823.ref016","first-page":"2515135518821625","article-title":"A review of H5Nx avian influenza viruses.","volume":"7","author":"IA Nunez","year":"2019","journal-title":"Ther Adv Vaccines Immunother"},{"key":"ppat.1008823.ref017","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s12035-019-01804-5","article-title":"The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region","volume":"57","author":"NR Das","year":"2020","journal-title":"Mol Neurobiol"},{"key":"ppat.1008823.ref018","doi-asserted-by":"crossref","first-page":"e31494","DOI":"10.1371\/journal.pone.0031494","article-title":"Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia","volume":"7","author":"Y Yamada","year":"2012","journal-title":"PLoS ONE"},{"key":"ppat.1008823.ref019","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1126\/science.289.5486.1925","article-title":"Signal transduction through prion protein","volume":"289","author":"S Mouillet-Richard","year":"2000","journal-title":"Science"},{"key":"ppat.1008823.ref020","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.200409127","article-title":"Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth","volume":"169","author":"A Santuccione","year":"2005","journal-title":"J Cell Biol"},{"key":"ppat.1008823.ref021","doi-asserted-by":"crossref","first-page":"69469","DOI":"10.1155\/JBB\/2006\/69469","article-title":"Cellular prion protein and caveolin-1 interaction in a neuronal cell line precedes Fyn\/Erk 1\/2 signal transduction.","volume":"2006","author":"M Toni","year":"2006","journal-title":"J Biomed Biotechnol"},{"key":"ppat.1008823.ref022","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00430-012-0284-8","article-title":"PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn","volume":"202","author":"Q Shi","year":"2013","journal-title":"Medical microbiology and immunology"},{"issue":"Suppl 5","key":"ppat.1008823.ref023","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/S0959-8049(02)80599-8","article-title":"Imatinib: a selective tyrosine kinase inhibitor","volume":"38","author":"PW Manley","year":"2002","journal-title":"Eur J Cancer"},{"key":"ppat.1008823.ref024","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1089\/153685903322328992","article-title":"Generation of antibodies against prion protein by scrapie-infected cell immunization of PrP(0\/0) mice.","volume":"22","author":"N Nakamura","year":"2003","journal-title":"Hybrid Hybridomics"},{"key":"ppat.1008823.ref025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2005.07.063","article-title":"Inhibition of prion propagation in scrapie-infected mouse neuroblastoma cell lines using mouse monoclonal antibodies against prion protein","volume":"335","author":"K Miyamoto","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ppat.1008823.ref026","doi-asserted-by":"crossref","first-page":"e1006470","DOI":"10.1371\/journal.ppat.1006470","article-title":"Prions amplify through degradation of the VPS10P sorting receptor sortilin","volume":"13","author":"K Uchiyama","year":"2017","journal-title":"PLoS Pathog"},{"key":"ppat.1008823.ref027","doi-asserted-by":"crossref","first-page":"512926","DOI":"10.1155\/2012\/512926","article-title":"The role of Src kinase in macrophage-mediated inflammatory responses.","volume":"2012","author":"SE Byeon","year":"2012","journal-title":"Mediators Inflamm."},{"key":"ppat.1008823.ref028","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1100\/2011\/213962","article-title":"Macrophage polarization in health and disease","volume":"11","author":"L Cassetta","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"ppat.1008823.ref029","doi-asserted-by":"crossref","first-page":"8917804","DOI":"10.1155\/2018\/8917804","article-title":"Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?","volume":"2018","author":"L Parisi","year":"2018","journal-title":"J Immunol Res"},{"key":"ppat.1008823.ref030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12931-017-0708-5","article-title":"GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte\/macrophage polarization.","volume":"19","author":"ES Halstead","year":"2018","journal-title":"Respir Res"},{"key":"ppat.1008823.ref031","doi-asserted-by":"crossref","first-page":"e91868","DOI":"10.1172\/jci.insight.91868","article-title":"M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.","volume":"2","author":"SL Cole","year":"2017","journal-title":"JCI Insight"},{"key":"ppat.1008823.ref032","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1126\/science.1094273","article-title":"Cross-linking cellular prion protein triggers neuronal apoptosis in vivo","volume":"303","author":"L Solforosi","year":"2004","journal-title":"Science"},{"key":"ppat.1008823.ref033","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature12402","article-title":"The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein","volume":"501","author":"T Sonati","year":"2013","journal-title":"Nature"},{"key":"ppat.1008823.ref034","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.1215579","article-title":"PrP antibodies do not trigger mouse hippocampal neuron apoptosis","volume":"335","author":"PC Klohn","year":"2012","journal-title":"Science"},{"key":"ppat.1008823.ref035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbamcr.2005.08.008","article-title":"Structure of caveolae","volume":"1746","author":"RV Stan","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"ppat.1008823.ref036","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.279.5352.827","article-title":"A transmembrane form of the prion protein in neurodegenerative disease","volume":"279","author":"RS Hegde","year":"1998","journal-title":"Science"},{"key":"ppat.1008823.ref037","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/emboj\/20.4.703","article-title":"Membrane topology influences N-glycosylation of the prion protein","volume":"20","author":"AR Walmsley","year":"2001","journal-title":"Embo J"},{"key":"ppat.1008823.ref038","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.febslet.2004.08.076","article-title":"Clustering of cellular prion protein induces ERK1\/2 and stathmin phosphorylation in GT1-7 neuronal cells","volume":"576","author":"C Monnet","year":"2004","journal-title":"FEBS Lett"},{"key":"ppat.1008823.ref039","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/nn.3178","article-title":"Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons","volume":"15","author":"JW Um","year":"2012","journal-title":"Nat Neurosci"},{"key":"ppat.1008823.ref040","article-title":"The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.","volume":"6","author":"B Wu","year":"2017","journal-title":"Elife"},{"key":"ppat.1008823.ref041","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1007\/s00018-015-1995-y","article-title":"Macrophage polarization in pathology","volume":"72","author":"A Sica","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"ppat.1008823.ref042","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/356577a0","article-title":"Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein","volume":"356","author":"H Bueler","year":"1992","journal-title":"Nature"},{"key":"ppat.1008823.ref043","doi-asserted-by":"crossref","first-page":"24202","DOI":"10.1074\/jbc.M804212200","article-title":"Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein\/doppel in mice","volume":"283","author":"D Yoshikawa","year":"2008","journal-title":"J Biol Chem"},{"key":"ppat.1008823.ref044","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.vaccine.2006.09.078","article-title":"Immunization with recombinant bovine but not mouse prion protein delays the onset of disease in mice inoculated with a mouse-adapted prion","volume":"25","author":"D Ishibashi","year":"2007","journal-title":"Vaccine"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008823","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T17:39:53Z","timestamp":1600105193000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008823"}},"subtitle":[],"editor":[{"given":"Ryan","family":"Langlois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,26]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008823","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1008823","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,26]]}}}