{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:00:14Z","timestamp":1768680014673,"version":"3.49.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM111741"],"award-info":[{"award-number":["GM111741"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI132507"],"award-info":[{"award-number":["AI132507"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI113134"],"award-info":[{"award-number":["AI113134"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI115834"],"award-info":[{"award-number":["AI115834"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008849","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T17:27:19Z","timestamp":1601573239000},"page":"e1008849","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["STAT3 imparts BRCAness\u00a0by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-3050","authenticated-orcid":true,"given":"Michael T.","family":"McIntosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva","family":"Koganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-2457","authenticated-orcid":true,"given":"J. Lucas","family":"Boatwright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9677-3478","authenticated-orcid":true,"given":"Salvatore V.","family":"Spadaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis C.","family":"Brantly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-7082","authenticated-orcid":true,"given":"Jasmine B.","family":"Ayers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon D.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-2288","authenticated-orcid":true,"given":"Eric M.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-6570","authenticated-orcid":true,"given":"Sandeepta","family":"Burgula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0025-9285","authenticated-orcid":true,"given":"Thomas","family":"MacCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-9497","authenticated-orcid":true,"given":"Sumita","family":"Bhaduri-McIntosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"issue":"13","key":"ppat.1008849.ref001","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1056\/NEJMra032015","article-title":"Persistence of the Epstein-Barr virus and the origins of associated lymphomas","volume":"350","author":"DA Thorley-Lawson","year":"2004","journal-title":"N Engl J Med"},{"key":"ppat.1008849.ref002","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-pathmechdis-012418-013023","article-title":"Epstein-Barr Virus and Cancer","volume":"14","author":"PJ Farrell","year":"2019","journal-title":"Annu Rev Pathol"},{"issue":"12","key":"ppat.1008849.ref003","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nrmicro2015","article-title":"The curious case of the tumour virus: 50 years of Burkitt's lymphoma","volume":"6","author":"DA Thorley-Lawson","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"ppat.1008849.ref004","doi-asserted-by":"crossref","first-page":"e13652","DOI":"10.1111\/ctr.13652","article-title":"Practice ASTIDCo. Post-transplant Lymphoproliferative Disorders, EBV infection and Disease in Solid Organ Transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","author":"UD Allen","year":"2019","journal-title":"Clin Transplant"},{"issue":"3","key":"ppat.1008849.ref005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11899-013-0162-5","article-title":"Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies","volume":"8","author":"Z Al-Mansour","year":"2013","journal-title":"Curr Hematol Malig Rep"},{"key":"ppat.1008849.ref006","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fonc.2019.00109","article-title":"Epstein Barr Virus Associated B-Cell Lymphomas and Iatrogenic Lymphoproliferative Disorders","volume":"9","author":"JL Crombie","year":"2019","journal-title":"Front Oncol"},{"key":"ppat.1008849.ref007","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.med.56.082103.104727","article-title":"Post-transplant lymphoproliferative disorders","volume":"56","author":"S Gottschalk","year":"2005","journal-title":"Annu Rev Med"},{"issue":"5","key":"ppat.1008849.ref008","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1399-3062.2009.00411.x","article-title":"Outcome of treatment of Epstein-Barr virus-related post-transplant lymphoproliferative disorder in hematopoietic stem cell recipients: a comprehensive review of reported cases","volume":"11","author":"J Styczynski","year":"2009","journal-title":"Transpl Infect Dis"},{"issue":"1","key":"ppat.1008849.ref009","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1128\/JVI.02601-13","article-title":"B lymphocytes from patients with a hypomorphic mutation in STAT3 resist Epstein-Barr virus-driven cell proliferation","volume":"88","author":"S Koganti","year":"2014","journal-title":"J Virol"},{"issue":"13","key":"ppat.1008849.ref010","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.1400683111","article-title":"STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation","volume":"111","author":"S Koganti","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ppat.1008849.ref011","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.virol.2019.11.017","article-title":"STAT3 activates the anti-apoptotic form of caspase 9 in oncovirus-infected B lymphocytes","volume":"540","author":"S Koganti","year":"2020","journal-title":"Virology"},{"issue":"28","key":"ppat.1008849.ref012","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1038\/onc.2008.17","article-title":"The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage","volume":"27","author":"EM Bahassi","year":"2008","journal-title":"Oncogene"},{"issue":"2","key":"ppat.1008849.ref013","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ncb1212","article-title":"The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair","volume":"7","author":"CS Sorensen","year":"2005","journal-title":"Nat Cell Biol"},{"issue":"11","key":"ppat.1008849.ref014","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.tibs.2015.08.006","article-title":"Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?","volume":"40","author":"A Sfeir","year":"2015","journal-title":"Trends Biochem Sci"},{"issue":"16","key":"ppat.1008849.ref015","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 mutations in the hyper-IgE syndrome","volume":"357","author":"SM Holland","year":"2007","journal-title":"N Engl J Med"},{"issue":"5","key":"ppat.1008849.ref016","doi-asserted-by":"crossref","first-page":"32R","DOI":"10.1203\/PDR.0b013e31819dc8c5","article-title":"Clinical manifestations, etiology, and pathogenesis of the hyper-IgE syndromes","volume":"65","author":"AF Freeman","year":"2009","journal-title":"Pediatr Res"},{"issue":"4","key":"ppat.1008849.ref017","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nsmb.2029","article-title":"Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication","volume":"18","author":"K Nakanishi","year":"2011","journal-title":"Nat Struct Mol Biol"},{"issue":"6566","key":"ppat.1008849.ref018","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/379645a0","article-title":"Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor","volume":"379","author":"N Meydan","year":"1996","journal-title":"Nature"},{"issue":"22","key":"ppat.1008849.ref019","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1200\/JCO.2008.16.0812","article-title":"A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair","volume":"26","author":"A. Ashworth","year":"2008","journal-title":"J Clin Oncol"},{"issue":"12","key":"ppat.1008849.ref020","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrc3399","article-title":"DNA repair dysregulation from cancer driver to therapeutic target","volume":"12","author":"NJ Curtin","year":"2012","journal-title":"Nat Rev Cancer"},{"issue":"22","key":"ppat.1008849.ref021","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1200\/JCO.2010.28.5791","article-title":"Personalizing therapy for ovarian cancer: BRCAness and beyond","volume":"28","author":"RC Bast","year":"2010","journal-title":"J Clin Oncol"},{"issue":"Suppl 1","key":"ppat.1008849.ref022","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/ejhg.2016.93","article-title":"The biological effects and clinical implications of BRCA mutations: where do we go from here?","volume":"24","author":"D. Stoppa-Lyonnet","year":"2016","journal-title":"Eur J Hum Genet"},{"issue":"1","key":"ppat.1008849.ref023","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1158\/2326-6066.CIR-18-0071","article-title":"PARP1 Suppresses the Transcription of PD-L1 by Poly(ADP-Ribosyl)ating STAT3","volume":"7","author":"L Ding","year":"2019","journal-title":"Cancer Immunol Res"},{"issue":"6","key":"ppat.1008849.ref024","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/cam4.317","article-title":"Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer","volume":"3","author":"TK Owonikoko","year":"2014","journal-title":"Cancer Med"},{"issue":"3","key":"ppat.1008849.ref025","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood.V88.3.809.809","article-title":"Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines","volume":"88","author":"RM Weber-Nordt","year":"1996","journal-title":"Blood"},{"issue":"7538","key":"ppat.1008849.ref026","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature14157","article-title":"Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination","volume":"518","author":"PA Mateos-Gomez","year":"2015","journal-title":"Nature"},{"issue":"6","key":"ppat.1008849.ref027","doi-asserted-by":"crossref","first-page":"e1000110","DOI":"10.1371\/journal.pgen.1000110","article-title":"Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair","volume":"4","author":"N Bennardo","year":"2008","journal-title":"PLoS Genet"},{"key":"ppat.1008849.ref028","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13740","article-title":"Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining","volume":"5","author":"T Kent","year":"2016","journal-title":"Elife"},{"issue":"22","key":"ppat.1008849.ref029","doi-asserted-by":"crossref","first-page":"12848","DOI":"10.1093\/nar\/gkx1056","article-title":"Secondary structure forming sequences drive SD-MMEJ repair of DNA double-strand breaks","volume":"45","author":"VY Khodaverdian","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"17","key":"ppat.1008849.ref030","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1093\/nar\/gkq379","article-title":"Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions","volume":"38","author":"AM Yu","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"ppat.1008849.ref031","first-page":"945","article-title":"Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention","volume":"8","author":"R Buettner","year":"2002","journal-title":"Clin Cancer Res"},{"issue":"4","key":"ppat.1008849.ref032","doi-asserted-by":"crossref","first-page":"e1001046","DOI":"10.1371\/journal.pbio.1001046","article-title":"A user's guide to the encyclopedia of DNA elements (ENCODE)","volume":"9","author":"EP Consortium","year":"2011","journal-title":"PLoS Biol"},{"issue":"7391","key":"ppat.1008849.ref033","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/nature11005","article-title":"Systematic identification of genomic markers of drug sensitivity in cancer cells","volume":"483","author":"MJ Garnett","year":"2012","journal-title":"Nature"},{"issue":"21","key":"ppat.1008849.ref034","doi-asserted-by":"crossref","first-page":"11438","DOI":"10.1128\/JVI.01762-13","article-title":"Signal transducer and activator of transcription 3 limits Epstein-Barr virus lytic activation in B lymphocytes","volume":"87","author":"ER Hill","year":"2013","journal-title":"J Virol"},{"issue":"3","key":"ppat.1008849.ref035","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00007890-200208150-00017","article-title":"Constitutive activation of Jak\/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder","volume":"74","author":"RR Nepomuceno","year":"2002","journal-title":"Transplantation"},{"issue":"2","key":"ppat.1008849.ref036","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrc1275","article-title":"The STATs of cancer\u2014new molecular targets come of age","volume":"4","author":"H Yu","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"57","key":"ppat.1008849.ref037","doi-asserted-by":"crossref","first-page":"31077","DOI":"10.18632\/oncotarget.25780","article-title":"STAT3 is constitutively activated in chronic active Epstein-Barr virus infection and can be a therapeutic target","volume":"9","author":"E Onozawa","year":"2018","journal-title":"Oncotarget"},{"issue":"22","key":"ppat.1008849.ref038","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1056\/NEJMoa1611310","article-title":"Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer","volume":"375","author":"MR Mirza","year":"2016","journal-title":"N Engl J Med"},{"issue":"16","key":"ppat.1008849.ref039","doi-asserted-by":"crossref","first-page":"8109","DOI":"10.1158\/0008-5472.CAN-06-0140","article-title":"Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.","volume":"66","author":"N McCabe","year":"2006","journal-title":"Cancer Res"},{"issue":"4","key":"ppat.1008849.ref040","article-title":"beta-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage","volume":"8","author":"JA Snow","year":"2019","journal-title":"Pathogens"},{"issue":"2","key":"ppat.1008849.ref041","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10549-012-2188-0","article-title":"Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib","volume":"135","author":"A Daemen","year":"2012","journal-title":"Breast Cancer Res Treat"},{"issue":"22","key":"ppat.1008849.ref042","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1200\/JCO.2009.27.5719","article-title":"Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer","volume":"28","author":"PA Konstantinopoulos","year":"2010","journal-title":"J Clin Oncol"},{"key":"ppat.1008849.ref043","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41540-017-0011-6","article-title":"Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm","volume":"3","author":"DJ McGrail","year":"2017","journal-title":"NPJ Syst Biol Appl"},{"issue":"10","key":"ppat.1008849.ref044","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/ng.3934","article-title":"A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer","volume":"49","author":"P Polak","year":"2017","journal-title":"Nat Genet"},{"issue":"3","key":"ppat.1008849.ref045","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/bcr3670","article-title":"Genomic scars as biomarkers of homologous recombination deficiency and drug response in breast and ovarian cancers","volume":"16","author":"JA Watkins","year":"2014","journal-title":"Breast Cancer Res"},{"key":"ppat.1008849.ref046","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.isci.2018.03.016","article-title":"SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair","volume":"2","author":"S Chakraborty","year":"2018","journal-title":"iScience"},{"issue":"6750","key":"ppat.1008849.ref047","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/45843","article-title":"The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites","volume":"401","author":"B Hendrich","year":"1999","journal-title":"Nature"},{"issue":"19","key":"ppat.1008849.ref048","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1038\/sj.emboj.7600812","article-title":"ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage","volume":"24","author":"L Chen","year":"2005","journal-title":"EMBO J"},{"issue":"6","key":"ppat.1008849.ref049","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1128\/MCB.18.6.3580","article-title":"The nucleic acid binding activity of bleomycin hydrolase is involved in bleomycin detoxification","volume":"18","author":"W Zheng","year":"1998","journal-title":"Mol Cell Biol"},{"issue":"5828","key":"ppat.1008849.ref050","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"S Matsuoka","year":"2007","journal-title":"Science"},{"issue":"11","key":"ppat.1008849.ref051","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1074\/jbc.274.11.7278","article-title":"AP-4, a novel protein complex related to clathrin adaptors","volume":"274","author":"EC Dell'Angelica","year":"1999","journal-title":"J Biol Chem"},{"issue":"7463","key":"ppat.1008849.ref052","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"LB Alexandrov","year":"2013","journal-title":"Nature"},{"issue":"1","key":"ppat.1008849.ref053","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/viro.1995.1157","article-title":"Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigens 2A (EBNA2A) and 2B (EBNA2B)","volume":"208","author":"E Kremmer","year":"1995","journal-title":"Virology"},{"issue":"17","key":"ppat.1008849.ref054","doi-asserted-by":"crossref","first-page":"14806","DOI":"10.1074\/jbc.M210862200","article-title":"Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation","volume":"278","author":"M Gatei","year":"2003","journal-title":"J Biol Chem"},{"key":"ppat.1008849.ref055","volume-title":"Bioinformatics and Computational Biology Solutions using R and Bioconductor","author":"GK Smyth","year":"2005"},{"issue":"1","key":"ppat.1008849.ref056","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression Shrinkage and Selection via the Lasso","volume":"58","author":"R. Tibshirani","year":"1996","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"issue":"2","key":"ppat.1008849.ref057","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1467-9868.2005.00503.x","article-title":"Regularization and variable selection via the elastic net","volume":"67","author":"HaH, T. Zou","year":"2005","journal-title":"Journal of the Royal Statistical Society: Series B (Statistical Methodology)"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T20:50:43Z","timestamp":1696798243000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008849"}},"subtitle":[],"editor":[{"given":"Nicholas","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008849","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]}}}