{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:08:36Z","timestamp":1791443316451,"version":"4.3.3"},"update-to":[{"DOI":"10.1371\/journal.ppat.1008929","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2015-0055"],"award-info":[{"award-number":["PICT 2015-0055"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2017-1317"],"award-info":[{"award-number":["PICT-2017-1317"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"crossref","award":["PIP 112-2013-0100202"],"award-info":[{"award-number":["PIP 112-2013-0100202"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["ANRS2014-049"],"award-info":[{"award-number":["ANRS2014-049"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["ANRS2018-1"],"award-info":[{"award-number":["ANRS2018-1"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["ANRS2020-01"],"award-info":[{"award-number":["ANRS2020-01"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1008929","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T13:56:40Z","timestamp":1601560600000},"page":"e1008929","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1\u03b1 activation"],"prefix":"10.1371","volume":"16","author":[{"given":"Melanie","family":"Genoula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Mar\u00edn Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Dolotowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-6546","authenticated-orcid":true,"given":"Malena","family":"Ferreyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ayel\u00e9n","family":"Milillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-2786","authenticated-orcid":true,"given":"R\u00e9mi","family":"Mascarau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Jos\u00e9","family":"Mora\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7496-5492","authenticated-orcid":true,"given":"Domingo","family":"Palmero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Matteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Barrionuevo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-5885","authenticated-orcid":true,"given":"Olivier","family":"Neyrolles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cougoule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-8491","authenticated-orcid":true,"given":"Geanncarlo","family":"Lugo-Villarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"V\u00e9rollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Carmen","family":"Sasiain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-3572","authenticated-orcid":true,"given":"Luciana","family":"Balboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"ppat.1008929.ref001","unstructured":"World Health Organization. WHO | Global tuberculosis report 2019. WHO\/CDS\/TB\/2019.15; 2019."},{"key":"ppat.1008929.ref002","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni.1781","article-title":"Foamy macrophages and the progression of the human tuberculosis granuloma","volume":"10","author":"DG Russell","year":"2009","journal-title":"Nat Immunol"},{"key":"ppat.1008929.ref003","article-title":"Evolution of granulomas in lungs of mice infected aerogenically with Mycobacterium tuberculosis","author":"PJ Cardona","year":"2000","journal-title":"Scand J Immunol"},{"key":"ppat.1008929.ref004","article-title":"Rationale for the histological spectrum of tuberculosis. A basis for classification","author":"DS Ridley","year":"1987","journal-title":"Pathology"},{"key":"ppat.1008929.ref005","article-title":"Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype","author":"V Singh","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ppat.1008929.ref006","article-title":"Formation of foamy macrophages by tuberculous pleural effusions is triggered by the interleukin-10\/signal transducer and activator of transcription 3 axis through ACAT upregulation.","author":"M Genoula","year":"2018","journal-title":"Front Immunol."},{"key":"ppat.1008929.ref007","article-title":"M-1\/M-2 Macrophages and the Th1\/Th2 Paradigm.","author":"CD Mills","year":"2000","journal-title":"J Immunol"},{"key":"ppat.1008929.ref008","article-title":"M1 and M2 Macrophages: Oracles of Health and Disease.","author":"C. Mills","year":"2012","journal-title":"Crit Rev Immunol."},{"key":"ppat.1008929.ref009","article-title":"Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis","author":"A Kahnert","year":"2006","journal-title":"Eur J Immunol"},{"key":"ppat.1008929.ref010","article-title":"Gene expression profiles of bronchoalveolar cells in pulmonary TB","author":"B Raju","year":"2008","journal-title":"Tuberculosis"},{"key":"ppat.1008929.ref011","doi-asserted-by":"crossref","DOI":"10.36198\/9783838531748","article-title":"Alternative Activation of Macrophages: An Immunologic Functional Perspective","author":"FO Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ppat.1008929.ref012","article-title":"Hypoxic gene activation by lipopolysaccharide in macrophages: Implication of hypoxia-inducible factor 1\u03b1","author":"CC Blouin","year":"2004","journal-title":"Blood"},{"key":"ppat.1008929.ref013","article-title":"Orchestration of metabolism by macrophages","author":"SK Biswas","year":"2012","journal-title":"Cell Metabolism"},{"key":"ppat.1008929.ref014","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"SCC Huang","year":"2014","journal-title":"Nat Immunol"},{"key":"ppat.1008929.ref015","article-title":"The immune system as a sensor of the metabolic state","author":"JI Odegaard","year":"2013","journal-title":"Immunity"},{"key":"ppat.1008929.ref016","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic Pathways in Immune Cell Activation and Quiescence","volume":"38","author":"EL Pearce","year":"2013","journal-title":"Immunity"},{"key":"ppat.1008929.ref017","article-title":"Oxidative metabolism and PGC-1\u03b2 attenuate macrophage-mediated inflammation.","author":"D Vats","year":"2006","journal-title":"Cell Metab."},{"key":"ppat.1008929.ref018","article-title":"A general introduction to the biochemistry of mitochondrial fatty acid \u03b2-oxidation","author":"SM Houten","year":"2010","journal-title":"Journal of Inherited Metabolic Disease"},{"key":"ppat.1008929.ref019","article-title":"Tan S, Liu Y, Russell DG. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny","author":"L Huang","year":"2018","journal-title":"J Exp Med"},{"key":"ppat.1008929.ref020","article-title":"Tuberculous pleural effusions: Advances and controversies","author":"MJ Vorster","year":"2015","journal-title":"Journal of Thoracic Disease"},{"key":"ppat.1008929.ref021","article-title":"Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10\/STAT3 axis","author":"C Lastrucci","year":"2015","journal-title":"Cell Res"},{"key":"ppat.1008929.ref022","article-title":"M2-IL4-STAT6-enhancer-regulation_CellImmu2018.","author":"Z Czimmerer","year":"2018","journal-title":"Immunity"},{"key":"ppat.1008929.ref023","article-title":"Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease","author":"SJ Van Dyken","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"ppat.1008929.ref024","article-title":"A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice","author":"Y Chiba","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ppat.1008929.ref025","article-title":"Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis","author":"AS Divakaruni","year":"2018","journal-title":"Cell Metab"},{"key":"ppat.1008929.ref026","article-title":"Carnitine transport and fatty acid oxidation","author":"N Longo","year":"2016","journal-title":"Biochim Biophys Acta\u2014Mol Cell Res"},{"key":"ppat.1008929.ref027","article-title":"Immunometabolism governs dendritic cell and macrophage function","author":"LAJ O\u2019Neill","year":"2016","journal-title":"J Exp Med"},{"key":"ppat.1008929.ref028","article-title":"Pyruvate kinase M2 regulates hif-1\u03b1 activity and il-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","author":"EM Palsson-Mcdermott","year":"2015","journal-title":"Cell Metab"},{"key":"ppat.1008929.ref029","article-title":"HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression","author":"D Huang","year":"2014","journal-title":"Cell Rep"},{"key":"ppat.1008929.ref030","article-title":"Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.","author":"A Siddiq","year":"2009","journal-title":"J Neurosci"},{"key":"ppat.1008929.ref031","article-title":"Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism","author":"MJ Kim","year":"2010","journal-title":"EMBO Mol Med"},{"key":"ppat.1008929.ref032","article-title":"Foamy macrophages from tuberculous patients\u2019 granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","author":"P Peyron","year":"2008","journal-title":"PLoS Pathog"},{"key":"ppat.1008929.ref033","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tube.2006.11.003","article-title":"Pathology of postprimary tuberculosis in humans and mice: Contradiction of long-held beliefs","volume":"87","author":"RL Hunter","year":"2007","journal-title":"Tuberculosis"},{"key":"ppat.1008929.ref034","article-title":"Infection of macrophages with Mycobacterium tuberculosis induces global modifications to phagosomal function","author":"M Podinovskaia","year":"2013","journal-title":"Cell Microbiol"},{"key":"ppat.1008929.ref035","article-title":"Mycobacterial surface moieties are released from infected macrophages by a constitutive exocytic event","author":"WL Beatty","year":"2001","journal-title":"Eur J Cell Biol"},{"key":"ppat.1008929.ref036","article-title":"Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: Characterization of a new model of the granulomatous response to mycobacterial components","author":"ER Rhoades","year":"2005","journal-title":"Tuberculosis"},{"key":"ppat.1008929.ref037","article-title":"Mycobacterium and the coat of many lipids","author":"DG Russell","year":"2002","journal-title":"Journal of Cell Biology"},{"key":"ppat.1008929.ref038","article-title":"Modified immunohistological staining allows detection of Ziehl-Neelsen-negative Mycobacterium tuberculosis organisms and their precise localization in human tissue","author":"T Ulrichs","year":"2005","journal-title":"J Pathol"},{"key":"ppat.1008929.ref039","article-title":"Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific","author":"V Guerrini","year":"2018","journal-title":"PLoS Pathog"},{"key":"ppat.1008929.ref040","article-title":"Necrosis driven triglyceride synthesis primes macrophages for inflammation during Mycobacterium tuberculosis infection","author":"N Jaisinghani","year":"2018","journal-title":"Front Immunol"},{"key":"ppat.1008929.ref041","article-title":"Diagnostic performance of different pleural fluid biomarkers in Tuberculous pleurisy","author":"J Klimiuk","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"ppat.1008929.ref042","article-title":"Interleukin 4 Potently Enhances Murine Macrophage Mannose Receptor Activity: A Marker of Alternative Immunologic Macrophage Activation By Michael Stein, Satish Keshav, Neil Harris,* and Siamon Gordon","author":"M Stein","year":"1992","journal-title":"Receptor"},{"key":"ppat.1008929.ref043","article-title":"Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies.","author":"L Martinez-Pomares","year":"2003","journal-title":"J Leukoc Biol"},{"key":"ppat.1008929.ref044","article-title":"SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function","author":"NL Price","year":"2012","journal-title":"Cell Metab"},{"key":"ppat.1008929.ref045","article-title":"PPAR\u03b1 and PPAR\u03b3 activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression","author":"G Ye","year":"2019","journal-title":"Cell Death Dis"},{"key":"ppat.1008929.ref046","article-title":"Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization","author":"D Namgaladze","year":"2014","journal-title":"Biochim Biophys Acta\u2014Mol Cell Biol Lipids"},{"key":"ppat.1008929.ref047","article-title":"Fatty acid oxidation in macrophage polarization","author":"M Nomura","year":"2016","journal-title":"Nature Immunology"},{"key":"ppat.1008929.ref048","article-title":"Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation","author":"MI Malandrino","year":"2015","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ppat.1008929.ref049","article-title":"Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis","author":"C-H Tsao","year":"2014","journal-title":"J Lipid Res"},{"key":"ppat.1008929.ref050","article-title":"CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis","author":"CE Dodd","year":"2016","journal-title":"J Immunol"},{"key":"ppat.1008929.ref051","article-title":"Small Molecule Mediated Restoration of Mitochondrial Function Augments Anti-Mycobacterial Activity of Human Macrophages Subjected to Cholesterol Induced Asymptomatic Dyslipidemia.","author":"S Asalla","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"ppat.1008929.ref052","article-title":"Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages","author":"MS Koo","year":"2012","journal-title":"Cell Commun Signal"},{"key":"ppat.1008929.ref053","article-title":"Pathogenicity of Mycobacterium tuberculosis Is Expressed by Regulating Metabolic Thresholds of the Host Macrophage.","author":"P Mehrotra","year":"2014","journal-title":"PLoS Pathog"},{"key":"ppat.1008929.ref054","article-title":"Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs","author":"L Shi","year":"2015","journal-title":"Sci Rep"},{"key":"ppat.1008929.ref055","article-title":"Lesion-specific immune response in granulomas of patients with pulmonary tuberculosis: A pilot study.","author":"S Subbian","year":"2015","journal-title":"PLoS One"},{"key":"ppat.1008929.ref056","article-title":"HIF-1\u03b1 Is an Essential Mediator of IFN-\u03b3\u2013Dependent Immunity to Mycobacterium tuberculosis","author":"J Braverman","year":"2016","journal-title":"J Immunol"},{"key":"ppat.1008929.ref057","article-title":"The E3 ligase VHL controls alveolar macrophage function via metabolic\u2013epigenetic regulation","author":"W Zhang","year":"2018","journal-title":"J Exp Med"},{"key":"ppat.1008929.ref058","article-title":"Dual role of hypoxia-inducible factor 1 \u03b1 in experimental pulmonary tuberculosis: Its implication as a new therapeutic target","author":"GJ Baay-Guzman","year":"2018","journal-title":"Future Microbiol"},{"key":"ppat.1008929.ref059","article-title":"Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-\u03b3\/HIF-1\u03b1 signaling and supports host defense.","author":"M Knight","year":"2018","journal-title":"PLoS Pathog."},{"key":"ppat.1008929.ref060","article-title":"Rewiring cellular metabolism via the AKT\/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells","author":"E Lachmandas","year":"2016","journal-title":"Eur J Immunol"},{"key":"ppat.1008929.ref061","article-title":"HIF-1\u03b1 and HIF-2\u03b1 are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1\u03b1-mediated fatty acid \u03b2-oxidation","author":"Y Liu","year":"2014","journal-title":"Toxicol Lett"},{"key":"ppat.1008929.ref062","article-title":"Manipulation of the mononuclear phagocyte system by mycobacterium tuberculosis","author":"G Lugo-Villarino","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ppat.1008929.ref063","article-title":"Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms","author":"JT Mattila","year":"2013","journal-title":"J Immunol"},{"key":"ppat.1008929.ref064","article-title":"Differential polarization of alveolar macrophages and bone marrow-derived monocytes following chemically and pathogen-induced chronic lung inflammation","author":"EF Redente","year":"2010","journal-title":"J Leukoc Biol"},{"key":"ppat.1008929.ref065","article-title":"Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection","author":"S Marino","year":"2015","journal-title":"Infect Immun"},{"key":"ppat.1008929.ref066","article-title":"Emerging trends in the formation and function of tuberculosis granulomas","author":"G Lugo-Villarino","year":"2012","journal-title":"Front Immunol"},{"key":"ppat.1008929.ref067","article-title":"Macrophage Polarization in Bacterial Infections.","author":"M Benoit","year":"2008","journal-title":"J Immunol"},{"key":"ppat.1008929.ref068","article-title":"Update on tuberculous pleural effusion.","author":"RW Light","year":"2010","journal-title":"Respirology"},{"key":"ppat.1008929.ref069","article-title":"Evaluation of foam cell formation in cultured macrophages: An improved method with Oil Red O staining and DiI-oxLDL uptake","author":"S Xu","year":"2010","journal-title":"Cytotechnology"},{"key":"ppat.1008929.ref070","article-title":"A rapid enzymatic assay for glycerol","author":"PB Garland","year":"1962","journal-title":"Nature"},{"key":"ppat.1008929.ref071","article-title":"The 1996 Guide for the Care and Use of Laboratory Animals.","author":"JD Clark","year":"1997","journal-title":"ILAR J."}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1008929","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T13:30:59Z","timestamp":1669037459000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1008929"}},"subtitle":[],"editor":[{"given":"Padmini","family":"Salgame","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":71,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1008929","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2019.12.13.876300","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]}}}