{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:32:00Z","timestamp":1792873920590,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008920","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000}}],"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI020566"],"award-info":[{"award-number":["AI020566"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008920","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T14:13:03Z","timestamp":1601475183000},"page":"e1008920","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-904X","authenticated-orcid":true,"given":"Pranav N. M.","family":"Shah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-1644","authenticated-orcid":true,"given":"David J.","family":"Filman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishanthi S.","family":"Karunatilaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-0061","authenticated-orcid":true,"given":"Emma L.","family":"Hesketh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Groppelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0986-2868","authenticated-orcid":true,"given":"Mike","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3655-1504","authenticated-orcid":true,"given":"James M.","family":"Hogle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ppat.1008920.ref001","first-page":"153","volume-title":"Chapter 11\u2014Picornavirus.","author":"W-S Ryu","year":"2017"},{"key":"ppat.1008920.ref002","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.2994218","article-title":"Three-dimensional structure of poliovirus at 2.9 A resolution","volume":"229","author":"JM Hogle","year":"1985","journal-title":"Science"},{"key":"ppat.1008920.ref003","doi-asserted-by":"crossref","first-page":"e20191619","DOI":"10.1542\/peds.2019-1619","article-title":"Acute Flaccid Myelitis in the United States: 2015\u20132017","volume":"144","author":"T Ayers","year":"2019","journal-title":"Pediatrics"},{"key":"ppat.1008920.ref004","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/cid\/ciw372","article-title":"Acute Flaccid Myelitis in the United States, August-December 2014: Results of Nationwide Surveillance","volume":"63","author":"JJ Sejvar","year":"2016","journal-title":"Clin Infect Dis"},{"key":"ppat.1008920.ref005","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(89)90690-9","article-title":"Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily","volume":"56","author":"CL Mendelsohn","year":"1989","journal-title":"Cell"},{"key":"ppat.1008920.ref006","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1349-7006.2003.tb01499.x","article-title":"Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization","volume":"94","author":"Y Takai","year":"2003","journal-title":"Cancer Sci."},{"key":"ppat.1008920.ref007","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1128\/JVI.03101-14","article-title":"Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry","volume":"89","author":"M Strauss","year":"2015","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref008","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/jmbi.1999.3483","article-title":"Stabilization of poliovirus by capsid-binding antiviral drugs is due to entropic effects","volume":"296","author":"SK Tsang","year":"2000","journal-title":"J Mol Biol"},{"key":"ppat.1008920.ref009","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/j.1460-2075.1989.tb03541.x","article-title":"Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus","volume":"8","author":"DJ Filman","year":"1989","journal-title":"The EMBO Journal"},{"key":"ppat.1008920.ref010","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1128\/JVI.74.3.1342-1354.2000","article-title":"Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus","volume":"74","author":"DM Belnap","year":"2000","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref011","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/JVI.64.5.1934-1945.1990","article-title":"Cell-induced conformational change in poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding","volume":"64","author":"CE Fricks","year":"1990","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref012","first-page":"554","article-title":"Studies on the in vitro uncoating of poliovirus II. Characteristics of the membrane-modified particle","volume":"78","author":"J de Sena","year":"1977","journal-title":"Virology. Academic Press"},{"key":"ppat.1008920.ref013","first-page":"212","article-title":"Early interactions between poliovirus and ERK cells: Some observations on the nature and significance of the rejected particles","volume":"18","author":"ML Fenwick","year":"1962","journal-title":"Virology. Academic Press"},{"key":"ppat.1008920.ref014","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1128\/JVI.01949-13","article-title":"Cryo-Electron Microscopy Reconstruction Shows Poliovirus 135S Particles Poised for Membrane Interaction and RNA Release","volume":"88","author":"C Butan","year":"2014","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref015","first-page":"439","article-title":"The adsorption and early fate of purified poliovirus in HeLa cells","volume":"13","author":"WK Joklik","year":"1961","journal-title":"Virology. Academic Press"},{"key":"ppat.1008920.ref016","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/JVI.8.4.509-515.1971","article-title":"Specific alterations of coxsackievirus B3 eluted from HeLa cells","volume":"8","author":"RL Crowell","year":"1971","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref017","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.1128\/JVI.70.10.7125-7131.1996","article-title":"The poliovirus 135S particle is infectious","volume":"70","author":"S Curry","year":"1996","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref018","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1128\/JVI.74.18.8757-8761.2000","article-title":"Is the 135S Poliovirus Particle an Intermediate during Cell Entry?","volume":"74","author":"Y Huang","year":"2000","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref019","doi-asserted-by":"crossref","first-page":"E12209","DOI":"10.1073\/pnas.1803347115","article-title":"Molecular basis for the acid-initiated uncoating of human enterovirus D68","volume":"115","author":"Y Liu","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"ppat.1008920.ref020","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1038\/s41467-018-07531-0","article-title":"Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating","volume":"9","author":"L Zhu","year":"2018","journal-title":"Nature Communications. Nature Publishing Group"},{"key":"ppat.1008920.ref021","doi-asserted-by":"crossref","first-page":"20063","DOI":"10.1073\/pnas.1312128110","article-title":"Uncoating of common cold virus is preceded by RNA switching as determined by X-ray and cryo-EM analyses of the subviral A-particle","volume":"110","author":"A Pickl-Herk","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ppat.1008920.ref022","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/ncomms2889","article-title":"Picornavirus uncoating intermediate captured in atomic detail","volume":"4","author":"J Ren","year":"2013","journal-title":"Nature Communications"},{"key":"ppat.1008920.ref023","doi-asserted-by":"crossref","first-page":"e1003240","DOI":"10.1371\/journal.ppat.1003240","article-title":"The enterovirus 71 A-particle forms a gateway to allow genome release: a cryoEM study of picornavirus uncoating","volume":"9","author":"KL Shingler","year":"2013","journal-title":"PLoS Pathog."},{"key":"ppat.1008920.ref024","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1128\/JVI.00299-14","article-title":"Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle","volume":"88","author":"LJ Organtini","year":"2014","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref025","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41467-017-00477-9","article-title":"Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody","volume":"8","author":"L Xu","year":"2017","journal-title":"Nature Communications."},{"key":"ppat.1008920.ref026","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1128\/JVI.03029-13","article-title":"Human enterovirus 71 uncoating captured at atomic resolution.","volume":"88","author":"K Lyu","year":"2014","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref027","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/327482a0","article-title":"Myristylation of picornavirus capsid protein VP4 and its structural significance","volume":"327","author":"M Chow","year":"1987","journal-title":"Nature."},{"key":"ppat.1008920.ref028","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/JVI.80.1.172-180.2006","article-title":"Characterization of Early Steps in the Poliovirus Infection Process: Receptor-Decorated Liposomes Induce Conversion of the Virus to Membrane-Anchored Entry-Intermediate Particles","volume":"80","author":"TJ Tuthill","year":"2006","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref029","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/JVI.03209-12","article-title":"RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors","volume":"87","author":"M Strauss","year":"2013","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref030","doi-asserted-by":"crossref","first-page":"e1006197","DOI":"10.1371\/journal.ppat.1006197","article-title":"Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes. Sarnow P, editor","volume":"13","author":"E Groppelli","year":"2017","journal-title":"PLoS Pathog."},{"key":"ppat.1008920.ref031","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1128\/JVI.68.6.3965-3970.1994","article-title":"Poliovirus neutralization by antibodies to internal epitopes of VP4 and VP1 results from reversible exposure of these sequences at physiological temperature","volume":"68","author":"Q Li","year":"1994","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref032","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1006\/viro.1993.1427","article-title":"An Immunodominant N-Terminal Region of VP1 Protein of Poliovirion That Is Buried in Crystal Structure Can Be Exposed in Solution.","volume":"195","author":"M Roivainen","year":"1993","journal-title":"Virology."},{"key":"ppat.1008920.ref033","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1128\/JVI.05990-11","article-title":"Structure of the Fab-labeled \u201cbreathing\u201d state of native poliovirus.","volume":"86","author":"J Lin","year":"2012","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref034","doi-asserted-by":"crossref","first-page":"e01443","DOI":"10.1128\/JVI.01443-16","article-title":"Cryo-electron Microscopy Structures of Expanded Poliovirus with VHHs Sample the Conformational Repertoire of the Expanded State","volume":"91","author":"M Strauss","year":"2017","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref035","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1128\/JVI.02393-09","article-title":"Catching a virus in the act of RNA release: a novel poliovirus uncoating intermediate characterized by cryo-electron microscopy","volume":"84","author":"HC Levy","year":"2010","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref036","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.1128\/JVI.05013-11","article-title":"An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles","volume":"85","author":"J Lin","year":"2011","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref037","doi-asserted-by":"crossref","first-page":"e2006191","DOI":"10.1371\/journal.pbio.2006191","article-title":"Structure of the herpes simplex virus portal-vertex. Sugden B, editor","volume":"16","author":"M McElwee","year":"2018","journal-title":"Plos Biol."},{"key":"ppat.1008920.ref038","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41586-018-0852-1","article-title":"Calicivirus VP2 forms a portal-like assembly following receptor engagement","volume":"565","author":"MJ Conley","year":"2019","journal-title":"Nature."},{"key":"ppat.1008920.ref039","doi-asserted-by":"crossref","first-page":"e3000649","DOI":"10.1371\/journal.pbio.3000649","article-title":"Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM","volume":"18","author":"JS Snowden","year":"2020","journal-title":"Plos Biol"},{"key":"ppat.1008920.ref040","doi-asserted-by":"crossref","first-page":"7745","DOI":"10.1128\/JVI.79.12.7745-7755.2005","article-title":"The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes","volume":"79","author":"D Bubeck","year":"2005","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref041","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1128\/JVI.64.10.4697-4702.1990","article-title":"Neutralization of poliovirus by cell receptors expressed in insect cells","volume":"64","author":"G Kaplan","year":"1990","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref042","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1006\/viro.1993.1621","article-title":"Characterization of poliovirus conformational alteration mediated by soluble cell receptors","volume":"197","author":"AG G\u00f3mez Yafal","year":"1993","journal-title":"Virology"},{"key":"ppat.1008920.ref043","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1099\/0022-1317-72-10-2541","article-title":"Influence of different ionic and pH environments on structural alterations of poliovirus and their possible relation to virus uncoating","volume":"72","author":"K Wetz","year":"1991","journal-title":"Journal of General Virology"},{"key":"ppat.1008920.ref044","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1128\/JVI.75.11.4984-4989.2001","article-title":"Kinetic analysis of the effect of poliovirus receptor on viral uncoating: the receptor as a catalyst","volume":"75","author":"SK Tsang","year":"2001","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref045","doi-asserted-by":"crossref","first-page":"e1004294","DOI":"10.1371\/journal.ppat.1004294","article-title":"Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore","volume":"10","author":"A Panjwani","year":"2014","journal-title":"PLoS Pathog."},{"key":"ppat.1008920.ref046","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/JVI.71.1.507-511.1997","article-title":"Characterization of the ion channels formed by poliovirus in planar lipid membranes","volume":"71","author":"MT Tosteson","year":"1997","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref047","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1128\/JVI.77.9.5266-5274.2003","article-title":"Genome Delivery and Ion Channel Properties Are Altered in VP4 Mutants of Poliovirus","volume":"77","author":"P Danthi","year":"2003","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref048","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1128\/JVI.64.1.195-206.1990","article-title":"Mutations in Vp1 of Poliovirus Specifically Affect Both Encapsidation and Release of Viral RNA","volume":"64","author":"K. Kirkegaard","year":"1990","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref049","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1371\/journal.pbio.0050183","article-title":"Imaging Poliovirus Entry in Live Cells.","volume":"5","author":"B Brandenburg","year":"2007","journal-title":"Plos Biol."},{"key":"ppat.1008920.ref050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1128\/JVI.7.1.41-46.1971","article-title":"Biophysical and biochemical studies on rhinovirus and poliovirus. II. Chemical and hydrodynamic analysis of the rhinovirion","volume":"7","author":"S McGregor","year":"1971","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref051","first-page":"163","article-title":"New tools for automated high-resolution cryo-EM structure determination in RELION-3.","volume":"7","author":"J Zivanov","year":"2018","journal-title":"eLife Sciences."},{"key":"ppat.1008920.ref052","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1107\/S205225251801463X","article-title":"A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis.","volume":"6","author":"J Zivanov","year":"2019","journal-title":"IUCrJ"},{"key":"ppat.1008920.ref053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsb.2015.11.003","article-title":"Gctf: Real-time CTF determination and correction","volume":"193","author":"K. Zhang","year":"2016","journal-title":"Journal of Structural Biology"},{"key":"ppat.1008920.ref054","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s42003-019-0437-z","article-title":"SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM.","volume":"2","author":"T Wagner","year":"2019","journal-title":"Commun Biol."},{"key":"ppat.1008920.ref055","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/jsbi.1996.0030","article-title":"SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields","volume":"116","author":"J Frank","year":"1996","journal-title":"Journal of Structural Biology"},{"key":"ppat.1008920.ref056","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1128\/JVI.03017-15","article-title":"Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site.","volume":"90","author":"M Strauss","year":"2016","journal-title":"Journal of Virology"},{"key":"ppat.1008920.ref057","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"ppat.1008920.ref058","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"GN Murshudov","year":"1997","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"ppat.1008920.ref059","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1107\/S2059798318006551","article-title":"Real-space refinement in PHENIX for cryo-EM and crystallography","volume":"74","author":"PV Afonine","year":"2018","journal-title":"Acta Crystallogr D Struct Biol"},{"key":"ppat.1008920.ref060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"PD Adams","year":"2010","journal-title":"Acta Crystallogr Sect D Biol Crystallogr"},{"key":"ppat.1008920.ref061","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera?A visualization system for exploratory research and analysis","volume":"25","author":"EF Pettersen","year":"2004","journal-title":"J Comput Chem"},{"key":"ppat.1008920.ref062","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: Meeting modern challenges in visualization and analysis","volume":"27","author":"TD Goddard","year":"2018","journal-title":"Protein Science"},{"key":"ppat.1008920.ref063","doi-asserted-by":"crossref","first-page":"e01456","DOI":"10.7554\/eLife.01456","article-title":"Collaboration gets the most out of software.","volume":"2","author":"A Morin","year":"2013","journal-title":"eLife Sciences."}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008920","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008920","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T13:49:19Z","timestamp":1602510559000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008920"}},"subtitle":[],"editor":[{"given":"Z. Hong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":63,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008920","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.08.899112","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}